家畜人工授精诱导子宫免疫反应的因素及应对措施
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摘要
家畜在进行人工授精时,精液成分会引起子宫免疫炎症,进而造成精子损伤,影响繁殖效益。文章主要以动物繁殖免疫学理论为基础,阐述免疫细胞对精子趋化性和吞噬性的机制、免疫细胞在繁殖器官的分布情况、人工精液成分对子宫免疫反应的影响以及人工调控降低子宫免疫炎症对精子损伤的方法等,旨在为家畜人工授精技术的进一步发展提供理论基础和新的途径。
Artificial insemination technology is widely used in animal husbandry,however,the semen components can cause immune inflammation in the uterus,which results in sperm injury and affects production benefit. This article was mainly based on the theory of animal reproductive immunology,and analyzed the mechanism of immune cells to sperm chemotaxis and phagocytosis,the distribution of immune cells in the reproductive organs,the effect of artificial semen components on the uterine immune response,and the measures of artificially regulating and reducing the damage of uterus immune inflammation to the sperm,and made a systematic review. The aim of this paper was to provide a theoretical basis for the further development of artificial insemination technology in domestic animals,to improve reproductive efficiency through low-dose sperm,and to provide a new way for the development of artificial insemination technology.
Artificial insemination technology is widely used in animal husbandry,however,the semen components can cause immune inflammation in the uterus,which results in sperm injury and affects production benefit. This article was mainly based on the theory of animal reproductive immunology,and analyzed the mechanism of immune cells to sperm chemotaxis and phagocytosis,the distribution of immune cells in the reproductive organs,the effect of artificial semen components on the uterine immune response,and the measures of artificially regulating and reducing the damage of uterus immune inflammation to the sperm,and made a systematic review. The aim of this paper was to provide a theoretical basis for the further development of artificial insemination technology in domestic animals,to improve reproductive efficiency through low-dose sperm,and to provide a new way for the development of artificial insemination technology.
引文
[1]ROZEBOOM K J,TROEDSSON M H,HODSON H H,et al.The importance of seminal plasma on the fertility of subsequent artificial inseminations in swine[J].J Anim Sci,2000,78(2):443-448.
[2]FICHTNER T,KOTARSKI F,SILVA L,et al.14 composition of semen extenders and varying seminal plasma concentrations affects formation of neutrophil extracellular traps in the bovine system[J].Reprod Fertil Dev,2017,30(1):146-147.
[3]ROZEBOOM K J,TROEDSSON M H,MOLITOR T W,et al.The effect of spermatozoa and seminal plasma on leukocyte migration into the uterus of gilts[J].J Anim Sci,1999,77(8):2201.
[4]SNCHEZ-RODRGUEZ A,GUTIRREZ-CEPEDA L,FERNNDEZ-NOVO A,et al.Evaluation of the effect of seminal plasma in the post insemination uterine inflammatory dynamic by power doppler ultrasonography and low volume lavage in the mare[J].J Equine Vet Sci,2018,66:134.
[5]刘姗.抑制性中性粒细胞亚群通过CXCR4增强老龄脓毒症群体Treg细胞免疫抑制作用[D].大连:大连医科大学,2017.
[6]戴志民,王伍超.巨噬细胞吞噬作用的研究进展[J].世界最新医学信息文摘,2015(84):33-35.
[7]张少龙,樊竑冶.凋亡细胞清除过程中相关信号及机制的研究进展[J].中国免疫学杂志,2018,34(6):944-948.
[8]SILVA M T.When two is better than one:macrophages and neutrophils work in concert in innate immunity as complementary and cooperative partners of a myeloid phagocyte system[J].J Leukoc Biol,2010,87(1):93-106.
[9]李海鹏,姚建华.中性粒细胞在炎症反应中的作用及机制[J].医学综述,2015,21(9):1576-1578.
[10]SCOTT J L,KETHEESAN N,SUMMERS P M.Spermatozoa and seminal plasma induce a greater inflammatory response in the ovine uterus at oestrus than dioestrus[J].Reprod Fertil Dev,2009,21(7):817-826.
[11]李富宽,杨燕,吕慎金.影响母畜发情因素及其内分泌机理的研究进展[J].中国畜牧杂志,2017,53(8):10-14.
