摘要
目的了解食管鳞癌中Snail的表达及临床意义。方法采用Q-PCR、免疫组织化学SP法等方法检测Snail在47例食管鳞癌组织及其食管癌旁组织中的表达,并观察食管鳞癌患者的临床病理特点以及相关预后价值。结果 Snail在食管鳞癌组织中的阳性率[83%(38/47)]明显高于食管癌旁组织[15%(7/47)],其差异有统计学意义(P<0.05)。且Snail在食管鳞癌中的表达与肿瘤的浸润范围、淋巴结转移以及分化程度显著相关(P<0.05)。Kaplan-Meier生存分析显示Snail阳性的食管鳞癌患者预后较差,Snail阳性组和阴性组患者72个月生存率分别为23.6%、54.6%(P<0.05)。结论 Snail高表达可能促进食管鳞癌的发生、发展,可作为早期诊断及评价预后的重要标志物之一。
Objective To investigate the expression and clinical significance of Snail in esophageal squamous cell carcinoma(ESCC). Methods The expression of Snail in 47 cases of ESCC and adjacent esophageal carcinoma was detected by Q-PCR and immunohistochemical SP method. To observe the clinicopathological features and prognosis of ESCC. Results The positive rate of Snail in ESCC was 83%(38/47), which was significantly higher than that of esophageal cancer tissues(15%(7/47)). The difference was statistically significant(P<0.05). The expression of Snail in ESCC was closely related to tumor invasion, lymph node metastasis and differentiation(P<0.05). Kaplan-Meier survival analysis showed that patients with Snail positive ESCC had a poor prognosis. The 72-month survival rates of snail-positive and negative-nose patients were 23.6% and 54.6%, respectively(P<0.05). Conclusion Our study found that high expression of Snail can promote the occurrence and development of ESCC, and can be used as an important indicator for early diagnosis and assessment of prognosis.
引文
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