Apelin与糖尿病及并发症的研究进展
|
摘要
脂肪因子Apelin及受体APJ在体内广泛分布于各组织和器官中,因其参与机体的血压调节、血管生成、IR等多种生理过程而受到广泛关注。Apelin与T2DM、IR密切相关,参与糖尿病并发症的发生发展,本文对Apelin参与的糖尿病及并发症的研究进展进行综述。
Apelin,a fat factor,and its receptor APJ,were widely distributed in various tissues and organs. Both of them have aroused wide concern because of their participation in the body of blood pressure regulation,angiogenesis,insulin resistance(IR)and other physiological processes. Apelin is closely related to type 2 diabetes(T2 DM)and IR,and has been found to be involved in the development of diabetic vascular complications. Here,we reviewed the research progress of Apelin in diabetes and its complications.
Apelin,a fat factor,and its receptor APJ,were widely distributed in various tissues and organs. Both of them have aroused wide concern because of their participation in the body of blood pressure regulation,angiogenesis,insulin resistance(IR)and other physiological processes. Apelin is closely related to type 2 diabetes(T2 DM)and IR,and has been found to be involved in the development of diabetic vascular complications. Here,we reviewed the research progress of Apelin in diabetes and its complications.
引文
[1]Tatemoto K,Hosoya M,Habata Y,et al.Isolation and characterization of a novel endogenous peptide ligand for the human APJreceptor.Biochem Biophys Res Commun,1998,251:471-476.
[2]Dray C,Knauf C,Daviaud D,et al.Apelin stimulates glucose utilization in normal and obese insulin-resistant mice.Cell Metab,2008,8:437-445.
[3]Yue P,Jin H,Aillaud M,et al.Apelin is necessary for the maintenance of insulin sensitivity.Am J Physiol Endocrinol Metab,2010,298:E59-E67.
[4]Sato T,Suzuki T,Watanabe H,et al.Apelin is a positive regulator of ACE2 in failing hearts.J Clin Invest,2013,123:5203-5211.
[5]Chen D,Lee J,Gu X,et al.Intranasal Delivery of apelin-13 is neuroprotective and promotes angiogenesis after ischemic stroke in mice.Asn Neuro,2015,7.
[6]Samura M,Morikage N,Suehiro K,et al.Combinatorial treatment with apelin-13 enhances the therapeutic efficacy of a preconditioned cell-based therapy for peripheral ischemia.Sci Rep,2016,6:19379.
[7]Mckenzie JA,Fruttiger M,Abraham S,et al.Apelin is required for non-neovascular remodeling in the retina.Am J Pathol,2012,180:399-409.
[8]张小露.血清Apelin水平监测在糖尿病视网膜病变诊断中的意义.广东医学,2016,37:2779-2781.
[9]Boucher J,Masri B,Daviaud D,et al.Apelin,a newly identified adipokine up-regulated by insulin and obesity.Endocrinology,2005,146:1764-1771.
[10]O'Carroll AM,Lolait SJ,Harris LE,et al.The apelin receptor APJ:journey from an orphan to a multifaceted regulator of homeostasis.J Endocrinol,2013,219:13-35.
[11]Xu H,Barnes GT,Yang Q,et al.Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance.J Clin Invest,2003,112:1821-1830.
[12]Geurts L,Lazarevic V,Derrien M,et al.Altered gut microbiota and endocannabinoid system tone in obese and diabetic leptinresistant mice:impact on apelin regulation in adipose tissue.Front Microbiol,2011,2:149.
[13]Daviaud D,Boucher J,Gesta S,et al.TNFαup-regulates apelin expression in human and mouse adipose tissue.FASEB J,2006,20:1528-1530.
[14]Li L,He Q,Huang X,et al.NOX3-derived reactive oxygen species promote TNF-alpha-induced reductions in hepatocyte glycogen levels via a JNK pathway.Febs Letters,2010,584:995.
[15]Pitkin SL,Maguire J,Bonner TI,et al.International union of basic and clinical pharmacology.LXXIV.Apelin receptor nomenclature,distribution,pharmacology,and function.Pharmacol Rev,2010,62:331-342.
[16]Koguchi W,Kobayashi N,Takeshima H,et al.Cardioprotective effect of apelin-13 on cardiac performance and remodeling in end-stage heart failure.Circ J,2012,76:137-144.
[17]Akboga MK,Akyel A,Sahinarslan A,et al.Relationship between plasma apelin level and coronary collateral circulation.Atherosclerosis,2014,235:289-294.
[18]Xiang JZ,Li KZ,Hong XW,et al.Apelin protects heart against ischemia/reperfusion injury in rat.Peptides,2009,30:1144-1152.
