单宁酸的营养生理功能及其在单胃动物生产中的应用研究进展
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摘要
单宁酸是一种植物源水溶性多酚化合物,由于能够与蛋白质、消化酶、生物碱、多糖和金属离子等结合或络合形成沉淀,降低动物机体对养分的消化和吸收,通常被认为是一种抗营养因子。但近年来有研究发现,单宁酸的多元酚羟基使其本身具有收敛抗腹泻、抗氧化、抑菌和抗病毒等特性。适量的单宁酸可以为动物的生长性能和肠道健康带来良性的促进作用。本文综述了单宁酸的营养生理功能并总结了其在单胃动物生产中的应用效果,为单宁酸的进一步研究提供方向。
Tannic acid is a plant-derived water-soluble polyphenol compound. Tannic acid is generally considered as an anti-nutritional factor because it can bind with proteins,digestive enzymes,alkaloids,polysaccharides and metal ions to form a precipitate,which impairs the digestion and absorption of nutrients in animals.However,recent studies have found that the polyphenolic hydroxyl group of tannic acid not only has astringency to decrease diarrhea,but also has anti-oxidative,antibacterial,anti-viral activities and so on. Appropriate amount of tannic acid can promote growth performance and intestinal health of animals. This reviewsummarized the nutritional and physiological functions of tannic acid and summarizes its application in the production of monogastric animals,which would provide a direction for the further study of tannic acid.[Chinese Journal of Animal Nutrition,2019,31( 6) : 2544-2551]
Tannic acid is a plant-derived water-soluble polyphenol compound. Tannic acid is generally considered as an anti-nutritional factor because it can bind with proteins,digestive enzymes,alkaloids,polysaccharides and metal ions to form a precipitate,which impairs the digestion and absorption of nutrients in animals.However,recent studies have found that the polyphenolic hydroxyl group of tannic acid not only has astringency to decrease diarrhea,but also has anti-oxidative,antibacterial,anti-viral activities and so on. Appropriate amount of tannic acid can promote growth performance and intestinal health of animals. This reviewsummarized the nutritional and physiological functions of tannic acid and summarizes its application in the production of monogastric animals,which would provide a direction for the further study of tannic acid.[Chinese Journal of Animal Nutrition,2019,31( 6) : 2544-2551]
引文
[1]JEZIERNY D,MOSENTHIN R,BAUER E.The use of grain legumes as a protein source in pig nutrition:a review[J].Animal Feed Science and Technology,2012,157(3/4):111-128.
[2]DARVIN P,JOUNG Y H,KANG D Y,et al.Tannic acid inhibits EGFR/STAT1/3 and enhances p38/STAT1 signalling axis in breast cancer cells[J].Journal of Cellular and M olecular M edicine,2017,21(4):720-734.
[3]郭珊珊.石榴中类单宁的分离纯化、结构及活性研究[D].硕士学位论文.武汉:华中农业大学,2007.
[4]BHAT T K,KANNAN A,SINGH B,et al.Value addition of feed and fodder by alleviating the antinutritional effects of tannins[J].Agricultural Research,2013,2(3):189-206.
[5]EFSA Panel on Additives and Products or Substances used in Animal Feed.Scientific opinion on the safety and efficacy of tannic acid w hen used as feed flavouring for all animal species[J].EFSA Journal,2016,12(10):3828.
[6]FRASCA G,CARDILE V,PUGLIA C,et al.Gelatin tannate reduces the proinflammatory effects of lipopolysaccharide in human intestinal epithelial cells[J].Clinical and Experimental Gastroenterology,2012,5:61-67.
[7]侯海锋,刘彦慈,马可为,等.水解单宁酸对肉仔鸡生产性能、屠宰性能及肉品质的影响[J].今日畜牧兽医,2016(2):51-53.
[8]崔朝霞,张书杰,刘志伟.饲料原料中常见的抗营养因子及其消除方法[J].河南畜牧兽医(综合版),2007,28(10):27-28.
[9]OZKOSE E,KULOLU R,COMLEKCIOGLU U,et al.Effects of tannic acid on the fibrolytic enzyme activity and survival of some ruminal bacteria[J].International Journal of Agriculture&Biology,2011,13(3):386-390.
[10]CHUNG S Y,REED S.Removing peanut allergens by tannic acid[J].Food Chemistry,2012,134(3):1468-1473.
