脑胶质瘤多柔比星脑间质化疗有效性的回顾性分析
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摘要
目的:探讨脑胶质瘤术后用多柔比星进行间质化疗的有效性。方法:回顾性分析我院127例脑胶质瘤患者的临床资料及治疗结局,分别从Ki67、WHO分级、手术切除程度探讨脑胶质瘤术后不同辅助治疗下患者肿瘤进展时间(time to progression,TTP)、随访时总生存时间(overall survival,OS)的差异性。结果:Ki67≥10%、WHOⅢ~Ⅳ、手术全切组中行间质化疗较没有行间质化疗患者术后生存时间长。结论:术后用多柔比星进行脑间质化疗是一种有效的辅助治疗方式,可以延长Ki67≥10%、WHOⅢ~Ⅳ、手术全切患者的生存时间,降低病死率。
Objective : To evaluate the effectiveness of glioma treated by local chemotherapy with doxorubicin after operation. Methods: We collected the clinical data and clinical outcome of 127 glioma patients treated inour hospital. time to progression(TTP) and overall survival(OS)were fully analyzed of Ki67, the WHO classification and surgical removal of the degree. Results: In the groups of Ki67 ≥ 10%, WHOⅢ ~ Ⅳ,grossly total tumor resection, overall survival of patients treated by local chemotherapy with doxorubicin was longer than on lacal chemotherapy. Conclusion: Local chemotherapy with doxorubicin is an effective method and could reduce the death rate and extend the living time in the groups of Ki67≥ 10%, WHOⅢ~Ⅳ, grossly total tumor resection.
Objective : To evaluate the effectiveness of glioma treated by local chemotherapy with doxorubicin after operation. Methods: We collected the clinical data and clinical outcome of 127 glioma patients treated inour hospital. time to progression(TTP) and overall survival(OS)were fully analyzed of Ki67, the WHO classification and surgical removal of the degree. Results: In the groups of Ki67 ≥ 10%, WHOⅢ ~ Ⅳ,grossly total tumor resection, overall survival of patients treated by local chemotherapy with doxorubicin was longer than on lacal chemotherapy. Conclusion: Local chemotherapy with doxorubicin is an effective method and could reduce the death rate and extend the living time in the groups of Ki67≥ 10%, WHOⅢ~Ⅳ, grossly total tumor resection.
引文
[1]Rosenfeld M R,Pruitt A A.Management of malignant gliomas and primary CNS lymphoma:standard of care and future directions[J].Continuum(Minneap Minn),2012,18(2):406-415.
[2]郑翔,吴浩.Ommaya囊在恶性脑胶质瘤局部化疗中的临床应用研究[J].吉林医学,2013,34(32):6762-6763.
[3]林清,俞静,姚原,等.小剂量阿霉素联合放疗治疗人脑多形性胶质母细胞瘤的初步研究[J].实用诊断与治疗杂志,2007,21(6):432-435.
[4]宋宇.手术联合125 I粒子及缓释化疗粒子靶向治疗胶质瘤的临床研究[J].中国肿瘤外科杂志,2013,5(3):189-190.
[5]李贵平,黄凯,杜丽,等.脑胶质瘤病人131I-ch TNT单抗放射免疫治疗的临床初步应用[J].放射免疫学杂志,2010,23(4):361-363.
[6]Del Fabro A,Driul L,Anis O,et al.Gender ratio in recurrent miscarriages[J].Int J Womens Health,2011,3:213-217.
[7]Ohgaki H,Kleihues P.Population-based studies on incidence,survival rates,and genetic alterations in astrocytic and oligodendroglial gliomas[J].J Neuropathol Exp Neurol,2005,64:479-489.
[8]Horowitz P M,Chi J.Adult low-grade gliomas:surgery vs biopsy[J].Neurosurgery,2013,72:49.
[9]邓航,莫万彬,周晓坤,等.胶质瘤手术患者阿霉素局部化疗的并发症分析[J].山东医药,2010,50(30):11-12.
[2]郑翔,吴浩.Ommaya囊在恶性脑胶质瘤局部化疗中的临床应用研究[J].吉林医学,2013,34(32):6762-6763.
[3]林清,俞静,姚原,等.小剂量阿霉素联合放疗治疗人脑多形性胶质母细胞瘤的初步研究[J].实用诊断与治疗杂志,2007,21(6):432-435.
[4]宋宇.手术联合125 I粒子及缓释化疗粒子靶向治疗胶质瘤的临床研究[J].中国肿瘤外科杂志,2013,5(3):189-190.
[5]李贵平,黄凯,杜丽,等.脑胶质瘤病人131I-ch TNT单抗放射免疫治疗的临床初步应用[J].放射免疫学杂志,2010,23(4):361-363.
[6]Del Fabro A,Driul L,Anis O,et al.Gender ratio in recurrent miscarriages[J].Int J Womens Health,2011,3:213-217.
[7]Ohgaki H,Kleihues P.Population-based studies on incidence,survival rates,and genetic alterations in astrocytic and oligodendroglial gliomas[J].J Neuropathol Exp Neurol,2005,64:479-489.
[8]Horowitz P M,Chi J.Adult low-grade gliomas:surgery vs biopsy[J].Neurosurgery,2013,72:49.
[9]邓航,莫万彬,周晓坤,等.胶质瘤手术患者阿霉素局部化疗的并发症分析[J].山东医药,2010,50(30):11-12.