基于Hermia模型的中药鞣质模拟体系的膜过程污染机制研究
|
摘要
目的分析中药鞣质模拟体系的膜过程污染机制。方法以中药水提液中的鞣质和小分子药效物质(小檗碱、栀子苷)组成的模拟溶液为研究对象,考察不同模拟溶液的膜过程通量、共性高分子物质去除率、小分子药效物质透过率等指标,借助Hermia数学模型进行分析。结果对于鞣质模拟溶液、鞣质+小檗碱+栀子苷模拟溶液,其膜通量变化和滤饼过滤模型拟合程度较高。滤饼层的形成是其通量降低和膜污染的主要原因。滤饼层的存在使得小檗碱和栀子苷透过率(分别为67.63%和87.55%)并不理想。结论 Hermia数学模型可以作为研究中药提取液膜污染机制的重要手段,滤饼层的形成和存在可能是中药提取液膜污染严重的原因之一。
Objective To analyse the fouling mechanism of tannins simulated solution membrane process. Methods Taken the simulated solution consisting of tannins and small molecularly effective substances(berberine and geniposide) as an object of this study, the flux, the removal rate of the macromolecular substances, the size distribution of the different simulated solutions, and the was investigate by Hermia model in this study. Results For tannins simulated solution and tannins + berberine + gardenoside simulated solution, fouling occured within only one phase controlled by cake formation. Due to the presence of the cake layer, the permeation rate of berberine and geniposide was not ideal in the simulated solution(67.63% and 87.55%, respectively). Conclusion The Hermia mathematical model could be used as an important method to study the mechanism of the membrane fouling of Chinese herbal extracts. The formation and presence of the filter cake layer may be one of the reasons for the serious pollution of the traditional Chinese medicines' membrane process.
Objective To analyse the fouling mechanism of tannins simulated solution membrane process. Methods Taken the simulated solution consisting of tannins and small molecularly effective substances(berberine and geniposide) as an object of this study, the flux, the removal rate of the macromolecular substances, the size distribution of the different simulated solutions, and the was investigate by Hermia model in this study. Results For tannins simulated solution and tannins + berberine + gardenoside simulated solution, fouling occured within only one phase controlled by cake formation. Due to the presence of the cake layer, the permeation rate of berberine and geniposide was not ideal in the simulated solution(67.63% and 87.55%, respectively). Conclusion The Hermia mathematical model could be used as an important method to study the mechanism of the membrane fouling of Chinese herbal extracts. The formation and presence of the filter cake layer may be one of the reasons for the serious pollution of the traditional Chinese medicines' membrane process.
引文
[1]国务院关于印发中医药发展战略规划纲要(2016-2030年)的通知[DB/OL].[2016-02-26].http://www.gov.cn/.
[2]刘双双,刘丽芳,朱华旭,等.超滤膜技术用于脉络宁注射液废弃物中多糖分离及其活性筛选研究[J].中草药,2016,47(13):2288-2293.
[3]王北婴,王跃生,王焕魁,等.我国中药制药工业中亟需推广的高新技术[J].世界科学技术,2001,2(2):18-24.
[4]郭立玮.中药制药工业对膜科学技术的重大需求与关键问题[J].中草药,2009,40(12):1849-1855.
[5]郭立玮,陆敏,付廷明,等.基于中药复方小分子药效物质组“溶液结构”特征的膜分离技术优化原理与方法初探[J].膜科学与技术,2012,32(1):1-11.
[6]郭立玮,邢卫红,朱华旭,等.中药膜技术的“绿色制造”特征、国家战略需求及其关键科学问题与应对策略[J].中草药,2017,48(16):3267-3279.
[7]李博,张连军,郭立玮,等.预处理对黄连解毒汤综合模拟体系陶瓷膜微滤过程的研究[J].中草药,2013,44(22):3147-3153.
[8]李博,张连军,郭立玮,等.基于溶液环境调节理论的黄连解毒汤陶瓷膜微滤过程的预处理研究[J].中国中药杂志,2014,39(1):59-64.
[9]朱华旭,郭立玮,李博,等.基于“中药溶液环境”学术思想的膜过程研究模式及其优化策略与方法[J].膜科学与技术,2015,35(5):127-133.
[10]房康,吴高荣,王辉,等.黄连解毒汤自沉淀化学成分及其抗PC12细胞损伤研究[J].中草药,2017,48(18):3714-3719.
[11]钱智磊,李欢,朱华旭,等.黄连解毒汤中指标性成分药动学与药效学相关性的初步研究[J].中国实验方剂学杂志,2011,17(11):122-128.
[12]朱华旭,张新龙,曾明飞,等.黄连解毒汤中小檗碱在脑缺血模型大鼠体内药动学与药效学相关性研究[J].中草药,2012,43(3):546-551.
[13]董洁.基于模拟体系定量构效(QSAR)与传质模型和动力学分析的黄连解毒汤超滤机理研究[D].南京:南京中医药大学,2009.
[14]董洁,郭立玮,文红梅,等.中药水提液中鞣质含量测定方法研究[J].江苏中医药,2008,40(11):89-90.
[15]董洁,朱华旭,郭立玮.黄连解毒汤模拟体系的超滤膜过程研究[J].中国中药杂志,2009,34(19):2458-2462.
[16]Hermans P H,Bredée H L.Zur kenntnis der filtrationsgesetze[J].Recueil Trav Chim Pays-Bas,1935,54(9):680-700.
[17]Hermia J.Constant pressure blocking filtration lawsapplication to power-law non-newtonian fluids[J].Trans Chem E,1982,60(3):18-37.
