乳酸菌抗氧化活性研究进展
|
摘要
生物体内时刻进行着氧化还原反应,当活性氧水平升高,氧化还原平衡受到破坏。一些乳酸菌菌株已经被证明具有良好的抗氧化功能,也因此被广泛研究和应用。乳酸菌抗氧化活性是目前研究和应用的一个热点。该文回顾了国内外乳酸菌抗氧化活性研究的现状,包括乳酸菌抗氧化活性评价体系,乳酸菌抗氧化体系,目前研究中存在的问题。旨在为进一步深入研究乳酸菌抗氧化活性、建立全面系统的乳酸菌抗氧化活性评价体系提供思路。
The body undergoes a redox reaction at all times,and when the level of active oxygen increases,the redox balance is destroyed.Some lactic acid bacteria strains have been proven to have good antioxidant functions and are therefore widely studied and applied. The antioxidant activity of lactic acid bacteria is a hot spot in current research and application. The paper reviewed the current status of research on antioxidant activity of lactic acid bacteria at home and abroad,including the evaluation system of lactic acid bacteria antioxidant activity,the antioxidant system of lactic acid bacteria,and the problems existing in the current research.Designed to further study the antioxidant activity of lactic acid bacteria and establish a comprehensive and systematic evaluation system for the antioxidant activity of lactic acid bacteria.
The body undergoes a redox reaction at all times,and when the level of active oxygen increases,the redox balance is destroyed.Some lactic acid bacteria strains have been proven to have good antioxidant functions and are therefore widely studied and applied. The antioxidant activity of lactic acid bacteria is a hot spot in current research and application. The paper reviewed the current status of research on antioxidant activity of lactic acid bacteria at home and abroad,including the evaluation system of lactic acid bacteria antioxidant activity,the antioxidant system of lactic acid bacteria,and the problems existing in the current research.Designed to further study the antioxidant activity of lactic acid bacteria and establish a comprehensive and systematic evaluation system for the antioxidant activity of lactic acid bacteria.
引文
[1]LüJ M,Lin P H,Yao Q,et al.Chemical and molecular mechanisms of antioxidants:experimental approaches and model systems[J].Journal of cellular and molecular medicine,2010,14(4):840-860
[2]Pisoschi A M,Pop A.The role of antioxidants in the chemistry of oxidative stress:A review[J].European journal of medicinal chemistry,2015,97:55-74
[3]洪松虎,吴祖芳.乳酸菌抗氧化作用研究进展[J].宁波大学学报(理工版),2010,23(2):17-22
[4]Ianniello R G,Ricciardi A,Parente E,et al.Aeration and supplementation with heme and menaquinone affect survival to stresses and antioxidant capability of Lactobacillus casei strains[J].LWT-Food Science and Technology,2015,60(2):817-824
[5]彭新颜,于海洋,李杰,等.乳酸菌抗氧化作用研究进展[J].食品科学,2012,33(23):370-374
[6]Lin M Y,Chang F J.Antioxidative effect of intestinal bacteria Bifidobacterium longum ATCC 15708 and Lactobacillus acidophilus ATCC 4356[J].Digestive diseases and sciences,2000,45(8):1617-1622
[7]刘洋,郭宇星,潘道东.4种乳酸菌体外抗氧化能力的比较研究[J].食品科学,2012,33(11):25-29
[8]王刚,田丰伟,刘小鸣,等.2株具有优良体外抗氧化能力乳酸菌的筛选与鉴定[J].食品工业科技,2013,34(5):149-153,157
[9]Apak R,Gü觭lüK,Demirata B,et al.Comparative evaluation of various total antioxidant capacity assays applied to phenolic compounds with the CUPRAC assay[J].Molecules,2007,12(7):1496-1547
[10]Mu G,Gao Y,Tuo Y,et al.Assessing and comparing antioxidant activities of lactobacilli strains by using different chemical and cellular antioxidant methods[J].Journal of dairy science,2018,101(12):10792-10806
