轻度认知功能损害亚型与中医证候特征相关性分析
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摘要
目的探讨轻度认知功能损害(MCI)亚型与中医证候特征的相关性。方法采用简易精神状态检查、画钟测验和韦氏逻辑记忆亚测验对100例MCI患者进行测试,并将患者分为遗忘型MCI组(a MCI组)及非遗忘型MCI组(na MCI组),并对比2组患者中医证候特征。结果 a MIC组痰浊阻窍和气血亏虚的出现率以及评分均显著高于na MIC组(P均<0.05),2组其余中医证候特征分布和评分比较差异无统计学意义(P均>0.05)。肾精亏虚证和痰浊阻窍证评分均与画钟测验得分呈显著负相关(r=-0.128,-0.213;P<0.05);气血亏虚证评分与总体认知评分和韦氏逻辑记忆亚测验评分均呈显著负相关(r=-0.210,-0.234;P<0.05)。结论轻度认知功能损害亚型与中医证候特征存在一定相关,a MCI痰浊阻窍和气血亏虚的出现率以及评分均显著高于非遗忘型MCI。
Objective It is to investigate the correlation between mild cognitive impairment subtypes and TCM syndrome characteristics. Methods One hundred patients with mild cognitive impairment were tested by mini mental state examination,clock drawing test and Wechsler logical memory sub-test,then were divided into amnestic MCI( a MCI) group and non-amnestic MCI( na MCI) group,and compare the syndrome characteristics of patients in the two groups. Results The occurrence rate and score of phlegm obstructing orifice and Qi blood deficiency in group a MIC were significantly higher than those in group na MIC( all P < 0. 05). There was no significant difference in the distribution and score of the other TCM syndromes between the two groups( all P > 0. 05). There was a significant negative correlation between the scores of kidney essence deficiency syndrome and phlegm turbidity blocking syndrome( r =-0. 128,-0. 213,all P < 0. 05).There was a significant negative correlation between Qi blood deficiency syndrome scores and general cognitive scores and Wechsler logical memory sub-test scores( r =-0. 210,-0. 234,all P < 0. 05). Conclusion There is a certain correlation between mild cognitive impairment subtypes and TCM syndrome characteristics. The incidence and score of phlegm obstructing orifice and Qi blood deficiency in patients with a MCI are significantly higher than those in na MCI patients.
Objective It is to investigate the correlation between mild cognitive impairment subtypes and TCM syndrome characteristics. Methods One hundred patients with mild cognitive impairment were tested by mini mental state examination,clock drawing test and Wechsler logical memory sub-test,then were divided into amnestic MCI( a MCI) group and non-amnestic MCI( na MCI) group,and compare the syndrome characteristics of patients in the two groups. Results The occurrence rate and score of phlegm obstructing orifice and Qi blood deficiency in group a MIC were significantly higher than those in group na MIC( all P < 0. 05). There was no significant difference in the distribution and score of the other TCM syndromes between the two groups( all P > 0. 05). There was a significant negative correlation between the scores of kidney essence deficiency syndrome and phlegm turbidity blocking syndrome( r =-0. 128,-0. 213,all P < 0. 05).There was a significant negative correlation between Qi blood deficiency syndrome scores and general cognitive scores and Wechsler logical memory sub-test scores( r =-0. 210,-0. 234,all P < 0. 05). Conclusion There is a certain correlation between mild cognitive impairment subtypes and TCM syndrome characteristics. The incidence and score of phlegm obstructing orifice and Qi blood deficiency in patients with a MCI are significantly higher than those in na MCI patients.
引文
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[11]李娌,王学美,富宏,等.轻度认知障碍患者记忆损伤与中医证型的关系[J].中国组织工程研究与临床康复,2007,11(39):7826
[12]苗迎春,田金洲,时晶,等.遗忘型轻度认知损害患者认知功能与中医症候的相关性[J].中西医结合学报,2009,7(3):205
[13]刘峘,田金洲.老年人认知水平与中医证候的相关性研究[J].中国老年学杂志,2003,6(24):347-348
[2]赵晓东,时晶,房立岩.轻度认知损害的诊断、转归及其与中医证候的关系[J].中华中医药杂志,2007,22(6):379-380
[3]田金洲,时晶.《血管性痴呆诊断、辨证及疗效判定标准》中有关诊断标准和疗效评价方法的说明——兼回答读者提问[C].中国中医药学会内科延缓衰老专业委员会第三次学术会议,2001
[4]贾建平,王荫华,张振馨,等.中国痴呆与认知障碍诊治指南(三):神经心理评估的量表选择[J].中华医学杂志,2011,91(11):735-740
[5]梁新政,吴云波,时晶,等.神经心理学单项指标在诊断轻度认知损害中的意义[J].中华老年医学杂志,2013,32(6):615-617
[6]时晶,倪敬年,田金洲,等.中国痴呆诊疗指南——轻度认知损害诊疗指南解读[J/CD].中国医学前沿杂志:电子版,2012,4(10):67-70
[7]Fisk JD,Merry HR,Rockwood K.Variations in case definition affect prevalence but not outcomes of mild cognitive impairment[J].Neurology,2003,61(9):1179-1184
[8]钟剑,朱爱华,田金洲,等.参乌胶囊治疗老年轻度认知功能障碍认知损害临床对照研究[J].中国中药杂志,2007,32(17):1800-1803
[9]周如倩,袁泉.参银口服液治疗轻度认知功能损害的临床研究[J].中国中西医结合杂志,2007,27(9):793-795
[10]杨承芝,钟剑,朱爱华.老年人轻度认知损害的中医证候研究[J].北京中医药大学学报:中医临床版,2003,10(2):12-15
[11]李娌,王学美,富宏,等.轻度认知障碍患者记忆损伤与中医证型的关系[J].中国组织工程研究与临床康复,2007,11(39):7826
[12]苗迎春,田金洲,时晶,等.遗忘型轻度认知损害患者认知功能与中医症候的相关性[J].中西医结合学报,2009,7(3):205
[13]刘峘,田金洲.老年人认知水平与中医证候的相关性研究[J].中国老年学杂志,2003,6(24):347-348