红细胞分布宽度与血液透析患者心脑血管事件的相关性研究
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摘要
目的探讨红细胞分布宽度与血液透析患者心脑血管事件的相关性。方法选取景德镇市第二人民医院2015年5月～2016年12月诊治的300例血液透析患者作为研究对象,根据红细胞分布宽度分为正常组(187例)和异常组(113例),比较两组患者的心脑血管事件发生率。根据心脑血管事件分为发病组(107例)和未发病组(193例),比较两组患者的红细胞分布宽度。采用多因素Logistic回归法分析血液透析患者心脑血管事件的影响因素。分析红细胞分布宽度与血液透析患者心脑血管事件的相关性。结果异常组患者心脑血管事件发生率高于正常组(P<0.05)。发病组患者透析龄长于未发病组(P<0.05)。发病组患者红细胞分布宽度、高敏C反应蛋白、铁蛋白均高于未发病组(P<0.05)。发病组患者血红蛋白、白蛋白、血肌酐、尿素氮、尿酸、N末端脑钠肽前体均低于未发病组(P<0.05)。透析龄、红细胞分布宽度、血红蛋白、白蛋白、血肌酐、尿素氮、尿酸、N末端脑钠肽前体、高敏C反应蛋白、铁蛋白均是血液透析患者心脑血管事件的影响因素。红细胞分布宽度与血液透析患者心脑血管事件成明显正相关(r=0.439,P<0.05)。结论红细胞分布宽度是血液透析患者心脑血管事件的独立危险因素,二者成明显正相关。
Objective To explore the correlation between erythrocyte distribution width and cardiocerebrovascular events in patients with hemodialysis.Methods A total of 300 hemodialysis patients treated in the Second People′s Hospital of Jingdezhen City from May 2015 to December 2016 were selected as the research objects,according to the distribution width of erythrocyte,they were divided into normal group(187 cases) and abnormal group(113 cases),the incidence of cardiocerebrovascular events was compared between the two groups.According to the cardiocerebrovascular events,the patients were divided into two groups:the onset group(107 cases) and the non-onset group(193 cases),the distribution width of erythrocyte was compared between the two groups.Multiple factor Logistic regression was used to analyze the influencing factors of cardiocerebrovascular events in hemodialysis patients.The correlation between erythrocyte distribution width and cardiocerebrovascular events in hemodialysis patients was analyzed.Results The incidence of cardiocerebrovascular events in abnormal group was higher than that in normal group(P<0.05).The dialysis age of the patients was longer than that of the non-patients(P<0.05).The distribution width of erythrocyte,high sensitivity C-reactive protein and ferritin in the patients were higher than those in the non-patients(P<0.05).Hemoglobin,albumin,serum creatinine,urea nitrogen,uric acid and N-terminal brain natriuretic peptide precursors were lower in the onset group patients than in the non-patients(P <0.05).Dialysis age,erythrocyte distribution width,hemoglobin,albumin,serum creatinine,urea nitrogen,uric acid,N-terminal brain natriuretic peptide precursor,high-sensitivity C-reactive protein and ferritin are all influencing factors of cardiovascular and cerebrovascular events in hemodialysis patients.The distribution width of erythrocyte was positively correlated with cardiovascular and cerebrovascular events in hemodialysis patients(r=0.439,P<0.05).Conclusion Erythrocyte distribution width is an independent risk factor for cardiovascular and cerebrovascular events in hemodialysis patients,and there is a significant positive correlation between them.
Objective To explore the correlation between erythrocyte distribution width and cardiocerebrovascular events in patients with hemodialysis.Methods A total of 300 hemodialysis patients treated in the Second People′s Hospital of Jingdezhen City from May 2015 to December 2016 were selected as the research objects,according to the distribution width of erythrocyte,they were divided into normal group(187 cases) and abnormal group(113 cases),the incidence of cardiocerebrovascular events was compared between the two groups.According to the cardiocerebrovascular events,the patients were divided into two groups:the onset group(107 cases) and the non-onset group(193 cases),the distribution width of erythrocyte was compared between the two groups.Multiple factor Logistic regression was used to analyze the influencing factors of cardiocerebrovascular events in hemodialysis patients.The correlation between erythrocyte distribution width and cardiocerebrovascular events in hemodialysis patients was analyzed.Results The incidence of cardiocerebrovascular events in abnormal group was higher than that in normal group(P<0.05).The dialysis age of the patients was longer than that of the non-patients(P<0.05).The distribution width of erythrocyte,high sensitivity C-reactive protein and ferritin in the patients were higher than those in the non-patients(P<0.05).Hemoglobin,albumin,serum creatinine,urea nitrogen,uric acid and N-terminal brain natriuretic peptide precursors were lower in the onset group patients than in the non-patients(P <0.05).Dialysis age,erythrocyte distribution width,hemoglobin,albumin,serum creatinine,urea nitrogen,uric acid,N-terminal brain natriuretic peptide precursor,high-sensitivity C-reactive protein and ferritin are all influencing factors of cardiovascular and cerebrovascular events in hemodialysis patients.The distribution width of erythrocyte was positively correlated with cardiovascular and cerebrovascular events in hemodialysis patients(r=0.439,P<0.05).Conclusion Erythrocyte distribution width is an independent risk factor for cardiovascular and cerebrovascular events in hemodialysis patients,and there is a significant positive correlation between them.
