基于对肠道菌群调节探讨大黄醒脑开窍机制
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摘要
在中医经典中,大黄时常被用于治疗大便不通、实火头痛、癫狂惊悸等疾病,具有泄下攻积、醒脑开窍等功效。现代研究发现,大黄不光能影响肠道菌群结构,还对阿尔茨海默病、帕金森病、抑郁症、焦虑症、脑卒中等中枢神经及精神类疾病均有改善作用。值得注意的是,上述疾病同样与肠道菌群存在密切联系。故依据二者相关性推测,大黄可能通过影响肠道菌群的调节实现醒脑开窍的治疗目的。
In traditional Chinese medicine classics,rhubarb is often used to treat difficult defecation,headache due to real fire,palpitation and other diseases,with the effect of purging,opening and resuscitation. Modern studies have found that rhubarb not only affects intestinal flora,but also improves central nervous and mental disorders such as Alzheimer's disease,Parkinson's disease,depression,anxiety disorder,stroke and so on. Interestingly,these diseases are also closely related to the intestinal flora.Therefore,according to the correlation between the two,rhubarb may influence the regulation of intestinal flora to achieve the purpose of resuscitation.
In traditional Chinese medicine classics,rhubarb is often used to treat difficult defecation,headache due to real fire,palpitation and other diseases,with the effect of purging,opening and resuscitation. Modern studies have found that rhubarb not only affects intestinal flora,but also improves central nervous and mental disorders such as Alzheimer's disease,Parkinson's disease,depression,anxiety disorder,stroke and so on. Interestingly,these diseases are also closely related to the intestinal flora.Therefore,according to the correlation between the two,rhubarb may influence the regulation of intestinal flora to achieve the purpose of resuscitation.
引文
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[7]吴云,陈瑞,田维毅.苦寒中药对肠道菌群结构影响的研究进展[J].中国微生态学杂志,2015,27(2):235-239.
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[28] Scheperjans F,Aho V,Pereira P A B,et al. Gut microbiota are related to Parkinson's disease and clinical phenotype[J]. Movement Disorders,2015,30(3):350-358.
[29]周瑜,吕俊兰,袁海龙,等.中药大黄对便秘大鼠日服用次数合理性的初步研究[J].世界科学技术(中医药现代化),2011,13(3):518-522.
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[31]王霞,孟敏,吴玉琼,等.大黄素固相脂质纳米粒对大鼠帕金森模型的治疗效果[J].临床荟萃,2017,32(9):782-786.
[32] Wong M L,Inserra A,Lewis M D,et al. Inflammasome signaling affects anxiety-and depressive-like behavior and gut microbiome composition[J]. Molecular Psychiatry,2016,21(6):797-805.
[33] Bercik P,Denou E,Collins J,et al. The intestinal microbiota affect central levels of brain-derived neurotropic factor and behavior in mice.[J]. Gastroenterology,2011,141(2):599-609.
[34] Messaoudi M,Lalonde R,Violle N,et al. Assessment of psychotropic-like properties of a probiotic formulation(Lactobacillus helveticus R0052 and Bifidobacterium longum R0175)in rats and human subjects.[J]. British Journal of Nutrition,2011,105(5):755-764.
[35]周红伟,张惠实,朱宏飞,等.大黄素对大鼠抑郁症行为学变化和脑内单胺类神经递质的影响[J].华中科技大学学报(医学版),2017,46(2):150-154.
[36]童妍,郝安辉,李坤伦,等.大黄素甲醚对抑郁大鼠海马ERK、c AMP、CaMK的影响[J].中药药理与临床,2016,32(2):73-76.
[37]游超,尹恝.缺血性卒中与肠道菌群研究进展[J].临床荟萃,2018(3):194-198.
[38] Pevsner-Fischer M,Blacher E,Tatirovsky E,et al. The gut microbiome and hypertension[J]. Current Opinion in Nephrology&Hypertension,2017,26(1):1-8.
[39] Everard A,Lazarevic V,Derrien M,et al. Responses of gut microbiota and glucose and lipid metabolism to prebiotics in genetic obese and diet-induced leptin-resistant mice[J]. Diabetes,2011,60(11):2775-2786.
[40] Le C E,Nielsen T,Qin J,et al. Richness of human gut microbiome correlates with metabolic markers.[J]. Nature,2013,500(7464):541-546.
[41]房亚兰,罗玉敏,赵咏梅.大黄对缺血性脑血管病的保护作用及机制研究[J].首都医科大学学报,2015,36(5):718-722.
