基于缺血预处理诱导脑缺血耐受临床特点的动物模型分析
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摘要
通过分析临床上短暂性脑缺血发作(TIA)诱导脑缺血耐受的特点和影响因素,总结脑缺血耐受动物模型的特点和造模方法,比对临床相关症状,对现有动物模型与临床病症的吻合情况进行分析探讨,提出相应动物模型的评价及改进方法。脑缺血耐受造模方法较多,但缺少能反映脑缺血耐受临床特点的动物模型,建立合理的模型量化标准,完善模型评价方法,是脑缺血耐受动物模型的发展方向。
By summarizing clinical features and influential factors of BIT induced by TIA,the characteristics and preparation of BIT animal models were reviewed.The association between the anastomosis of the existing animal models and clinical disorders were discussed,and put forward the corresponding improvment of methods for BIT animal models induced by TIA.There are many approaches for BIT animal models inducing by preconditioning ways,however those BIT animal models can hardly reflect clinical disease characteristics.Establishing animal models that can present the clinical symptoms characteristic of BIT,and setting up justified criteria for animal models are the directions for further study.
By summarizing clinical features and influential factors of BIT induced by TIA,the characteristics and preparation of BIT animal models were reviewed.The association between the anastomosis of the existing animal models and clinical disorders were discussed,and put forward the corresponding improvment of methods for BIT animal models induced by TIA.There are many approaches for BIT animal models inducing by preconditioning ways,however those BIT animal models can hardly reflect clinical disease characteristics.Establishing animal models that can present the clinical symptoms characteristic of BIT,and setting up justified criteria for animal models are the directions for further study.
引文
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[25]吴孝军,朱路文,李宏玉,等.运动预处理诱导脑缺血耐受机制的研究进展[J].中国康复理论与实践,2015,21(6):657-661.
[26]陈晓梅,熊利泽,董海龙,等.高压氧预处理减少局灶性脑缺血后泛素化蛋白聚集[J].中华神经外科疾病研究杂志,2010,9(5):441-444.
[27]张维波,黄俊山.低氧诱导因子-1与低氧预处理诱导的脑缺血耐受[J].中国康复医学杂志,2007,22(4):377-379.
[28]NISHIO S,YUNOKI M,CHEN Z F,et al.Ischemic tolerance in the rat neocortex following hypothermic preconditioning[J].JNeurosurgery,2000,93(5):845-851.
[29]UNO H,KOBAYASHI H,HANDA Y,et al.Alterations of calcium calmodulin dependent protein kinaseⅡactivity in ischemia in-duced neuronal death and neuronal protection against ischemia in the gerbil hippocampus[J].Acta Neurochir,1999,141:287-294.
[30]谭帅,洪华.远端缺血预处理在脑梗死中应用的研究进展[J].广东医学,2015,36(18):2919-2921.
[31]文继月,陈志武.药物预处理的脑保护作用[J].淮南职业技术学院学报,2006,4(6):119-122.
[32]巴晓红.脑缺血耐受机制及脑缺血预处理的研究进展[J].中国康复医学杂志,2005,20(9):718-720.
[2]苗明三,马霄,史晶晶.药物提高脑缺血耐受探讨[J].时珍国医国药,2009,20(9):2288-2289.
[3]魏衡武.短暂性脑缺血发作的诊断及治疗临床分析[J].中国医药指南,2012,10(14):110-111.
[4]舒敏,章军建.ABCD3评分评价短暂性脑缺血发作患者早期发生脑梗死的风险[J].华中科技大学学报(医学版),2012,4(5):607-610.
[5]胡跃强,刘泰.脑缺血药物预处理研究进展[J].中西医结合心脑血管病杂志,2008,6(10):1203-1205.
[6]中华神经科学会,中华神经外科学会.各类脑血管疾病诊断要点[J].中华神经科杂志,1996,29(6):379-380.
[7]陈艳洁,于文霞,王彦,等.短暂性脑缺血发作持续时间与脑缺血预适应及后继脑梗死的相关性研究[J].现代中西医结合杂志,2014,23(30):3335-3336.
