补骨脂素的植物雌激素样作用研究进展
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摘要
补骨脂素是自中药补骨脂中提取的有效活性成分之一。研究发现补骨脂素具有雌激素样作用,能对雌激素受体起到一定调节作用。补骨脂素可以发挥抗肿瘤、抗骨质疏松、抗氧化和保护心血管等植物雌激素样作用。该文就补骨脂素的植物雌激素样作用研究进展作一综述。
Psoralen is one of the effective ingredients extracted from Chinese herbal medicine Psoralea corylifolia. Studies have found that psoralen has an estrogenic effect and can regulate the estrogen receptor. Psoralen can exert phytoestrogenic effects such as anti-tumor, anti-osteoporosis, anti-oxidation and protection of cardiovascular. This article reviewed the research progress of phytoestrogenic effects of psoralen.
Psoralen is one of the effective ingredients extracted from Chinese herbal medicine Psoralea corylifolia. Studies have found that psoralen has an estrogenic effect and can regulate the estrogen receptor. Psoralen can exert phytoestrogenic effects such as anti-tumor, anti-osteoporosis, anti-oxidation and protection of cardiovascular. This article reviewed the research progress of phytoestrogenic effects of psoralen.
引文
[1]Zhang X,Zhao W,Wang Y,et al.The chemical constituents and bioactivities of psoralea corylifolia Linn:a review[J].Am J Chin Med,2016,44(1):35-60.
[2]赵丕文,王大伟,王玲巧,等.用小鼠子宫增重法筛选淫羊藿等10种中药雌激素样作用的实验研究[J].北京中医药大学学报,2006,29(10):686-689.
[3]赵丕文.十种中药植物雌激素样作用及其机制的研究[D].北京:北京中医药大学,2007.
[4]May FE.Novel drugs that target the estrogen-related receptorα:their therapeutic potential in breast cancer[J].Cancer Manag Res,2014,6:225-252.
[5]Sirotkin AV,Harrath AH.Phytoestrogens and their effects[J].Eur J Pharmacol,2014,741:230-236.
[6]Vrta?nik P,Ostanek B,Mencej-Bedra?S,et al.The many faces of estrogen signaling[J].Biochem Med(Zagreb),2014,24(3):329-342.
[7]沈丽霞,赵丕文,牛建昭,等.补骨脂素对人类乳腺癌细胞增殖作用的影响[J].中国药理学通报,2007(11):1448-1451.
[8]赵丕文,牛建昭,王继峰,等.补骨脂素的植物雌激素作用及其机制探讨[J].中国中药杂志,2008,33(1):59-63.
[9]章文娟,谢保平,李伟娟,等.补骨脂素抑制破骨细胞形成及其机制的实验研究[J].第三军医大学学报,2017,39(7):641-645.
[10]杨琳,曾英,李劲平,等.补骨脂素对去势雌鼠E2、ERβ、TNF-α、IL-17的影响[J].中国骨质疏松杂志,2016,22(4):387-392.
[11]石书芳,俞超芹.植物雌激素及其作用靶点的研究进展[J].中西医结合学报,2005,3(5):78-80.
[12]Katzenellenbogen BS.Antiestrogen resistance:mechanisms by which breast cancer cells undermine the effectiveness of endocrine therapy[J].J Natl Cancer Inst,1991,83(20):1434-1435.
[13]Miller TW,Balko JM,Arteaga CL.Phosphatidylinositol 3-kinase and antiestrogen resistance in breast cancer[J].J Clin Oncol,2011,29(33):4452-4461.
[14]Herynk MH,Fuqua SA.Estrogen receptors in resistance to hormone therapy[J].Adv Exp Med Biol,2007,608(1):130-143.
[15]Chang M.Tamoxifen resistance in breast cancer[J].Biomol Ther(Seoul),2012,20(3):256-267.
[16]Panno ML,Giordano F.Effects of psoralens as anti-tumoral agents in breast cancer cells[J].World J Clin Oncol,2014,5(3):348-358.
[17]谭敏,孙静,宾晓农,等.补骨脂素对乳腺癌MCF-7细胞的体外抗肿瘤作用[J].广东医学,2008,29(11):1817-1819.
[18]Wu C,Sun Z,Ye Y,et al.Psoralen inhibits bone metastasis of breast cancer in mice[J].Fitoterapia,2013,91:205-210.