[19]Liu XY,Lu Q,Ouyang XP,et al.Apelin-13 increases expression of ATP-binding cassette transporter A1 via activating protein kinase Cαsignaling in THP-1 macrophage-derived foam cells.Atherosclerosis,2013,226:398-407.
[20]Rucker AJ,Crowley SD.The role of macrophages in hypertension and its complications.Pflugers Arch,2017,469:419-430.
[21]Nakao YM,Teramukai S,Tanaka S,et al.Effects of renin-angiotensin system blockades on cardiovascular outcomes in patients with diabetes mellitus:a systematic review and meta-analysis.Diabetes Res Clin Pract,2012,96:68-75.
[22]Przewlockakosmala M,Kotwica T,Mysiak A,et al.Reduced circulating apelin in essential hypertension and its association with cardiac dysfunction.J Hypertens,2011,29:971-979.
[23]Patel VB,Zhong JC,Grant MB,et al.Role of the ACE2/Angiotensin 1-7 Axis of the renin-angiotensin system in heart failure.Circ Res,2016,118:1313-1326.
[24]Xu R,Zhang Z,Chen LJ,et al.Ascending aortic adventitial remodeling and fibrosis are ameliorated with Apelin-13 in rats after TAC via suppression of the miRNA-122 and LGR4-β-catenin signaling.Peptides,2016,86:85-94.
[25]Qi GM,Jia LX,Li YL,et al.Adiponectin suppresses angiotensin II-induced inflammation and cardiac fibrosis through activation of macrophage autophagy.Endocrinol,2014,155:2254-2265.
[26]Chen F,Chen B,Xiao FQ,et al.Autophagy protects against senescence and apoptosis via the RAS-mitochondria in high-glucose-induced endothelial cells.Cell Physiol Biochem,2014,33:1058-1074.
[27]Mei Y,Thompson MD,Cohen RA,et al.Autophagy and oxidative stress in cardiovascular diseases.Biochim Biophys Acta,2015,1852:243-251.
[28]Wu D,He L,Chen L.Apelin/APJ system:a promising therapy target for hypertension.Mol Biol Rep,2014,41:6691-703.
[29]Nagano K,Ishida J,Unno M,et al.Apelin elevates blood pressure in ICR mice with L-NAME-induced endothelial dysfunction.Mol Med Rep,2013,7:1371-1375.
[30]Han X,Zhang DL,Yin DX,et al.Apelin-13 deteriorates hypertension in rats after damage of the vascular endothelium by AD-MA.Can J Physiol Pharmacol,2013,91:708-714.
[31]Day RT,Cavaglieri RC,Feliers D.Apelin retards the progression of diabetic nephropathy.Am J Physiol Renal Physiol,2013,304:F788-F800.
[32]Xie X,Xia W,Fei X,et al.Relaxin inhibits high glucose-induced matrix accumulation in human mesangial cells by interfering with TGF-β1 production and mesangial cells phenotypic transition.Biol Pharm Bull,2015,38:1464-1469.
[33]韦建辉,廖兰,关玉珍,等.Apelin-13对高糖诱导肾小管上皮细胞-间充质细胞转分化的影响.中国血液净化,2017,16:407-412.
[34]Zhang B,Wang W,Wang H,et al.Promoting effects of the adipokine,apelin,on diabetic nephropathy.PLoS One,2013,8:e60457.
[35]Wang B,Wang F,Zhang Y,et al.Effects of RAS inhibitors on diabetic retinopathy:a systematic review and meta-analysis.Lancet Diabetes Endocrinol,2015,3:263-274.
[36]Cavusoglu T,Karadeniz T,Cagiltay E,et al.The protective effect of losartan on diabetic neuropathy in a diabetic rat model.Exp Clin Endocrinol Diabetes,2015,123:479-484.
[37]Kasai A,Ishimaru Y,Kinjo T,et al.Apelin is a crucial factor for hypoxia-induced retinal angiogenesis.Arterioscler Thromb Vasc Biol,2010,30:2182-2187.
[38]Burke B,Giannoudis A,Corke KP,et al.Hypoxia-induced gene expression in human macrophages:implications for ischemic tissues and hypoxia-regulated gene therapy.Am J Pathol,2003,163:1233-1243.
[39]何敏慧,李红.2型糖尿病伴周围神经病变患者外周血单个核细胞中醛糖还原酶mRNA水平测定.浙江医学,2004,26:167-168.
[40]相爱霞,陈成华,董砚虎.糖尿病神经病变研究进展.国际内分泌代谢杂志,2004,24:424-425.
[41]Knopp M,Srikantha M,Rajabally YA.Insulin neuritis and diabetic cachectic neuropathy:a review.Curr Diabetes Rev,2013,9:267-274.
