基底细胞癌的共聚焦激光扫描显微镜特征初探

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英文篇名：Preliminary Morphologic Features of Basal Cell Carcinoma under Confocal Laser Scanning Microscopy 作者：马杰 ; 张晓燕 ; 吕永婧 ; 赵晨光 ; 李青 ; 杨雪萍 ; 赵建斌 英文作者：MA Jie;ZHANG Xiao-yan;LV Yong-jing;ZHAO Chen-guang;LI Qing;YANG Xue-ping;ZHAO Jian-bin;Department of Dermatology the First Peoples's Hospitlal of Xuzhou; 关键词：基底细胞癌 ; 共聚焦激光扫描显微镜 英文关键词：Basal cell carcinoma;;Confocal laser scanning microscopy 中文刊名：ZBFX 英文刊名：The Chinese Journal of Dermatovenereology 机构：徐州市第一人民医院皮肤科; 出版日期：2017-03-15 出版单位：中国皮肤性病学杂志 年：2017 期：v.31;No.234 基金：江苏省六大人才高峰第十一批次高层次人才选拔培养项目(SWYY-037);; 江苏省第四期“333工程”科研项目(BRA2014057) 语种：中文; 页：ZBFX201703040 页数：4 CN：03 ISSN：61-1197/R 分类号：111-114

摘要

目的探讨基底细胞癌的共聚焦激光扫描显微镜影像学特征。方法应用共聚焦激光扫描显微镜分析14例基底细胞癌患者皮损部位的影像学特征。结果共聚焦激光扫描显微镜检测发现,13例基底细胞癌患者可见到表皮层异常,14例患者均可见单一形态的拉长细胞核出现,10例患者可见肿瘤细胞团块、细胞核极化及组织间隙,7例患者可见明显的炎性细胞浸润,8例患者皮损表皮及真表皮交界处可见大量色素团块、树突状细胞,真皮内血管增加,管腔增粗,并可见白细胞沿管壁快速流动。结论共聚焦激光扫描显微镜作为一项无创新技术,可以用于基底细胞癌的辅助诊断。
        Objcetive To investigate the preliminary morphologic features of basal cell carcinoma( BCC) under confocal laser scanning microscopy( CLSM). Methods The lesions of fourteen patients with basal cell carcinoma were examined by CLSM. Results Under CLSM,there was pleomorphic epidermis found in thirteen BCC cases; elongated monomorphic nuclei found in all BCC cases. Meanwhile,nodular masses,polarized nuclei and interstitial spaces were shown in ten BCC cases. Significant inflammatory cell infiltrates were observed in seven BCC cases. Interestingly,there were a lot of pigmented aggregates and dendritic cells found in epidermis and dermo-epidermal junction in eight BCC cases,accompanied by increased vascularity,enlarged vessel lumen and rolling leukocytes. Conclusion CLSM can offer an alternative technique for noninvasive diagnosis of basal cell carcinoma in vivo.

引文

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