[19]陈书尚,翁铭芳,王水良,等.补骨脂素对前列腺癌LNCap-AD细胞增殖的影响及其分子机制研究[J].中华细胞与干细胞杂志(电子版),2017,7(4):219-223.
[20]Pravettoni A,Mornati O,Martini PG,et al.Estrogen receptorβ(ERβ)and inhibition of prostate cancer cell proliferation:studies on the possible mechanism of action in DU145 cells[J].Mol Cell Endocrinol,2007,263(1/2):46-54.
[21]李少鹏,蔡建通,翁铭芳,等.补骨脂素对前列腺癌LNCaP-AI细胞增殖和周期调控及雌激素受体β表达的影响[J].中华细胞与干细胞杂志(电子版),2018,8(1):1-5.
[22]谭敏,孙静,赵虹,等.补骨脂素对乳腺癌MCF-7和MDA-MB-231细胞体外作用的比较研究[J].广州中医药大学学报,2009,26(4):359-362.
[23]谭敏,宾晓农,肖刚,等.补骨脂素对乳腺癌MCF-7细胞基因表达谱的影响[J].肿瘤防治研究,2009,36(12):1008-1012.
[24]Wang X,Cheng K,Han Y,et al.Effects of psoralen as an anti-tumor agent in human breast cancer MCF-7/ADR cells[J].Biol Pharm Bull,2016,39(5):815-822.
[25]Szakács G,Paterson JK,Ludwig JA,et al.Targeting multidrug resistance in cancer[J].Nat Rev Drug Discov,2006,5(3):219-234.
[26]Hsieh MJ,Chen MK,Yu YY,et al.Psoralen reverses docetaxel-induced multidrug resistance in A549/D16 human lung cancer cells lines[J].Phytomedicine,2014,21(7):970-977.
[27]蔡宇,陈冰,张凤海,等.补骨脂素对人乳腺癌多药耐药Bcl-2基因蛋白表达的影响[J].中药材,2004,27(11):855-856.
[28]赵益业,蔡宇.补骨脂素逆转人乳腺癌耐药细胞株MCF-7多药耐药性研究[J].中华中医药杂志,2006,21(6):370-371.
[29]蔡天革,蔡宇,余绍蕾,等.补骨脂素对MCF-7/ADR耐药细胞内ADR及Ca2+浓度的影响[J].航天医学与医学工程,2007,20(5):313-316.
[30]Gennari L,Rotatori S,Bianciardi S,et al.Treatment needs and current options for postmenopausal osteoporosis[J].Expert Opin Pharmacother,2016,17(8):1141-1152.
[31]黄奎,邹季.补骨脂素对骨质疏松小鼠骨代谢指标和生物力学的影响[J].生物骨科材料与临床研究,2017,14(6):11-13.
[32]Yuan X,Bi Y,Yan Z,et al.Psoralen and isopsoralen ameliorate sex hormone deficiency-induced osteoporosis in female and male mice[J].Biomed Res Int,2016,2016:6869452.
[33]王建华,王艳,潘永梅.补骨脂素对大鼠成骨细胞增殖与分化的影响[J].天然产物研究与开发,2007,19(5):844-846.
[34]邢贞武.补骨脂素对绝经后骨质疏松患者骨髓间充质干细胞Notch信号通路的影响[J].中医学报,2017,32(11):2181-2184.
[35]Yang Z,Huang JH,Liu SF,et al.The osteoprotective effect of psoralen in ovariectomy-induced osteoporotic rats via stimulating the osteoblastic differentiation from bone mesenchymal stem cells[J].Menopause,2012,19(10):1156-1164.
[36]卞琴,刘书芬,黄建华,等.3种补肾中药有效成分对去卵巢骨质疏松大鼠骨髓间充质干细胞的调控作用[J].中华中医药杂志,2011,26(5):889-893.
[37]Tang DZ,Yang F,Yang Z,et al.Psoralen stimulates osteoblast differentiation through activation of BMP signaling[J].Biochem Biophys Res Commun,2011,405(2):256-261.
[38]Li F,Li Q,Huang X,et al.Psoralen stimulates osteoblast proliferation through the activation of nuclear factor-κB-mitogen-activated protein kinase signaling[J].Exp Ther Med,2017,14(3):2385-2391.
