基于自发性脑神经活动的足三里针刺效应分析
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摘要
目的:基于自发性脑神经活动进一步明确足三里针刺的中枢响应特征及属性。方法:系统检索中英文电子数据库,纳入基于局部一致性(ReHo)算法研究健康人针刺引出中枢响应改变的文献。汇总足三里和/或其他穴位针刺的脑功能影像数据进行SDM元分析,对仅针刺足三里的数据进行亚组分析。进而比较元分析和亚组分析结果的异同,以分辨足三里针刺引起的各效应脑区的广谱性和特异性属性。结果:共收集229篇中文文献和109篇英文文献,根据纳入标准和排除标准,最终对包含235名受试者的11篇论文进行了分析。亚组分析与元分析相同的结果是ReHo升高的左右前扣带回、右尾状核、左额上回、右额中回、右旁中央小叶和ReHo降低的左枕中下回、左右中央前后回;与元分析不同的结果是ReHo升高的右顶下小叶、左额中下回、右小脑后叶、左角回及ReHo降低的右额中上回。结论:健康受试者足三里针刺后引出的中枢响应确有不同属性,其相对广谱性与特异性表现为效应脑区定位的差别和相应的自发性脑神经活动的同步性水平差异两方面。
Objective To determine the attributes of responses of the higher nerve center to acupuncture stimulation of Zusanli(ST36)on the basis of spontaneous brain activity,so as to explore the synchronization level of different brain rejoins after acupuncture.Methods All studies using fMRI to investigate the effect of acupuncture stimulation of ST36 and/or other acupoints on the human brain(at least 10 healthy subjects or patients in one group)published in journals from January of 1995 to January of2018 were searched from databases of CNKI and PubMed by using keywords of acupuncture,electroacupuncture,and resting-state functional magnetic resonance images(rs-fMRI)or regional homogeneity(ReHo).Brain functional image data of acupuncture stimulation of ST36 and/or other acupoints were collected and analyzed with anisotropic effect size-signed differential mapping(AESSDM)software(Meta-analysis),and those of acupuncture of simple ST36 analyzed as a subgroup.Results A total of 229 papers in Chinese and 109 in English were collected.According to our inclusive and exclusive standards,11 papers containing 235 subjects were brought into analysis at last.Meta-analysis of brain image data of acupuncture at ST36 and/or other acupoints(comparison between pre-and post-acupuncture)revealed that the same brain regions(generality)which showed a significant increase in ReHo,are the right and left anterior cingulated gyrus,right caudate,left superior frontal gyrus,right middle frontal gyrus,and the right paracentral lobe,and those which showed a marked decrease of ReHo are the left mid-inferior occipital gyrus,left and right precentral and postcentral gyrus.The brain regions responding to acupuncture at ST36 only(specificity)are the right inferior parietal lobe,left middle inferior gyrus,right posterior lobe of cerebellum,and the left angular gyrus which displayed an increase of ReHo,and the right middle superior frontal gyrus which showed a decrease in ReHo.Conclusion After acupuncturing at ST36,the relative generality and specificity of the central response in healthy subjects reflected as the location of the affected brain regions and the difference in the synchronization level of the corresponding spontaneous brain activities.
