二甲双胍在初发2型糖尿病治疗中的应用研究
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摘要
目的探讨二甲双胍不同给药方法治疗初发2型糖尿病的临床效果。方法选取我院2017年6月—2018年3月期间收治的80例初发2型糖尿病患者作为研究对象,将其依照用药方法的不同分为研究组与对照组,每组40例。对照组患者依照2次/d,每次1 000 mg的给药方案治疗;研究组患者依照4次/d,每次500 mg的给药方案治疗,比较2组患者的临床治疗效果。结果治疗12周后,研究组患者空腹血糖水平明显低于对照组,差异具有统计学意义(P<0.05),而2组餐后血糖与糖化血红蛋白水平对比差异不具有统计学意义(P>0.05);治疗12周后,研究组患者胃肠道反应的发生率明显低于对照组,差异具有统计学意义(P<0.05)。结论二甲双胍每天给药4次,每次500mg的给药方案治疗初发2型糖尿病,能够有效降低患者空腹血糖水平,减少肠道副反应的发生率,值得临床推广应用。
Objective The clinical effects of different methods of administration of metformin on early onset type2 diabetes mellitus. Methods 80 patients with early onset type 2 diabetes treated by our hospital from June 2017 to March 2018 were selected as the subjects,and divided into study group and control group according to the method of administration,40 cases in each group;The patients in the control group were treated according to the dose regimen of 2 times/day and 1000 mg each time,and the patients in the study group were treated according to the dose regimen of 4 times/day and 500 mg each time,and then the clinical treatment effect of the two groups was observed and compared.Results After 12 weeks of treatment,the study was carried out.The fasting blood glucose level in the study group was significantly lower than that in the control group(P<0.05),but there was no significant difference between postprandial blood glucose and glycosylated hemoglobin index(P>0.05).The incidence of gastrointestinal reaction in the study group was significantly lower than that in the control group(P<0.05).Conclusion metformin,given 4 times a day and treated with 500 mg every time,can effectively reduce the level of fasting blood glucose and the incidence of intestinal side effects,so it is worth popularizing and applying in clinical samples.
Objective The clinical effects of different methods of administration of metformin on early onset type2 diabetes mellitus. Methods 80 patients with early onset type 2 diabetes treated by our hospital from June 2017 to March 2018 were selected as the subjects,and divided into study group and control group according to the method of administration,40 cases in each group;The patients in the control group were treated according to the dose regimen of 2 times/day and 1000 mg each time,and the patients in the study group were treated according to the dose regimen of 4 times/day and 500 mg each time,and then the clinical treatment effect of the two groups was observed and compared.Results After 12 weeks of treatment,the study was carried out.The fasting blood glucose level in the study group was significantly lower than that in the control group(P<0.05),but there was no significant difference between postprandial blood glucose and glycosylated hemoglobin index(P>0.05).The incidence of gastrointestinal reaction in the study group was significantly lower than that in the control group(P<0.05).Conclusion metformin,given 4 times a day and treated with 500 mg every time,can effectively reduce the level of fasting blood glucose and the incidence of intestinal side effects,so it is worth popularizing and applying in clinical samples.
引文
[1]吴震宇,薛长春,李洁超,等.二甲双胍在初发2型糖尿病治疗中的应用研究[J].世界临床医学,2017,11(2):256-257.
[2]高会敏.磷酸西格列汀与二甲双胍在初发性2型糖尿病治疗中的应用效果[J].北方药学,2017,14(4):88.
[3]力石加.分析二甲双胍在初发2型糖尿病治疗中的应用[J].世界最新医学信息文摘,2018,16(25):75-76.
[4]梁静瑛.磷酸西格列汀与二甲双胍在初发性2型糖尿病治疗中的应用效果[J].健康之路,2017,18(7):220-221.
[2]高会敏.磷酸西格列汀与二甲双胍在初发性2型糖尿病治疗中的应用效果[J].北方药学,2017,14(4):88.
[3]力石加.分析二甲双胍在初发2型糖尿病治疗中的应用[J].世界最新医学信息文摘,2018,16(25):75-76.
[4]梁静瑛.磷酸西格列汀与二甲双胍在初发性2型糖尿病治疗中的应用效果[J].健康之路,2017,18(7):220-221.