[11]Wolfe K L,Liu R H.Cellular antioxidant activity(CAA)assay for assessing antioxidants,foods,and dietary supplements[J].Journal of agricultural and food chemistry,2007,55(22):8896-8907
[12]Xing J,Wang G,Gu Z,et al.Cellular model to assess the antioxidant activity of lactobacilli[J].RSC Advances,2015,5(47):37626-37634
[13]Xing J,Wang G,Zhang Q,et al.Determining antioxidant activities of lactobacilli by cellular antioxidant assay in mammal cells[J].Journal of Functional Foods,2015,19:554-562
[14]Seth A,Yan F,Polk D B,et al.Probiotics ameliorate the hydrogen peroxide-induced epithelial barrier disruption by a PKC-and MAPkinase-dependent mechanism[J].American Journal of PhysiologyGastrointestinal and Liver Physiology,2008,294(4):G1060-G1069
[15]夏春燕,郭晓晖,李富华,等.细胞抗氧化活性方法在食物抗氧化活性评价中的研究进展[J].食品科学,2012,33(15):297-302
[16]Wang Y,Li Y,Xie J,et al.Protective effects of probiotic Lactobacillus casei Zhang against endotoxin-and d-galactosamine-induced liver injury in rats via anti-oxidative and anti-inflammatory capacities[J].International immunopharmacology,2013,15(1):30-37
[17]孟和毕力格,周雨霞,张和平,等.酸马奶中乳杆菌MG2-1株的抗氧化作用研究[J].中国乳品工业,2005,33(9):21-24
[18]Zhang Y,Du R,Wang L,et al.The antioxidative effects of probiotic Lactobacillus casei Zhang on the hyperlipidemic rats[J].European Food Research and Technology,2010,231(1):151-158
[19]Averina O V,Zakharevich N V,Danilenko V N.Identification and characterization of Whi B-like family proteins of the Bifidobacterium genus[J].Anaerobe,2012,18(4):421-429
[20]Zotta T,Ricciardi A,Guidone A,et al.Inactivation of ccp A and aeration affect growth,metabolite production and stress tolerance in Lactobacillus plantarum WCFS1[J].International journal of food microbiology,2012,155(1/2):51-59
[21]Li C,Sun J W,Zhang G F,et al.Effect of the absence of the Ccp Agene on growth,metabolic production,and stress tolerance in Lactobacillus delbrueckii ssp.bulgaricus[J].Journal of dairy science,2016,99(1):104-111
[22]Gaudu P,Lamberet G,Poncet S,et al.Ccp A regulation of aerobic and respiration growth in Lactococcus lactis[J].Molecular microbiology,2003,50(1):183-192
[23]Yang Y,Yin J,Liu J,et al.The copper homeostasis transcription factor Cop R is involved in H2O2Stress in Lactobacillus plantarum CAUH2[J].Front Microbiol,2017,8:2015
[24]Le Blanc J G,Del Carmen S,Miyoshi A,et al.Use of superoxide dismutase and catalase producing lactic acid bacteria in TNBS induced Crohn′s disease in mice[J].Journal of biotechnology,2011,151(3):287-293
[25]Oberg T S,Ward R E,Steele J L,et al.Transcriptome analysis of Bifidobacterium longum strains that show a differential response to hydrogen peroxide stress[J].Journal of biotechnology,2015,212:58-64
[26]Xiao M,Xu P,Zhao J,et al.Oxidative stress-related responses of Bifidobacterium longum subsp.longum BBMN68 at the proteomic level after exposure to oxygen[J].Microbiology,2011,157(6):1573-1588
[27]李维,孙开济,孙玉丽,等.乳酸菌缓解肠道氧化应激研究进展[J].动物营养学报,2016,28(1):9-14
[28]Tan SX,Greetham D,Raeth S,et al.The thioredoxin-thioredoxin reductase system canfunction in vivo as an alternative system to reduce oxidized glutathione in Saccharomyces cerevisiae[J].Journal of Biological Chemistry,2010,285(9):6118-6126
[29]于鑫,吕嘉枥,余芳.乳酸菌在不同培养基中产抗氧化酶活性的研究[J].中国调味品,2018,43(1):39-42
[30]Arasu M V,Al-Dhabi N A,Rejiniemon T S,et al.Identification and characterization of Lactobacillus brevis P68 with antifungal,antioxidant and probiotic functional properties[J].Indian Journal of Microbiology,2015,55(1):19-28