引文
[1]康阳阳,刘章锁,刘东伟.中国成人慢性肾脏病患病率荟萃分析[J].中国实用内科杂志,2016,36(9):785-789.
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[5]李秀季,张国娟,姜立萍,等.血液透析患者血压变异性与全因及心脑血管疾病死亡的关系[J].医学研究杂志,2017,46(10):116-120.
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[7]王天生,王盛琴,王东红,等.终末期肾病维持血液透析患者应用左卡尼汀治疗对T淋巴细胞亚群和可溶性白细胞介素2受体的影响[J].中国慢性病预防与控制,2016,24(2):144-146.
[8]王琦.红细胞分布宽度在冠心病患者中的研究进展[J].心血管病学进展,2013,34(6):791-794.
[9]卞锋全,何胜虎.红细胞分布宽度在常见心血管疾病诊疗中的应用进展[J].医学综述,2015,21(4):660-663.
[10]黄娟,汤圣兴.红细胞分布宽度与冠心病相关性的研究进展[J].安徽医学,2016,37(5):639-641.
[11]赵凯,李永健.老年心绞痛患者冠脉病变程度与红细胞分布宽度的相关性[J].中国老年学杂志,2016,36(5):1089-1091.
[12]梁雁,尹俊皓,郭军,等.红细胞分布宽度变化与急性心肌梗死预后的相关性[J].实用医学杂志,2016,32(12):1972-1975.
[13]黄基立,李辉,陈金光,等.维持性血液透析患者红细胞体积分布宽度与心脑血管事件的相关性研究[J].中国医学创新,2017,14(24):17-20.
[14]王军,华琦,王丽,等.红细胞分布宽度对置入药物洗脱支架急性ST段抬高心肌梗死患者晚期预后的影响[J].中国介入心脏病学杂志,2015,23(3):156-162.
[15]莫立仪,李志莲,徐丽霞,等.红细胞分布宽度升高是血液透析患者心血管死亡的独立危险因素[J].中国血液净化,2016,15(1):5-9.
[2]黄文瀚,唐琳,蔡莹,等.重庆市渝中区成人慢性肾脏病流行病学调查及相关因素分析[J].上海交通大学学报(医学版),2014,34(5):725-729.
[3]王逸申,盛晓华,汪年松,等.糖尿病肾病所致终末期肾脏病维持性血液透析患者贫血的多中心临床研究[J].中国血液净化,2014,13(6):433-436.
[4]胡学芹,陈文,李军.维持性血液透析老年终末期肾脏病患者营养状况及其影响因素分析[J].疑难病杂志,2014,13(5):527-528.
[5]李秀季,张国娟,姜立萍,等.血液透析患者血压变异性与全因及心脑血管疾病死亡的关系[J].医学研究杂志,2017,46(10):116-120.
[6]崔英,眭建.维持性血液透析患者并发心脑血管疾病的危险因素研究[J].中国中西医结合肾病杂志,2016,17(11):1006-1007.
[7]王天生,王盛琴,王东红,等.终末期肾病维持血液透析患者应用左卡尼汀治疗对T淋巴细胞亚群和可溶性白细胞介素2受体的影响[J].中国慢性病预防与控制,2016,24(2):144-146.
[8]王琦.红细胞分布宽度在冠心病患者中的研究进展[J].心血管病学进展,2013,34(6):791-794.
[9]卞锋全,何胜虎.红细胞分布宽度在常见心血管疾病诊疗中的应用进展[J].医学综述,2015,21(4):660-663.
[10]黄娟,汤圣兴.红细胞分布宽度与冠心病相关性的研究进展[J].安徽医学,2016,37(5):639-641.
[11]赵凯,李永健.老年心绞痛患者冠脉病变程度与红细胞分布宽度的相关性[J].中国老年学杂志,2016,36(5):1089-1091.
[12]梁雁,尹俊皓,郭军,等.红细胞分布宽度变化与急性心肌梗死预后的相关性[J].实用医学杂志,2016,32(12):1972-1975.
[13]黄基立,李辉,陈金光,等.维持性血液透析患者红细胞体积分布宽度与心脑血管事件的相关性研究[J].中国医学创新,2017,14(24):17-20.
[14]王军,华琦,王丽,等.红细胞分布宽度对置入药物洗脱支架急性ST段抬高心肌梗死患者晚期预后的影响[J].中国介入心脏病学杂志,2015,23(3):156-162.
[15]莫立仪,李志莲,徐丽霞,等.红细胞分布宽度升高是血液透析患者心血管死亡的独立危险因素[J].中国血液净化,2016,15(1):5-9.