健胃散对胃黏膜损伤的保护作用及对胃肠道蠕动的推进作用
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摘要
目的:探讨健胃散对胃黏膜损伤的保护作用及对胃肠道蠕动的推进作用。方法:将小鼠随机分成空白对照组、模型组、低剂量组、中剂量组、高剂量组,制作急性酒精性胃黏膜损伤模型,测量胃黏膜出血点或出血带的长度和宽度。胃肠道蠕动推进作用以碳末推进率表示。结果:健胃散能有效减少无水乙醇导致的胃黏膜出血,并能提高胃肠蠕动的肠推进率。结论:健胃散可剂量依赖地推进胃肠道蠕动,并对胃黏膜损伤具有保护作用。
Objective:To explore the protective effect of Jianwei powder on gastric mucosal injury and its propulsive effect on gastrointestinal peristalsis.Methods:The mice were randomly divided into control group,model group,low dose group,middle dose group,high dose group,acute alcoholic gastric injury model,gastric mucosal bleeding or hemorrhage.With the length and width of gastrointestinal motility promoting advance rate in carbon.Results:Jianwei Powder could effectively reduce gastric mucosal bleeding caused by anhydrous alcohol and increase the intestinal propulsive rate of gastrointestinal peristalsis.Conclusion:Jianwei Powder can promote gastrointestinal peristalsis in a dose-dependent manner and has protective effect on gastric mucosal injury.
Objective:To explore the protective effect of Jianwei powder on gastric mucosal injury and its propulsive effect on gastrointestinal peristalsis.Methods:The mice were randomly divided into control group,model group,low dose group,middle dose group,high dose group,acute alcoholic gastric injury model,gastric mucosal bleeding or hemorrhage.With the length and width of gastrointestinal motility promoting advance rate in carbon.Results:Jianwei Powder could effectively reduce gastric mucosal bleeding caused by anhydrous alcohol and increase the intestinal propulsive rate of gastrointestinal peristalsis.Conclusion:Jianwei Powder can promote gastrointestinal peristalsis in a dose-dependent manner and has protective effect on gastric mucosal injury.
引文
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[3] 刘翠玲.黄芪苷类对乙醇诱导GES-1细胞株损伤的保护及机制研究[D].广州:广州中医药大学,2014.
[4] 王宝庆,郭宇莲,练有扬,等.鸡内金化学成分及药理作用研究进展[J].安徽农业科学,2017,45(33):137-139.
[5] 迟玉森,马成印,邵允琪,等.鸡内金有效成分的提取及其改善肠道保健功能的研究[J].食品工业科技,1999,20(4):21-22.
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[7] 王莹,褚扬,李伟,等.三七中皂苷成分及其药理作用的研究进展[J].中草药,2015,46(9):1381-1392.