[8]MONCAYO J,FREITASGR D E,BOGOUSSLAVSKY J,et al.Do transient ischemic attacks have a neuroprotective effect?[J].Neurology,2000,54(11):2089-2094.
[9]尤群生.短暂性脑缺血发作对后继脑梗死神经保护作用的临床研究[J].中国医学工程,2009,17(12):21-23.
[10]李庆华,唐静怡,王玉敏.短暂性脑缺血发作的人脑缺血耐受作用[J].第四军医大学学报,2001,22(22):2094-2095.
[11]蒋文静.远程缺血预适应训练预防脑中风30例临床分析[J].中外健康文摘,2011,31(6):1672-5085
[12]仲忠,张云.远程缺血预适应训练对缺血性脑血管疾病治疗40例分析[J].中国伤残医学,2013,12(6):159-160
[13]国家中医药管理局脑病急症协作.中风病诊断与疗效评定标准(试行)[J].北京中医药大学学报,1996,19(1):55-56.
[14]杨传军,范玲.短暂性脑缺血发作对脑缺血耐受的影响[J].中国卒中杂志,2007,2(12):979-981.
[15]常四鹏,牛敬忠.预先短暂性脑缺血发作时间、次数等对后继脑梗死神经保护的研究[J].中国实用神经疾病杂志,2015,18(10):30-31.
[16]张桂莲,吴海琴,李觉慧,等.短暂性脑缺血发作的脑保护作用研究[J].卒中与神经疾病,2003,10(2):80-82.
[17]ZHANG J,YANG Z J,KLAUS J A,et al.Delayed tolerance with repetitive transient focal ischemic preconditioning in the mouse[J].Stroke,2008,39(3):967-974.
[18]饶明利.中国脑血管病防治指南[M].北京:人民卫生出版社,2007:35.
[19]吉玲.猪脑缺血模型的研究进展[J].实用医院临床杂志,2013,10(2):154-156.
[20]刘盼功,杜洋,赵晓峰,等.脑缺血动物模型动物选择研究[J].时珍国医国药,2010,21(9):2372-2373.
[21]秦福成,刘瑞举.脑缺血模型的研究进展[J].青岛大学医学院学报,2001,37(2):168.
[22]陈虎,蔡定芳.脑缺血耐受及其机制的研究进展[J].国外医学(脑血管疾病分册),2002,10(3):232-236.
[23]王树,张力.脑缺血及脑缺血再灌注损伤动物模型制备方法及评价[J].神经药理学报,2011,1(3):31-40.
[24]孙忠人,唐伟,单丽莉,等.针刺诱导脑缺血耐受的实验研究[J].中国临床康复,2005,9(1):122-123.
[25]吴孝军,朱路文,李宏玉,等.运动预处理诱导脑缺血耐受机制的研究进展[J].中国康复理论与实践,2015,21(6):657-661.
[26]陈晓梅,熊利泽,董海龙,等.高压氧预处理减少局灶性脑缺血后泛素化蛋白聚集[J].中华神经外科疾病研究杂志,2010,9(5):441-444.
[27]张维波,黄俊山.低氧诱导因子-1与低氧预处理诱导的脑缺血耐受[J].中国康复医学杂志,2007,22(4):377-379.
[28]NISHIO S,YUNOKI M,CHEN Z F,et al.Ischemic tolerance in the rat neocortex following hypothermic preconditioning[J].JNeurosurgery,2000,93(5):845-851.
[29]UNO H,KOBAYASHI H,HANDA Y,et al.Alterations of calcium calmodulin dependent protein kinaseⅡactivity in ischemia in-duced neuronal death and neuronal protection against ischemia in the gerbil hippocampus[J].Acta Neurochir,1999,141:287-294.
[30]谭帅,洪华.远端缺血预处理在脑梗死中应用的研究进展[J].广东医学,2015,36(18):2919-2921.
[31]文继月,陈志武.药物预处理的脑保护作用[J].淮南职业技术学院学报,2006,4(6):119-122.
[32]巴晓红.脑缺血耐受机制及脑缺血预处理的研究进展[J].中国康复医学杂志,2005,20(9):718-720.
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