[42]陈俊红,陈俊荣,牟兆新,等.酒大黄对动脉粥样硬化兔血脂和NO及主动脉i NOS表达的影响[J].中国实验方剂学杂志,2011,17(6):160-164.
[43]周丽嫦,徐艳燕,陈伟标,等.大黄素改善肥胖型2型糖尿病小鼠糖脂代谢的实验研究[J].中药材,2012,35(9):1487-1490.
[44]潘海珍.单味大黄治疗缺血性脑中风的临床疗效观察[J].中国医药指南,2013,11(32):515-516.
[2]覃佩兰,成泽东.基于脑肠轴学说探讨针灸对肠道菌群调节的思考[J].时珍国医国药,2015,26(11):2712-2714.
[3] Clarke G,Grenham S,Scully P,et al. The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner[J]. Molecular Psychiatry,2013,18(6):666-673.
[4]詹红丽,王雯.肠道菌群影响大脑途径的研究进展[J].胃肠病学,2017,22(9):572-574.
[5]容悦莹,冯素香,吴纯伟,等.大黄化学成分的药动学及其代谢的研究进展[J].中国实验方剂学杂志,2016,22(10):199-203.
[6]谭玉柱,童婷婷,赵高琼,等.基于一测多评法对大黄地上部位提取物的质量控制研究[J].中草药,2013,44(9):1190-1194.
[7]吴云,陈瑞,田维毅.苦寒中药对肠道菌群结构影响的研究进展[J].中国微生态学杂志,2015,27(2):235-239.
[8]王金轩.大黄对急性闭合性颅脑损伤患者肠道菌群的影响[J].山东中医杂志,2009,28(1):25-26.
[9]何群,张冉,沈凤燕,等.早期生大黄治疗对重度颅脑损伤患者TNF-α、IL-6含量的变化与临床意义[J].中华中医药学刊,2011,29(5):1186-1187.
[10]邹川,吴禹池,罗丽,等.中药大黄复方灌肠对慢性肾脏病5期(非透析)肠道菌群和肠道屏障功能影响的临床研究[J].辽宁中医杂志,2012,39(7):1309-1311.
[11]翟璐,高巧营.大黄调控肠道水通道蛋白对脓毒症大鼠肠道菌群的影响[J].中国实验方剂学杂志,2016,22(3):127-131.
[12]李丹,任爱民,王红,等.中药复方通腑颗粒对抗生素相关性肠炎大鼠肠黏膜微生态屏障损伤的保护作用[J].首都医科大学学报,2012,33(3):315-321.
[13]王瑞风,雷海燕,臧璞,等.大黄酸对糖尿病小鼠肠道菌群影响的初步研究[J].中国微生态学杂志,2016,28(1):21-24+46.
[14]李瑞生,李晓娟,王仲霞,等.桃核承气汤对肝性脑病大鼠肠道菌群的影响分析[J].实验动物科学,2016,33(4):63-66.
[15]王文建,郑跃杰.肠道菌群与中枢神经系统相互作用及相关疾病[J].中国微生态学杂志,2016,28(2):240-245.
[16]周珂新,徐雷艇,马银娟,等.阿尔茨海默病与肠道菌群的关系及菌群调节对其防治的展望[J].中国药理学与毒理学杂志,2016,30(11):1198-1205.
[17]杨璐,李庆华,许玲,等.粪菌移植对阿尔茨海默病小鼠学习记忆能力的影响[J].郑州大学学报(医学版),2017,52(6):702-706.
[18]马丽娜,刘剑刚,李浩.肠道微生物与阿尔茨海默病的相关性研究进展[J].中国药理学通报,2017,33(7):893-896.
[19] Friedland R P. Mechanisms of molecular mimicry involving the microbiota in neurodegeneration[J]. Journal of Alzheimers Disease,2015,45(2):349-362.
[20]张静,史宏,刘美莲,等.茵陈五苓散对阿尔茨海默病模型小鼠学习记忆及脑组织抗氧化能力的影响[J].贵阳中医学院学报,2009,31(2):31-33.
[21]刘涛,胡海涛.大黄素抗Aβ25-35诱导原代大鼠皮层细胞氧化应激损伤的机制[J].中国老年学杂志,2013,33(18):4475-4478.
[22]陶莉,王诗,谢剑梅,等.芦荟大黄素对痴呆小鼠学习记忆功能的改善研究[J].现代食品科技,2014,30(12):7-10,29.
