小儿腹泻病血锌水平检测的意义
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摘要
目的探讨小儿腹泻病血锌水平检测的意义。方法 2013年1月至2016年3月福建医科大学附属三明第一医院儿科收治住院的腹泻病患儿90例为观察组,同期选取本院健康体检儿童90例为正常对照组,检测不同年龄段锌缺乏率,腹泻患儿不同年龄、不同病程、不同病情的血锌水平,感染性腹泻与非感染性腹泻的血锌水平。结果不同年龄段患儿与同龄健康儿童比较,差异均有统计学意义(P<0.05)。观察组不同年龄段之间血锌水平比较差异均有统计学意义(P<0.05),不同病程之间血锌水平比较差异均有统计学意义(P<0.05)。感染性腹泻患儿血锌水平为(56.71±12.11)μmol/L,低于非感染性腹泻患儿(67.99±14.56)μmol/L,差异有统计学意义(P<0.05)。中重型腹泻患儿血锌水平为(57.88±13.46)μmol/L,低于轻型腹泻患儿(69.01±15.16)μmol/L,差异有统计学意义(P<0.05)。结论小儿腹泻病患儿血锌水平低于同龄健康儿童,应常规进行血锌水平检测,其中年幼患儿、感染性、重型腹泻病及病程长的患儿是检测重点。
Objective To investigate the significance of blood zinc level in children with diarrhea.Methods From January 2013 to March 2016,90 children with diarrhea were admitted to the Pediatric Ward of the Sanming First Hospital Affiliated to Fujian Medical University,and 90 cases were selected as the normal control group.The rate of zinc deficiency in different age groups was detected;the level of blood zinc in children with diarrhea at different ages,and with different courses and conditions was detected;the level of blood zinc in infectious diarrhea and non-infectious diarrhea was also determined.Results In the diarrhea group,the incidence of zinc deficiency gradually decreased with age,compared with healthy children of the same age,the difference was statistically significant(P<0.01).The level of blood zinc in diarrhea group was related to age and the course of disease,and the difference was statistically significant(P<0.05).Compared with non-infectious and light diarrhea children,the level of blood zinc decreased significantly in infectious and severe diarrhea patients[(67.99±14.56)μmol/L vs.(56.71 ±12.11)μmol/L,(69.01±15.16)μmol/L vs.(57.88±13.46)μmol/L,P<0.05].Conclusion The blood zinc level of children with diarrhea is lower than that of healthy children of the same age.Blood zinc levels should be routinely measured,and among them,young children and children with infectious and severe diarrhea and long course of disease are the focus of testing.
Objective To investigate the significance of blood zinc level in children with diarrhea.Methods From January 2013 to March 2016,90 children with diarrhea were admitted to the Pediatric Ward of the Sanming First Hospital Affiliated to Fujian Medical University,and 90 cases were selected as the normal control group.The rate of zinc deficiency in different age groups was detected;the level of blood zinc in children with diarrhea at different ages,and with different courses and conditions was detected;the level of blood zinc in infectious diarrhea and non-infectious diarrhea was also determined.Results In the diarrhea group,the incidence of zinc deficiency gradually decreased with age,compared with healthy children of the same age,the difference was statistically significant(P<0.01).The level of blood zinc in diarrhea group was related to age and the course of disease,and the difference was statistically significant(P<0.05).Compared with non-infectious and light diarrhea children,the level of blood zinc decreased significantly in infectious and severe diarrhea patients[(67.99±14.56)μmol/L vs.(56.71 ±12.11)μmol/L,(69.01±15.16)μmol/L vs.(57.88±13.46)μmol/L,P<0.05].Conclusion The blood zinc level of children with diarrhea is lower than that of healthy children of the same age.Blood zinc levels should be routinely measured,and among them,young children and children with infectious and severe diarrhea and long course of disease are the focus of testing.
引文
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[11]金芳,李启亮.1159例儿童外周血微量元素水平分析[J].医学临床研究,2011,28(11):2164-2165.
[12]鲁军.3962例0~6岁儿童血锌调查分析[J].中国卫生标准管理,2015,6(1):18-19.
[13]刘定远,蒲友华,胡波,等.葡萄糖酸锌治疗儿童持续性腹泻53例疗效观察[J].中国中西医结合儿科学,2011,3(4):346-348.
[14]黄瑞茶,何立花,李双玲,等.腹泻小儿血锌变化及补锌疗效观察[J].河北医药,2013,35(15):2321-2322.
[15]魏利锋,诸侃.腹泻患儿血锌水平的变化情况及其影响因素[J].中国妇幼保健,2016,31(16):3309-3311.
[16]应爱娟,舒小莉,顾伟忠,等.锌缺乏对生长期大鼠小肠黏膜形态和消化酶活性的影响[J].中华儿科杂志,2011,49(4):249-254.
[2]顾春健,施耀成.迁延性腹泻儿童血清免疫球蛋白、血锌水平分析及葡萄糖酸锌的临床应用探讨[J].中国妇幼保健,2013,28(32):5316-5318.
[3]Sampaio DL,Mattos AP,Ribeiro TC,Leite ME,et al.Zinc and other micronutrients supplementation through the use of sprinkles:impact on the occurrence of diarrhea and respiratory infections in institutionalized children[J].J Pediatr(Rio J),2013,89(3):286-293.
[4]卢小蕴,夏巧湘.血锌检测对患儿急性腹泻的监控意义[J].中国妇幼保健,2014,29(36):6055-6057.
[5]王冬萌,毕晶,孙正纤,等.小儿迁延性腹泻与锌缺乏病发病关系研究[J].中国全科医学,2011,14(2):196-197.
[6]段炼.婴幼儿腹泻病补充锌制剂临床观察[J].中国实用医药,2013,8(9):156-157.
[7]凌如娟,杨延萍.急性腹泻患儿血锌的变化及临床意义[J].齐齐哈尔医学院学报,2015,36(5):657-658.
[8]张晓杰,李玥.婴幼儿腹泻血清锌含量变化及补锌治疗临床疗效观察[J].中国妇幼保健,2014,29(29):4772-4773.
[9]黄卓信,覃炳兆.急性腹泻患儿血锌水平变化及补锌的辅助治疗效果[J].基层医学论坛,2016,20(2):192-193.
[10]王秀丽,刘进生,方辉,等.婴幼儿急性腹泻病血锌水平及补锌治疗的临床观察[J].安徽医学,2013,34(4):434-436.
[11]金芳,李启亮.1159例儿童外周血微量元素水平分析[J].医学临床研究,2011,28(11):2164-2165.
[12]鲁军.3962例0~6岁儿童血锌调查分析[J].中国卫生标准管理,2015,6(1):18-19.
[13]刘定远,蒲友华,胡波,等.葡萄糖酸锌治疗儿童持续性腹泻53例疗效观察[J].中国中西医结合儿科学,2011,3(4):346-348.
[14]黄瑞茶,何立花,李双玲,等.腹泻小儿血锌变化及补锌疗效观察[J].河北医药,2013,35(15):2321-2322.
[15]魏利锋,诸侃.腹泻患儿血锌水平的变化情况及其影响因素[J].中国妇幼保健,2016,31(16):3309-3311.
[16]应爱娟,舒小莉,顾伟忠,等.锌缺乏对生长期大鼠小肠黏膜形态和消化酶活性的影响[J].中华儿科杂志,2011,49(4):249-254.