[12]李井春,李雁冰,张乃博,等.影响家畜人工授精诱导子宫免疫反应的因素的研究进展[J].黑龙江八一农垦大学学报,2012,24(6):29-32.
[13]陆姗姗.Pam3CSK4增强GM-CSF诱导的中性粒细胞对MRSA的杀菌功能及机制研究[D].南昌:南昌大学,2018.
[14]崔建东,赵忠胜,李大全,等.动物繁殖免疫技术[J].黑龙江畜牧兽医,2002(9):53-54.
[15]张安国,刘瑞风,刘新峰,等.精浆和精子对母兔子宫免疫及孕向发育的影响[J].黑龙江动物繁殖,2017,25(2):3-6.
[16]李井春,李雁冰,舟桥弘晃.猪精浆和卵黄调控体外牛嗜中性粒细胞对精子的趋化和吞噬活性的研究[J].中国畜牧杂志,2013,49(11):27-30.
[17]李井春,李琦,韩淑敏,等.肝素调控猪嗜中性粒细胞对精子的趋化和吞噬作用[J].畜牧与饲料科学,2018(3):13-15.
[18]O'LEARY S,JASPER M J,WARNES G M,et al.Seminal plasma regulates endometrial cytokine expression,leukocyte recruitment and embryo development in the pig[J].Reproduction,2004,128(2):237-247.
[19]靖凯霖.特异性卵黄抗体对灿烂弧菌感染仿刺参的保护作用研究[D].大连:大连理工大学,2016.
[20]贾佩.猪卵巢卵母细胞体外受精的研究[D].西宁:青海大学,2015.
[21]LI J C,YAMAGUCHI S,KONDO Y,et al.Caffeine,dibutyryl cyclic-AMP and heparin affect the chemotactic and phagocytotic activities of neutrophils for boar sperm in vitro[J].Theriogenology,2011,75(7):1336-1345.
[22]康翼鹏,周颖,薛小燕,等.巨噬细胞吞噬中性粒细胞的协同抗炎作用[J].生理科学进展,2012,43(6):455-458.
[23]SCOTT D A,KRAUSS J.Neutrophils in periodontal inflammation[J].Front Oral Biol,2012,15:56.
[24]梅军四,江中良,袁勤科,等.维生素E对不同品种的种公猪精液品质的影响[J].黑龙江畜牧兽医,2016(02下):87-90.
[25]王林芳.影响种公猪繁殖性能的营养因素[J].吉林畜牧兽医,2018,39(3):22-27.
[26]乔利敏,曹授俊,肖西山,等.猪适度深部输精技术的应用进展[J].山东畜牧兽医,2017(12):96-98.
[27]付永利,张宝东,于海霞,等.母猪深部输精与常规输精技术应用效果的比较研究[J].中国畜牧兽医文摘,2018,34(6):136-137.
[28]赵晶,王相国,齐晓龙,等.猪深部输精技术对母猪繁殖性能的影响[J].中国农学通报,2017,33(32):108-112.
[30]崔茂盛,付永利,李志,等.猪场低剂量深部输精技术应用研究[J].中国畜牧杂志,2018,54(4):47-49.
[31]胡玥.雌激素调节猪炎性子宫内膜细胞的分子机制[D].重庆:西南大学,2017.
[2]FICHTNER T,KOTARSKI F,SILVA L,et al.14 composition of semen extenders and varying seminal plasma concentrations affects formation of neutrophil extracellular traps in the bovine system[J].Reprod Fertil Dev,2017,30(1):146-147.
[3]ROZEBOOM K J,TROEDSSON M H,MOLITOR T W,et al.The effect of spermatozoa and seminal plasma on leukocyte migration into the uterus of gilts[J].J Anim Sci,1999,77(8):2201.
[4]SNCHEZ-RODRGUEZ A,GUTIRREZ-CEPEDA L,FERNNDEZ-NOVO A,et al.Evaluation of the effect of seminal plasma in the post insemination uterine inflammatory dynamic by power doppler ultrasonography and low volume lavage in the mare[J].J Equine Vet Sci,2018,66:134.
[5]刘姗.抑制性中性粒细胞亚群通过CXCR4增强老龄脓毒症群体Treg细胞免疫抑制作用[D].大连:大连医科大学,2017.