[31]Zuo F,Yu R,Feng X,et al.Combination of heterogeneous catalase and superoxide dismutase protects Bifidobacterium longum strain NCC2705 from oxidative stress[J].Applied microbiology and biotechnology,2014,98(17):7523-7534
[32]Lin J,Zou Y,Cao K,et al.The impact of heterologous catalase expression and superoxide dismutase overexpression on enhancing the oxidative resistance in Lactobacillus casei[J].Journal of industrial microbiology&biotechnology,2016,43(5):703-711
[33]An H,Zhai Z,Yin S,et al.Coexpression of the superoxide dismutase and the catalase provides remarkable oxidative stress resistance in Lactobacillus rhamnosus[J].Journal of agricultural and food chemistry,2011,59(8):3851-3856
[34]Watanabe M,van der Veen S,Nakajima H,et al.Effect of respiration and manganese on oxidative stress resistance of Lactobacillus plantarum WCFS1[J].Microbiology,2012,158(1):293-300
[35]Yousten AA,Johnson JL,Salin M.Oxygen metabolism of catalasenegative and catalase-positive strains of Lactobacillus plantarum[J].Journal of bacteriology,1975,123(1):242-247
[36]Hayashi K,Maekawa I,Tanaka K,et al.Purification and characterization of oxygen-inducible haem catalase from oxygen-tolerant Bifidobacterium asteroids[J].Microbiology,2013,159(1):89-95
[37]Kono Y,Fridovich I.Isolation and characterization of the pseudocatalase of Lactobacillus plantarum[J].Journal of Biological Chemistry,1983,258(10):6015-6019
[38]Igarashi T,Kono Y,Tanaka K.Molecular cloning of manganese catalase from Lactobacillus plantarum[J].Journal of Biological Chemistry,1996,271(47):29521-29524
[39]Richie J P,Nichenametla S,Neidig W,et al.Randomized controlled trial of oral glutathione supplementation on body stores of glutathione[J].European journal of nutrition,2015,54(2):251-263
[40]ZUO F,YU R,FENG X,et al.Combination of heterogeneous catalase and superoxide dismutase protects Bifidobacterium longum strain NCC2705 from oxidative stress[J].Applied Microbiology and Biotechnology,2014,98(17):7523-7534
[41]Kullisaar T,Songisepp E,Aunapuu M,et al.Complete glutathione system in probiotic Lactobacillus fermentum ME-3[J].Applied biochemistry and microbiology,2010,46(5):481-486
[42]Wang T,Lu W,Lu S,et al.Protective role of glutathione against oxidative stress in Streptococcus thermophilus[J].International Dairy Journal,2015,45:41-47
[43]Allocati N,Federici L,Masulli M,et al.Distribution of glutathione transferases in Gram-positive bacteria and Archaea[J].Biochimie,2012,94(3):588-596
[44]赵彤,钟宜科,荀一萍,等.乳酸菌抗氧化性及其作用机制研究进展[J].中国食品添加剂,2018,9:028
[45]Lu J,Holmgren A.The thioredoxin antioxidant system[J].Free Radical Biology and Medicine,2014,66:75-87
[46]Zeller Tanja,Klug Gabriele.Thioredoxins in bacteria:functions in oxidative stress response and regulation of thioredoxin genes[J].Naturwissenschaften,2006,93(6):259-266
[47]杨郁荭,白明.乳酸菌抗氧化机理的初步探讨[J].中国乳业,2011(7):68-73
[48]Serrano L M,Molenaar D,Wels M,et al.Thioredoxin reductase is a key factor in the oxidative stress response of Lactobacillus plantarum WCFS1[J].Microbial Cell Factories,2007,6(1):29
[49]Higuchi M,Yamamoto Y,Kamio Y.Molecular biology of oxygen tolerance in lactic acid bacteria:functions of NADH oxidases and Dpr in oxidative stress[J].Journal of bioscience and bioengineering,2000,90(5):484-493
[50]J覿nsch A,Freiding S,Behr J,et al.Contribution of the NADH-oxidase(Nox)to the aerobic life of Lactobacillus sanfranciscensis DSM20451T[J].Food microbiology,2011,28(1):29-37
