金属有机骨架在生物分子固定化中的应用研究进展
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摘要
金属有机骨架(MOFs)是由金属离子簇与有机配体组成的三维复合结构,具有比表面积大、种类多、负载量大、结构稳定等特征,其多孔结构能够维持生物分子构型、增强生物稳定性、提高生物分子负载效率。生物或药物分子通过表面固定、扩散固定或封装固定负载在MOFs表面或内部,MOFs能够通过调节金属离子簇与有机配体设计出具有不同孔隙率、不同孔径的生物亲和性多孔骨架结构。对近年来MOFs在酶固定化、细胞固定化、核酸固定化、药物固定化方面的应用研究进展进行了综述,为生物分子固定载体材料的研究提供了新的方向与理论支持。
The metal-organic frameworks(MOFs) have a typical three-dimensional composite structure,which are constituted by metal ions or cluster and organic ligands.MOFs have the characteristics of large specific surface areas,various types,capacity of more loads,and stable structures.The porous structure of MOFs can maintain biomolecular configuration,enhance biological stability,and improve the loading efficiency of biomolecules.Biomolecules can be stably loaded on the surface or inside of MOFs by surface immobilization,diffusion immobilization or encapsulation immobilization.By adjusting metal ions or cluster and organic ligands,MOFs can be designed with different porosity,pore size,bioaffinity,which can adapt the requirements of the loaded material.We systematically summarize the application and research progress of MOFs in enzyme immobilization,cell immobilization,nucleic acid immobilization,and drug immobilization,which can provide a new research direction for the biomolecule immobilization carrier.
The metal-organic frameworks(MOFs) have a typical three-dimensional composite structure,which are constituted by metal ions or cluster and organic ligands.MOFs have the characteristics of large specific surface areas,various types,capacity of more loads,and stable structures.The porous structure of MOFs can maintain biomolecular configuration,enhance biological stability,and improve the loading efficiency of biomolecules.Biomolecules can be stably loaded on the surface or inside of MOFs by surface immobilization,diffusion immobilization or encapsulation immobilization.By adjusting metal ions or cluster and organic ligands,MOFs can be designed with different porosity,pore size,bioaffinity,which can adapt the requirements of the loaded material.We systematically summarize the application and research progress of MOFs in enzyme immobilization,cell immobilization,nucleic acid immobilization,and drug immobilization,which can provide a new research direction for the biomolecule immobilization carrier.
引文
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[2] LI P,MOON S Y,GUELTA M A,et al.Nanosizing a metal-organic framework enzyme carrier for accelerating nerve agent hydrolysis[J].ACS Nano,2016,10(10):9174-9182.
[3] ZHANG Y,WANG F,LIU C,et al.Nanozyme decorated metal-organic frameworks for enhanced photodynamic therapy[J].ACS Nano,2018,12(1):651-661.
[4] HE H M,ZHU Q Q,SUN F X,et al.Two 3D metal-organic frameworks based on CoⅡ and ZnⅡ clusters for Knoevenagel condensation reaction and highly selective luminescence sensing[J].Crystal Growth & Design,2018,18(9):5573-5581.
[5] CHEPLAKOVA A M,SOLOVIEVA A O,POZMOGOVA T N,et al.Nanosized mesoporous metal-organic framework MIL-101 as a nanocarrier for photoactive hexamolybdenum cluster compounds[J].Journal of Inorganic Biochemistry,2017,166:100-107.
[6] JING T,CHEN L,JIANG F L,et al.Fabrication of a robust lanthanide metal-organic framework as a multifunctional material for Fe(Ⅲ) detection,CO2 capture,and utilization[J].Crystal Growth & Design,2018,18(5):2956-2963.
[7] GUSTAFSON J A,WILMER C T.Optimizing information content in MOFs sensor arrays for analyzing methane-air mixtures[J].Sensors and Actuators B:Chemical,2018,267:483-493.
[8] QIN J S,YUAN S,LOLLAR C T,et al.Stable metal-organic frameworks as host platform for catalysis and biomimetics[J].Chemical Communications,2018,54(34):4231-4239.