Objective To determine the attributes of responses of the higher nerve center to acupuncture stimulation of Zusanli(ST36)on the basis of spontaneous brain activity,so as to explore the synchronization level of different brain rejoins after acupuncture.Methods All studies using fMRI to investigate the effect of acupuncture stimulation of ST36 and/or other acupoints on the human brain(at least 10 healthy subjects or patients in one group)published in journals from January of 1995 to January of2018 were searched from databases of CNKI and PubMed by using keywords of acupuncture,electroacupuncture,and resting-state functional magnetic resonance images(rs-fMRI)or regional homogeneity(ReHo).Brain functional image data of acupuncture stimulation of ST36 and/or other acupoints were collected and analyzed with anisotropic effect size-signed differential mapping(AESSDM)software(Meta-analysis),and those of acupuncture of simple ST36 analyzed as a subgroup.Results A total of 229 papers in Chinese and 109 in English were collected.According to our inclusive and exclusive standards,11 papers containing 235 subjects were brought into analysis at last.Meta-analysis of brain image data of acupuncture at ST36 and/or other acupoints(comparison between pre-and post-acupuncture)revealed that the same brain regions(generality)which showed a significant increase in ReHo,are the right and left anterior cingulated gyrus,right caudate,left superior frontal gyrus,right middle frontal gyrus,and the right paracentral lobe,and those which showed a marked decrease of ReHo are the left mid-inferior occipital gyrus,left and right precentral and postcentral gyrus.The brain regions responding to acupuncture at ST36 only(specificity)are the right inferior parietal lobe,left middle inferior gyrus,right posterior lobe of cerebellum,and the left angular gyrus which displayed an increase of ReHo,and the right middle superior frontal gyrus which showed a decrease in ReHo.Conclusion After acupuncturing at ST36,the relative generality and specificity of the central response in healthy subjects reflected as the location of the affected brain regions and the difference in the synchronization level of the corresponding spontaneous brain activities.
引文
[1]IWABUCHI S,KRISHNADAS R,LI C,et al.Localized connectivity in depression:a meta-analysis of resting state functional imaging studies[J].Neurosci Biobehav Rev,2015,51:77-86.
[2]HUANG W,PACH D,NAPADOW V,et al.Characterizing acupuncture stimuli using brain imaging with fMRI-a systematic review and meta-analysis of the literature[J].PLoSOne,2012,7(4):e32960.
[3]CHAE Y,CHANG D S,LEE S H,et al.Inserting needles into the body:a meta-analysis of brain activity associated with acupuncture needle stimulation[J].J Pain,2013,14(3):215-222.
[4]NAPADOW V,DHOND R,PARK K,et al.Time-variant fMRI activity in the brainstem and higher structures in response to acupuncture[J].Neuroimage,2009,47(1):289-301.
[5]BAI L,QIN W,TIAN J,et al.Time-varied characteristics of acupuncture effects in fMRI studies[J].Hum Brain Mapp,2009,30(11):3445-3460.
[6]JIANG L,XU T,HE Y,et al.Toward neurobiological characterization of functional homogeneity in the human cortex:regional variation,morphological association and functional covariance network organization[J].Brain Struct Funct,2015,220(5):2485-2507.
[7]朱兵.穴位的效应特征:广谱性和特异性[J].针刺研究,2016,41(5):388-388.
[8]HE T,ZHU W,DU S Q,et al.Neural mechanisms of acupuncture as revealed by fMRI studies[J].Auton Neurosci Basic,2015,190:1-9.
[9]RADUA J,MATAIX-COLS D,PHILLIPS M L,et al.Anew meta-analytic method for neuroimaging studies that combines reported peak coordinates and statistical parametric maps[J].Eur Psychiat,2012,27(8):605-611.
[10]段小慧,刘波,陈俊,等.利用局部一致性方法对针刺足三里穴后脑效应的研究[J].中国中西医结合影像学杂志,2012,10(1):10-12.
[11]李腊梅,吕发金,郭仲杰,等.针刺对不同敏感度正常人大脑局部一致性影响差异的功能性磁共振研究[J].针刺研究,2013,38(4):306-313.
[12]钟治平,刘波,吴珊珊,等.足三里穴中枢神经网络作用机制的静息态脑功能磁共振成像研究[J].新中医,2014,46(4):174-177.
[13]刘连生,曾道辉,孟贞贞,等.针刺足三里的静息态脑功能局部一致性研究[J].生物医学工程与临床,2014,18(2):146-149.
[14]吴珊珊,陈俊,刘波,等.针刺足三里穴后续效应的脑功能成像研究[J].广州中医药大学学报,2011,28(1):29-32.
[15]唐劲松,翁国盛,胡建平.基于ReHo方法的针刺合谷穴静息态脑功能磁共振研究[J].福建中医药,2016,47(4):1-3.