[51]Kang T S,Korber D R,Tanaka T.Influence of oxygen on NADH recycling and oxidative stress resistance systems in Lactobacillus panis PM1[J].AMB Express,2013,3(1):10
[52]Kawasaki S,Satoh T,Todoroki M,et al.b-type dihydroorotate dehydrogenase is purified as a H2O2-forming NADH oxidase from Bifidobacterium bifidum[J].Applied and environmental microbiology,2009,75(3):629-636
[53]van de Guchte M,Serror P,Chervaux C,et al.Stress responses in lactic acid bacteria[J].Antonie Van Leeuwenhoek,2002,82(1/4):187-216
[54]Labuschagne C F,Stigter E C A,Hendriks M M W B,et al.Quantification of in vivo oxidative damage in Caenorhabditis elegans during aging by endogenous F3-isoprostane measurement[J].Aging cell,2013,12(2):214-223
[55]Duwat P,Ehrlich S D,Gruss A.The rec A gene of Lactococcus lactis:characterization and involvement in oxidative and thermal stress[J].Molecular microbiology,1995,17(6):1121-1131
[56]Cappa F,Cattivelli D,Cocconcelli P S.The uvr A gene is involved in oxidative and acid stress responses in Lactobacillus helveticus CN-BL1156[J].Research in microbiology,2005,156(10):1039-1047
[57]Lee J,Hwang K T,Chung M Y,et al.Resistance of Lactobacillus casei KCTC 3260 to reactive oxygen species(ROS):role for a metal ion chelating effect[J].Journal of Food Science,2005,70(8):m388-m391
[58]Qing L,Wang T.Lactic acid bacteria prevent alcohol-induced steatohepatitis in rats by acting on the pathways of alcohol metabolism[J].Clinical and experimental medicine,2008,8(4):187
[59]Jain S,Yadav H,Sinha P R.Antioxidant and cholesterol assimilation activities of selected lactobacilli and lactococci cultures[J].Journal of dairy research,2009,76(4):385-391
[60]Lee B J,Kim J S,Kang Y M,et al.Antioxidant activity andγ-aminobutyric acid(GABA)content in sea tangle fermented by Lactobacillus brevis BJ20 isolated from traditional fermented foods[J].Food Chemistry,2010,122(1):271-276
[61]Zhang S,Liu L,Su Y,et al.Antioxidative activity of lactic acid bacteria in yogurt[J].African Journal of Microbiology Research,2011,5(29):5194-5201
[62]Banjoko I O,Adeyanju M M,Ademuyiwa O,et al.Hypolipidemic effects of lactic acid bacteria fermented cereal in rats[J].Lipids in health and disease,2012,11(1):170
[63]Achuthan A A,Duary R K,Madathil A,et al.Antioxidative potential of lactobacilli isolated from the gut of Indian people[J].Molecular biology reports,2012,39(8):7887-7897
[64]李盛钰,李达,赵玉娟,等.植物乳杆菌C88对H2O2诱导氧化损伤的Caco-2细胞的保护作用[J].中国农业科学,2012,46(3):606-613
[65]GAO D W,GAO Z R,ZHU G H.Antioxidant effects of Lactobacillus plantarum via activation of transcription factor Nrf2[J].Food and Function,2013,4(6):982-989
[66]湛剑龙,王杰霖,胡萍,等.一株乳酸菌DPPH自由基清除率影响因素研究[J].食品科技,2015(8):21-25
[67]Manaer T,Yu L,Zhang Y,et al.Anti-diabetic effects of shubat in type 2 diabetic rats induced by combination of high-glucose-fat diet and low-dose streptozotocin[J].Journal of ethnopharmacology,2015,169:269-274
[68]HASHEMI S M B,SHAHIDI F,MORTAZAVI S A,et al.Effect of Lactobacillus plantarum LSS on oxidative stability and lipid modifications of Doogh[J].International Journal of Dairy Technology,2016,69(4):550-558
[69]Furumoto H,Nanthirudjanar T,Kume T,et al.10-Oxo-trans-11-octadecenoic acid generated from linoleic acid by a gut lactic acid bacterium Lactobacillus plantarum is cytoprotective against oxidative stress[J].Toxicology and applied pharmacology,2016,296:1-9
