基质金属蛋白质酶-9与血管内皮生长因子在糖尿病血管生成中作用的研究进展
摘要
<正>机体的某些病理状况影响着血管的生成,称为病理性血管生成。糖尿病状态下因外周循环、冠状动脉循环功能受损,导致伤口血供较差,从而使伤口难以愈合。内皮细胞是糖尿病血管病变的关键靶细胞。血管内皮生长因子(VEGF)是调节血管生成的关键性因素。基质金属蛋白酶(MMPs)通过促进内皮细胞迁移、毛细血管基底膜破裂和细胞外周纤
引文
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[28]Yuan W,Wei J,Nakano K,et al.Expression and correlation analysis ofβ-adrenoceptors VEGF,MMP-9 and caspase-3in different phases of infantile hemangioma[J].J Hard Tissue Biol,2013,22(1):51-58.
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[41]de Vriese AS,Tilton RG,Elger M,et al.Antibodies against vascular endothelial growth factor improve early renal dysfunction in experimental diabetes[J].J Am Soc Nephrol,2001,12(5):993-1000.
[42]Yamamoto Y,Maeshima Y,Kitayama H,et al. Tumstatin peptide,an inhibitor of angiogenesis,prevents glomerular hypertrophy in the early stage of diabetic nephropathy[J].Diabetes,2004,53(7):1831-1840
[43]Liu ZJ,Velazquez OC.Hyperoxia,endothelial progenitor cell mobilization,and diabetic wound healing[J].Antioxid Redox Signal,2008,10:1869-1882.
[44]Gallagher KA,Liu ZJ,Xiao M,et al.Diabetic impairmentsin NO-mediated endothelial progenitor cell mobilization and homing are reversed by hyperoxia and SDF-1 alpha[J].J Clin Invest,2007,11 7:1249-1259.
[45]Heljasvaara R,Nyberg P,Luostarinen J,et al.Generation of biologically active endostatin fragments from human collagen XVIII by distinct matrix metalloproteases[J].Exp Cell Res,2005,307(2):292-304.
[46]Li N,Luo HC,Yang C, et al.Cationic star-shaped polymer as an siRNA carrier for reducing MMP-9 expression in skin fibroblast cells and promoting wound healing in diabetic rats[J].Int J Nanomedicine,2014,9:3377-3387.
[47]Soo C,Shaw WW,Zhang X,et al.Differential Expression of Matrix Metalloproteinases and Their Tissue-Derived Inhibitors in Cutaneous Wound Repair[J].Plast Reconstr Surg,2000,105(2):638-647.
[48]Rayment EA,Upton Z,Shooter GK.Increased matrix metalloproteinase-9.(MMP-9)activity observed in chronic wound fluid is related to the clinicalseverity of the ulcer[J].Br J Dermatol,2008,1 58(5):951-961.
[2]李文娟,陈伟,付小兵,等.基质金属蛋白酶及其抑制因子在增生性瘢痕中的表达特征及意义[J].感染、炎症、修复,2005,6(4):207-209.
[3]Farina AR,Mackay AR.Gelatinase B/MMP9 in tumour pathogenesis and progression[J].Cancers,2014,6(1):240-296.
[4]杜晓辉,李荣.血管内皮生长因子及其抗肿瘤治疗的研究进展[J].感染、炎症、修复,2005,6(1):51-53.
[5]Goel HL, Mercurio AM.VEGF targets the tumour cell[J].Nature Rev Cancer,2013,13(12):871-882.
[6]Koch S, Claesson-W elsh L.Signal transduction by vascular endothelial growth factor[J].Receptors,2012,2(7):a6502.
[7]Geudens I,Gerhardt H.Coordinating cell behaviour during blood vessel formation[J].Development,201 1,1 38(21):4 5 69-4583.
[8]Reynolds LP,Grazul-Bilska AT,Redmer DA.Angiogenesis in the female reproductive organs:Pathological implications[J].Int J Exp Pathol,2002,83:151-163.
[9]Fukumura DAI,Jain RK.Imaging angiogenesis and the microenv ironment[J].APMIS,2008,116:695-715.
[10]Folkman J.Angiogenesis in cancer,ascular,rheumatoid and other disease[J].Nat.Med,1995,1:27-31.
