经导管动脉化疗栓塞术联合微波消融治疗肝癌的临床研究

详细信息    查看全文 | 推荐本文 |

英文篇名：Clinical study of transcatheter arterial chemoembolization combined with microwave ablation in the treatment of liver cancer 作者：卢钦荣 英文作者：LU Qin-rong;Department of Oncology,Meizhou Hospital of Traditional Chinese Medicine in Guangdong Province; 关键词：经导管动脉化疗栓塞 ; 微波消融 ; 肝癌 ; 生存率 英文关键词：Transcatheter arterial chemoembolization;;Microwave ablation;;Liver cancer;;Survival rate 中文刊名：ZGUD 英文刊名：China Modern Medicine 机构：广东省梅州市中医医院肿瘤科; 出版日期：2019-03-18 出版单位：中国当代医药 年：2019 期：v.26;No.531 语种：中文; 页：ZGUD201908022 页数：3 CN：08 ISSN：11-5786/R 分类号：77-79

摘要

目的探讨经导管动脉化疗栓塞(TACE)术联合微波消融治疗肝癌的临床效果。方法选取2014年6月～2015年10月我院收治的36例肝癌患者作为研究对象,按照随机数字表法分为对照组和研究组,每组各18例,对照组患者进行TACE术治疗,研究组患者进行TACE术联合微波消融治疗。比较两组患者的近期和远期疗效。结果研究组治疗2个月后的肿瘤完全坏死率(83.33%)明显高于对照组(16.67%),差异有统计学意义(P<0.05);研究组治疗2个月后的部分坏死率(16.67%)明显低于对照组(83.33%),差异有统计学意义(P<0.05);研究组患者的1年生存率(83.33%)明显高于对照组(44.44%),差异有统计学意义(P<0.05);研究组患者的2年生存率(44.44%)明显高于对照组(5.56%),差异有统计学意义(P<0.05)。结论 TACE术联合微波消融治疗肝癌,肿瘤完全坏死率高,有良好的近期和远期疗效,值得临床推广应用。
        Objective To investigate the clinical effect of transcatheter arterial chemoembolization(TACE) combined with microwave ablation in the treatment of liver cancer. Methods Thirty-six patients with liver cancer admitted to our hospital from June 2014 to October 2015 were selected as the study subjects, they were divided into control group and study group according to random number table method, with 18 cases in each group, the control group was treated with TACE and the study group was treated with TACE combined with microwave ablation. The short-term and long-term effects of the two groups were compared. Results The total necrosis rate of tumors(83.33%) in the study group was significantly higher than that in the control group(16.67%) after 2 months of treatment, the difference was significant(P<0.05). The partial necrosis rate(16.67%) in the study group was significantly lower than that in the control group(83.33%) after 2 months of treatment, the difference was significant(P<0.05). The one-year survival rate of the study group(83.33%) was significantly higher than that of the control group(44.44%), the difference was significant(P<0.05).The two-year survival rate of the study group(44.44%) was significantly higher than that of the control group(5.56%),the difference was significant(P<0.05). Conclusion TACE combined with microwave ablation in the treatment of liver cancer has a high rate of complete necrosis and good short-term and long-term efficacy, which is worthy of clinical application.

引文

[1]霍祥辉,张浩,李子祥.经导管肝动脉化疗栓塞联合微波消融治疗大肝癌的近期疗效与安全性分析[J].医学影像学杂志,2017,27(4):677-681.
    [2]胡媛媛,肖红兵,孙东旭,等.经导管动脉化疗栓塞联合微波消融治疗中晚期肝癌的远期疗效及影响因素研究[J].实用癌症杂志,2015,30(5):704-707.
    [3]徐娟,赵晔,崔永慧,等.射频消融与大功率微波消融联合肝动脉化疗栓塞治疗中大肝癌的疗效与安全性对比研究[J].中国医学装备,2017,14(5):76-80.
    [4]王新亭,张传雷,陈晓琦,等.微波消融联合肝动脉插管化疗栓塞术与手术切除巴塞罗那B期原发性肝癌的临床疗效分析[J].中国当代医药,2016,23(34):69-71.
    [5]马英,孙韬,李玉苓,等.原发性肝癌TACE术后射频消融联合生物治疗对免疫功能及血管内皮生长因子的影响研究[J].河北医药,2016,38(12):1828-1832.
    [6]曾立,何永越,王道笃,等.选择性肝动脉化疗栓塞术联合经皮微波消融治疗大肝癌的临床观察[J].中国当代医药,2016,23(11):42-44.
    [7]周平,汪俊州,刘建平,等.肝动脉化疗栓塞术联合微波消融治疗原发性大肝癌的临床疗效观察[J].临床合理用药杂志,2016,9(8):114-115.
    [8]宋振民,李慧,强亚杰.观察肝动脉化疗栓塞术联合微波消融治疗原发性大肝癌的疗效[J].中国继续医学教育,2016,8(23):100-102.
    [9]尹立楠,刘岩.微波消融治疗肝癌187例的临床疗效评价研究[J].实用肿瘤学杂志,2015,29(5):395-399.
    [10]邓兴,胡鸿,游箭,等.TACE联合微波消融治疗原发性肝癌的效果分析[J].西部医学,2016,28(4):524-527.
    [11]吴轩,蔡豹,王东红.TACE联合冷循环微波消融治疗原发性肝癌的疗效观察[J].中国医药科学,2017,7(9):214-216.
    [12]陈奇峰,贾振宇,杨正强,等.肝动脉化疗栓塞联合微波消融与单独肝动脉化疗栓塞治疗大肝癌疗效meta分析[J].介入放射学杂志,2017,26(3):225-231.
    [13]郭飞,张晓阳,聂双发,等.经导管化疗栓塞联合经皮微波消融治疗中晚期原发性肝癌患者的疗效研究[J].实用癌症杂志,2015,30(6):877-879.
    [14]饶瑶,陆伟,张宁宁,等.大功率微波消融联合肝动脉化疗栓塞治疗较大肝癌的疗效观察[J].中国中西医结合急救杂志,2016,23(2):186-190.
    [15]程黎,苟剑林,刘燕,等.经肝动脉化疗栓塞术联合微波消融对中晚期肝癌细胞免疫功能和预后的影响[J].中国临床保健杂志,2016,19(2):135-137.