针刺对失眠大鼠5-HT及其受体、HPA轴相关激素影响的研究进展
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摘要
失眠是指睡眠的始发或维持发生障碍,如何认识和治疗失眠,改善睡眠质量,已成为亟待解决的问题。而研究表明睡眠与HPA轴(下丘脑-垂体-肾上腺轴)相关单胺类神经递质及激素相关。目前,失眠的治疗主要分为药物治疗和非药物治疗两类方面。针灸是治疗失眠重要的非药物治疗方法,与药物治疗相比,具有无不良反应、无依赖性、无成瘾性等优点,且研究表明针刺疗法能够调整中枢神经递质,从而全面治疗失眠。近年来,神经递质5-羟色胺(5-HT)及HPA轴对睡眠的影响也备受研究学者关注。因此,对针刺治疗失眠大鼠对其5-HT及其受体、HPA轴相关激素影响的研究进展进行论述。
Insomnia means the onset or maintenance of sleep disorders. How to understand and treat insomnia to improve sleep quality has become an urgent problem to be solved. And studies have shown that HPA axis( hypothalamus-pituitary-adrenal axis)-related monoamine neurotransmitters and hormones have relations with sleep. Currently,the treatment of insomnia is divided into two major aspects:drug treatment and non-drug therapy. Compared with drug therapy,acupuncture,which has no side-effects,no dependence and no addiction,is an important non-drug treatment of insomnia. What's more,studies have shown that acupuncture therapy can adjust the central neurotransmitter and have a comprehensive treatment of insomnia. Recently,the impacts of the neurotransmitter serotonin(5-HT) and HPA axis on insomnia has also caught scholars attention. Therefore,the research progress of effects of acupuncture treatment on 5-HT,its receptors and HPA-related hormones in rats with insomnia would be discussed in this paper.
Insomnia means the onset or maintenance of sleep disorders. How to understand and treat insomnia to improve sleep quality has become an urgent problem to be solved. And studies have shown that HPA axis( hypothalamus-pituitary-adrenal axis)-related monoamine neurotransmitters and hormones have relations with sleep. Currently,the treatment of insomnia is divided into two major aspects:drug treatment and non-drug therapy. Compared with drug therapy,acupuncture,which has no side-effects,no dependence and no addiction,is an important non-drug treatment of insomnia. What's more,studies have shown that acupuncture therapy can adjust the central neurotransmitter and have a comprehensive treatment of insomnia. Recently,the impacts of the neurotransmitter serotonin(5-HT) and HPA axis on insomnia has also caught scholars attention. Therefore,the research progress of effects of acupuncture treatment on 5-HT,its receptors and HPA-related hormones in rats with insomnia would be discussed in this paper.
引文
[1]中华学会神经病学分会睡眠障碍学组.中国成人失眠诊断与治疗指南[J].中华神经科杂志,2012,45(7):534-540.
[2]苏丹,王晓丽,贾孟辉.回药阿夫忒蒙丸对失眠大鼠下丘脑5-HT和5-HIAA含量的影响[J].中国名族医药杂志,2016(7):54-55.
[3]安雪梅、高红.探讨耳穴贴压联合足浴对肝火扰心型失眠患者5-HT、DA含量的影响及护理[J].中国医药指南,2016(4):102-105.
[4]李红,陈莹.围绝经期非器质性失眠肝郁患者血清5-HT水平、SDS、SAS积分的相关性研究[J].中华中医药杂志,2016(6):58-61.
[5]吴雪芬,郑雪娜,郭鑫,等.针刺干预HPA轴相关激素改善睡眠的研究进展[J].针灸临床杂志,2017(8):69-71.
[6]吴绮雯,诸毅晖,刘萍,等.从睡眠机制探讨神门、三阴交治疗失眠的作用[J].时珍国医国药,2014,25(2):402-403.
[7]周艳丽.针刺不同腧穴对失眠模型大鼠脑内神经递质5-HT、DA影响的实验研究[J].中国中医基础医学杂志,2012,18(8):887-888.
[8]兰妮.失眠大鼠电针后不同时间单胺类和氨基酸类递质的变化[D].广州:暨南大学,2010.
[9]李倩,黄迎华,刘曜纶,等.针刺对应激性胃黏膜损伤大鼠睡眠时间及纹状体中五羟色胺、多巴胺含量的影响[J].中国中医药信息杂志,2015,22(5):48-51.
[10]杨波,岳明.酸枣仁汤对睡眠剥夺大鼠认知功能及海马NA,GABA,5-HT的影响[J].陕西中医,2015,36(1):123-124.