[18]Bindon K A,Carew A L,Mierczynska-Vasilev A,et al.Characterization of macromolecular complexes in red wine:Composition,molecular mass distribution and particle size[J].Food Chem,2016,199:838-846.
[19]Mondal M,De S.Enrichment of(-)epigallocatechin gallate(EGCG)from aqueous extract of green tea leaves by hollow fiber microfiltration:Modeling of flux decline and identification of optimum operating conditions[J].Sep Purif Technol,2018,206:107-117.
[20]郭立玮,付廷明,李玲娟.面向中药复杂体系的陶瓷膜污染机理研究思路与方法[J].膜科学与技术,2009,29(1):1-7.
[21]徐南平.面向应用过程的陶瓷膜材料的设计、制备与应用[M].上海:科学出版社,2005.
[22]Charfi A,Jang H,Kim J.Membrane fouling by sodium alginate in high salinity conditions to simulate biofouling during seawater desalination[J].Bioresour Technol,2017,240:106-114.
[23]Duong H C,Xia L,Ma Z,et al.Assessing the performance of solar thermal driven membrane distillation for seawater desalination by computer simulation[J].J Membrane Sci,2017,542:133-142.
[2]刘双双,刘丽芳,朱华旭,等.超滤膜技术用于脉络宁注射液废弃物中多糖分离及其活性筛选研究[J].中草药,2016,47(13):2288-2293.
[3]王北婴,王跃生,王焕魁,等.我国中药制药工业中亟需推广的高新技术[J].世界科学技术,2001,2(2):18-24.
[4]郭立玮.中药制药工业对膜科学技术的重大需求与关键问题[J].中草药,2009,40(12):1849-1855.
[5]郭立玮,陆敏,付廷明,等.基于中药复方小分子药效物质组“溶液结构”特征的膜分离技术优化原理与方法初探[J].膜科学与技术,2012,32(1):1-11.
[6]郭立玮,邢卫红,朱华旭,等.中药膜技术的“绿色制造”特征、国家战略需求及其关键科学问题与应对策略[J].中草药,2017,48(16):3267-3279.
[7]李博,张连军,郭立玮,等.预处理对黄连解毒汤综合模拟体系陶瓷膜微滤过程的研究[J].中草药,2013,44(22):3147-3153.
[8]李博,张连军,郭立玮,等.基于溶液环境调节理论的黄连解毒汤陶瓷膜微滤过程的预处理研究[J].中国中药杂志,2014,39(1):59-64.
[9]朱华旭,郭立玮,李博,等.基于“中药溶液环境”学术思想的膜过程研究模式及其优化策略与方法[J].膜科学与技术,2015,35(5):127-133.
[10]房康,吴高荣,王辉,等.黄连解毒汤自沉淀化学成分及其抗PC12细胞损伤研究[J].中草药,2017,48(18):3714-3719.
[11]钱智磊,李欢,朱华旭,等.黄连解毒汤中指标性成分药动学与药效学相关性的初步研究[J].中国实验方剂学杂志,2011,17(11):122-128.
[12]朱华旭,张新龙,曾明飞,等.黄连解毒汤中小檗碱在脑缺血模型大鼠体内药动学与药效学相关性研究[J].中草药,2012,43(3):546-551.
[13]董洁.基于模拟体系定量构效(QSAR)与传质模型和动力学分析的黄连解毒汤超滤机理研究[D].南京:南京中医药大学,2009.
[14]董洁,郭立玮,文红梅,等.中药水提液中鞣质含量测定方法研究[J].江苏中医药,2008,40(11):89-90.
[15]董洁,朱华旭,郭立玮.黄连解毒汤模拟体系的超滤膜过程研究[J].中国中药杂志,2009,34(19):2458-2462.
[16]Hermans P H,Bredée H L.Zur kenntnis der filtrationsgesetze[J].Recueil Trav Chim Pays-Bas,1935,54(9):680-700.
[17]Hermia J.Constant pressure blocking filtration lawsapplication to power-law non-newtonian fluids[J].Trans Chem E,1982,60(3):18-37.
[18]Bindon K A,Carew A L,Mierczynska-Vasilev A,et al.Characterization of macromolecular complexes in red wine:Composition,molecular mass distribution and particle size[J].Food Chem,2016,199:838-846.
[19]Mondal M,De S.Enrichment of(-)epigallocatechin gallate(EGCG)from aqueous extract of green tea leaves by hollow fiber microfiltration:Modeling of flux decline and identification of optimum operating conditions[J].Sep Purif Technol,2018,206:107-117.
[20]郭立玮,付廷明,李玲娟.面向中药复杂体系的陶瓷膜污染机理研究思路与方法[J].膜科学与技术,2009,29(1):1-7.
[21]徐南平.面向应用过程的陶瓷膜材料的设计、制备与应用[M].上海:科学出版社,2005.
[22]Charfi A,Jang H,Kim J.Membrane fouling by sodium alginate in high salinity conditions to simulate biofouling during seawater desalination[J].Bioresour Technol,2017,240:106-114.
[23]Duong H C,Xia L,Ma Z,et al.Assessing the performance of solar thermal driven membrane distillation for seawater desalination by computer simulation[J].J Membrane Sci,2017,542:133-142.
© 2004-2018 中国地质图书馆版权所有 京ICP备05064691号 京公网安备11010802017129号 地址：北京市海淀区学院路29号 邮编：100083 电话：办公室：(+86 10)66554848；文献借阅、咨询服务、科技查新：66554700 |