常见阴道微生态异常与高危型HPV感染及子宫颈癌相关性研究进展
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摘要
子宫颈癌是严重危害女性健康的第二大肿瘤,其相关病因学研究由来已久。其中高危型HPV病毒持续感染已被证实是导致子宫颈癌的主要因素。近年来,随着分子生物学的不断发展,越来越多的研究显示,机体微生态环境与病毒感染息息相关。阴道作为子宫毗邻器官,其微生态环境状态可直接影响着女性的子宫颈健康。因此,本文即从阴道微生态环境出发,综述了由阴道微生态失衡所导致的常见阴道微生态异常与子宫颈高危型HPV感染及宫颈癌发生的相关性。
Cervical cancer is the second-most common malignant neoplasm in women,the etiology study about cervical cancer has been studied for a long time.Persistent infection of high-risk human papillomavirus(HR-HPV)has been proved to be the main cause of cervical cancer.In recent years,with the continuous development of molecular biology,more and more studies have shown that the microbial ecosystem of the organism is closely related to virus infection.As adjacent organ of the uterus,vaginal microbial ecosystem can directly influence cervix health.Therefore,this review focus on the vaginal microbial ecosystem and explore the correlation between abnormal microbial ecosystem and HR-HPV infection,cervical cancer.
Cervical cancer is the second-most common malignant neoplasm in women,the etiology study about cervical cancer has been studied for a long time.Persistent infection of high-risk human papillomavirus(HR-HPV)has been proved to be the main cause of cervical cancer.In recent years,with the continuous development of molecular biology,more and more studies have shown that the microbial ecosystem of the organism is closely related to virus infection.As adjacent organ of the uterus,vaginal microbial ecosystem can directly influence cervix health.Therefore,this review focus on the vaginal microbial ecosystem and explore the correlation between abnormal microbial ecosystem and HR-HPV infection,cervical cancer.
引文
[1]刘迎春,刘翠.新疆塔城农村地区汉族和哈萨克族妇女宫颈癌发病率及相关高危因素分析[J].疾病预防控制通报, 2016, 31(3):1-3.
[2]刘慧燕.子宫颈人乳头瘤病毒感染与阴道环境相关因素的研究[J].临床合理用药杂志, 2016, 9(22):144-145.
[3] MITRA A, MACINTYRE D A, MARCHESI J R, et al. The vaginal microbiota, human papillomavirus infection and cervical intraepithelial neoplasia:what do we know and where are we going next[J]. Microbiome, 2016, 4(1):58.
[4] PLUMMER M, SCHIFFMAN M, CASTLE P, et al. A 2-year prospective study of human papillomavirus persistence among women with a cytological diagnosis of atypical squamous cells of undetermined significance or low-grade squamous intraepithelial lesion.[J]. The Journal of Infectious Diseases, 2007, 195(11):1582-1589.
[5]王美藏,高建宏,杨雅琴.乳酸杆菌半定量、阴道清洁度及阴道炎症与HPV感染的关系[J].中国妇幼保健, 2016, 31(22):4734-4736.
[6]丁尚玮,柳露,李芹.宫颈细胞学ASCUS与阴道炎症相关性分析[J].湖南中医药大学学报, 2016, 36:491-492.
[7] WILKS J, GOLOVKINA T. Influence of microbiota on viral infections[J]. PLoS Pathog, 2012, 8(5):e1002681.
[8] SENDER R, FUCHS S, MILO R. Are we really vastly outnumbered?revisiting the ratio of bacterial to host cells in humans[J]. Cell, 2016,164(3):337-340.
[9] DETHLEFSEN L, MCFALL-NGAI M, RELMAN DA. An ecological and evolutionary perspective on human-microbe mutualism and disease[J]. Nature, 2007, 449(7164):811-818.
[10] MOTEVASELI E, AZAM R, AKRAMI S M, et al. The effect of Lactobacillus crispatus and Lactobacillus rhamnosus culture supernatants on expression of autophagy genes and HPV E6 and E7oncogenes in The HeLa Cell Line[J]. Cell J, 2016, 17(4):601-607.