[11]Carmeliet P,Jain RK.Angiogenesis in cancer and other diseases[J].Nature,2000,407:249-257.
[12]Carmeliet P.Angiogenesis in life,disease and medicine[J].Nat ure,2005,438:932-936.
[13]Kerbel R S.Tumor angiogenesis[J].N Engl J Med,2008,358:2039-2049.
[14]Nissen NN,Polverini PJ, Koch AE,et al.Vascular endothelial growth factor mediates angiogenic activity during the proliferative phase of wound healing[J].Am J Pathol,1998,152:1445-1452.
[15]Fowler MJ.Microvascular and macrovascular complications of diabetes[J].Clin.Diabetes,2011,29:1 16-122.
[16]Rask-Madsen C, King GL.Mechanisms of disease:endothelia dysfunction in insulin resistance and diabetes[J].Nat Clin Pra Endocrinol Metab,2007,3(1):46-56.
[17]Brown DI,Griendling KK.Regulation of signal transduction by reactive oxygen species in the cardiovascular system[J].Circ Res,2015,116(3):531-549.
[18]Yamagishi S,Nakamura K,Matsui T,et al.Pigment epitheliumderived factor inhibits advanced glycation end productinduced retinal vascular hyperpermeability by blocking reactive oxygen species-mediated vascular endothelial growth factor expression[J].J Biol Chem,2006,281(29):20213-20.
[19]Lee CH,Shieh YS,Hsiao FC,et al.High glucose induces hum an endothelial dysfunction through an Axl-dependent mechanism[J].Cardiovasc Diabetol,2014,13:53.
[20]Kanesaki Y,Suzuki D,Uehara G,et al.Vascular endothelial growth factor gene expression is correlated with glomerular neovascularization in human diabetic nephropathy[J].Am J Kidney Dis,2005,45(2):288-294.
[21]Tsuchida K, Makita Z,Yamagishi S,et al.Suppression of transforming growth factor beta and vascular endothelial growth factor in diabetic nephropathy in rats by a novel advanced glycation end product inhibitor,OPB-9195[J].Diabetolog ia,1999,42(5):579-588.
[22]Nakagawa T,Sato W,Kosugi T,et al.Uncoupling of VEGF with endothelial NO as a potential mechanism for abnormal angiogenesis in the diabetic nephropathy[J].J Diabetes Res,2013,2013:184539
[23]Dinh T,Veves A.Microcirculation of the diabetic foot[J].Curr Pharm Des,2005,1 1:2301-2309.
[24]Seitz O,Schurmann C,Hermes N,et al. Wound healing in mice with high-fat diet-or ob gene-induced diabetes-obesity syndromes:A comparative study[J].Exp Diabetes Res,2010,2010:476969.
[25]Moldovan NI.Angiogenesis,l'enfant terrible of vascular biology is coming of age[J].J Cell Mol Med,2005,9(14):775-776.
[26]韩根良.胰腺癌血清中MMP9和VEGF检测及相关性分析[J].中国药物经济学,2014,9(3):259-260.
[27]赵忠芳,吕仁荣,霍然,等.普萘洛尔治疗增生期血管瘤患儿血清中血管内皮生长因子及基质金属蛋白酶-9的变化[J].中华整形外科杂志,2011,27(5):359-361.
[28]Yuan W,Wei J,Nakano K,et al.Expression and correlation analysis ofβ-adrenoceptors VEGF,MMP-9 and caspase-3in different phases of infantile hemangioma[J].J Hard Tissue Biol,2013,22(1):51-58.
[29]Mira E,Lacalle RA,Buesa JM,et al.Secreted MM9 promotes angiogenesis more efficiently than constitutive active MMP9 bound to the tumor cell surface[J].J Cell Sci,20014,117:1847,117MM
[30]Yu W,Chen L,Yang YQ,et al.Cytochrome P450ω-hydroxylase promotes angiogenesis and metastasis by upregulation of VEGF and MMP-9 in non-small cell lung cancer[J].Cancer Chemother Pharmacol,201 1,68(3):619-29.
[31]Mu H,Ohashi R,Yan S,et al.Adipokine resistin promotes in vitro angiogenesis of human endothelial cells[J].Cardiovasc Res,2006,70(1):146-157.