[70]Xu S,Liu T,Radji C A I,et al.Isolation,identification,and evaluation of new lactic acid bacteria strains with both cellular antioxidant and bile salt hydrolase activities in vitro[J].Journal of food protection,2016,79(11):1919-1928
[71]Huang L,Duan C,Zhao Y,et al.Reduction of aflatoxin B1 toxicity by Lactobacillus plantarum C88:a potential probiotic strain isolated from Chinese traditional fermented food“Tofu”[J].Plo S one,2017,12(1):e0170109
[72]Chen J,Wu Y,Yang C,et al.Antioxidant and hypolipidemic effects of soymilk fermented via Lactococcus acidophilus MF204[J].Food&function,2017,8(12):4414-4420
[73]Kim S H,Lee J Y,Balolong M P,et al.Identification and Characterization of a Novel Antioxidant Peptide from Bovine Skim Milk Fermented by Lactococcus lactis SL6[J].Korean journal for food science of animal resources,2017,37(3):402
[74]唐宇,张将,高原,等.菌株Lactobacillus casei-16发酵豆浆的抗氧化特性研究[J].食品研究与开发,2018,39(8):1-9
[75]陈卫,田丰伟,赵鑫,等.乳酸菌干预氧化应激的研究进展[J].中国食品学报,2012,12(11):1-7
[2]Pisoschi A M,Pop A.The role of antioxidants in the chemistry of oxidative stress:A review[J].European journal of medicinal chemistry,2015,97:55-74
[3]洪松虎,吴祖芳.乳酸菌抗氧化作用研究进展[J].宁波大学学报(理工版),2010,23(2):17-22
[4]Ianniello R G,Ricciardi A,Parente E,et al.Aeration and supplementation with heme and menaquinone affect survival to stresses and antioxidant capability of Lactobacillus casei strains[J].LWT-Food Science and Technology,2015,60(2):817-824
[5]彭新颜,于海洋,李杰,等.乳酸菌抗氧化作用研究进展[J].食品科学,2012,33(23):370-374
[6]Lin M Y,Chang F J.Antioxidative effect of intestinal bacteria Bifidobacterium longum ATCC 15708 and Lactobacillus acidophilus ATCC 4356[J].Digestive diseases and sciences,2000,45(8):1617-1622
[7]刘洋,郭宇星,潘道东.4种乳酸菌体外抗氧化能力的比较研究[J].食品科学,2012,33(11):25-29
[8]王刚,田丰伟,刘小鸣,等.2株具有优良体外抗氧化能力乳酸菌的筛选与鉴定[J].食品工业科技,2013,34(5):149-153,157
[9]Apak R,Gü觭lüK,Demirata B,et al.Comparative evaluation of various total antioxidant capacity assays applied to phenolic compounds with the CUPRAC assay[J].Molecules,2007,12(7):1496-1547
[10]Mu G,Gao Y,Tuo Y,et al.Assessing and comparing antioxidant activities of lactobacilli strains by using different chemical and cellular antioxidant methods[J].Journal of dairy science,2018,101(12):10792-10806
[11]Wolfe K L,Liu R H.Cellular antioxidant activity(CAA)assay for assessing antioxidants,foods,and dietary supplements[J].Journal of agricultural and food chemistry,2007,55(22):8896-8907
[12]Xing J,Wang G,Gu Z,et al.Cellular model to assess the antioxidant activity of lactobacilli[J].RSC Advances,2015,5(47):37626-37634
[13]Xing J,Wang G,Zhang Q,et al.Determining antioxidant activities of lactobacilli by cellular antioxidant assay in mammal cells[J].Journal of Functional Foods,2015,19:554-562
[14]Seth A,Yan F,Polk D B,et al.Probiotics ameliorate the hydrogen peroxide-induced epithelial barrier disruption by a PKC-and MAPkinase-dependent mechanism[J].American Journal of PhysiologyGastrointestinal and Liver Physiology,2008,294(4):G1060-G1069
[15]夏春燕,郭晓晖,李富华,等.细胞抗氧化活性方法在食物抗氧化活性评价中的研究进展[J].食品科学,2012,33(15):297-302
[16]Wang Y,Li Y,Xie J,et al.Protective effects of probiotic Lactobacillus casei Zhang against endotoxin-and d-galactosamine-induced liver injury in rats via anti-oxidative and anti-inflammatory capacities[J].International immunopharmacology,2013,15(1):30-37
