W/O/W型双乳液滴在微通道内生成过程的研究
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摘要
以双乳液滴为模板制备的新型腔室型微颗粒为物质封装提供了一个受保护的内部空间,研究三相流速对双乳液滴生成机制的影响,对合成单分散微粒及精确调控有重要指导意义。采用实验和数值模拟相结合的方法研究了三相同轴毛细管微通道内W/O/W型双乳液滴的生成过程,主要考察了三相流速对双乳液滴生成模式、尺寸的影响。结果表明,随着外相流量的增加,双乳液滴的尺寸急剧减小,频率显著增加,液滴生成模式由Dripping流转换为Narrowing Jetting流,双重乳液的单分散度降低。随着中间相流量的增大,双乳液滴外径大幅增加,而内径却呈相反规律变化,液滴生成频率先增大后趋于稳定。此时液滴生成模式由Dripping流转换为Widening Jetting流;当Q2/Q1>6后,将会生成多核型双乳液滴,在未添加表面活性剂的情况下,内部液核将自发相互融合。双乳液滴的内径随内相流量的增加而显著增大,在外部水相流量一定条件下,双乳液滴外径与内、中相流量之和成正比,与二者之比Q1/Q2无关。通过三相流量调节实现了对生成双乳液滴的尺寸规格、核-壳比率及其所含内部腔室结构等的精确操控。
Novel compartment microparticles produced with double emulsion droplets as templates provide a protected internal space for material encapsulation. The effect of three-phase flow rate on the micro-droplet generation of double emulsion mechanism is available for reference to produce precise size and highly monodisperse particles. The influence of three-phase flow rate on the formation mode and size of the emulsion droplets was mainly investigated by making use of experiment and numerical simulation. The size of compound droplets decreases and the frequency increases with the increasing outer fluid flow rate. The monodispersity of the double emulsion reduces due to transition from dripping to narrowing jetting regime. Outer droplet size increases with the increasing flow rate of the middle fluid,whereas inner droplet size is the opposite. The frequency increases and then stabilizes,which leads to a widening regime. When Q2/Q1> 6,multi-core type double emulsion droplets are produced. Droplet coalescence occurs when surfactant is not considered. As Q1 increases,there is an increasing tendency for inner drop size. The outer drop size is proportional to the sum of the inner and middle flow rate,and that is regardless of Q1/Q2. For drop size,ratio of core-shell and internal structure are precisely controlled by adjusting three-phase flow rate respectively.
Novel compartment microparticles produced with double emulsion droplets as templates provide a protected internal space for material encapsulation. The effect of three-phase flow rate on the micro-droplet generation of double emulsion mechanism is available for reference to produce precise size and highly monodisperse particles. The influence of three-phase flow rate on the formation mode and size of the emulsion droplets was mainly investigated by making use of experiment and numerical simulation. The size of compound droplets decreases and the frequency increases with the increasing outer fluid flow rate. The monodispersity of the double emulsion reduces due to transition from dripping to narrowing jetting regime. Outer droplet size increases with the increasing flow rate of the middle fluid,whereas inner droplet size is the opposite. The frequency increases and then stabilizes,which leads to a widening regime. When Q2/Q1> 6,multi-core type double emulsion droplets are produced. Droplet coalescence occurs when surfactant is not considered. As Q1 increases,there is an increasing tendency for inner drop size. The outer drop size is proportional to the sum of the inner and middle flow rate,and that is regardless of Q1/Q2. For drop size,ratio of core-shell and internal structure are precisely controlled by adjusting three-phase flow rate respectively.
引文
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6 Utada A S,Chu L Y,Fernandez-Nieves A,Link D R,Holtze C,Weitz D A.Mrs.Bull.,2007,32(9):702-708
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8 Kim S H,Kim J W,Chao J C,Weitz D A.Lab Chip,2011,11(18):3162-3166
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10 Qiu Y,Wang F,Liu Y M,Chu L Y,Wang H Y.Sci.Rep.,2015,5(1):13060
11 Okushima S,Nisisako T,Torii T,Higuchi T.Langmuir,2004,20(23):9905-9908
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13 Shao T,Feng X,Jin Y,Cheng Y.Chem.Eng.Sci.,2013,104(50):55-63
14 Zhou C,Yue P,Feng J J.Phys.Fluids,2006,18(9):1250-1264
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16 Chen Y,Liu X,Shi M.Appl.Phys.Lett.,2013,102(5):051609
17 SHEN Feng,LI Yi,LIU Zhao-Miao,CAO Ren-Tuo,WANG Gui-Ren.Chinese J.Anal.Chem.,2015,43(12):1942-1954申峰,李易,刘赵淼,曹刃拓,王贵人.分析化学,2015,43(12):1942-1954
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25 Zhao H,Xu J H,Wang T,Luo G S.Lab Chip,2014,14(11):1901-1906
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