[11]BARSZCZ M,TACIAK M,SKOMIAJ.A dose-response effects of tannic acid and protein on grow th performance,caecal fermentation,colon morphology,andβ-glucuronidase activity of rats[J].Journal of Animal and Feed Sciences,2011,20(4):613-625.
[12]KING D,FAN M Z,EJETA G,et al.The effects of tannins on nutrient utilisation in the White Pekin duck[J].British Poultry Science,2000,41(5):630-639.
[13]ZUCKER W V.Tannins:does structure determine function?An ecological perspective[J].The American Naturalist,1983,121(3):335-365.
[14]OKE D B,OKE M O,ADEYEMI O A.Protein quality of autoclaved cow pea varieties as influenced by antinutritional factors[J].Nigerian Journal of Animal Production,2004,31(1):17-21.
[15]LAVIN S R,CHEN Z S,ABRAMS S A.Effect of tannic acid on iron absorption in straw-colored fruit bats(Eidolon helvum)[J].Zoo Biology,2010,29(3):335-343.
[16]LEE S H,SHINDE P,CHOI J Y,et al.Effects of tannic acid added to diets containing low level of iron on performance,blood hematology,iron status and fecal microflora in w eanling pigs[J].Journal of Animal Science and Technology,2009,51(6):503-510.
[17]LEE S H,SHINDE P L,CHOI J Y,et al.Effects of tannic acid supplementation on grow th performance,blood hematology,iron status and faecal microflora in w eanling pigs[J].Livestock Science,2010,131(2/3):281-286.
[18]辛苏文.鞣酸对断奶仔猪生长性能和腹泻的影响[J].畜禽业,2015(3):26-27.
[19]FAIRBROTHER J M,NADEAU,GYLES C L.Escherichia coli in postw eaning diarrhea in pigs:an update on bacterial types,pathogenesis,and prevention strategies[J].Animal Health Research Review s,2005,6(1):17-19.
[20]UEDA K,KAWABATA R,IRIE T,et al.Inactivation of pathogenic viruses by plant-derived tannins:strong effects of extracts from persimmon(Diospyros kaki)on a broad range of viruses[J].PLoS One,2013,8(1):e55343.
[21]安文亭,刘树栋,郭佳伟,等.单宁酸对仔猪营养物质利用率及健康的影响[C]//中国畜牧兽医学会动物营养学分会第七届中国饲料营养学术研讨会论文集.郑州:中国畜牧兽医学会动物营养学分会,2014.
[22]隋慧,付莉,史丽华,等.单宁酸对断奶仔猪腹泻率和生长性能的影响[J].饲料研究,2013(7):50-53.
[23]孙展英,李建涛,陈宝江.单宁酸对仔猪生长性能、营养物质利用率及相关消化酶活性的影响[J].饲料研究,2014(1):46-49.
[24]REZAR V,SALOBIR J.Effects of tannin-rich sweet chestnut(Castanea sativa mill.)w ood extract supplementation on nutrient utilisation and excreta dry matter content in broiler chickens[J].European Poultry Science,2014,78,doi:10.1399/eps.2014.42.
[25]YANG Y,LUO H H,SONG X,et al.Preparation of Galla chinensis oral solution as w ell as its stability,safety,and antidiarrheal activity evaluation[J].Evidence-Based Complementary and Alternative M edicine,2017,2017:1851459.
[26]GIRARD M,THANNER S,PRADERVAND N,et al.Hydrolysable chestnut tannins for reduction of postweaning diarrhea:efficacy on an experimental ETEC F4model[J].PLoS One,2018,13(5):e0197878.
[27]BOSSI A,RINALDUCCI S,ZOLLA L,et al.Effect of tannic acid on Lactobacillus hilgardii analysed by a proteomic approach[J].Journal of Applied M icrobiology,2007,102(3):787-795.
[28]ELIZONDO A M,MERCADO E C,RABINOVITZ BC,et al.Effect of tannins on the in vitro grow th of Clostridium perfringens[J].Veterinary M icrobiology,2010,145(3/4):308-314.
[29]TOSI G,MASSI P,ANTONGIOVANNI M,et al.Efficacy test of a hydrolysable tannin extract against necrotic enteritis in challenged broiler chickens[J].Italian Journal of Animal Science,2013,12(3):e62.
