仪花属植物化学成分及药理活性研究进展
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摘要
豆科仪花属植物,主要分布于我国南部。该属植物主要含有间苯三酚类、黄酮类、二苯乙烯类、三萜类等化学成分,具有抗氧化、扩张血管、抗心律失常和镇痛等多种药理活性,民间主要用于治疗跌打损伤、骨折和外伤出血。本文较系统的综述了近十年国内外对仪花属植物的化学成分及药理活性的研究进展,以期为仪花属植物的开发利用提供一定的科学依据。
Genus Lysidice( Fabaceae) which belongs to Leguminosae,consists of two species,Lysidice rhodostegia Hance and Lysidice brevicalyx Wei. They are widely distributed in the south and southwestern parts of China,such as Guangdong,Guangxi,Yunnan and Guizhou Provinces,and in Chinese folk medicine,their roots have been used for the treatment of pains,fracture and hemorrhage. During the previous studies on bioactive constituents from the Genus,phloroglucinols,flavonoids,stilbenes,triterpenes and lignans had been detected. These components were proved to have a wide range of pharmacological effects including anti-oxygenation,hemangiectasia,anti-arrhythmia,analgesia,etc. This paper summarized the chemical components and pharmacological activities of Genus Lysidice plants by consulting the existing literatures over the past decade. It was in order to provide a reference for further research and development of this Genus.
Genus Lysidice( Fabaceae) which belongs to Leguminosae,consists of two species,Lysidice rhodostegia Hance and Lysidice brevicalyx Wei. They are widely distributed in the south and southwestern parts of China,such as Guangdong,Guangxi,Yunnan and Guizhou Provinces,and in Chinese folk medicine,their roots have been used for the treatment of pains,fracture and hemorrhage. During the previous studies on bioactive constituents from the Genus,phloroglucinols,flavonoids,stilbenes,triterpenes and lignans had been detected. These components were proved to have a wide range of pharmacological effects including anti-oxygenation,hemangiectasia,anti-arrhythmia,analgesia,etc. This paper summarized the chemical components and pharmacological activities of Genus Lysidice plants by consulting the existing literatures over the past decade. It was in order to provide a reference for further research and development of this Genus.
引文
1 He RM(何日明),et al.Urban landscaping fine species-Lysidice rhodostegia Hance.J Chin Urban Fore(中国城市林业),2007,5(5):63-64.
2 Editorial Board of Flora Republicae Popularis Sinicae,Chinese Academy of Sciences(中国科学院中国植物志编辑委员会).Flora Republicae Popularis Sinicae(中国植物志).Beijing:Science Press,1998.42:204.
3 Editorial of Nanjing University of Chinese Medicine.A Dictionary of Traditional Chinese Medicine(中药大辞典).Shanghai:Shanghai Science and Technology Press,2014.3899-3900.
4 Wei SJ(韦松基),et al.Microscopic differentiate of two poisonous medical plants.Guangxi Sci(广西科学),2007,14:400-404.
5 Pan W(潘文),et al.Resistance of Rhodoleia championii and other plants to sulfur dioxide and nitrogen dioxide.Ecol Environ Sci(生态环境学报),2012,21:1851-1858.
6 Shi DY(石东扬),et al.Studies on the selection of pavement tree species in Liuzhou city.J Guangxi Acade Sci(广西科学院学报),2006,22(2):90-93.
7 Qu J,et al.Structural characterization of constituents with molecular diversity in fractions from Lysidice brevicalyx by liquid chromatography/diode-array detection electrospray ionization tandem mass spectrometry and liquid chromatography/nu-clear magnetic resonance.Rapid Commun Mass Spectrom,2008,22:755-765.
8 Gao S,et al.Two New Phloroglucinol Glycosides from Lysidice rhodostega Hance.Chin Chem Lett,2004,15:313-315.
9 Gao S,et al.Resveratrol/phloroglucinol glycosides from the roots of Lysidice rhodostegia.Planta Med,2007,73:163-166.
10 Yang HL(杨华良).Studies on chemical constituents from leaves of Lysidice brevicalyx.Shenyang:Shenyang Pharmaceutical University(沈阳药科大学),MSc.2008.
