多囊卵巢综合征中医证型与性激素、卵巢体积相关性研究
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摘要
目的:探讨多囊卵巢综合征(PCOS)中医证型与性激素及卵巢体积、腰臀比、体质量指数、饮食偏好的相关性,为多囊卵巢综合征的中医辨证分型提供客观指标。方法:对98例PCOS患者进行中医辨证分型、检测性激素6项、妇科超声、应用方差分析、Logistic回归模型探讨不同中医证型PCOS与性激素、卵巢体积、腰臀比、体质量指数、饮食偏好的相关性。结果:肾虚型LH较高,痰瘀互结型FSH较高,肾虚型E~2较高,脾虚痰湿型T较高但差异无统计学意义;肾虚型LH/FSH比值较高,脾虚痰湿型BMI、WHR值较高,卵巢体积较大差异有统计学意义;肾虚型PCOS与LH/FSH比值具有相关性,脾虚痰湿型PCOS与BMI、WHR、卵巢体积、饮食偏好具有相关性,痰瘀互结型与饮食偏好、BMI具有相关性。结论:肾虚型PCOS与黄体生成素/卵泡刺激素具有相关性,与黄体生成素、卵泡刺激素、雌二醇、孕酮、睾酮、卵巢体积无相关性,脾虚痰湿型与卵巢体积、体质量指数、腰臀比、饮食偏好具有相关性,痰瘀互结型与饮食偏好、BMI具有相关性。
Object: Study on the correlation between Chinese medicine syndrome type of polycystic ovary syndrome and ovarian morphology and sex hormone,providing objective indicators for TCM syndrome differentiation of polycystic ovary syndrome.Method: Collecting 98 cases of polycystic ovary syndrome( PCOS) patients,classifying according to syndrome differentiation,detecting sex hormone and gynecologic ultrasound,then study the correlation between Chinese medicine syndrome type of polycystic ovary syndrome and ovarian morphology and sex hormone and BMI and WRH and dietary preferences.Results: 1. LH of kidney deficiency type is higher,FSH of intermingled phlegm and blood stasis type is higher,E2 of kidney deficiency type is higher,T of splenic deficiency dampness type is higher,but the difference is not statistically significant.LH/FSH of kidney deficiency type is higher,BMI and WHR and ovarian morphology of splenic deficiency dampness type is higher the difference is statistically significant. 2. There was correlation between kidney deficiency and LH/FSH,There was correlation between Splenic deficiency dampness type and ovary volume,BMI,WRH and dietary preferences. There was correlation between intermingled phlegm and blood stasis type and dietary preferences and BMI.Conclusion: There was correlation between kidney deficiency and LH/FSH. There was correlation between Splenic deficiency dampness type and ovary volume,BMI,WRH dietary preferences. There was correlation between intermingled phlegm and blood stasis type dietary preferences and BMI.
Object: Study on the correlation between Chinese medicine syndrome type of polycystic ovary syndrome and ovarian morphology and sex hormone,providing objective indicators for TCM syndrome differentiation of polycystic ovary syndrome.Method: Collecting 98 cases of polycystic ovary syndrome( PCOS) patients,classifying according to syndrome differentiation,detecting sex hormone and gynecologic ultrasound,then study the correlation between Chinese medicine syndrome type of polycystic ovary syndrome and ovarian morphology and sex hormone and BMI and WRH and dietary preferences.Results: 1. LH of kidney deficiency type is higher,FSH of intermingled phlegm and blood stasis type is higher,E2 of kidney deficiency type is higher,T of splenic deficiency dampness type is higher,but the difference is not statistically significant.LH/FSH of kidney deficiency type is higher,BMI and WHR and ovarian morphology of splenic deficiency dampness type is higher the difference is statistically significant. 2. There was correlation between kidney deficiency and LH/FSH,There was correlation between Splenic deficiency dampness type and ovary volume,BMI,WRH and dietary preferences. There was correlation between intermingled phlegm and blood stasis type and dietary preferences and BMI.Conclusion: There was correlation between kidney deficiency and LH/FSH. There was correlation between Splenic deficiency dampness type and ovary volume,BMI,WRH dietary preferences. There was correlation between intermingled phlegm and blood stasis type dietary preferences and BMI.
引文
[1]慶二元,莫朝晖.内分泌学[M].北京:人民卫生出版社,2007:1134-1135.
[2]谢幸,苟文丽.妇产科学[M].北京:人民卫生出版社,2015:8.
[3]康培培,谈勇.多囊卵巢综合征中医证型分布规律及性激素水平、糖代谢特点[J].中国中西医结合杂志,2016,25(7):801-805.
[4]ROTTERDAM ESHRE/ASRM-SPONSORED PCOS CONSENSUS WORKSHOP GROUP. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome[J]. Fertil Steril,2004,81(1):19-25.
[5]中华人民共和国卫生部.中药新药临床研究指导原则[S].2版.北京:中国医药科技出版社,2002:239-243.
[6]李小平,郑春盛,洪哲晶,等.多囊卵巢综合征患者性激素和胰岛素水平与中医证型的相关性[J].中国中西医结合杂志,2007,27(1):996.
[7]乐杰.妇产科学[M].北京:人民卫生出版社,2008:19-20.
[8]王永炎,王耀庭.今日中医妇科[M].北京:人民卫生出版社,2000:403.
[9]尹晓丹,何军琴.多囊卵巢综合征中医证型的发病因素及与性激素相关性的研究[J].辽宁中医杂志,2015,42(4):764-765.
[10]韩布威,常惠,吴效科,等.饮食因素与多囊卵巢综合征的研究进展[J].中国中医药现代远程教育,2017,15(19):153-155.
[11]朱震亨.丹溪治法心要[M].济南:山东科学技术出版社,1985:204.
[12]LE DONNE M,ALIBRANDI A,GIARRUSSO R,et al. Diet,metformin and inositol in overweight and obese women with polycystic ovary syndrome:effects on body composition[J].Minerva Ginecol,2012,64(1):23-29.
[2]谢幸,苟文丽.妇产科学[M].北京:人民卫生出版社,2015:8.
[3]康培培,谈勇.多囊卵巢综合征中医证型分布规律及性激素水平、糖代谢特点[J].中国中西医结合杂志,2016,25(7):801-805.
[4]ROTTERDAM ESHRE/ASRM-SPONSORED PCOS CONSENSUS WORKSHOP GROUP. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome[J]. Fertil Steril,2004,81(1):19-25.
[5]中华人民共和国卫生部.中药新药临床研究指导原则[S].2版.北京:中国医药科技出版社,2002:239-243.
[6]李小平,郑春盛,洪哲晶,等.多囊卵巢综合征患者性激素和胰岛素水平与中医证型的相关性[J].中国中西医结合杂志,2007,27(1):996.
[7]乐杰.妇产科学[M].北京:人民卫生出版社,2008:19-20.
[8]王永炎,王耀庭.今日中医妇科[M].北京:人民卫生出版社,2000:403.
[9]尹晓丹,何军琴.多囊卵巢综合征中医证型的发病因素及与性激素相关性的研究[J].辽宁中医杂志,2015,42(4):764-765.
[10]韩布威,常惠,吴效科,等.饮食因素与多囊卵巢综合征的研究进展[J].中国中医药现代远程教育,2017,15(19):153-155.
[11]朱震亨.丹溪治法心要[M].济南:山东科学技术出版社,1985:204.
[12]LE DONNE M,ALIBRANDI A,GIARRUSSO R,et al. Diet,metformin and inositol in overweight and obese women with polycystic ovary syndrome:effects on body composition[J].Minerva Ginecol,2012,64(1):23-29.