[17]孟和毕力格,周雨霞,张和平,等.酸马奶中乳杆菌MG2-1株的抗氧化作用研究[J].中国乳品工业,2005,33(9):21-24
[18]Zhang Y,Du R,Wang L,et al.The antioxidative effects of probiotic Lactobacillus casei Zhang on the hyperlipidemic rats[J].European Food Research and Technology,2010,231(1):151-158
[19]Averina O V,Zakharevich N V,Danilenko V N.Identification and characterization of Whi B-like family proteins of the Bifidobacterium genus[J].Anaerobe,2012,18(4):421-429
[20]Zotta T,Ricciardi A,Guidone A,et al.Inactivation of ccp A and aeration affect growth,metabolite production and stress tolerance in Lactobacillus plantarum WCFS1[J].International journal of food microbiology,2012,155(1/2):51-59
[21]Li C,Sun J W,Zhang G F,et al.Effect of the absence of the Ccp Agene on growth,metabolic production,and stress tolerance in Lactobacillus delbrueckii ssp.bulgaricus[J].Journal of dairy science,2016,99(1):104-111
[22]Gaudu P,Lamberet G,Poncet S,et al.Ccp A regulation of aerobic and respiration growth in Lactococcus lactis[J].Molecular microbiology,2003,50(1):183-192
[23]Yang Y,Yin J,Liu J,et al.The copper homeostasis transcription factor Cop R is involved in H2O2Stress in Lactobacillus plantarum CAUH2[J].Front Microbiol,2017,8:2015
[24]Le Blanc J G,Del Carmen S,Miyoshi A,et al.Use of superoxide dismutase and catalase producing lactic acid bacteria in TNBS induced Crohn′s disease in mice[J].Journal of biotechnology,2011,151(3):287-293
[25]Oberg T S,Ward R E,Steele J L,et al.Transcriptome analysis of Bifidobacterium longum strains that show a differential response to hydrogen peroxide stress[J].Journal of biotechnology,2015,212:58-64
[26]Xiao M,Xu P,Zhao J,et al.Oxidative stress-related responses of Bifidobacterium longum subsp.longum BBMN68 at the proteomic level after exposure to oxygen[J].Microbiology,2011,157(6):1573-1588
[27]李维,孙开济,孙玉丽,等.乳酸菌缓解肠道氧化应激研究进展[J].动物营养学报,2016,28(1):9-14
[28]Tan SX,Greetham D,Raeth S,et al.The thioredoxin-thioredoxin reductase system canfunction in vivo as an alternative system to reduce oxidized glutathione in Saccharomyces cerevisiae[J].Journal of Biological Chemistry,2010,285(9):6118-6126
[29]于鑫,吕嘉枥,余芳.乳酸菌在不同培养基中产抗氧化酶活性的研究[J].中国调味品,2018,43(1):39-42
[30]Arasu M V,Al-Dhabi N A,Rejiniemon T S,et al.Identification and characterization of Lactobacillus brevis P68 with antifungal,antioxidant and probiotic functional properties[J].Indian Journal of Microbiology,2015,55(1):19-28
[31]Zuo F,Yu R,Feng X,et al.Combination of heterogeneous catalase and superoxide dismutase protects Bifidobacterium longum strain NCC2705 from oxidative stress[J].Applied microbiology and biotechnology,2014,98(17):7523-7534
[32]Lin J,Zou Y,Cao K,et al.The impact of heterologous catalase expression and superoxide dismutase overexpression on enhancing the oxidative resistance in Lactobacillus casei[J].Journal of industrial microbiology&biotechnology,2016,43(5):703-711
[33]An H,Zhai Z,Yin S,et al.Coexpression of the superoxide dismutase and the catalase provides remarkable oxidative stress resistance in Lactobacillus rhamnosus[J].Journal of agricultural and food chemistry,2011,59(8):3851-3856
[34]Watanabe M,van der Veen S,Nakajima H,et al.Effect of respiration and manganese on oxidative stress resistance of Lactobacillus plantarum WCFS1[J].Microbiology,2012,158(1):293-300
[35]Yousten AA,Johnson JL,Salin M.Oxygen metabolism of catalasenegative and catalase-positive strains of Lactobacillus plantarum[J].Journal of bacteriology,1975,123(1):242-247