[32]Madsen-Bouterse SA,Mohammad G,Kanwar M,et al. Role of mitochondrial DNA damage in the development of diabetic retinopathy,and the metabolic memory phenomenon associated with its progression[J].Antioxid Redox Signal,2010,1 3(6):797-805.
[33]Madsen-Bouterse S,Zhong Q,Mohammad G,et al.Oxidative damage of mitochondrial DNA in diabetes,and its protection by manganese superoxide dismutase[J].Free Radio Res,2010,44:313-21.
[34]Kowluru RA,Mohammad G,Dos Santos JM,et al. Abrogation of MMP9 gene protects against the development of retinopathy in diabetic mice by preventing mitochondrial damage[J].Diabet es,2011,60:3023-33.
[35]Jin M,Kashiwagi K,Iizuka Y,et al. Matrix metalloproteinases in human diabetic and nondiabetic vitreous[J].Retina,2001,2 1:28-33.
[36]Kowluru RA,Kanwar M.Oxidative stress and the development of diabetic retinopathy:contributory role of matrix metalloproteinase-2[J].Free Radic Biol Med,2009,46:1 677-1 685.
[37]Das A,McGuire PG,Eriqat C,et al.Human diabetic neovascular membranes contain high levels of urokinase and metalloproteinase enzymes[J].Invest Ophthalmol Vis Sci,1999,40:809-813.
[38]Kermorvant-Duchemin E,Sapieha P,Sirinyan M,et al.Understanding ischemic retinopathies:emerging concepts from oxygen-induced ret inopathy[J].Doc Ophthalmol,2010,120:51-60.
[39]Kundu S,Pushpakumar SB,Tyagi A,et al.Hydrogensulfide deficiency and diabetic renal remodeling:role of matrix metalloproteinase-9[J].Am J Physiol Endocrinol Metab,2013,304:E1365-1378.
[40]Tsuchida K,Makita Z,Yamagishi S,et al.Suppression of transforming growth factor beta and vascular endothelial growth factor in diabetic nephropathy in rats by a novel advanced glycation end product inhibitor,OPB-9195[J].Diabetologia,1999,42(5):5 79-88.
[41]de Vriese AS,Tilton RG,Elger M,et al.Antibodies against vascular endothelial growth factor improve early renal dysfunction in experimental diabetes[J].J Am Soc Nephrol,2001,12(5):993-1000.
[42]Yamamoto Y,Maeshima Y,Kitayama H,et al. Tumstatin peptide,an inhibitor of angiogenesis,prevents glomerular hypertrophy in the early stage of diabetic nephropathy[J].Diabetes,2004,53(7):1831-1840
[43]Liu ZJ,Velazquez OC.Hyperoxia,endothelial progenitor cell mobilization,and diabetic wound healing[J].Antioxid Redox Signal,2008,10:1869-1882.
[44]Gallagher KA,Liu ZJ,Xiao M,et al.Diabetic impairmentsin NO-mediated endothelial progenitor cell mobilization and homing are reversed by hyperoxia and SDF-1 alpha[J].J Clin Invest,2007,11 7:1249-1259.
[45]Heljasvaara R,Nyberg P,Luostarinen J,et al.Generation of biologically active endostatin fragments from human collagen XVIII by distinct matrix metalloproteases[J].Exp Cell Res,2005,307(2):292-304.
[46]Li N,Luo HC,Yang C, et al.Cationic star-shaped polymer as an siRNA carrier for reducing MMP-9 expression in skin fibroblast cells and promoting wound healing in diabetic rats[J].Int J Nanomedicine,2014,9:3377-3387.
[47]Soo C,Shaw WW,Zhang X,et al.Differential Expression of Matrix Metalloproteinases and Their Tissue-Derived Inhibitors in Cutaneous Wound Repair[J].Plast Reconstr Surg,2000,105(2):638-647.
[48]Rayment EA,Upton Z,Shooter GK.Increased matrix metalloproteinase-9.(MMP-9)activity observed in chronic wound fluid is related to the clinicalseverity of the ulcer[J].Br J Dermatol,2008,1 58(5):951-961.