[30]VAN PARYS A,BOYEN F,DEWULF J,et al.The use of tannins to control Salmonella typhimurium infections in pigs[J].Zoonoses and Public Health,2010,57(6):423-428.
[31]JAMROZ D,WILICZKIEWICZ A,SKORUPINSKAJ,et al.Effect of sw eet chestnut tannin(SCT)on the performance,microbial status of intestine and histological characteristics of intestine w all in chickens[J].British Poultry Science,2009,50(6):687-699.
[32]TINTINO S R,OLIVEIRA-TINTINO C D M,CAM PINA F F,et al.Evaluation of the tannic acid inhibitory effect against the NorA efflux pump of Staphylococcus aureus[J].M icrobial Pathogenesis,2016,97:9-13.
[33]刘秀丽.植物缩合单宁对大肠杆菌的抑制作用及抑菌机理的研究[D].博士学位论文.呼和浩特:内蒙古农业大学,2013.
[34]VOHR H W.Oxidative stress[M]//VOHR H W.Encyclopedic reference of immunotoxicology.Berlin,Heidelberg:Springer,2005.
[35]YE M H,NAN Y L,DING M M,et al.Effects of dietary tannic acid on the grow th,hepatic gene expression,and antioxidant enzyme activity in Brandt’s voles(Microtus brandti)[J].Comparative Biochemistry and Physiology Part B:Biochemistry and M olecular Biology,2016,196-197:19-26.
[36]GLIN,HUYUT Z,ELMASTAM,et al.Radical scavenging and antioxidant activity of tannic acid[J].Arabian Journal of Chemistry,2010,3(1):43-53.
[37]刘倩.单宁酸对布氏田鼠代谢的影响[D].硕士学位论文.扬州:扬州大学,2014.
[38]LIU H W,DONG X F,TONG J M,et al.A comparative study of grow th performance and antioxidant status of rabbits w hen fed w ith or w ithout chestnut tannins under high ambient temperature[J].Animal Feed Science and Technology,2011,164(1/2):89-95.
[39]魏海峰,魏雁虹,李相军,等.单宁酸对糖尿病大鼠抗氧化能力及体外蛋白质非酶糖基化作用的影响[J].中国实验诊断学,2011,15(6):977-979.
[40]WEYDERT C J,CULLEN J J.Measurement of superoxide dismutase,catalase and glutathione peroxidase in cultured cells and tissue[J].Nature Protocols,2010,5(1):51-66.
[41]ZHANG X F,DAI Y C,ZHONG W M,et al.Tannic acid inhibited norovirus binding to HBGA receptors,a study of 50 Chinese medicinal herbs[J].Bioorganic&M edicinal Chemistry,2012,20(4):1616-1623.
[42]THEISEN L L,ERDELMEIER C A J,SPODEN GA,et al.Tannins from Hamamelis virginiana bark extract:characterization and improvement of the antiviral efficacy against influenza A virus and human papillomavirus[J].PLoS One,2014,9(1):e88062.
[43]LEE M H,CHIOU J F,YEN K Y,et al.EBV DNApolymerase inhibition of tannins from Eugenia uniflora[J].Cancer Letters,2000,154(2):131-136.
[44]YANG Y J,XIU J H,LIU J N,et al.Chebulagic acid,a hydrolyzable tannin,exhibited antiviral activity in vitro and in vivo against human enterovirus 71[J].International Journal of M olecular Sciences,2013,14(5):9618-9627.
[45]LIU S H,CHEN R,HAGEDORN C H.Tannic acid inhibits hepatitis C virus entry into Huh7.5 cells[J].PLoS One,2015,10(7):e0131358.
[46]魏昆鹏,朱子洁.水解单宁酸对家禽肠道健康的促进作用[J].中国动物保健,2016,18(7):30-31.
[47]MIN B R,HART S P,MILLER D,et al.The effect of grazing forage containing condensed tannins on gastrointestinal parasite infection and milk composition in angora does[J].Veterinary Parasitology,2005,130(1/2):105-113.
[48]WILLIAMS A R,FRYGANAS C,RAMSAY A,et al.Direct anthelmintic effects of condensed tannins from diverse plant sources against Ascaris suum[J].PLoSOne,2014,9(5):e97053.