[23]董晓华,张力,张丹参,等.大黄酚对Aβ25-35致阿尔茨海默氏病模型小鼠学习记忆障碍及脑内谷氨酸含量的影响[J].河北北方学院学报(医学版),2010,27(2):1-3.
[24]薛占霞,高永山,沈丽霞,等.大黄酚通过抗氧化应激改善高血氨小鼠学习记忆功能障碍[J].中国药理学通报,2015,31(9):1330-1331.
[25]严贵亮,张丹参.大黄酚联合多奈哌齐对阿尔茨海默病模型大鼠的防治作用[J].中国实验方剂学杂志,2014,20(24):151-154.
[26]李林,张博爱.帕金森病患者便秘的研究进展[J].中国神经精神疾病杂志,2011,37(1):60-61.
[27] Svensson E,Horváth‐PuhóE,Thomsen R W,et al. Vagotomy and subsequent risk of Parkinson's disease[J]. Annals of Neurology,2015,78(4):522-529.
[28] Scheperjans F,Aho V,Pereira P A B,et al. Gut microbiota are related to Parkinson's disease and clinical phenotype[J]. Movement Disorders,2015,30(3):350-358.
[29]周瑜,吕俊兰,袁海龙,等.中药大黄对便秘大鼠日服用次数合理性的初步研究[J].世界科学技术(中医药现代化),2011,13(3):518-522.
[30]范玉珍,谢阳春,林毅.大黄粉贴敷神阙穴对帕金森病功能性便秘的疗效观察[J].中药药理与临床,2015,31(2):173-174.
[31]王霞,孟敏,吴玉琼,等.大黄素固相脂质纳米粒对大鼠帕金森模型的治疗效果[J].临床荟萃,2017,32(9):782-786.
[32] Wong M L,Inserra A,Lewis M D,et al. Inflammasome signaling affects anxiety-and depressive-like behavior and gut microbiome composition[J]. Molecular Psychiatry,2016,21(6):797-805.
[33] Bercik P,Denou E,Collins J,et al. The intestinal microbiota affect central levels of brain-derived neurotropic factor and behavior in mice.[J]. Gastroenterology,2011,141(2):599-609.
[34] Messaoudi M,Lalonde R,Violle N,et al. Assessment of psychotropic-like properties of a probiotic formulation(Lactobacillus helveticus R0052 and Bifidobacterium longum R0175)in rats and human subjects.[J]. British Journal of Nutrition,2011,105(5):755-764.
[35]周红伟,张惠实,朱宏飞,等.大黄素对大鼠抑郁症行为学变化和脑内单胺类神经递质的影响[J].华中科技大学学报(医学版),2017,46(2):150-154.
[36]童妍,郝安辉,李坤伦,等.大黄素甲醚对抑郁大鼠海马ERK、c AMP、CaMK的影响[J].中药药理与临床,2016,32(2):73-76.
[37]游超,尹恝.缺血性卒中与肠道菌群研究进展[J].临床荟萃,2018(3):194-198.
[38] Pevsner-Fischer M,Blacher E,Tatirovsky E,et al. The gut microbiome and hypertension[J]. Current Opinion in Nephrology&Hypertension,2017,26(1):1-8.
[39] Everard A,Lazarevic V,Derrien M,et al. Responses of gut microbiota and glucose and lipid metabolism to prebiotics in genetic obese and diet-induced leptin-resistant mice[J]. Diabetes,2011,60(11):2775-2786.
[40] Le C E,Nielsen T,Qin J,et al. Richness of human gut microbiome correlates with metabolic markers.[J]. Nature,2013,500(7464):541-546.
[41]房亚兰,罗玉敏,赵咏梅.大黄对缺血性脑血管病的保护作用及机制研究[J].首都医科大学学报,2015,36(5):718-722.
[42]陈俊红,陈俊荣,牟兆新,等.酒大黄对动脉粥样硬化兔血脂和NO及主动脉i NOS表达的影响[J].中国实验方剂学杂志,2011,17(6):160-164.
[43]周丽嫦,徐艳燕,陈伟标,等.大黄素改善肥胖型2型糖尿病小鼠糖脂代谢的实验研究[J].中药材,2012,35(9):1487-1490.
[44]潘海珍.单味大黄治疗缺血性脑中风的临床疗效观察[J].中国医药指南,2013,11(32):515-516.