11 Hu YC,et al.Novel Phloroglucinol Derivatives from the Roots of Lysidice rhodostegia.Org Lett,2006,8:2269-2272.
12 Wu XF,et al.Two new compounds from the roots of Lysidice rhodostegia.J Asian Nat Prod Res,2007,9:471-477.
13 Wu XF,et al.Lysidicins F-H,Three New Phloroglucinols from Lysidice rhodostegia.Org Lett,2010,12:2390-2393.
14 Wu XF,et al.Antioxidative acylphloroglucinols from the roots of Lysidice rhodostegia.Tetrahedron Lett,2011,67:8155-8159.
15 Wu XF(吴先富).Study on chemical constituents from roots and leaves of Lysidice rhodostegia,and fruits of Iliicium simonsii Maxim.Beijing:Chinese Academy of Medical Sciences&Peking Union Medical College(中国医学科学院&北京协和医学院),PhD.2009.
16 Yang HL(杨华良),et al.Studies on chemical constituents from leaves of Lysidice brevicalyx.Chin J Chin Mater Med(中国中药杂志),2008,33:2633-2635.
17 Hu YC,et al.Structural characterization of trace stilbene glycosides in Lysidice brevicalyx Wei using liquid chromatography/diode-array detection/electrospray ionization tandem mass spectrometry.J Chromatog B,2010,878:1-7.
18 Hu YC,et al.Phenolic glycosides isolated from the bark of Lysidice brevicalyx Wei.J Asian Nat Prod Res,2010,12:516-521.
19 Gao S,et al.Flavonoids from Lysidice rhodostegia Hance.J Integ Plant Biol,2005,47:759-763.
20 Gao S,et al.Vasodilator constituents from the roots of Lysidice rhodostega.Planta Med,2004,70:1128-1134.
21 Gao S(郜嵩).Study on the active constituents from the roots of Lysidice rhodostegia and primary chiral total synthesis of phena-throindolizidine alkaloids.Beijing:Chinese Academy of Medical Sciences&Peking Union Medical College(中国医学科学院&北京协和医学院),PhD.2004.
22 Hu YC(胡友财).Study on the bioactive ingredients from barks of Lysidice brevicalyx based on bioactivity and chemical screening.Beijing:Chinese Academy of Medical Sciences&Peking Union Medical College(中国医学科学院&北京协和医学院),PhD.2008.
23 Hu YC,et al.Targeted isolation and structure elucidation of stilbene glycosides from the bark of Lysidice brevicalyx Wei guided by biological and chemical screening.J Nat Prod,2008,71:1800-1805.
24 Qu J(屈晶).Chemical study on the cytotoxic components of Erthrophleum fordii Oliver.Online analytical methods study of the chemical components of Lysidice brevicalyx and trace cassaine-type amides from Erthrophleum fordii Oliver.Beijing:Chinese Academy of Medical Sciences&Peking Union Medical College(中国医学科学院&北京协和医学院),PhD.2007.
25 Zhou LZ(周林宗),et al.Studies on landscape plants of Lysidice genus.J Anhui Agric Sci(安徽农业科技),2010,38:16215-16217.
26 Gao S(郜嵩),et al.Study on the chemical constituents from roots of Lysidice rhodostegia Hance.Chin J Nat Med(中国天然药物),2005,3:144-147.
27 Ogura Y,et al.Total synthesis of(±)-lysidicin A.Tetrahedr Lett,2012,68:1723-1728.
28 Ogura Y,et al.Efficient construction of the core framework of lysidicin A via three Claisen rearrangements including a cascade reaction.Tetrahedr Lett,2010,51:3294-3296.
29 Liu YB,et al.Structures and absolute configurations of penicillactones A-C from an endophytic microorganism,Penicillium dangeardii Pitt.Org Lett,2013,15:5206-5209.
30 Wang JM,et al.Thiodiketopiperazines produced by the endophytic fungus Epicoccum nigrum.J Nat Prod,2010,73:1240-1249.
31 Ding GZ,et al.Secondary metabolites from the endophytic fungi Penicillium polonicum and Aspergillus fumigatus.J Asian Nat Prod Res,2013,15:446-452.