[6]戴志民,王伍超.巨噬细胞吞噬作用的研究进展[J].世界最新医学信息文摘,2015(84):33-35.
[7]张少龙,樊竑冶.凋亡细胞清除过程中相关信号及机制的研究进展[J].中国免疫学杂志,2018,34(6):944-948.
[8]SILVA M T.When two is better than one:macrophages and neutrophils work in concert in innate immunity as complementary and cooperative partners of a myeloid phagocyte system[J].J Leukoc Biol,2010,87(1):93-106.
[9]李海鹏,姚建华.中性粒细胞在炎症反应中的作用及机制[J].医学综述,2015,21(9):1576-1578.
[10]SCOTT J L,KETHEESAN N,SUMMERS P M.Spermatozoa and seminal plasma induce a greater inflammatory response in the ovine uterus at oestrus than dioestrus[J].Reprod Fertil Dev,2009,21(7):817-826.
[11]李富宽,杨燕,吕慎金.影响母畜发情因素及其内分泌机理的研究进展[J].中国畜牧杂志,2017,53(8):10-14.
[12]李井春,李雁冰,张乃博,等.影响家畜人工授精诱导子宫免疫反应的因素的研究进展[J].黑龙江八一农垦大学学报,2012,24(6):29-32.
[13]陆姗姗.Pam3CSK4增强GM-CSF诱导的中性粒细胞对MRSA的杀菌功能及机制研究[D].南昌:南昌大学,2018.
[14]崔建东,赵忠胜,李大全,等.动物繁殖免疫技术[J].黑龙江畜牧兽医,2002(9):53-54.
[15]张安国,刘瑞风,刘新峰,等.精浆和精子对母兔子宫免疫及孕向发育的影响[J].黑龙江动物繁殖,2017,25(2):3-6.
[16]李井春,李雁冰,舟桥弘晃.猪精浆和卵黄调控体外牛嗜中性粒细胞对精子的趋化和吞噬活性的研究[J].中国畜牧杂志,2013,49(11):27-30.
[17]李井春,李琦,韩淑敏,等.肝素调控猪嗜中性粒细胞对精子的趋化和吞噬作用[J].畜牧与饲料科学,2018(3):13-15.
[18]O'LEARY S,JASPER M J,WARNES G M,et al.Seminal plasma regulates endometrial cytokine expression,leukocyte recruitment and embryo development in the pig[J].Reproduction,2004,128(2):237-247.
[19]靖凯霖.特异性卵黄抗体对灿烂弧菌感染仿刺参的保护作用研究[D].大连:大连理工大学,2016.
[20]贾佩.猪卵巢卵母细胞体外受精的研究[D].西宁:青海大学,2015.
[21]LI J C,YAMAGUCHI S,KONDO Y,et al.Caffeine,dibutyryl cyclic-AMP and heparin affect the chemotactic and phagocytotic activities of neutrophils for boar sperm in vitro[J].Theriogenology,2011,75(7):1336-1345.
[22]康翼鹏,周颖,薛小燕,等.巨噬细胞吞噬中性粒细胞的协同抗炎作用[J].生理科学进展,2012,43(6):455-458.
[23]SCOTT D A,KRAUSS J.Neutrophils in periodontal inflammation[J].Front Oral Biol,2012,15:56.
[24]梅军四,江中良,袁勤科,等.维生素E对不同品种的种公猪精液品质的影响[J].黑龙江畜牧兽医,2016(02下):87-90.
[25]王林芳.影响种公猪繁殖性能的营养因素[J].吉林畜牧兽医,2018,39(3):22-27.
[26]乔利敏,曹授俊,肖西山,等.猪适度深部输精技术的应用进展[J].山东畜牧兽医,2017(12):96-98.
[27]付永利,张宝东,于海霞,等.母猪深部输精与常规输精技术应用效果的比较研究[J].中国畜牧兽医文摘,2018,34(6):136-137.
[28]赵晶,王相国,齐晓龙,等.猪深部输精技术对母猪繁殖性能的影响[J].中国农学通报,2017,33(32):108-112.
[30]崔茂盛,付永利,李志,等.猪场低剂量深部输精技术应用研究[J].中国畜牧杂志,2018,54(4):47-49.
[31]胡玥.雌激素调节猪炎性子宫内膜细胞的分子机制[D].重庆:西南大学,2017.