[11]Pujol JF,Buguet A,Froment JL,et al.The central metabolism of serotonin in the cat during insomnia.A neurophysiological and biochemical study after administration of pchlorophenylalanine or destruction of the raphe system[J].Brain Res,1971,29:195-212.
[12]陶明,施慎逊,顾牛范.5-羟色胺受体的研究现状[J].中华精神科杂志,1998,31(3):184-186.
[13]Sue J,Wilson A,Jayne E,et al.The use of sleep measures to compare a new 5HT1A agonist with buspirone in humans[J].Nutt J Psychopharma-col,2005,19(6):609-613.
[14]Landolt HP,Wehrle P.Antagonism of serotonergic 5-HT2A/2C receptors mutual improvement of sleep,cognition and mood.[J].Eur J Neurosci,2009,29(9):1795-1809.
[15]程希智.董氏之五花穴配镇静穴治疗失眠的临床与实验研究[D].广州:广州中医药大学,2016.
[16]罗本华,王燕,张亚飞.三种针法对PCPA失眠大鼠海马5-HT、5-HIAA含量的影响[J].中国中医基础医学杂志,2016,22(11):1517-1519.
[17]王慧,陈天琪,王嫣.针刺对失眠大鼠脑干5-羟色胺的影响[J].江苏中医药,2011,43(1):88-89.
[18]张殿全,孙忠人,徐先伟.针刺四神聪对失眠大鼠脑内5-HT、5-HIAA含量的影响[J].中华中医药学刊,2009,27(9):1975-1977.
[19]李裕和,张林挺.针刺对运动性失眠大鼠大脑5-HT和NGF水平的影响[J].浙江中医杂志,2009,44(6):402-403.
[20]胡金凤,王朝辉,齐燕英,等.针刺五脏俞穴调五脏神针法对失眠大鼠单胺类神经递质的影响[J].长春中医药大学学报,2008,24(4):369-370.
[21]蒋洁,赵百孝,赵华.不同波形电针对PCPA致失眠大鼠脑内单胺类神经递质含量的影响[J].中医药导报,2015,21(21):34-36.
[22]兰妮,赵仓焕,徐拥建.失眠大鼠5-HT、5-HIAA、NE的针刺时效研究[J].黑龙江中医药,2013,88(2):48-49.
[23]Kimura M,Miiller-Preuss P,Lu A,et al.Conditional Corticotrophin-releasing hormone overexpression in the mouse forebrain enhances rapid eye movement sleep[J].Molecular Psychiatry,2010,15:154e65.
[24]李志华.原发性失眠和抑郁共病失眠患者认知功能、和水平的变化差别[D].合肥:安徽医科大学,2011.
[25]张亚晶,卢才义,高磊.睡眠剥夺对大鼠血清促肾上腺皮质激素、促甲状腺激素及皮质醇的影响[J].中华老年多器官疾病杂志,2009,8(1):61-63.
[26]陈桦,唐汉庆,郑建宇等.针刺联合壮医药线点灸对睡眠剥夺大鼠相关神经递质的影响[J].世界科学技术-中医药现代化,2015,17(10):2088-2092.
[27]吴绮雯.电针神门、三阴交对心理应激失眠大鼠HPA轴功能的影响研究[D].成都:成都中医药大学,2014.
[28]刘臻.基于褪黑素及其受体研究电针申脉照海调节失眠大鼠昼夜节律的效应机制[D].上海:上海中医药大学,2014.
[29]肖爱娇,王河宝,刘海云,等.热敏灸对失眠大鼠模型血清内分泌激素水平的影响[J].江西中医学院学报,2013,25(4):32-35.
[30]吴雪芬,岳增辉,郑雪娜,等.按经选穴针刺对失眠大鼠下丘脑-垂体-肾上腺皮质轴相关激素的影响[J].中国中医药信息杂志,2017,24(11):53-57.
[2]苏丹,王晓丽,贾孟辉.回药阿夫忒蒙丸对失眠大鼠下丘脑5-HT和5-HIAA含量的影响[J].中国名族医药杂志,2016(7):54-55.
[3]安雪梅、高红.探讨耳穴贴压联合足浴对肝火扰心型失眠患者5-HT、DA含量的影响及护理[J].中国医药指南,2016(4):102-105.
[4]李红,陈莹.围绝经期非器质性失眠肝郁患者血清5-HT水平、SDS、SAS积分的相关性研究[J].中华中医药杂志,2016(6):58-61.
[5]吴雪芬,郑雪娜,郭鑫,等.针刺干预HPA轴相关激素改善睡眠的研究进展[J].针灸临床杂志,2017(8):69-71.
[6]吴绮雯,诸毅晖,刘萍,等.从睡眠机制探讨神门、三阴交治疗失眠的作用[J].时珍国医国药,2014,25(2):402-403.