[49]HOSTE H,JACKSON F,ATHANASIADOU S,et al.The effects of tannin-rich plants on parasitic nematodes in ruminants[J].Trends in Parasitology,2006,22(6):253-261.
[50]BONELLI F,TURINI L,SARRI G,et al.Oral administration of chestnut tannins to reduce the duration of neonatal calf diarrhea[J].BM C Veterinary Research,2018,14:227.
[51]TONDA R M,RUBACH J K,LUMPKINS B S,et al.Effects of tannic acid extract on performance and intestinal health of broiler chickens follow ing coccidiosis vaccination and/or a mixed-species Eimeria challenge[J].Poultry Science,2018,97(9):3031-3042.
[52]王文霞,周冉,刘宝庆,等.植物缩合单宁对草食动物的抗寄生虫性[J].动物营养学报,2014,26(9):2483-2490.
[53]BIAGI G,CIPOLLINI I,PAULICKS B R,et al.Effect of tannins on grow th performance and intestinal ecosystem in w eaned piglets[J].Archives of Animal Nutrition,2010,64(2):121-135.
[54]CANDEK-POTOKAR M,KRLEP M,LUKACN B,et al.Hydrolysable tannin fed to entire male pigs affects intestinal production,tissue deposition and hepatic clearance of skatole[J].The Veterinary Journal,2015,204(2):162-167.
[55]刘树栋,安文亭,郭佳伟,等.单宁酸对生长育肥猪生长性能、营养物质利用率及健康的影响[C]//中国畜牧兽医学会动物营养学分会第七届中国饲料营养学术研讨会论文集.郑州:中国畜牧兽医学会动物营养学分会,2014.
[56]宋之波,苏成文,徐相亭,等.坚木单宁对育肥猪生产性能及胴体性状的影响[J].黑龙江畜牧兽医,2017(11):120-122.
[57]CENGIZ,KKSAL B H,TATLI O,et al.Effect of dietary tannic acid supplementation in corn-or barleybased diets on grow th performance,intestinal viscosity,litter quality,and incidence and severity of footpad dermatitis in broiler chickens[J].Livestock Science,2017,202:52-57.
[58]REDONDO L M,CHACANA P A,DOMINGUEZ JE,et al.Perspectives in the use of tannins as alternative to antimicrobial grow th promoter factors in poultry[J].Frontiers in Microbiology,2014,5:118.
[59]SCHIAVONE A,GUO K,TASSONE S,et al.Effects of a natural extract of chestnut w ood on digestibility,performance traits,and nitrogen balance of broiler chicks[J].Poultry Science,2008,87(3):521-527.
[60]侯海锋,高宗旺,李茜.水解单宁酸对蛋鸡生产性能及肠道健康的影响[J].中国饲料,2017(12):21-23.
[61]SAMUEL K G,WANG J,YUE H Y,et al.Effects of dietary gallic acid supplementation on performance,antioxidant status,and jejunum intestinal morphology in broiler chicks[J].Poultry Science,2017,96(8):2768-2775.
[62]STARCEVI C'K,KRSTULOVI C'L,BROZI C'D,et al.Production performance,meat composition and oxidative susceptibility in broiler chicken fed w ith different phenolic compounds[J].Journal of the Science of Food and Agriculture,2015,95(6):1172-1178.
[63]INSERRA L,LUCIANO G,BELLA M,et al.Effect of including carob pulp in the diet of fattening pigs on the fatty acid composition and oxidative stability of pork[J].Meat Science,2015,100:256-261.
[2]DARVIN P,JOUNG Y H,KANG D Y,et al.Tannic acid inhibits EGFR/STAT1/3 and enhances p38/STAT1 signalling axis in breast cancer cells[J].Journal of Cellular and M olecular M edicine,2017,21(4):720-734.
[3]郭珊珊.石榴中类单宁的分离纯化、结构及活性研究[D].硕士学位论文.武汉:华中农业大学,2007.
[4]BHAT T K,KANNAN A,SINGH B,et al.Value addition of feed and fodder by alleviating the antinutritional effects of tannins[J].Agricultural Research,2013,2(3):189-206.
[5]EFSA Panel on Additives and Products or Substances used in Animal Feed.Scientific opinion on the safety and efficacy of tannic acid w hen used as feed flavouring for all animal species[J].EFSA Journal,2016,12(10):3828.