[9] LIANG K,WANG R,BOUTTER M,et al.Biomimetic mineralization of metal-organic frameworks around polysaccharides[J].Chemical Communications,2017,53(7):1249-1252.
[10] NING D,LIU Q,WANG Q,et al.Luminescent MOFs nanosheets for enzyme assisted detection of H2O2 and glucose and activity assay of glucose oxidase[J].Sensors and Actuators B:Chemical,2019,282:443-448.
[11] LIU W L,LO S H,SINGCO B,et al.Novel trypsin-FITC@MOFs bioreactor efficiently catalyzes protein digestion[J].Journal of Materials Chemistry B,2013,1(7):928-932.
[12] GASCóN-PéREZ V,JIMéNEZ M B,BLANCO R M,et al.Semi-crystalline Fe-BTC MOFs material as an efficient support for enzyme immobilization[J].Catalysis Today,2018,304:119-126.
[13] LI P,CHEN Q S,WANG T C,et al.Hierarchically engineered mesoporous metal-organic frameworks toward cell-free immobilized enzyme systems[J].Chem,2018,4(5):1022-1034.
[14] LI J,XIA J F,ZHANG F F,et al.An electrochemical sensor based on copper-based metal-organic frameworks-graphene composites for determination of dihydroxybenzene isomers in water[J].Talanta,2018,181:80-86.
[15] JIANG W,WANG X H,CHEN J W,et al.Deuterohemin-peptide enzyme mimic-embedded metal-organic frameworks through biomimetic mineralization with efficient ATRP catalytic activity[J].ACS Applied Materials & Interfaces,2017,9(32):26948-26957.
[16] LIANG K,RICCO R,DOHERTY C M,et al.Biomimetic mineralization of metal-organic frameworks as protective coatings for biomacromolecules[J].Nature Communications,2015,6:7240-7249.
[17] LI Y A,ZHAO C W,ZHU N X,et al.Nanoscale UiO-MOFs-based luminescent sensors for highly selective detection of cysteine and glutathione and their application in bioimaging[J].Chemical Communications,2015,51(100):17672-17675.
[18] LIANG K,RICHARDSON J J,CUI J W,et al.Metal-organic framework coatings as cytoprotective exoskeletons for living cells[J].Advanced Materials,2016,28(36):8066.
[19] LIANG K,RICHARDSON J J,DOONAN C J,et al.An enzyme-coated metal-organic framework shell for synthetically adaptive cell survival[J].Angewandte Chemie International Edition,2017,56(29):8510-8515.
[20] ZHOU N,SU F F,GUO C P,et al.Two-dimensional oriented growth of Zn-MOFs-on-Zr-MOFs architecture:a highly sensitive and selective platform for detecting cancer markers[J].Biosensors and Bioelectronics,2019,123:51-58.
[21] CUI L,WU J,LI J,et al.Electrochemical sensor for lead cation sensitized with a DNA functionalized porphyrinic metal-organic framework[J].Analytical Chemistry,2015,87(20):10635-10641.
[22] DONG K,ZHANG Y,ZHANG L,et al.Facile preparation of metal-organic frameworks-based hydrophobic anticancer drug delivery nanoplatform for targeted and enhanced cancer treatment[J].Talanta,2019,194:703-708.
[23] ABáNADES-LáZARO I,FORGAN R S.Application of zirconium MOFs in drug delivery and biomedicine[J].Coordination Chemistry Reviews,2019,380:230-259.
[24] ABUCAFY M P,CAETANO B L,CHIRARI-ANDREO B G,et al.Supramolecular cyclodextrin-based metal-organic framework as efficient carriers for anti-inflammatory drugs[J].European Journal of Pharmaceutics & Biopharmaceutics,2018,127:112-119.
[25] JIANG K,ZHANG L,HU Q,et al.A zirconium-based metal-organic framework with encapsulated anionic drug for uncommonly controlled oral drug delivery[J].Microporous and Mesoporous Materials,2019,275:229-234.