32 Lv HN(吕海宁),et al.Study on secondary metabolites of endophytic fungi Penicillium dangeardii.Chin J Chin Mater Med(中国中药杂志),2015,40:1759-1761.
33 Liu J(刘静),et al.Study on secondary metabolites of endophytic fungi Penicillium dangeardii.Chin J Chin Mater Med(中国中药杂志),2014,39:3974-3977.
34 Zhang HQ(张惠勤),et al.Study on anti-arrhythmia effect of Lysidice rhodostegia Hance.Chin J Trad Med Sci Tech(中国中医药科技),2005,12:229-230.
35 Lan ZH(蓝子花).A Chinese medicinal composition containing Herba Antenoronis Neofiliformis root and having effects in activating collaterals and relieving pain(一种含金钱草根的活络镇痛药).CN1814069A,2006-8-9.
36 Wang SG(王曙光),et al.Experiment of Lysidice rhodostegia Hance on mouse pain models.Yunnan J Trad Med Mater Med(云南中医中药杂志),2012,33(12):55-57.
2 Editorial Board of Flora Republicae Popularis Sinicae,Chinese Academy of Sciences(中国科学院中国植物志编辑委员会).Flora Republicae Popularis Sinicae(中国植物志).Beijing:Science Press,1998.42:204.
3 Editorial of Nanjing University of Chinese Medicine.A Dictionary of Traditional Chinese Medicine(中药大辞典).Shanghai:Shanghai Science and Technology Press,2014.3899-3900.
4 Wei SJ(韦松基),et al.Microscopic differentiate of two poisonous medical plants.Guangxi Sci(广西科学),2007,14:400-404.
5 Pan W(潘文),et al.Resistance of Rhodoleia championii and other plants to sulfur dioxide and nitrogen dioxide.Ecol Environ Sci(生态环境学报),2012,21:1851-1858.
6 Shi DY(石东扬),et al.Studies on the selection of pavement tree species in Liuzhou city.J Guangxi Acade Sci(广西科学院学报),2006,22(2):90-93.
7 Qu J,et al.Structural characterization of constituents with molecular diversity in fractions from Lysidice brevicalyx by liquid chromatography/diode-array detection electrospray ionization tandem mass spectrometry and liquid chromatography/nu-clear magnetic resonance.Rapid Commun Mass Spectrom,2008,22:755-765.
8 Gao S,et al.Two New Phloroglucinol Glycosides from Lysidice rhodostega Hance.Chin Chem Lett,2004,15:313-315.
9 Gao S,et al.Resveratrol/phloroglucinol glycosides from the roots of Lysidice rhodostegia.Planta Med,2007,73:163-166.
10 Yang HL(杨华良).Studies on chemical constituents from leaves of Lysidice brevicalyx.Shenyang:Shenyang Pharmaceutical University(沈阳药科大学),MSc.2008.
11 Hu YC,et al.Novel Phloroglucinol Derivatives from the Roots of Lysidice rhodostegia.Org Lett,2006,8:2269-2272.
12 Wu XF,et al.Two new compounds from the roots of Lysidice rhodostegia.J Asian Nat Prod Res,2007,9:471-477.
13 Wu XF,et al.Lysidicins F-H,Three New Phloroglucinols from Lysidice rhodostegia.Org Lett,2010,12:2390-2393.
14 Wu XF,et al.Antioxidative acylphloroglucinols from the roots of Lysidice rhodostegia.Tetrahedron Lett,2011,67:8155-8159.
15 Wu XF(吴先富).Study on chemical constituents from roots and leaves of Lysidice rhodostegia,and fruits of Iliicium simonsii Maxim.Beijing:Chinese Academy of Medical Sciences&Peking Union Medical College(中国医学科学院&北京协和医学院),PhD.2009.
16 Yang HL(杨华良),et al.Studies on chemical constituents from leaves of Lysidice brevicalyx.Chin J Chin Mater Med(中国中药杂志),2008,33:2633-2635.