[42]Quattrini C,Jeziorska M,Boulton AJ,et al.Reduced vascular endothelial growth factor expression and intra-epidermal nerve fiber loss in human diabetic neuropathy.Diabetes Care,2008,31:140-145.
[43]Bilir B,Ekiz B,Yilmaz I,et al.Association of apelin,endoglin and endocan with diabetic peripheral neuropathy in type 2 diabetic patients.Eur Rev Med Pharmacol Sci,2016,20:892-898.
[44]Pauli A,Norris ML,Valen E,et al.Toddler:an embryonic signal that promotes cell movement via apelin receptors.Science,2010,343:99-101.
[45]Chng SC,Ho L,Tian J,et al.ELABELA:a hormone essential for heart development signals via the apelin receptor.Developmental Cell,2013,27:672-680.
[2]Dray C,Knauf C,Daviaud D,et al.Apelin stimulates glucose utilization in normal and obese insulin-resistant mice.Cell Metab,2008,8:437-445.
[3]Yue P,Jin H,Aillaud M,et al.Apelin is necessary for the maintenance of insulin sensitivity.Am J Physiol Endocrinol Metab,2010,298:E59-E67.
[4]Sato T,Suzuki T,Watanabe H,et al.Apelin is a positive regulator of ACE2 in failing hearts.J Clin Invest,2013,123:5203-5211.
[5]Chen D,Lee J,Gu X,et al.Intranasal Delivery of apelin-13 is neuroprotective and promotes angiogenesis after ischemic stroke in mice.Asn Neuro,2015,7.
[6]Samura M,Morikage N,Suehiro K,et al.Combinatorial treatment with apelin-13 enhances the therapeutic efficacy of a preconditioned cell-based therapy for peripheral ischemia.Sci Rep,2016,6:19379.
[7]Mckenzie JA,Fruttiger M,Abraham S,et al.Apelin is required for non-neovascular remodeling in the retina.Am J Pathol,2012,180:399-409.
[8]张小露.血清Apelin水平监测在糖尿病视网膜病变诊断中的意义.广东医学,2016,37:2779-2781.
[9]Boucher J,Masri B,Daviaud D,et al.Apelin,a newly identified adipokine up-regulated by insulin and obesity.Endocrinology,2005,146:1764-1771.
[10]O'Carroll AM,Lolait SJ,Harris LE,et al.The apelin receptor APJ:journey from an orphan to a multifaceted regulator of homeostasis.J Endocrinol,2013,219:13-35.
[11]Xu H,Barnes GT,Yang Q,et al.Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance.J Clin Invest,2003,112:1821-1830.
[12]Geurts L,Lazarevic V,Derrien M,et al.Altered gut microbiota and endocannabinoid system tone in obese and diabetic leptinresistant mice:impact on apelin regulation in adipose tissue.Front Microbiol,2011,2:149.
[13]Daviaud D,Boucher J,Gesta S,et al.TNFαup-regulates apelin expression in human and mouse adipose tissue.FASEB J,2006,20:1528-1530.
[14]Li L,He Q,Huang X,et al.NOX3-derived reactive oxygen species promote TNF-alpha-induced reductions in hepatocyte glycogen levels via a JNK pathway.Febs Letters,2010,584:995.
[15]Pitkin SL,Maguire J,Bonner TI,et al.International union of basic and clinical pharmacology.LXXIV.Apelin receptor nomenclature,distribution,pharmacology,and function.Pharmacol Rev,2010,62:331-342.
[16]Koguchi W,Kobayashi N,Takeshima H,et al.Cardioprotective effect of apelin-13 on cardiac performance and remodeling in end-stage heart failure.Circ J,2012,76:137-144.
[17]Akboga MK,Akyel A,Sahinarslan A,et al.Relationship between plasma apelin level and coronary collateral circulation.Atherosclerosis,2014,235:289-294.
[18]Xiang JZ,Li KZ,Hong XW,et al.Apelin protects heart against ischemia/reperfusion injury in rat.Peptides,2009,30:1144-1152.
[19]Liu XY,Lu Q,Ouyang XP,et al.Apelin-13 increases expression of ATP-binding cassette transporter A1 via activating protein kinase Cαsignaling in THP-1 macrophage-derived foam cells.Atherosclerosis,2013,226:398-407.
[20]Rucker AJ,Crowley SD.The role of macrophages in hypertension and its complications.Pflugers Arch,2017,469:419-430.
[21]Nakao YM,Teramukai S,Tanaka S,et al.Effects of renin-angiotensin system blockades on cardiovascular outcomes in patients with diabetes mellitus:a systematic review and meta-analysis.Diabetes Res Clin Pract,2012,96:68-75.
[22]Przewlockakosmala M,Kotwica T,Mysiak A,et al.Reduced circulating apelin in essential hypertension and its association with cardiac dysfunction.J Hypertens,2011,29:971-979.