[6]FRASCA G,CARDILE V,PUGLIA C,et al.Gelatin tannate reduces the proinflammatory effects of lipopolysaccharide in human intestinal epithelial cells[J].Clinical and Experimental Gastroenterology,2012,5:61-67.
[7]侯海锋,刘彦慈,马可为,等.水解单宁酸对肉仔鸡生产性能、屠宰性能及肉品质的影响[J].今日畜牧兽医,2016(2):51-53.
[8]崔朝霞,张书杰,刘志伟.饲料原料中常见的抗营养因子及其消除方法[J].河南畜牧兽医(综合版),2007,28(10):27-28.
[9]OZKOSE E,KULOLU R,COMLEKCIOGLU U,et al.Effects of tannic acid on the fibrolytic enzyme activity and survival of some ruminal bacteria[J].International Journal of Agriculture&Biology,2011,13(3):386-390.
[10]CHUNG S Y,REED S.Removing peanut allergens by tannic acid[J].Food Chemistry,2012,134(3):1468-1473.
[11]BARSZCZ M,TACIAK M,SKOMIAJ.A dose-response effects of tannic acid and protein on grow th performance,caecal fermentation,colon morphology,andβ-glucuronidase activity of rats[J].Journal of Animal and Feed Sciences,2011,20(4):613-625.
[12]KING D,FAN M Z,EJETA G,et al.The effects of tannins on nutrient utilisation in the White Pekin duck[J].British Poultry Science,2000,41(5):630-639.
[13]ZUCKER W V.Tannins:does structure determine function?An ecological perspective[J].The American Naturalist,1983,121(3):335-365.
[14]OKE D B,OKE M O,ADEYEMI O A.Protein quality of autoclaved cow pea varieties as influenced by antinutritional factors[J].Nigerian Journal of Animal Production,2004,31(1):17-21.
[15]LAVIN S R,CHEN Z S,ABRAMS S A.Effect of tannic acid on iron absorption in straw-colored fruit bats(Eidolon helvum)[J].Zoo Biology,2010,29(3):335-343.
[16]LEE S H,SHINDE P,CHOI J Y,et al.Effects of tannic acid added to diets containing low level of iron on performance,blood hematology,iron status and fecal microflora in w eanling pigs[J].Journal of Animal Science and Technology,2009,51(6):503-510.
[17]LEE S H,SHINDE P L,CHOI J Y,et al.Effects of tannic acid supplementation on grow th performance,blood hematology,iron status and faecal microflora in w eanling pigs[J].Livestock Science,2010,131(2/3):281-286.
[18]辛苏文.鞣酸对断奶仔猪生长性能和腹泻的影响[J].畜禽业,2015(3):26-27.
[19]FAIRBROTHER J M,NADEAU,GYLES C L.Escherichia coli in postw eaning diarrhea in pigs:an update on bacterial types,pathogenesis,and prevention strategies[J].Animal Health Research Review s,2005,6(1):17-19.
[20]UEDA K,KAWABATA R,IRIE T,et al.Inactivation of pathogenic viruses by plant-derived tannins:strong effects of extracts from persimmon(Diospyros kaki)on a broad range of viruses[J].PLoS One,2013,8(1):e55343.
[21]安文亭,刘树栋,郭佳伟,等.单宁酸对仔猪营养物质利用率及健康的影响[C]//中国畜牧兽医学会动物营养学分会第七届中国饲料营养学术研讨会论文集.郑州:中国畜牧兽医学会动物营养学分会,2014.
[22]隋慧,付莉,史丽华,等.单宁酸对断奶仔猪腹泻率和生长性能的影响[J].饲料研究,2013(7):50-53.
[23]孙展英,李建涛,陈宝江.单宁酸对仔猪生长性能、营养物质利用率及相关消化酶活性的影响[J].饲料研究,2014(1):46-49.
[24]REZAR V,SALOBIR J.Effects of tannin-rich sweet chestnut(Castanea sativa mill.)w ood extract supplementation on nutrient utilisation and excreta dry matter content in broiler chickens[J].European Poultry Science,2014,78,doi:10.1399/eps.2014.42.
[25]YANG Y,LUO H H,SONG X,et al.Preparation of Galla chinensis oral solution as w ell as its stability,safety,and antidiarrheal activity evaluation[J].Evidence-Based Complementary and Alternative M edicine,2017,2017:1851459.