[11] ROUND J L, LEE S M, LI J, et al. The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota[J].Science, 2011, 332(6032):974-977.
[12] KINDINGER L M, MACINTYRE D A, LEE Y S, et al. Relationship between vaginal microbial dysbiosis, inflammation, and pregnancy outcomes in cervical cerclage[J]. Sci Transl Med, 2016, 8(350):350ra102.
[13]肖冰冰,廖秦平.阴道微生态研究进展[J].国际妇产科学杂志,2011, 38(6):479-482.
[14]王扣琴.不同检测方法在细菌性阴道病诊断中应用价值比较[J].淮海医药, 2017, 35(2):206-208.
[15]许苏容,宗利丽,刘木彪,等. Illumina测序16S r RNA标签法分析细菌性阴道病患者阴道菌群多样性[J].南方医科大学学报,2013, 33(5):672-677.
[16]张琴,丁雪婧,赵菊芬,等.细菌性阴道病五项联合测定试剂盒在临床诊断中的应用价值[J].西南军医, 2012, 14(5):721-722.
[17] CARTWRIGHT C P, LEMBKE B D, RAMACHANDRAN K, et al.Comparison of nucleic acid amplification assays with BD affirm VPIII for diagnosis of vaginitis in symptomatic women[J]. J Clin Microbiol, 2013, 51(11):3694-3699.
[18] BYUN S W, PARK Y J, HUR S Y. Affirm VPIII microbial identification test can be used to detect gardnerella vaginalis,Candida albicans and trichomonas vaginalis microbial infections in Korean women[J]. J Obstet Gynaecol Res, 2016, 42(4):422-426.
[19] ESCHENBACH D A, THWIN S S, PATTON D L, et al. Influence of the normal menstrual cycle on vaginal tissue, discharge, and microflora[J]. Clinical Infectious Diseases, 2000, 30(6):901-907.
[20]孟龄婷,薛艳,岳婷,等. HPV感染与BV、VVC、TV的相关性基于1261例妇科门诊患者的临床研究[J].中华妇产科杂志, 2016, 51(10):730-733.
[21] GIAKOUMELOU S, WHEELHOUSE N, CUSCHIERI K, et al. The role of infection in miscarriage[J]. Hum Reprod Update, 2016, 22(1):116-133.
[22]刘风燕.阴道加德纳菌研究进展[J].中国微生态学杂志, 2007, 19(2):231-232, 235.
[23] GILLET E, MEYS J F, VERSTRAELEN H, et al. Bacterial vaginosis is associated with uterine cervical human papillomavirus infection:a meta-analysis[J]. BMC Infectious Diseases, 2011,(1):10.
[24]卢晓英,郭玲.加德纳菌与临床细菌性阴道病的相关性[J].西部医学, 2015, 27(3):395-397.
[25] GILLET E, MEYS J F A, VERSTRAELEN H, et al. Association between bacterial vaginosis and cervical intraepithelial neoplasia:systematic review and meta-analysis[J]. PLoS ONE, 2012(10):e45201.
[26]阎冰冰.阴道内环境与宫颈高危人乳头瘤病毒感染的关系[J].中国医药指南, 2018, 16(9):99-100.
[27]欧阳才颜.第二代高通量测序分析VVC及RVVC患者阴道菌群结构[D].重庆:南方医科大学, 2014.
[28]薛凤霞,王宝晨,王辰.下生殖道感染诊治中面临的问题与挑战[J].中国妇产科临床杂志, 2016, 17(6):481-482.
[29] GHOSH I, MANDAL R, KUNDU P, et al. Association of genital infections other than human papillomavirus with pre-invasive and invasive cervical neoplasia[J]. J Clin Diagn Res, 2016, 10(2):XE01-XE06.
[30]张静,李晓苗,苗姚霞,等. 1426例阴道毛滴虫感染者临床特征及感染因素分析[J].中国病原生物学杂志, 2016(10):947-949,954.