[23]Patel VB,Zhong JC,Grant MB,et al.Role of the ACE2/Angiotensin 1-7 Axis of the renin-angiotensin system in heart failure.Circ Res,2016,118:1313-1326.
[24]Xu R,Zhang Z,Chen LJ,et al.Ascending aortic adventitial remodeling and fibrosis are ameliorated with Apelin-13 in rats after TAC via suppression of the miRNA-122 and LGR4-β-catenin signaling.Peptides,2016,86:85-94.
[25]Qi GM,Jia LX,Li YL,et al.Adiponectin suppresses angiotensin II-induced inflammation and cardiac fibrosis through activation of macrophage autophagy.Endocrinol,2014,155:2254-2265.
[26]Chen F,Chen B,Xiao FQ,et al.Autophagy protects against senescence and apoptosis via the RAS-mitochondria in high-glucose-induced endothelial cells.Cell Physiol Biochem,2014,33:1058-1074.
[27]Mei Y,Thompson MD,Cohen RA,et al.Autophagy and oxidative stress in cardiovascular diseases.Biochim Biophys Acta,2015,1852:243-251.
[28]Wu D,He L,Chen L.Apelin/APJ system:a promising therapy target for hypertension.Mol Biol Rep,2014,41:6691-703.
[29]Nagano K,Ishida J,Unno M,et al.Apelin elevates blood pressure in ICR mice with L-NAME-induced endothelial dysfunction.Mol Med Rep,2013,7:1371-1375.
[30]Han X,Zhang DL,Yin DX,et al.Apelin-13 deteriorates hypertension in rats after damage of the vascular endothelium by AD-MA.Can J Physiol Pharmacol,2013,91:708-714.
[31]Day RT,Cavaglieri RC,Feliers D.Apelin retards the progression of diabetic nephropathy.Am J Physiol Renal Physiol,2013,304:F788-F800.
[32]Xie X,Xia W,Fei X,et al.Relaxin inhibits high glucose-induced matrix accumulation in human mesangial cells by interfering with TGF-β1 production and mesangial cells phenotypic transition.Biol Pharm Bull,2015,38:1464-1469.
[33]韦建辉,廖兰,关玉珍,等.Apelin-13对高糖诱导肾小管上皮细胞-间充质细胞转分化的影响.中国血液净化,2017,16:407-412.
[34]Zhang B,Wang W,Wang H,et al.Promoting effects of the adipokine,apelin,on diabetic nephropathy.PLoS One,2013,8:e60457.
[35]Wang B,Wang F,Zhang Y,et al.Effects of RAS inhibitors on diabetic retinopathy:a systematic review and meta-analysis.Lancet Diabetes Endocrinol,2015,3:263-274.
[36]Cavusoglu T,Karadeniz T,Cagiltay E,et al.The protective effect of losartan on diabetic neuropathy in a diabetic rat model.Exp Clin Endocrinol Diabetes,2015,123:479-484.
[37]Kasai A,Ishimaru Y,Kinjo T,et al.Apelin is a crucial factor for hypoxia-induced retinal angiogenesis.Arterioscler Thromb Vasc Biol,2010,30:2182-2187.
[38]Burke B,Giannoudis A,Corke KP,et al.Hypoxia-induced gene expression in human macrophages:implications for ischemic tissues and hypoxia-regulated gene therapy.Am J Pathol,2003,163:1233-1243.
[39]何敏慧,李红.2型糖尿病伴周围神经病变患者外周血单个核细胞中醛糖还原酶mRNA水平测定.浙江医学,2004,26:167-168.
[40]相爱霞,陈成华,董砚虎.糖尿病神经病变研究进展.国际内分泌代谢杂志,2004,24:424-425.
[41]Knopp M,Srikantha M,Rajabally YA.Insulin neuritis and diabetic cachectic neuropathy:a review.Curr Diabetes Rev,2013,9:267-274.
[42]Quattrini C,Jeziorska M,Boulton AJ,et al.Reduced vascular endothelial growth factor expression and intra-epidermal nerve fiber loss in human diabetic neuropathy.Diabetes Care,2008,31:140-145.
[43]Bilir B,Ekiz B,Yilmaz I,et al.Association of apelin,endoglin and endocan with diabetic peripheral neuropathy in type 2 diabetic patients.Eur Rev Med Pharmacol Sci,2016,20:892-898.
[44]Pauli A,Norris ML,Valen E,et al.Toddler:an embryonic signal that promotes cell movement via apelin receptors.Science,2010,343:99-101.
[45]Chng SC,Ho L,Tian J,et al.ELABELA:a hormone essential for heart development signals via the apelin receptor.Developmental Cell,2013,27:672-680.