[36]Hayashi K,Maekawa I,Tanaka K,et al.Purification and characterization of oxygen-inducible haem catalase from oxygen-tolerant Bifidobacterium asteroids[J].Microbiology,2013,159(1):89-95
[37]Kono Y,Fridovich I.Isolation and characterization of the pseudocatalase of Lactobacillus plantarum[J].Journal of Biological Chemistry,1983,258(10):6015-6019
[38]Igarashi T,Kono Y,Tanaka K.Molecular cloning of manganese catalase from Lactobacillus plantarum[J].Journal of Biological Chemistry,1996,271(47):29521-29524
[39]Richie J P,Nichenametla S,Neidig W,et al.Randomized controlled trial of oral glutathione supplementation on body stores of glutathione[J].European journal of nutrition,2015,54(2):251-263
[40]ZUO F,YU R,FENG X,et al.Combination of heterogeneous catalase and superoxide dismutase protects Bifidobacterium longum strain NCC2705 from oxidative stress[J].Applied Microbiology and Biotechnology,2014,98(17):7523-7534
[41]Kullisaar T,Songisepp E,Aunapuu M,et al.Complete glutathione system in probiotic Lactobacillus fermentum ME-3[J].Applied biochemistry and microbiology,2010,46(5):481-486
[42]Wang T,Lu W,Lu S,et al.Protective role of glutathione against oxidative stress in Streptococcus thermophilus[J].International Dairy Journal,2015,45:41-47
[43]Allocati N,Federici L,Masulli M,et al.Distribution of glutathione transferases in Gram-positive bacteria and Archaea[J].Biochimie,2012,94(3):588-596
[44]赵彤,钟宜科,荀一萍,等.乳酸菌抗氧化性及其作用机制研究进展[J].中国食品添加剂,2018,9:028
[45]Lu J,Holmgren A.The thioredoxin antioxidant system[J].Free Radical Biology and Medicine,2014,66:75-87
[46]Zeller Tanja,Klug Gabriele.Thioredoxins in bacteria:functions in oxidative stress response and regulation of thioredoxin genes[J].Naturwissenschaften,2006,93(6):259-266
[47]杨郁荭,白明.乳酸菌抗氧化机理的初步探讨[J].中国乳业,2011(7):68-73
[48]Serrano L M,Molenaar D,Wels M,et al.Thioredoxin reductase is a key factor in the oxidative stress response of Lactobacillus plantarum WCFS1[J].Microbial Cell Factories,2007,6(1):29
[49]Higuchi M,Yamamoto Y,Kamio Y.Molecular biology of oxygen tolerance in lactic acid bacteria:functions of NADH oxidases and Dpr in oxidative stress[J].Journal of bioscience and bioengineering,2000,90(5):484-493
[50]J覿nsch A,Freiding S,Behr J,et al.Contribution of the NADH-oxidase(Nox)to the aerobic life of Lactobacillus sanfranciscensis DSM20451T[J].Food microbiology,2011,28(1):29-37
[51]Kang T S,Korber D R,Tanaka T.Influence of oxygen on NADH recycling and oxidative stress resistance systems in Lactobacillus panis PM1[J].AMB Express,2013,3(1):10
[52]Kawasaki S,Satoh T,Todoroki M,et al.b-type dihydroorotate dehydrogenase is purified as a H2O2-forming NADH oxidase from Bifidobacterium bifidum[J].Applied and environmental microbiology,2009,75(3):629-636
[53]van de Guchte M,Serror P,Chervaux C,et al.Stress responses in lactic acid bacteria[J].Antonie Van Leeuwenhoek,2002,82(1/4):187-216
[54]Labuschagne C F,Stigter E C A,Hendriks M M W B,et al.Quantification of in vivo oxidative damage in Caenorhabditis elegans during aging by endogenous F3-isoprostane measurement[J].Aging cell,2013,12(2):214-223
[55]Duwat P,Ehrlich S D,Gruss A.The rec A gene of Lactococcus lactis:characterization and involvement in oxidative and thermal stress[J].Molecular microbiology,1995,17(6):1121-1131