[39]王建华,郭敏,郑丽,等.补骨脂素干预大鼠成骨细胞骨保护素/核因子κB受体激活因子配体mRNA的表达[J].中国组织工程研究与临床康复,2010,14(37):6927-6930.
[40]Guo J,Weng X,Wu H,et al.Antioxidants from a Chinese medicinal herb:Psoralea corylifolia L.[J].Food Chem,2005,91(2):287-292.
[41]Menazza S,Murphy E.The expanding complexity of estrogen receptor signaling in the cardiovascular system[J].Circ Res,2016,118(6):994-1007.
[42]钟佩茹,高秀梅,陈彤,等.补骨脂素对人脐静脉内皮细胞活力及TNF-α诱导组织因子产生的影响[J].辽宁中医杂志,2012,39(11):2247-2249.
[2]赵丕文,王大伟,王玲巧,等.用小鼠子宫增重法筛选淫羊藿等10种中药雌激素样作用的实验研究[J].北京中医药大学学报,2006,29(10):686-689.
[3]赵丕文.十种中药植物雌激素样作用及其机制的研究[D].北京:北京中医药大学,2007.
[4]May FE.Novel drugs that target the estrogen-related receptorα:their therapeutic potential in breast cancer[J].Cancer Manag Res,2014,6:225-252.
[5]Sirotkin AV,Harrath AH.Phytoestrogens and their effects[J].Eur J Pharmacol,2014,741:230-236.
[6]Vrta?nik P,Ostanek B,Mencej-Bedra?S,et al.The many faces of estrogen signaling[J].Biochem Med(Zagreb),2014,24(3):329-342.
[7]沈丽霞,赵丕文,牛建昭,等.补骨脂素对人类乳腺癌细胞增殖作用的影响[J].中国药理学通报,2007(11):1448-1451.
[8]赵丕文,牛建昭,王继峰,等.补骨脂素的植物雌激素作用及其机制探讨[J].中国中药杂志,2008,33(1):59-63.
[9]章文娟,谢保平,李伟娟,等.补骨脂素抑制破骨细胞形成及其机制的实验研究[J].第三军医大学学报,2017,39(7):641-645.
[10]杨琳,曾英,李劲平,等.补骨脂素对去势雌鼠E2、ERβ、TNF-α、IL-17的影响[J].中国骨质疏松杂志,2016,22(4):387-392.
[11]石书芳,俞超芹.植物雌激素及其作用靶点的研究进展[J].中西医结合学报,2005,3(5):78-80.
[12]Katzenellenbogen BS.Antiestrogen resistance:mechanisms by which breast cancer cells undermine the effectiveness of endocrine therapy[J].J Natl Cancer Inst,1991,83(20):1434-1435.
[13]Miller TW,Balko JM,Arteaga CL.Phosphatidylinositol 3-kinase and antiestrogen resistance in breast cancer[J].J Clin Oncol,2011,29(33):4452-4461.
[14]Herynk MH,Fuqua SA.Estrogen receptors in resistance to hormone therapy[J].Adv Exp Med Biol,2007,608(1):130-143.
[15]Chang M.Tamoxifen resistance in breast cancer[J].Biomol Ther(Seoul),2012,20(3):256-267.
[16]Panno ML,Giordano F.Effects of psoralens as anti-tumoral agents in breast cancer cells[J].World J Clin Oncol,2014,5(3):348-358.
[17]谭敏,孙静,宾晓农,等.补骨脂素对乳腺癌MCF-7细胞的体外抗肿瘤作用[J].广东医学,2008,29(11):1817-1819.
[18]Wu C,Sun Z,Ye Y,et al.Psoralen inhibits bone metastasis of breast cancer in mice[J].Fitoterapia,2013,91:205-210.
[19]陈书尚,翁铭芳,王水良,等.补骨脂素对前列腺癌LNCap-AD细胞增殖的影响及其分子机制研究[J].中华细胞与干细胞杂志(电子版),2017,7(4):219-223.
[20]Pravettoni A,Mornati O,Martini PG,et al.Estrogen receptorβ(ERβ)and inhibition of prostate cancer cell proliferation:studies on the possible mechanism of action in DU145 cells[J].Mol Cell Endocrinol,2007,263(1/2):46-54.
[21]李少鹏,蔡建通,翁铭芳,等.补骨脂素对前列腺癌LNCaP-AI细胞增殖和周期调控及雌激素受体β表达的影响[J].中华细胞与干细胞杂志(电子版),2018,8(1):1-5.