[16]WU C,QU S,ZHANG J,et al.Correlation between the effects of acupuncture at Taichong(LR3)and functional brain areas:a resting-state functional magnetic resonance imaging study using true versus sham acupuncture[J].Evid Based Complement Alternat Med,2014,2014:729091.
[17]LIU Z,WEI W,BAI L,et al.Exploring the patterns of acupuncture on mild cognitive impairment patients using regional homogeneity[J].PLoS One,2014,9(6):e99335.
[18]LIU L,WU Y,ZHENG J,et al.Cerebral activation effects of acupuncture using Zusanli(ST36)and Yanglingquan(GB34)points based on regional homogeneity indices:a resting-state fMRI study[J].J X-ray Sci Technol,2016,24(2):297-308.
[19]ZHU B,WANG Y,ZHANG G,et al.Acupuncture at KI3in healthy volunteers induces specific cortical functional activity:an fMRI study[J].BMC Complement Altern Med,2015,15:361.
[20]霍梦娟,张岳,刘波,等.针刺单穴和组穴的fMRI研究[J].放射学实践,2016,31(3):219-223.
[21]HUI K,LIU J,MARINA O,et al.The integrated response of the human cerebro-cerebellar and limbic systems to acupuncture stimulation at ST36as evidenced by fMRI[J].Neuroimage,2005,27(3):479-496.
[22]LIU B,CHEN J,WANG J,et al.Altered small-world efficiency of brain functional networks in acupuncture at ST36:a functional MRI study[J].PLoS One,2012,7(6):e39342.
[23]李春华,徐大钊,刘玉祁,等.近10年国内经穴特异性研究进展[J].针刺研究,2013,38(4):324-329.
[24]REN L,ZHANG W,FANG N,et al.The influence of electro-acupuncture on neural plasticity in acute cerebral infarction[J].Neurol Res,2008,30(9):985-989.
[25]徐晓白,刘璐,赵洛鹏,等.针刺治疗慢性偏头痛神经可塑性影响机制[J].中国针灸,2017,37(10):1134-1140.
[26]赵慧英,牟萍,董岩,等.病理条件下的神经可塑性及在针灸研究中的可能应用[J].针刺研究,2008,33(1):41-46.
[27]LO Y,CUI S,FOOK-CHONG S.The effect of acupuncture on motor cortex excitability and plasticity[J].Neurosci Lett,2005,384(1-2):145-149.
[28]NAPADOWV,LIU J,LI M,et al.Somatosensory cortical plasticity in carpal tunnel syndrome treated by acupuncture[J].Hum Brain Mapp,2007,28(3):159-171.
[29]GUERRA-CARRILLO B,MACKEY A,BUNGE S.Resting-state fMRI:a window into human brain plasticity[J].Neuroscientist,2014,20(5):522-533.
[2]HUANG W,PACH D,NAPADOW V,et al.Characterizing acupuncture stimuli using brain imaging with fMRI-a systematic review and meta-analysis of the literature[J].PLoSOne,2012,7(4):e32960.
[3]CHAE Y,CHANG D S,LEE S H,et al.Inserting needles into the body:a meta-analysis of brain activity associated with acupuncture needle stimulation[J].J Pain,2013,14(3):215-222.
[4]NAPADOW V,DHOND R,PARK K,et al.Time-variant fMRI activity in the brainstem and higher structures in response to acupuncture[J].Neuroimage,2009,47(1):289-301.
[5]BAI L,QIN W,TIAN J,et al.Time-varied characteristics of acupuncture effects in fMRI studies[J].Hum Brain Mapp,2009,30(11):3445-3460.
[6]JIANG L,XU T,HE Y,et al.Toward neurobiological characterization of functional homogeneity in the human cortex:regional variation,morphological association and functional covariance network organization[J].Brain Struct Funct,2015,220(5):2485-2507.
[7]朱兵.穴位的效应特征:广谱性和特异性[J].针刺研究,2016,41(5):388-388.
[8]HE T,ZHU W,DU S Q,et al.Neural mechanisms of acupuncture as revealed by fMRI studies[J].Auton Neurosci Basic,2015,190:1-9.