[31] WHO. Report on global sexually transmitted infection surveillance2013[EB/OL]. 2016. http://www.who.int/reproductivehealth/publications/rtis/stis-surveillance-2013/en/.
[32] LAZENBY G B, TAYLOR P T, BADMAN B S, et al. An association between Trichomonas vaginalis and high-risk human papillomavirus in rural Tanzanian women undergoing cervical cancer screening[J]. Clin Ther, 2014, 36(1):38-45.
[33]李东燕,郝敏.阴道微生态平衡与高危型HPV感染分析[J].中国微生态学杂志, 2016, 28(5):594-597.
[34]王宝晨,夏玉洁,王辰,等.高危型人乳头瘤病毒感染子宫颈上皮内瘤变患者阴道微生态分析[J].中国妇产科临床杂志, 2016, 17(6):486-489.
[35]李敏.育龄妇女生殖道感染患病情况及影响因素调查[J].中国医药导报, 2015, 12(8):82-86.
[2]刘慧燕.子宫颈人乳头瘤病毒感染与阴道环境相关因素的研究[J].临床合理用药杂志, 2016, 9(22):144-145.
[3] MITRA A, MACINTYRE D A, MARCHESI J R, et al. The vaginal microbiota, human papillomavirus infection and cervical intraepithelial neoplasia:what do we know and where are we going next[J]. Microbiome, 2016, 4(1):58.
[4] PLUMMER M, SCHIFFMAN M, CASTLE P, et al. A 2-year prospective study of human papillomavirus persistence among women with a cytological diagnosis of atypical squamous cells of undetermined significance or low-grade squamous intraepithelial lesion.[J]. The Journal of Infectious Diseases, 2007, 195(11):1582-1589.
[5]王美藏,高建宏,杨雅琴.乳酸杆菌半定量、阴道清洁度及阴道炎症与HPV感染的关系[J].中国妇幼保健, 2016, 31(22):4734-4736.
[6]丁尚玮,柳露,李芹.宫颈细胞学ASCUS与阴道炎症相关性分析[J].湖南中医药大学学报, 2016, 36:491-492.
[7] WILKS J, GOLOVKINA T. Influence of microbiota on viral infections[J]. PLoS Pathog, 2012, 8(5):e1002681.
[8] SENDER R, FUCHS S, MILO R. Are we really vastly outnumbered?revisiting the ratio of bacterial to host cells in humans[J]. Cell, 2016,164(3):337-340.
[9] DETHLEFSEN L, MCFALL-NGAI M, RELMAN DA. An ecological and evolutionary perspective on human-microbe mutualism and disease[J]. Nature, 2007, 449(7164):811-818.
[10] MOTEVASELI E, AZAM R, AKRAMI S M, et al. The effect of Lactobacillus crispatus and Lactobacillus rhamnosus culture supernatants on expression of autophagy genes and HPV E6 and E7oncogenes in The HeLa Cell Line[J]. Cell J, 2016, 17(4):601-607.
[11] ROUND J L, LEE S M, LI J, et al. The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota[J].Science, 2011, 332(6032):974-977.
[12] KINDINGER L M, MACINTYRE D A, LEE Y S, et al. Relationship between vaginal microbial dysbiosis, inflammation, and pregnancy outcomes in cervical cerclage[J]. Sci Transl Med, 2016, 8(350):350ra102.
[13]肖冰冰,廖秦平.阴道微生态研究进展[J].国际妇产科学杂志,2011, 38(6):479-482.
[14]王扣琴.不同检测方法在细菌性阴道病诊断中应用价值比较[J].淮海医药, 2017, 35(2):206-208.
[15]许苏容,宗利丽,刘木彪,等. Illumina测序16S r RNA标签法分析细菌性阴道病患者阴道菌群多样性[J].南方医科大学学报,2013, 33(5):672-677.