17 Hu YC,et al.Structural characterization of trace stilbene glycosides in Lysidice brevicalyx Wei using liquid chromatography/diode-array detection/electrospray ionization tandem mass spectrometry.J Chromatog B,2010,878:1-7.
18 Hu YC,et al.Phenolic glycosides isolated from the bark of Lysidice brevicalyx Wei.J Asian Nat Prod Res,2010,12:516-521.
19 Gao S,et al.Flavonoids from Lysidice rhodostegia Hance.J Integ Plant Biol,2005,47:759-763.
20 Gao S,et al.Vasodilator constituents from the roots of Lysidice rhodostega.Planta Med,2004,70:1128-1134.
21 Gao S(郜嵩).Study on the active constituents from the roots of Lysidice rhodostegia and primary chiral total synthesis of phena-throindolizidine alkaloids.Beijing:Chinese Academy of Medical Sciences&Peking Union Medical College(中国医学科学院&北京协和医学院),PhD.2004.
22 Hu YC(胡友财).Study on the bioactive ingredients from barks of Lysidice brevicalyx based on bioactivity and chemical screening.Beijing:Chinese Academy of Medical Sciences&Peking Union Medical College(中国医学科学院&北京协和医学院),PhD.2008.
23 Hu YC,et al.Targeted isolation and structure elucidation of stilbene glycosides from the bark of Lysidice brevicalyx Wei guided by biological and chemical screening.J Nat Prod,2008,71:1800-1805.
24 Qu J(屈晶).Chemical study on the cytotoxic components of Erthrophleum fordii Oliver.Online analytical methods study of the chemical components of Lysidice brevicalyx and trace cassaine-type amides from Erthrophleum fordii Oliver.Beijing:Chinese Academy of Medical Sciences&Peking Union Medical College(中国医学科学院&北京协和医学院),PhD.2007.
25 Zhou LZ(周林宗),et al.Studies on landscape plants of Lysidice genus.J Anhui Agric Sci(安徽农业科技),2010,38:16215-16217.
26 Gao S(郜嵩),et al.Study on the chemical constituents from roots of Lysidice rhodostegia Hance.Chin J Nat Med(中国天然药物),2005,3:144-147.
27 Ogura Y,et al.Total synthesis of(±)-lysidicin A.Tetrahedr Lett,2012,68:1723-1728.
28 Ogura Y,et al.Efficient construction of the core framework of lysidicin A via three Claisen rearrangements including a cascade reaction.Tetrahedr Lett,2010,51:3294-3296.
29 Liu YB,et al.Structures and absolute configurations of penicillactones A-C from an endophytic microorganism,Penicillium dangeardii Pitt.Org Lett,2013,15:5206-5209.
30 Wang JM,et al.Thiodiketopiperazines produced by the endophytic fungus Epicoccum nigrum.J Nat Prod,2010,73:1240-1249.
31 Ding GZ,et al.Secondary metabolites from the endophytic fungi Penicillium polonicum and Aspergillus fumigatus.J Asian Nat Prod Res,2013,15:446-452.
32 Lv HN(吕海宁),et al.Study on secondary metabolites of endophytic fungi Penicillium dangeardii.Chin J Chin Mater Med(中国中药杂志),2015,40:1759-1761.
33 Liu J(刘静),et al.Study on secondary metabolites of endophytic fungi Penicillium dangeardii.Chin J Chin Mater Med(中国中药杂志),2014,39:3974-3977.
34 Zhang HQ(张惠勤),et al.Study on anti-arrhythmia effect of Lysidice rhodostegia Hance.Chin J Trad Med Sci Tech(中国中医药科技),2005,12:229-230.
35 Lan ZH(蓝子花).A Chinese medicinal composition containing Herba Antenoronis Neofiliformis root and having effects in activating collaterals and relieving pain(一种含金钱草根的活络镇痛药).CN1814069A,2006-8-9.
36 Wang SG(王曙光),et al.Experiment of Lysidice rhodostegia Hance on mouse pain models.Yunnan J Trad Med Mater Med(云南中医中药杂志),2012,33(12):55-57.