[56]Cappa F,Cattivelli D,Cocconcelli P S.The uvr A gene is involved in oxidative and acid stress responses in Lactobacillus helveticus CN-BL1156[J].Research in microbiology,2005,156(10):1039-1047
[57]Lee J,Hwang K T,Chung M Y,et al.Resistance of Lactobacillus casei KCTC 3260 to reactive oxygen species(ROS):role for a metal ion chelating effect[J].Journal of Food Science,2005,70(8):m388-m391
[58]Qing L,Wang T.Lactic acid bacteria prevent alcohol-induced steatohepatitis in rats by acting on the pathways of alcohol metabolism[J].Clinical and experimental medicine,2008,8(4):187
[59]Jain S,Yadav H,Sinha P R.Antioxidant and cholesterol assimilation activities of selected lactobacilli and lactococci cultures[J].Journal of dairy research,2009,76(4):385-391
[60]Lee B J,Kim J S,Kang Y M,et al.Antioxidant activity andγ-aminobutyric acid(GABA)content in sea tangle fermented by Lactobacillus brevis BJ20 isolated from traditional fermented foods[J].Food Chemistry,2010,122(1):271-276
[61]Zhang S,Liu L,Su Y,et al.Antioxidative activity of lactic acid bacteria in yogurt[J].African Journal of Microbiology Research,2011,5(29):5194-5201
[62]Banjoko I O,Adeyanju M M,Ademuyiwa O,et al.Hypolipidemic effects of lactic acid bacteria fermented cereal in rats[J].Lipids in health and disease,2012,11(1):170
[63]Achuthan A A,Duary R K,Madathil A,et al.Antioxidative potential of lactobacilli isolated from the gut of Indian people[J].Molecular biology reports,2012,39(8):7887-7897
[64]李盛钰,李达,赵玉娟,等.植物乳杆菌C88对H2O2诱导氧化损伤的Caco-2细胞的保护作用[J].中国农业科学,2012,46(3):606-613
[65]GAO D W,GAO Z R,ZHU G H.Antioxidant effects of Lactobacillus plantarum via activation of transcription factor Nrf2[J].Food and Function,2013,4(6):982-989
[66]湛剑龙,王杰霖,胡萍,等.一株乳酸菌DPPH自由基清除率影响因素研究[J].食品科技,2015(8):21-25
[67]Manaer T,Yu L,Zhang Y,et al.Anti-diabetic effects of shubat in type 2 diabetic rats induced by combination of high-glucose-fat diet and low-dose streptozotocin[J].Journal of ethnopharmacology,2015,169:269-274
[68]HASHEMI S M B,SHAHIDI F,MORTAZAVI S A,et al.Effect of Lactobacillus plantarum LSS on oxidative stability and lipid modifications of Doogh[J].International Journal of Dairy Technology,2016,69(4):550-558
[69]Furumoto H,Nanthirudjanar T,Kume T,et al.10-Oxo-trans-11-octadecenoic acid generated from linoleic acid by a gut lactic acid bacterium Lactobacillus plantarum is cytoprotective against oxidative stress[J].Toxicology and applied pharmacology,2016,296:1-9
[70]Xu S,Liu T,Radji C A I,et al.Isolation,identification,and evaluation of new lactic acid bacteria strains with both cellular antioxidant and bile salt hydrolase activities in vitro[J].Journal of food protection,2016,79(11):1919-1928
[71]Huang L,Duan C,Zhao Y,et al.Reduction of aflatoxin B1 toxicity by Lactobacillus plantarum C88:a potential probiotic strain isolated from Chinese traditional fermented food“Tofu”[J].Plo S one,2017,12(1):e0170109
[72]Chen J,Wu Y,Yang C,et al.Antioxidant and hypolipidemic effects of soymilk fermented via Lactococcus acidophilus MF204[J].Food&function,2017,8(12):4414-4420
[73]Kim S H,Lee J Y,Balolong M P,et al.Identification and Characterization of a Novel Antioxidant Peptide from Bovine Skim Milk Fermented by Lactococcus lactis SL6[J].Korean journal for food science of animal resources,2017,37(3):402
[74]唐宇,张将,高原,等.菌株Lactobacillus casei-16发酵豆浆的抗氧化特性研究[J].食品研究与开发,2018,39(8):1-9
[75]陈卫,田丰伟,赵鑫,等.乳酸菌干预氧化应激的研究进展[J].中国食品学报,2012,12(11):1-7