[7]周艳丽.针刺不同腧穴对失眠模型大鼠脑内神经递质5-HT、DA影响的实验研究[J].中国中医基础医学杂志,2012,18(8):887-888.
[8]兰妮.失眠大鼠电针后不同时间单胺类和氨基酸类递质的变化[D].广州:暨南大学,2010.
[9]李倩,黄迎华,刘曜纶,等.针刺对应激性胃黏膜损伤大鼠睡眠时间及纹状体中五羟色胺、多巴胺含量的影响[J].中国中医药信息杂志,2015,22(5):48-51.
[10]杨波,岳明.酸枣仁汤对睡眠剥夺大鼠认知功能及海马NA,GABA,5-HT的影响[J].陕西中医,2015,36(1):123-124.
[11]Pujol JF,Buguet A,Froment JL,et al.The central metabolism of serotonin in the cat during insomnia.A neurophysiological and biochemical study after administration of pchlorophenylalanine or destruction of the raphe system[J].Brain Res,1971,29:195-212.
[12]陶明,施慎逊,顾牛范.5-羟色胺受体的研究现状[J].中华精神科杂志,1998,31(3):184-186.
[13]Sue J,Wilson A,Jayne E,et al.The use of sleep measures to compare a new 5HT1A agonist with buspirone in humans[J].Nutt J Psychopharma-col,2005,19(6):609-613.
[14]Landolt HP,Wehrle P.Antagonism of serotonergic 5-HT2A/2C receptors mutual improvement of sleep,cognition and mood.[J].Eur J Neurosci,2009,29(9):1795-1809.
[15]程希智.董氏之五花穴配镇静穴治疗失眠的临床与实验研究[D].广州:广州中医药大学,2016.
[16]罗本华,王燕,张亚飞.三种针法对PCPA失眠大鼠海马5-HT、5-HIAA含量的影响[J].中国中医基础医学杂志,2016,22(11):1517-1519.
[17]王慧,陈天琪,王嫣.针刺对失眠大鼠脑干5-羟色胺的影响[J].江苏中医药,2011,43(1):88-89.
[18]张殿全,孙忠人,徐先伟.针刺四神聪对失眠大鼠脑内5-HT、5-HIAA含量的影响[J].中华中医药学刊,2009,27(9):1975-1977.
[19]李裕和,张林挺.针刺对运动性失眠大鼠大脑5-HT和NGF水平的影响[J].浙江中医杂志,2009,44(6):402-403.
[20]胡金凤,王朝辉,齐燕英,等.针刺五脏俞穴调五脏神针法对失眠大鼠单胺类神经递质的影响[J].长春中医药大学学报,2008,24(4):369-370.
[21]蒋洁,赵百孝,赵华.不同波形电针对PCPA致失眠大鼠脑内单胺类神经递质含量的影响[J].中医药导报,2015,21(21):34-36.
[22]兰妮,赵仓焕,徐拥建.失眠大鼠5-HT、5-HIAA、NE的针刺时效研究[J].黑龙江中医药,2013,88(2):48-49.
[23]Kimura M,Miiller-Preuss P,Lu A,et al.Conditional Corticotrophin-releasing hormone overexpression in the mouse forebrain enhances rapid eye movement sleep[J].Molecular Psychiatry,2010,15:154e65.
[24]李志华.原发性失眠和抑郁共病失眠患者认知功能、和水平的变化差别[D].合肥:安徽医科大学,2011.
[25]张亚晶,卢才义,高磊.睡眠剥夺对大鼠血清促肾上腺皮质激素、促甲状腺激素及皮质醇的影响[J].中华老年多器官疾病杂志,2009,8(1):61-63.
[26]陈桦,唐汉庆,郑建宇等.针刺联合壮医药线点灸对睡眠剥夺大鼠相关神经递质的影响[J].世界科学技术-中医药现代化,2015,17(10):2088-2092.
[27]吴绮雯.电针神门、三阴交对心理应激失眠大鼠HPA轴功能的影响研究[D].成都:成都中医药大学,2014.
[28]刘臻.基于褪黑素及其受体研究电针申脉照海调节失眠大鼠昼夜节律的效应机制[D].上海:上海中医药大学,2014.
[29]肖爱娇,王河宝,刘海云,等.热敏灸对失眠大鼠模型血清内分泌激素水平的影响[J].江西中医学院学报,2013,25(4):32-35.
[30]吴雪芬,岳增辉,郑雪娜,等.按经选穴针刺对失眠大鼠下丘脑-垂体-肾上腺皮质轴相关激素的影响[J].中国中医药信息杂志,2017,24(11):53-57.
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