甘精胰岛素注射液联合阿卡波糖片对继发性磺脲类药物失效的2型糖尿病影响研究
|
摘要
目的观察甘精胰岛素注射液联合阿卡波糖片对继发性磺脲类药物失效的2型糖尿病影响。方法本次样本研究时间开始于2016年1月结束于2018年8月,将我院收治的97例继发性磺脲类药物失效的2型糖尿病患者作为研究样本,根据治疗方法的不同分为联合治疗组(n=49)和单一治疗组(n=48),单一治疗组予以阿卡波糖片治疗,联合治疗组予以甘精胰岛素注射液+阿卡波糖片治疗。而后对比两组患者血糖控制情况、体质量以及低血糖发生率。结果联合治疗组FPG(5.62±0.93)、2hPG(6.42±2.61)、Hba1c(6.71±0.62)、体质量(60.17±10.58)与单一治疗组(6.11±0.82)、(7.58±2.87)、(7.33±0.58)、(64.72±10.26)比较,差异显著,P<0.05,经比较显示t值分别为:2.7502、2.0833、5.0837、2.1495,P值分别为:0.0071、0.0399、0.0000;联合治疗组低血糖发生率为2.04%低于单一治疗组为12.5%,经比较显示t值为3.9615,P值为0.0465,差异显著,P <0.05。结论甘精胰岛素注射液联合阿卡波糖片对继发性磺脲类药物失效的2型糖尿病影响颇为显著,值得临床一线工作人员将其广泛应用。
Objective To observe effect of insulin glargine injection combined with acarbose tablets on type 2 diabetes mellitus with secondary sulfonylurea failure. Methods Treat 97 cases type 2 diabetes mellitus patients with secondary sulfonylurea failure in our hospital from January 2016 to August 2018 as study samples. Divide them into combination treatment group(n=49) and single treatment group(n=48) according to different treatment methods. Single treatment group was treated with acarbose tablets, and combination treatment group with insulin glargine injection and acarbose tablets. Compare blood sugar control, body mass and hypoglycemia incidence between two groups.Results FPG(5.62±0.93), 2 hPG(6.42±2.61), Hba1 c(6.71±0.62), body mass(60.17±10.58) showed significant difference against single treatment group,(6.11±0.82),(7.58±2.87),(7.33±0.58),(64.72±10.26), P<0.05. Comparison showed t value was 2.7502, 2.0833, 5.0837, 2.1495 respectively, and P value was 0.0071, 0.0399, 0.0000 respectively. Hypoglycemia incidence of combination treatment group was 2.04%, lower than 12.5% of single treatment group, comparison showed t value was 3.9615, and P value was 0.0465, with significant difference,(P<0.05). Conclusion Insulin glargine injection combined with acarbose tablets has significant effect on type 2 diabetes mellitus with secondary sulfonylurea failure,which is worthy of wide application by front-line clinical staffs.
Objective To observe effect of insulin glargine injection combined with acarbose tablets on type 2 diabetes mellitus with secondary sulfonylurea failure. Methods Treat 97 cases type 2 diabetes mellitus patients with secondary sulfonylurea failure in our hospital from January 2016 to August 2018 as study samples. Divide them into combination treatment group(n=49) and single treatment group(n=48) according to different treatment methods. Single treatment group was treated with acarbose tablets, and combination treatment group with insulin glargine injection and acarbose tablets. Compare blood sugar control, body mass and hypoglycemia incidence between two groups.Results FPG(5.62±0.93), 2 hPG(6.42±2.61), Hba1 c(6.71±0.62), body mass(60.17±10.58) showed significant difference against single treatment group,(6.11±0.82),(7.58±2.87),(7.33±0.58),(64.72±10.26), P<0.05. Comparison showed t value was 2.7502, 2.0833, 5.0837, 2.1495 respectively, and P value was 0.0071, 0.0399, 0.0000 respectively. Hypoglycemia incidence of combination treatment group was 2.04%, lower than 12.5% of single treatment group, comparison showed t value was 3.9615, and P value was 0.0465, with significant difference,(P<0.05). Conclusion Insulin glargine injection combined with acarbose tablets has significant effect on type 2 diabetes mellitus with secondary sulfonylurea failure,which is worthy of wide application by front-line clinical staffs.
引文
[1]李冬玲,李远,陈燕铭.甘精胰岛素联合格列美脲和阿卡波糖治疗磺脲类药物治疗失效的2型糖尿病的疗效观察[J].现代药物与临床,2017,32(3):423-427.
[2]冯茜.两种联合用药方法治疗经磺脲类降糖药物治疗继发失效的2型糖尿病的研究[J]中国处方药,2015,13(10):14-15.
[3]李晓蕾,陈明卫.甘精胰岛素联合格列美脲及阿卡波糖治疗磺脲类治疗失效的2型糖尿病患者血糖控制效果的观察[J].中国糖尿病杂志,2016,24(4):344-347.
[4]罗敏,曹洁.甘精胰岛素联合阿卡波糖片治疗老年糖尿病疗效与安全性评价[J].临床医药文献电子杂志,2017,4(29):5687.
[5]苏建军,林瑞典.甘精胰岛素联合阿卡波糖对2型糖尿病患者胰岛功能的影响[J].北方药学,2016,13(11):19-20.
[6]葛红英.2型糖尿病应用甘精胰岛素与阿卡波糖联合治疗的疗效分析[J].中国现代药物应用,2015,9(18):134-135.
[7]马剑,王春儿.胰岛素泵持续输注门冬胰岛素强化治疗对磺脲类药物继发性失效的T2DM患者胰岛功能与炎性因子的影响[J].江苏医药,2016,42(14):1592-1595.
[8]杨华,许学忠,祁平,等.甘精胰岛素注射液联合阿卡波糖片治疗继发性磺脲类药物失效的2型糖尿病的临床研究[J].中国临床药理学杂志,2017,33(3):219-221.
[2]冯茜.两种联合用药方法治疗经磺脲类降糖药物治疗继发失效的2型糖尿病的研究[J]中国处方药,2015,13(10):14-15.
[3]李晓蕾,陈明卫.甘精胰岛素联合格列美脲及阿卡波糖治疗磺脲类治疗失效的2型糖尿病患者血糖控制效果的观察[J].中国糖尿病杂志,2016,24(4):344-347.
[4]罗敏,曹洁.甘精胰岛素联合阿卡波糖片治疗老年糖尿病疗效与安全性评价[J].临床医药文献电子杂志,2017,4(29):5687.
[5]苏建军,林瑞典.甘精胰岛素联合阿卡波糖对2型糖尿病患者胰岛功能的影响[J].北方药学,2016,13(11):19-20.
[6]葛红英.2型糖尿病应用甘精胰岛素与阿卡波糖联合治疗的疗效分析[J].中国现代药物应用,2015,9(18):134-135.
[7]马剑,王春儿.胰岛素泵持续输注门冬胰岛素强化治疗对磺脲类药物继发性失效的T2DM患者胰岛功能与炎性因子的影响[J].江苏医药,2016,42(14):1592-1595.
[8]杨华,许学忠,祁平,等.甘精胰岛素注射液联合阿卡波糖片治疗继发性磺脲类药物失效的2型糖尿病的临床研究[J].中国临床药理学杂志,2017,33(3):219-221.