[16]张琴,丁雪婧,赵菊芬,等.细菌性阴道病五项联合测定试剂盒在临床诊断中的应用价值[J].西南军医, 2012, 14(5):721-722.
[17] CARTWRIGHT C P, LEMBKE B D, RAMACHANDRAN K, et al.Comparison of nucleic acid amplification assays with BD affirm VPIII for diagnosis of vaginitis in symptomatic women[J]. J Clin Microbiol, 2013, 51(11):3694-3699.
[18] BYUN S W, PARK Y J, HUR S Y. Affirm VPIII microbial identification test can be used to detect gardnerella vaginalis,Candida albicans and trichomonas vaginalis microbial infections in Korean women[J]. J Obstet Gynaecol Res, 2016, 42(4):422-426.
[19] ESCHENBACH D A, THWIN S S, PATTON D L, et al. Influence of the normal menstrual cycle on vaginal tissue, discharge, and microflora[J]. Clinical Infectious Diseases, 2000, 30(6):901-907.
[20]孟龄婷,薛艳,岳婷,等. HPV感染与BV、VVC、TV的相关性基于1261例妇科门诊患者的临床研究[J].中华妇产科杂志, 2016, 51(10):730-733.
[21] GIAKOUMELOU S, WHEELHOUSE N, CUSCHIERI K, et al. The role of infection in miscarriage[J]. Hum Reprod Update, 2016, 22(1):116-133.
[22]刘风燕.阴道加德纳菌研究进展[J].中国微生态学杂志, 2007, 19(2):231-232, 235.
[23] GILLET E, MEYS J F, VERSTRAELEN H, et al. Bacterial vaginosis is associated with uterine cervical human papillomavirus infection:a meta-analysis[J]. BMC Infectious Diseases, 2011,(1):10.
[24]卢晓英,郭玲.加德纳菌与临床细菌性阴道病的相关性[J].西部医学, 2015, 27(3):395-397.
[25] GILLET E, MEYS J F A, VERSTRAELEN H, et al. Association between bacterial vaginosis and cervical intraepithelial neoplasia:systematic review and meta-analysis[J]. PLoS ONE, 2012(10):e45201.
[26]阎冰冰.阴道内环境与宫颈高危人乳头瘤病毒感染的关系[J].中国医药指南, 2018, 16(9):99-100.
[27]欧阳才颜.第二代高通量测序分析VVC及RVVC患者阴道菌群结构[D].重庆:南方医科大学, 2014.
[28]薛凤霞,王宝晨,王辰.下生殖道感染诊治中面临的问题与挑战[J].中国妇产科临床杂志, 2016, 17(6):481-482.
[29] GHOSH I, MANDAL R, KUNDU P, et al. Association of genital infections other than human papillomavirus with pre-invasive and invasive cervical neoplasia[J]. J Clin Diagn Res, 2016, 10(2):XE01-XE06.
[30]张静,李晓苗,苗姚霞,等. 1426例阴道毛滴虫感染者临床特征及感染因素分析[J].中国病原生物学杂志, 2016(10):947-949,954.
[31] WHO. Report on global sexually transmitted infection surveillance2013[EB/OL]. 2016. http://www.who.int/reproductivehealth/publications/rtis/stis-surveillance-2013/en/.
[32] LAZENBY G B, TAYLOR P T, BADMAN B S, et al. An association between Trichomonas vaginalis and high-risk human papillomavirus in rural Tanzanian women undergoing cervical cancer screening[J]. Clin Ther, 2014, 36(1):38-45.
[33]李东燕,郝敏.阴道微生态平衡与高危型HPV感染分析[J].中国微生态学杂志, 2016, 28(5):594-597.
[34]王宝晨,夏玉洁,王辰,等.高危型人乳头瘤病毒感染子宫颈上皮内瘤变患者阴道微生态分析[J].中国妇产科临床杂志, 2016, 17(6):486-489.
[35]李敏.育龄妇女生殖道感染患病情况及影响因素调查[J].中国医药导报, 2015, 12(8):82-86.