治疗性血浆置换术救治高脂血症急性胰腺炎疗效分析
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摘要
目的探讨治疗性血浆置换术在高脂血症急性胰腺炎治疗中的应用及疗效。方法选取本院在2015~2016年住院的16例高脂血症急性胰腺炎患者,予以治疗性血浆置换术治疗,统计患者治疗前后甘油三酯(triacylglyceride,TG)、淀粉酶(amylase,AMY)和脂肪酶(lipase,LPS)的水平。结果 16例高脂急性胰腺炎患者平均置换3次,单次平均置换量2000 ml。治疗后TG(11.96±5.66 mmol/L vs 3.56±1.06 mmol/L)、AMY(259.14±173.40 IU/L vs 41.71±25.25 IU/L)、LPS(341.92±257.10 IU/L vs 43.5±19.54 IU/L)均下降,差异有统计学意义(P<0.05)。结论治疗性血浆置换是快速治疗高脂血症急性胰腺炎的有效手段。
Objective To investigate the therapeutic effect of plasmapheresis in treatment of acute hyperlipidemic pancreatitis(AHP). Methods A total of 16 AHP patients in the hospital between 2015 and 2016 were collected and treated with therapeutic plasmapheresis. The levels of triglyceride(TG),amylase(AMY) and lipase(LPS) before and after treatments were examined. Results Sixteen AHP patients who received plasmapheresis with the average of 3 treatments,2000 mL for each,showed significant decreases in TG(11.96±5.66 mmol/L vs 3.56±1.06 mmol/L),AMY(259.14±173.40 IU/L vs 4 1. 7 1 ±2 5. 2 5 IU/L),and LPS(3 4 1. 92±257. 10 IU/L vs 4 3. 5±19. 54 IU/L)(P <0. 0 5). Conclusion Therapeutic plasma exchange is an effective method for treatment of acute hyperlipidemic pancreatitis.
Objective To investigate the therapeutic effect of plasmapheresis in treatment of acute hyperlipidemic pancreatitis(AHP). Methods A total of 16 AHP patients in the hospital between 2015 and 2016 were collected and treated with therapeutic plasmapheresis. The levels of triglyceride(TG),amylase(AMY) and lipase(LPS) before and after treatments were examined. Results Sixteen AHP patients who received plasmapheresis with the average of 3 treatments,2000 mL for each,showed significant decreases in TG(11.96±5.66 mmol/L vs 3.56±1.06 mmol/L),AMY(259.14±173.40 IU/L vs 4 1. 7 1 ±2 5. 2 5 IU/L),and LPS(3 4 1. 92±257. 10 IU/L vs 4 3. 5±19. 54 IU/L)(P <0. 0 5). Conclusion Therapeutic plasma exchange is an effective method for treatment of acute hyperlipidemic pancreatitis.
引文
1谈定玉,徐继扬.床边血浆置换治疗重症高脂血症性急性胰腺炎疗效观察[J].实用医学杂志,2012,28(11):1832-1834.
2 黄文丽.床边血浆置换治疗重症高脂血症性急性胰腺炎的效果分析[J].世界最新医学信息文摘:连续型电子期刊,2016,15(30):55-56.
3 郁国强,曾军红.血浆置换联合血液透析滤过治疗重症急性胰腺炎临床疗效分析[J].临床荟萃,2011,26(9):760-765.
4 李兆滔,崔西玉,刘欣.血浆置换在治疗重症高脂血症性急性胰腺炎中的应用[J].现代消化及介入诊疗,2014,(2):102-104.
5 张杏.高脂血症性急性胰腺炎的研究现状[J].中国当代医药,2013,20(31):17-18.
6 万洪波.血浆置换联合持续性血液滤过在高脂血症性重症急性胰腺炎中的疗效观察[J].江西医药,2011,46(4):337-339.
7 赵明.血浆置换治疗重症高脂血症性急性胰腺炎的临床疗效[J].社区医学杂志,2015,13(10):85-86.
8 白刃.床边血浆置换治疗重症高脂血症性急性胰腺炎的疗效[J].中国实用医药,2014,(18):41-43.
9 韩冰,王晓.轻中度高脂血症性急性胰腺炎采用早期血浆置换治疗的临床疗效观察[J].中国医药指南,2015,(1):187-188.
10 Berger Z,Quera R,Poniachik J,et al.Heparin and insulin treatment of acute pancreatitis caused by hypertriglyceridemia Experience of 5 case[J].Rev Med Chil,2001,129(12):1373-1378.
11庞辉,赵曙光,孙廷强,等.血浆置换联合血液灌流在急性有机磷农药中毒救治中的应用[J].临床输血与检验,2015,17(6):484-486.
12 刘建洛,薛玉龙,张彦华.血液净化在高脂血症性胰腺炎中的应用[J].中国医药指南,2013,11(1):563-564.
2 黄文丽.床边血浆置换治疗重症高脂血症性急性胰腺炎的效果分析[J].世界最新医学信息文摘:连续型电子期刊,2016,15(30):55-56.
3 郁国强,曾军红.血浆置换联合血液透析滤过治疗重症急性胰腺炎临床疗效分析[J].临床荟萃,2011,26(9):760-765.
4 李兆滔,崔西玉,刘欣.血浆置换在治疗重症高脂血症性急性胰腺炎中的应用[J].现代消化及介入诊疗,2014,(2):102-104.
5 张杏.高脂血症性急性胰腺炎的研究现状[J].中国当代医药,2013,20(31):17-18.
6 万洪波.血浆置换联合持续性血液滤过在高脂血症性重症急性胰腺炎中的疗效观察[J].江西医药,2011,46(4):337-339.
7 赵明.血浆置换治疗重症高脂血症性急性胰腺炎的临床疗效[J].社区医学杂志,2015,13(10):85-86.
8 白刃.床边血浆置换治疗重症高脂血症性急性胰腺炎的疗效[J].中国实用医药,2014,(18):41-43.
9 韩冰,王晓.轻中度高脂血症性急性胰腺炎采用早期血浆置换治疗的临床疗效观察[J].中国医药指南,2015,(1):187-188.
10 Berger Z,Quera R,Poniachik J,et al.Heparin and insulin treatment of acute pancreatitis caused by hypertriglyceridemia Experience of 5 case[J].Rev Med Chil,2001,129(12):1373-1378.
11庞辉,赵曙光,孙廷强,等.血浆置换联合血液灌流在急性有机磷农药中毒救治中的应用[J].临床输血与检验,2015,17(6):484-486.
12 刘建洛,薛玉龙,张彦华.血液净化在高脂血症性胰腺炎中的应用[J].中国医药指南,2013,11(1):563-564.