[9]RADUA J,MATAIX-COLS D,PHILLIPS M L,et al.Anew meta-analytic method for neuroimaging studies that combines reported peak coordinates and statistical parametric maps[J].Eur Psychiat,2012,27(8):605-611.
[10]段小慧,刘波,陈俊,等.利用局部一致性方法对针刺足三里穴后脑效应的研究[J].中国中西医结合影像学杂志,2012,10(1):10-12.
[11]李腊梅,吕发金,郭仲杰,等.针刺对不同敏感度正常人大脑局部一致性影响差异的功能性磁共振研究[J].针刺研究,2013,38(4):306-313.
[12]钟治平,刘波,吴珊珊,等.足三里穴中枢神经网络作用机制的静息态脑功能磁共振成像研究[J].新中医,2014,46(4):174-177.
[13]刘连生,曾道辉,孟贞贞,等.针刺足三里的静息态脑功能局部一致性研究[J].生物医学工程与临床,2014,18(2):146-149.
[14]吴珊珊,陈俊,刘波,等.针刺足三里穴后续效应的脑功能成像研究[J].广州中医药大学学报,2011,28(1):29-32.
[15]唐劲松,翁国盛,胡建平.基于ReHo方法的针刺合谷穴静息态脑功能磁共振研究[J].福建中医药,2016,47(4):1-3.
[16]WU C,QU S,ZHANG J,et al.Correlation between the effects of acupuncture at Taichong(LR3)and functional brain areas:a resting-state functional magnetic resonance imaging study using true versus sham acupuncture[J].Evid Based Complement Alternat Med,2014,2014:729091.
[17]LIU Z,WEI W,BAI L,et al.Exploring the patterns of acupuncture on mild cognitive impairment patients using regional homogeneity[J].PLoS One,2014,9(6):e99335.
[18]LIU L,WU Y,ZHENG J,et al.Cerebral activation effects of acupuncture using Zusanli(ST36)and Yanglingquan(GB34)points based on regional homogeneity indices:a resting-state fMRI study[J].J X-ray Sci Technol,2016,24(2):297-308.
[19]ZHU B,WANG Y,ZHANG G,et al.Acupuncture at KI3in healthy volunteers induces specific cortical functional activity:an fMRI study[J].BMC Complement Altern Med,2015,15:361.
[20]霍梦娟,张岳,刘波,等.针刺单穴和组穴的fMRI研究[J].放射学实践,2016,31(3):219-223.
[21]HUI K,LIU J,MARINA O,et al.The integrated response of the human cerebro-cerebellar and limbic systems to acupuncture stimulation at ST36as evidenced by fMRI[J].Neuroimage,2005,27(3):479-496.
[22]LIU B,CHEN J,WANG J,et al.Altered small-world efficiency of brain functional networks in acupuncture at ST36:a functional MRI study[J].PLoS One,2012,7(6):e39342.
[23]李春华,徐大钊,刘玉祁,等.近10年国内经穴特异性研究进展[J].针刺研究,2013,38(4):324-329.
[24]REN L,ZHANG W,FANG N,et al.The influence of electro-acupuncture on neural plasticity in acute cerebral infarction[J].Neurol Res,2008,30(9):985-989.
[25]徐晓白,刘璐,赵洛鹏,等.针刺治疗慢性偏头痛神经可塑性影响机制[J].中国针灸,2017,37(10):1134-1140.
[26]赵慧英,牟萍,董岩,等.病理条件下的神经可塑性及在针灸研究中的可能应用[J].针刺研究,2008,33(1):41-46.
[27]LO Y,CUI S,FOOK-CHONG S.The effect of acupuncture on motor cortex excitability and plasticity[J].Neurosci Lett,2005,384(1-2):145-149.
[28]NAPADOWV,LIU J,LI M,et al.Somatosensory cortical plasticity in carpal tunnel syndrome treated by acupuncture[J].Hum Brain Mapp,2007,28(3):159-171.
[29]GUERRA-CARRILLO B,MACKEY A,BUNGE S.Resting-state fMRI:a window into human brain plasticity[J].Neuroscientist,2014,20(5):522-533.
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