[26]GIRARD M,THANNER S,PRADERVAND N,et al.Hydrolysable chestnut tannins for reduction of postweaning diarrhea:efficacy on an experimental ETEC F4model[J].PLoS One,2018,13(5):e0197878.
[27]BOSSI A,RINALDUCCI S,ZOLLA L,et al.Effect of tannic acid on Lactobacillus hilgardii analysed by a proteomic approach[J].Journal of Applied M icrobiology,2007,102(3):787-795.
[28]ELIZONDO A M,MERCADO E C,RABINOVITZ BC,et al.Effect of tannins on the in vitro grow th of Clostridium perfringens[J].Veterinary M icrobiology,2010,145(3/4):308-314.
[29]TOSI G,MASSI P,ANTONGIOVANNI M,et al.Efficacy test of a hydrolysable tannin extract against necrotic enteritis in challenged broiler chickens[J].Italian Journal of Animal Science,2013,12(3):e62.
[30]VAN PARYS A,BOYEN F,DEWULF J,et al.The use of tannins to control Salmonella typhimurium infections in pigs[J].Zoonoses and Public Health,2010,57(6):423-428.
[31]JAMROZ D,WILICZKIEWICZ A,SKORUPINSKAJ,et al.Effect of sw eet chestnut tannin(SCT)on the performance,microbial status of intestine and histological characteristics of intestine w all in chickens[J].British Poultry Science,2009,50(6):687-699.
[32]TINTINO S R,OLIVEIRA-TINTINO C D M,CAM PINA F F,et al.Evaluation of the tannic acid inhibitory effect against the NorA efflux pump of Staphylococcus aureus[J].M icrobial Pathogenesis,2016,97:9-13.
[33]刘秀丽.植物缩合单宁对大肠杆菌的抑制作用及抑菌机理的研究[D].博士学位论文.呼和浩特:内蒙古农业大学,2013.
[34]VOHR H W.Oxidative stress[M]//VOHR H W.Encyclopedic reference of immunotoxicology.Berlin,Heidelberg:Springer,2005.
[35]YE M H,NAN Y L,DING M M,et al.Effects of dietary tannic acid on the grow th,hepatic gene expression,and antioxidant enzyme activity in Brandt’s voles(Microtus brandti)[J].Comparative Biochemistry and Physiology Part B:Biochemistry and M olecular Biology,2016,196-197:19-26.
[36]GLIN,HUYUT Z,ELMASTAM,et al.Radical scavenging and antioxidant activity of tannic acid[J].Arabian Journal of Chemistry,2010,3(1):43-53.
[37]刘倩.单宁酸对布氏田鼠代谢的影响[D].硕士学位论文.扬州:扬州大学,2014.
[38]LIU H W,DONG X F,TONG J M,et al.A comparative study of grow th performance and antioxidant status of rabbits w hen fed w ith or w ithout chestnut tannins under high ambient temperature[J].Animal Feed Science and Technology,2011,164(1/2):89-95.
[39]魏海峰,魏雁虹,李相军,等.单宁酸对糖尿病大鼠抗氧化能力及体外蛋白质非酶糖基化作用的影响[J].中国实验诊断学,2011,15(6):977-979.
[40]WEYDERT C J,CULLEN J J.Measurement of superoxide dismutase,catalase and glutathione peroxidase in cultured cells and tissue[J].Nature Protocols,2010,5(1):51-66.
[41]ZHANG X F,DAI Y C,ZHONG W M,et al.Tannic acid inhibited norovirus binding to HBGA receptors,a study of 50 Chinese medicinal herbs[J].Bioorganic&M edicinal Chemistry,2012,20(4):1616-1623.
[42]THEISEN L L,ERDELMEIER C A J,SPODEN GA,et al.Tannins from Hamamelis virginiana bark extract:characterization and improvement of the antiviral efficacy against influenza A virus and human papillomavirus[J].PLoS One,2014,9(1):e88062.
[43]LEE M H,CHIOU J F,YEN K Y,et al.EBV DNApolymerase inhibition of tannins from Eugenia uniflora[J].Cancer Letters,2000,154(2):131-136.
[44]YANG Y J,XIU J H,LIU J N,et al.Chebulagic acid,a hydrolyzable tannin,exhibited antiviral activity in vitro and in vivo against human enterovirus 71[J].International Journal of M olecular Sciences,2013,14(5):9618-9627.
