枸橼酸铋钾调控NADPH氧化酶参与的氧化应激改善老年消化性溃疡的疗效
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摘要
目的:观察枸橼酸铋钾调控还原型烟酰胺腺嘌呤二核苷酸磷酸(NADPH)氧化酶参与的氧化应激改善老年消化性溃疡的治疗效果。方法:将200例消化性溃疡患者随机分为观察组和对照组,每组100例。对照组给予常规治疗,观察组在对照组治疗的基础上给予枸橼酸铋钾。比较两组临床疗效及氧化氢酶(CAT)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSHPX)、丙二醛(MDA)和NADPH氧化酶P22、P47亚基水平。结果:观察组治疗总有效率为96.0%,显著高于对照组的83.0%(P<0.05)。治疗后,与对照组比较,观察组CAT、SOD及GSHPX水平明显升高,而MDA、P22亚基和P47亚基水平明显降低(P<0.05)。结论:枸橼酸铋钾能有效改善老年消化性溃疡的治疗效果,可能与影响NADPH氧化酶亚基表达水平有关。
Objective:To investigate the effect of Bismuth potassium citrate in the treatment of senile peptic ulcer and the regulation of NADPH oxidase.Methods:A total of 200 patients with peptic ulcer treated in our hospital from May 2014 to May 2017 were selected,and randomized to receive either conventional treatment(control group,n=100)or conventional therapy combined with Bismuth potassium citrate(observation group,n=100).The therapeutic effect and the levels of catalase(CAT),superoxide dismutase(SOD),glutathion peroxidase(GSHPX),malondialdehyde(MDA)and NADPH oxidase P22,P47 subunits were compared.Results:The total effective rate in the observation group was 96.0%,which was significantly higher than that in the control group(83.0%)(P<0.05).After treatment,the levels of CAT,SOD and GSHPX were increased,while the levels of MDA,P22 subunits and P47 subunits were decreased in the observation group,compared with the control group(P<0.05).Conclusion:Bismuth potassium citrate effectively improved the curative effect of senile peptic ulcer possibly via the regulation of NADPH oxidase mediated oxidative stress.
Objective:To investigate the effect of Bismuth potassium citrate in the treatment of senile peptic ulcer and the regulation of NADPH oxidase.Methods:A total of 200 patients with peptic ulcer treated in our hospital from May 2014 to May 2017 were selected,and randomized to receive either conventional treatment(control group,n=100)or conventional therapy combined with Bismuth potassium citrate(observation group,n=100).The therapeutic effect and the levels of catalase(CAT),superoxide dismutase(SOD),glutathion peroxidase(GSHPX),malondialdehyde(MDA)and NADPH oxidase P22,P47 subunits were compared.Results:The total effective rate in the observation group was 96.0%,which was significantly higher than that in the control group(83.0%)(P<0.05).After treatment,the levels of CAT,SOD and GSHPX were increased,while the levels of MDA,P22 subunits and P47 subunits were decreased in the observation group,compared with the control group(P<0.05).Conclusion:Bismuth potassium citrate effectively improved the curative effect of senile peptic ulcer possibly via the regulation of NADPH oxidase mediated oxidative stress.
引文
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[2]李阳.分析综合护理干预对慢性胃炎及消化性溃疡患者生活质量的影响[J].临床研究,2018,26(3):164-166.
[3]侯荔.康复新液联合雷贝拉唑治疗老年消化性溃疡的疗效及对生活质量的影响[J].临床合理用药杂志,2018(7):77-78.
[4]冯珍.复方枸橼酸铋钾胶囊联合奥美拉唑镁肠溶片用于根除伴十二指肠溃疡的幽门螺杆菌感染的临床研究[D].武汉:华中科技大学,2016.
[5]王仁花.多学科综合护理干预对消化性溃疡患者氧化应激和Th17/IL-17炎症轴的影响[J].中国卫生检验杂志,2017,27(18):2645-2647.
[6]黄晨恺,张望,甘达凯,等.NADPH氧化酶介导的氧化应激在细胞骨架相关调控活动中的作用[J].中国细胞生物学学报,2018,40(2):269-274.
[7]许文虎,金春子,王晓龙,等.NADPH氧化酶在高脂诱导的人脐静脉血管内皮细胞氧化应激损伤中的作用[J].中国药理学通报,2017,33(11):1574-1578.
[8]陈志荣.消化系溃疡的诊治规范[J].苏州医学,2008,31(2):59-61.
[9]罗君,王军.雷尼替丁与次枸橼酸铋钾联合治疗小儿消化性溃疡的效果观察[J].中南医学科学杂志,2017,45(4):408-411.
[10]张立华.枸橼酸铋钾辅助常规三联药物方案治疗Hp感染阳性消化性溃疡临床研究[J].湖南师范大学学报(医学版),2016,13(4):77-79.
[11]陆明,王晓.奥美拉唑和枸橼酸铋钾治疗消化性溃疡患者的临床疗效观察[J].中国医药指南,2016,14(8):186-187.
[12]朱海龙,王军,张毅,等.早期肠内营养+丙氨酰谷胺酰胺对SAP患者肠道菌群、炎症及氧化反应的影响[J].海南医学院学报,2017,23(24):3389-3392.
[13]李雪琳,顾燕云,张翼飞.益生菌改善2型糖尿病的相关机制[J].上海交通大学学报(医学版),2017,37(9):1309-1314.
[14]焦德圣.不同术式对急性胃穿孔患者术后胃肠动力、围术期血浆炎性和氧化应激状态的影响[J].临床医学研究与实践,2017,2(16):84-85.