乳腺癌手术中植入氟尿嘧啶植入剂间质化疗疗效分析
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摘要
目的分析乳腺癌手术中植入氟尿嘧啶植入剂的间质化疗疗效。方法依据整群随机抽样的方法回顾性选取河南省商丘市第一人民医院2015年5月至2017年5月收治的乳腺癌患者80例,依据术中植入氟尿嘧啶植入剂与否将这些患者分为植入组(n=40)和未植入组(n=40)。对两组患者的切口愈合情况、不良反应发生情况、局部复发、远处转移、带瘤生存情况进行统计分析。结果两组患者切口均一期愈合,无切口感染,植入组患者的局部复发率、远处转移率、带瘤生存率2. 5%[(1/40)、10. 0%(4/40)、7. 5%(3/40)]均显著低于未植入组[12. 5%(5/40)、17. 5%(7/40)、15. 0%(6/40)](P <0. 05),带瘤生存率15. 0%(6/40)显著高于植入组7. 5%(3/40)(P <0. 05),但两组患者的不良反应发生率[15. 0%(6/40) vs. 12. 5%(5/40)]之间差异无统计学意义(P> 0. 05)。结论乳腺癌手术中植入氟尿嘧啶植入剂间质化疗疗效较未植入显著,同时具有较高的安全性,值得推广应用。
Objective To analyze the efficacy of interstitial chemotherapy with fluorouracil implants in breast cancer surgery. Methods Eighty patients with breast cancer in this hospital during May 2015 to May 2017 in this hospital were selected based on the cluster random sampling method,these patients were divided into implantation group( n = 40) and non-implantation group( n = 40) two groups according to fluorouracil implant implantation or not,the wound healing and adverse reactions,incidences of local recurrence,distant metastasis,survival rates of of these two groups were statistically analyzed. Results The incisions of patients in these two groups were healed,no incision infection,the local recurrence rate,distant metastasis rate and survival rate of implantation group were 2. 5%( 1/40),10%( 4/40) and 7. 5%( 3/40)〗 respectively,and they were significantly lower than those of non-implantation group [12. 5%( 5/40),17. 5%( 7/40),15%( 6/40) ]( P < 0. 05),but the difference in incidence of adverse reactions of these two groups [15. 0%( 6/40) vs. 12. 5%( 5/40) ]was not significant( P > 0. 05). Conclusion Interstitial chemotherapy combined with fluorouracil implant is more effective in treatment of breast cancer than that in non implantation group,at the same time,it has higher safety,hence it is worthy to be popularized.
Objective To analyze the efficacy of interstitial chemotherapy with fluorouracil implants in breast cancer surgery. Methods Eighty patients with breast cancer in this hospital during May 2015 to May 2017 in this hospital were selected based on the cluster random sampling method,these patients were divided into implantation group( n = 40) and non-implantation group( n = 40) two groups according to fluorouracil implant implantation or not,the wound healing and adverse reactions,incidences of local recurrence,distant metastasis,survival rates of of these two groups were statistically analyzed. Results The incisions of patients in these two groups were healed,no incision infection,the local recurrence rate,distant metastasis rate and survival rate of implantation group were 2. 5%( 1/40),10%( 4/40) and 7. 5%( 3/40)〗 respectively,and they were significantly lower than those of non-implantation group [12. 5%( 5/40),17. 5%( 7/40),15%( 6/40) ]( P < 0. 05),but the difference in incidence of adverse reactions of these two groups [15. 0%( 6/40) vs. 12. 5%( 5/40) ]was not significant( P > 0. 05). Conclusion Interstitial chemotherapy combined with fluorouracil implant is more effective in treatment of breast cancer than that in non implantation group,at the same time,it has higher safety,hence it is worthy to be popularized.
引文
[1]师金,梁迪,李道娟,等.全球女性乳腺癌流行情况研究[J].中国肿瘤,2017,26(9):683-690.
[2]刘先领,马宏志.原发灶切除在转移性乳腺癌治疗中的地位[J].医学与哲学,2014,35(8B):19-20,42.
[3]黄锦远,姜杰,曹锡朝,等.胃肠癌术中植入缓释5-氟尿嘧啶的临床效果观察[J].微创医学,2016,11(4):600-601.
[4]钱小英,胡春宏.吉西他滨对乳腺癌细胞凋亡作用及其对Bcl-2、Bax蛋白表达的影响[J].临床和实验医学杂志,2016,15(14):1394-1398.
[5]尹会义,于洋.术中局部植入氟尿嘧啶缓释剂在胃肠道肿瘤治疗中的应用体会[J].现代诊断与治疗,2015,26(3):579-580.
[6]邱喆夫,关山,李新宇,等.中人氟安植入剂在乳腺癌手术中的应用[J].中国肿瘤临床与康复,2012,19(3):271-273.
[7]王强,竺达毅.结肠癌根治术中植入氟尿嘧啶缓释剂的远期效果观察[J].中国乡村医药,2017,24(15):8-9.
[8]粟劲松,郭力维.缓释氟尿嘧啶在原发性肝癌术中植入的应用效果观察[J].肝脏,2017,22(2):156-158.
[9]Ahn SG,Bae SJ,Yoon C,et al.Chemosensitivity to doxorubicin of ER-positive/HER2-negative breast cancers with high 21-gene recurrence score:A study based on in vitro chemoresponse assay[J].PLo SOne,2017,12(11):e0187679.
[10]Moreno AC,Lin YH,Bedrosian I,et al.Use of regional nodal irradiation and its association with survival for women with high-risk,early stage breast cancer:A National Cancer Database analysis[J].Adv Radiat Oncol,2017,2(3):291-300.
[2]刘先领,马宏志.原发灶切除在转移性乳腺癌治疗中的地位[J].医学与哲学,2014,35(8B):19-20,42.
[3]黄锦远,姜杰,曹锡朝,等.胃肠癌术中植入缓释5-氟尿嘧啶的临床效果观察[J].微创医学,2016,11(4):600-601.
[4]钱小英,胡春宏.吉西他滨对乳腺癌细胞凋亡作用及其对Bcl-2、Bax蛋白表达的影响[J].临床和实验医学杂志,2016,15(14):1394-1398.
[5]尹会义,于洋.术中局部植入氟尿嘧啶缓释剂在胃肠道肿瘤治疗中的应用体会[J].现代诊断与治疗,2015,26(3):579-580.
[6]邱喆夫,关山,李新宇,等.中人氟安植入剂在乳腺癌手术中的应用[J].中国肿瘤临床与康复,2012,19(3):271-273.
[7]王强,竺达毅.结肠癌根治术中植入氟尿嘧啶缓释剂的远期效果观察[J].中国乡村医药,2017,24(15):8-9.
[8]粟劲松,郭力维.缓释氟尿嘧啶在原发性肝癌术中植入的应用效果观察[J].肝脏,2017,22(2):156-158.
[9]Ahn SG,Bae SJ,Yoon C,et al.Chemosensitivity to doxorubicin of ER-positive/HER2-negative breast cancers with high 21-gene recurrence score:A study based on in vitro chemoresponse assay[J].PLo SOne,2017,12(11):e0187679.
[10]Moreno AC,Lin YH,Bedrosian I,et al.Use of regional nodal irradiation and its association with survival for women with high-risk,early stage breast cancer:A National Cancer Database analysis[J].Adv Radiat Oncol,2017,2(3):291-300.