[45]LIU S H,CHEN R,HAGEDORN C H.Tannic acid inhibits hepatitis C virus entry into Huh7.5 cells[J].PLoS One,2015,10(7):e0131358.
[46]魏昆鹏,朱子洁.水解单宁酸对家禽肠道健康的促进作用[J].中国动物保健,2016,18(7):30-31.
[47]MIN B R,HART S P,MILLER D,et al.The effect of grazing forage containing condensed tannins on gastrointestinal parasite infection and milk composition in angora does[J].Veterinary Parasitology,2005,130(1/2):105-113.
[48]WILLIAMS A R,FRYGANAS C,RAMSAY A,et al.Direct anthelmintic effects of condensed tannins from diverse plant sources against Ascaris suum[J].PLoSOne,2014,9(5):e97053.
[49]HOSTE H,JACKSON F,ATHANASIADOU S,et al.The effects of tannin-rich plants on parasitic nematodes in ruminants[J].Trends in Parasitology,2006,22(6):253-261.
[50]BONELLI F,TURINI L,SARRI G,et al.Oral administration of chestnut tannins to reduce the duration of neonatal calf diarrhea[J].BM C Veterinary Research,2018,14:227.
[51]TONDA R M,RUBACH J K,LUMPKINS B S,et al.Effects of tannic acid extract on performance and intestinal health of broiler chickens follow ing coccidiosis vaccination and/or a mixed-species Eimeria challenge[J].Poultry Science,2018,97(9):3031-3042.
[52]王文霞,周冉,刘宝庆,等.植物缩合单宁对草食动物的抗寄生虫性[J].动物营养学报,2014,26(9):2483-2490.
[53]BIAGI G,CIPOLLINI I,PAULICKS B R,et al.Effect of tannins on grow th performance and intestinal ecosystem in w eaned piglets[J].Archives of Animal Nutrition,2010,64(2):121-135.
[54]CANDEK-POTOKAR M,KRLEP M,LUKACN B,et al.Hydrolysable tannin fed to entire male pigs affects intestinal production,tissue deposition and hepatic clearance of skatole[J].The Veterinary Journal,2015,204(2):162-167.
[55]刘树栋,安文亭,郭佳伟,等.单宁酸对生长育肥猪生长性能、营养物质利用率及健康的影响[C]//中国畜牧兽医学会动物营养学分会第七届中国饲料营养学术研讨会论文集.郑州:中国畜牧兽医学会动物营养学分会,2014.
[56]宋之波,苏成文,徐相亭,等.坚木单宁对育肥猪生产性能及胴体性状的影响[J].黑龙江畜牧兽医,2017(11):120-122.
[57]CENGIZ,KKSAL B H,TATLI O,et al.Effect of dietary tannic acid supplementation in corn-or barleybased diets on grow th performance,intestinal viscosity,litter quality,and incidence and severity of footpad dermatitis in broiler chickens[J].Livestock Science,2017,202:52-57.
[58]REDONDO L M,CHACANA P A,DOMINGUEZ JE,et al.Perspectives in the use of tannins as alternative to antimicrobial grow th promoter factors in poultry[J].Frontiers in Microbiology,2014,5:118.
[59]SCHIAVONE A,GUO K,TASSONE S,et al.Effects of a natural extract of chestnut w ood on digestibility,performance traits,and nitrogen balance of broiler chicks[J].Poultry Science,2008,87(3):521-527.
[60]侯海锋,高宗旺,李茜.水解单宁酸对蛋鸡生产性能及肠道健康的影响[J].中国饲料,2017(12):21-23.
[61]SAMUEL K G,WANG J,YUE H Y,et al.Effects of dietary gallic acid supplementation on performance,antioxidant status,and jejunum intestinal morphology in broiler chicks[J].Poultry Science,2017,96(8):2768-2775.
[62]STARCEVI C'K,KRSTULOVI C'L,BROZI C'D,et al.Production performance,meat composition and oxidative susceptibility in broiler chicken fed w ith different phenolic compounds[J].Journal of the Science of Food and Agriculture,2015,95(6):1172-1178.
[63]INSERRA L,LUCIANO G,BELLA M,et al.Effect of including carob pulp in the diet of fattening pigs on the fatty acid composition and oxidative stability of pork[J].Meat Science,2015,100:256-261.