针刺治疗原发性高血压病机制的研究概况
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摘要
检索从1999年1月1日至2018年2月28日中国期刊全文数据库(CNKI)和PubMed数据库中原发性高血压病(essentialhypertension,EH)的发病机制、针刺治疗EH的临床疗效观察及作用机制的相关文献,旨在总结探讨针刺降压的作用机制。经分析发现,针刺是通过多系统、多靶点、多层面的调节机制发挥降压作用,如针刺抑制中枢及外周交感神经活动、针刺调节免疫及炎性反应因子的表达、针刺调节肾素-血管紧张素-醛固酮系统(renin-angiotensin-aldosterone system,RAAS)平衡、针刺改善血管结构及功能、针刺的抗氧化应激作用、针刺促进自噬等。
The relevant literature of pathogenesis of essential hypertension(EH) and the clinical efficacy of acupuncture treatment of EH was retrieved from January 1, 1999 to February 28, 2018 in the CNKI and PubMed databases, and aimed to summarize and explore the mechanism of antihypertensive by acupuncture.It has been found that acupuncture exerts antihypertensive effect by coordinating multi-system, multi-target, multi-layer adjustment mechanism, such as acupuncture inhibiting of central and peripheral sympathetic nerve activity, rejusting immune system and expression of inflammatory response factors, regulating the balance of renin-angiotensin-aldosterone system(RAAS), improving vascular structure and function, the anti-oxidative stress and promoting autophagy.
The relevant literature of pathogenesis of essential hypertension(EH) and the clinical efficacy of acupuncture treatment of EH was retrieved from January 1, 1999 to February 28, 2018 in the CNKI and PubMed databases, and aimed to summarize and explore the mechanism of antihypertensive by acupuncture.It has been found that acupuncture exerts antihypertensive effect by coordinating multi-system, multi-target, multi-layer adjustment mechanism, such as acupuncture inhibiting of central and peripheral sympathetic nerve activity, rejusting immune system and expression of inflammatory response factors, regulating the balance of renin-angiotensin-aldosterone system(RAAS), improving vascular structure and function, the anti-oxidative stress and promoting autophagy.
引文
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[14]李宏宝,鲁彦,郑天珍.头端延髓腹外侧区与原发性高血压病[J].中华高血压杂志, 2011, 19(10):917-919.
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[16] LiM,Tjen-A-LooiSC,GuoZL.Repetitiveelectroacupuncture attenuatescold-inducedhypertensionthroughenkephalininthe rostral ventral lateral medulla[J]. Sci Rep, 2016, 24(6):35791.
[17] LiM,Tjen-A-LooiSC,GuoZL,etal.Repetitive electroacupuncturecausesprolongedincreasedmet-enkephalin expressioninther VLMofconsciousrats[J].AutonNeurosci,2012, 170(1-2):30-35.
[18] Tjen-A-LooiSC,LiP,LonghurstJC.MidbrainvIPAGinhibits r VLMcardiovascularsympathoexcitatoryresponsesduring acupuncture[J].AmJPhysiolHeartCircPhysiol,2006,290(6):H2543-H2553.
[19]沈攀攀,陈月婷,肖双凯,等.“太冲”配“内关”针刺对自发性高血压大鼠血压及延髓头端腹外侧区天冬氨酸及谷氨酸水平的影响[J].针刺研究, 2017, 42(2):102-106.
[20]赵瑞利,郭长青,郭妍.基于基因芯片技术研究针刺人迎穴对原发性高血压大鼠下丘脑相关基因表达谱的影响[J].中医药导报, 2018, 24(1):6-12.
[21]曹丹娜,王丰,张帆,等.应用功能磁共振技术分析针刺太溪穴的降压机制[J].中国老年学杂志, 2015, 35(15):4314-4316.
[22]郭妍,石学敏,马田.基于PET脑功能成像研究针刺人迎穴对自发性高血压大鼠的中枢调节机制[J].中医药导报,2018,24(3):24-28.
[23] McMasterWG,KiraboA,MadhurMS,etal.Inflammation,immunity, and hypertensive end-organ damage[J]. Circ Res, 2015,116(6):1022-1033.
[24] Amador CA, Barrientos V, Pena J, et al. Spironolactone decreases DOCA-salt-induced organ damage by blocking the activation of T helper 17 and the downregulation of regulatory T lymphocytes[J].Hypertension, 2014, 63(4):797-803.
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[26]王晶,林晓杰,罗晓舟,等.针刺太溪穴降低SHR血压及调节延髓TNF-α、IL-6蛋白表达[J].暨南大学学报(自然科学与医学版), 2016, 37(4):327-330.
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