[22]谭敏,孙静,赵虹,等.补骨脂素对乳腺癌MCF-7和MDA-MB-231细胞体外作用的比较研究[J].广州中医药大学学报,2009,26(4):359-362.
[23]谭敏,宾晓农,肖刚,等.补骨脂素对乳腺癌MCF-7细胞基因表达谱的影响[J].肿瘤防治研究,2009,36(12):1008-1012.
[24]Wang X,Cheng K,Han Y,et al.Effects of psoralen as an anti-tumor agent in human breast cancer MCF-7/ADR cells[J].Biol Pharm Bull,2016,39(5):815-822.
[25]Szakács G,Paterson JK,Ludwig JA,et al.Targeting multidrug resistance in cancer[J].Nat Rev Drug Discov,2006,5(3):219-234.
[26]Hsieh MJ,Chen MK,Yu YY,et al.Psoralen reverses docetaxel-induced multidrug resistance in A549/D16 human lung cancer cells lines[J].Phytomedicine,2014,21(7):970-977.
[27]蔡宇,陈冰,张凤海,等.补骨脂素对人乳腺癌多药耐药Bcl-2基因蛋白表达的影响[J].中药材,2004,27(11):855-856.
[28]赵益业,蔡宇.补骨脂素逆转人乳腺癌耐药细胞株MCF-7多药耐药性研究[J].中华中医药杂志,2006,21(6):370-371.
[29]蔡天革,蔡宇,余绍蕾,等.补骨脂素对MCF-7/ADR耐药细胞内ADR及Ca2+浓度的影响[J].航天医学与医学工程,2007,20(5):313-316.
[30]Gennari L,Rotatori S,Bianciardi S,et al.Treatment needs and current options for postmenopausal osteoporosis[J].Expert Opin Pharmacother,2016,17(8):1141-1152.
[31]黄奎,邹季.补骨脂素对骨质疏松小鼠骨代谢指标和生物力学的影响[J].生物骨科材料与临床研究,2017,14(6):11-13.
[32]Yuan X,Bi Y,Yan Z,et al.Psoralen and isopsoralen ameliorate sex hormone deficiency-induced osteoporosis in female and male mice[J].Biomed Res Int,2016,2016:6869452.
[33]王建华,王艳,潘永梅.补骨脂素对大鼠成骨细胞增殖与分化的影响[J].天然产物研究与开发,2007,19(5):844-846.
[34]邢贞武.补骨脂素对绝经后骨质疏松患者骨髓间充质干细胞Notch信号通路的影响[J].中医学报,2017,32(11):2181-2184.
[35]Yang Z,Huang JH,Liu SF,et al.The osteoprotective effect of psoralen in ovariectomy-induced osteoporotic rats via stimulating the osteoblastic differentiation from bone mesenchymal stem cells[J].Menopause,2012,19(10):1156-1164.
[36]卞琴,刘书芬,黄建华,等.3种补肾中药有效成分对去卵巢骨质疏松大鼠骨髓间充质干细胞的调控作用[J].中华中医药杂志,2011,26(5):889-893.
[37]Tang DZ,Yang F,Yang Z,et al.Psoralen stimulates osteoblast differentiation through activation of BMP signaling[J].Biochem Biophys Res Commun,2011,405(2):256-261.
[38]Li F,Li Q,Huang X,et al.Psoralen stimulates osteoblast proliferation through the activation of nuclear factor-κB-mitogen-activated protein kinase signaling[J].Exp Ther Med,2017,14(3):2385-2391.
[39]王建华,郭敏,郑丽,等.补骨脂素干预大鼠成骨细胞骨保护素/核因子κB受体激活因子配体mRNA的表达[J].中国组织工程研究与临床康复,2010,14(37):6927-6930.
[40]Guo J,Weng X,Wu H,et al.Antioxidants from a Chinese medicinal herb:Psoralea corylifolia L.[J].Food Chem,2005,91(2):287-292.
[41]Menazza S,Murphy E.The expanding complexity of estrogen receptor signaling in the cardiovascular system[J].Circ Res,2016,118(6):994-1007.
[42]钟佩茹,高秀梅,陈彤,等.补骨脂素对人脐静脉内皮细胞活力及TNF-α诱导组织因子产生的影响[J].辽宁中医杂志,2012,39(11):2247-2249.
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