肌动蛋白细胞骨架重构调节免疫细胞功能的研究进展
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摘要
肌动蛋白细胞骨架重构与细胞迁移、胞质分裂、囊泡运输等多个过程密切相关。近些年研究表明,肌动蛋白细胞骨架重构也与多种免疫细胞(包括T细胞、B细胞、巨噬细胞等)的功能密切相关。其可参与免疫突触的形成和T细胞发育成熟,从而影响T细胞功能。也可通过调节BCR信号和抗原内化提呈影响B细胞功能。此外,肌动蛋白细胞骨架重构对巨噬细胞的趋化作用和吞噬作用也有一定的影响。本文就肌动蛋白细胞骨架重构调节免疫细胞功能的研究进展做一综述,有助于靶向肌动蛋白的免疫相关疾病(包括肿瘤)治疗策略的制定。
Actin cytoskeleton remodeling is closely related to cell migration, cytokinesis and vesicle transport.Recently, it was reported that actin cytoskeleton remodeling also affects the activation of some immune cells,including T-cell, B-cell and macrophage. Actin cytoskeleton remodeling can participate in the formation of immunological synapses and ensure T-cell development and maturation. Actin cytoskeleton remodeling also affects BCR signaling, antigen extraction and B-cell presentation. Furthermore, actin cytoskeleton remodeling affects the chemotaxis and phagocytosis in macrophage. This article reviews the progresses of the regulatory effects of actin cytoskeleton remodeling on the regulation of immune cells function, which is useful for actin-targeted therapeutics in some immune-related diseases such as tumors.
Actin cytoskeleton remodeling is closely related to cell migration, cytokinesis and vesicle transport.Recently, it was reported that actin cytoskeleton remodeling also affects the activation of some immune cells,including T-cell, B-cell and macrophage. Actin cytoskeleton remodeling can participate in the formation of immunological synapses and ensure T-cell development and maturation. Actin cytoskeleton remodeling also affects BCR signaling, antigen extraction and B-cell presentation. Furthermore, actin cytoskeleton remodeling affects the chemotaxis and phagocytosis in macrophage. This article reviews the progresses of the regulatory effects of actin cytoskeleton remodeling on the regulation of immune cells function, which is useful for actin-targeted therapeutics in some immune-related diseases such as tumors.
引文
[1]Ono S.A plague of actin disassembly[J].J Biol Chem,2017,292(19):8101-8102.
[2]Jo S,Kim HR,Mun Y,et al.Transgelin-2 in immunity:Its implication in cell therapy[J].J Leukoc Biol,2018,104(5):903-910.
[3]Fritzsche M,Fernandes RA,Chang VT,et al.Cytoskeletal actin dynamics shape a ramifying actin network underpinning immunological synapse formation[J].Sci Adv,2017,3(6):e1603032-e1603050.
[4]Na BR,Jun CD.TAGLN2-mediated actin stabilization at the immunological synapse:implication for cytotoxic T cell control of target cells[J].BMB Rep,2015,48(7):369-370.
[5]Phee H,Au Yeung BB,Pryshchep O,et al.Pak2 is required for actin cytoskeleton remodeling,TCR signaling,and normal thymocyte development and maturation[J].Elife,2014,3:e02270-e02293.
[6]Jankowska KI,Williamson EK,Roy NH,et al.Integrins modulate T cell receptor signaling by constraining actin flow at the immunological synapse[J].Front Immunol,2018,9:25-43.
[7]Kumari S,Curado S,Mayya V,et al.T cell antigen receptor activation and actin cytoskeleton remodeling[J].Biochim Biophys Acta,2014,1838(2):546-556.
[8]伍仙凤,盛德乔.外周免疫耐受机制的研究进展[J].免疫学杂志,2013,29(8):710-714.
[9]Mallick CA,Dudley EC,Viney JL,et al.Rearrangement and diversity of T cell receptorbeta chain genes in thymocytes:a critical role for the beta chain in development[J].Cell,1993,73(3):513-519.
[10]Takada K,Wang X,Hart GT,et al.Kruppel-likefactor 2 is required for trafficking but not quiescence in postactivated T cells[J].J Immunol,2011,186(2):775-783.
[11]Zhao ZS,Manser E.PAK and other Rho-associated kinases-effectors with surprisingly diverse mechanismsof regulation[J].Biochem J,2005,386(Pt2):201-214.
[12]Tybulewicz VLJ,Henderson RB.Rho family GTPases and their regulators in lymphocytes[J].Nat Rev Immunol,2009,9(9):630-644.
[13]Tybulewicz VL.Vav-family proteins in T-cell signaling[J].Curr Opin Immunol,2005,17(3):267-274.
[14]Guo F,Zhang S,Tripathi P,et al.Distinct roles of Cdc42 in thymopoiesis and effector and memory T cell differentiation[J].PLoS One,2011,6(3):e18002-e18014.
[15]Del Valle Batalla F,Lennon Duménil AM,Yuseff MI.Tuning B cell responsesto antigens by cell polarity and membrane trafficking[J].Mol Immunol,2018,101:140-145.
[16]Burbage M,Keppler SJ.Shaping the humoral immune response:Actin regulators modulate antigen presentation and influence B-T interactions[J].Mol Immunol,2018,101:370-376.
[17]Tolar P.Cytoskeletal control of B cell responses to antigens[J].Nat Rev Immunol,2017,17(10):621-634.
[18]Keppler SJ,Burbage M,Gasparrini F,et al.The Lack of WIP binding to actin results in impaired B cell migration and altered humoral immune responses[J].Cell Rep,2018,24(3):619-629.
[19]Treanor B,Depoil D,Gonzalez Granja A,et al.The membrane skeleton controls diffusion dynamics and signaling through the B cell receptor[J].Immunity,2010,32(2):187-199.
[20]Harwood NE,Batista FD.Early events in B cell activation[J].Ann Rev Immunol,2010,28:185-210.
[21]Fleire SJ.B cell ligand discrimination through a spreading and contraction response[J].Science,2006,312(5774):738-741.
[22]Song W,Liu C,Upadhyaya A.The pivotal position of the actin cytoskeleton in the initiation and regulation of B cell receptor activation[J].Biochim Biophys Acta,2013,1838(2):569-578.
[23]Batista FD,Iber D,Neuberger MS.B cells acquire antigen from target cells after synapse formation[J].Nature,2001,411(6836):489-494.
[24]Wang JC,Lee JY,Christian S,et al.The Rap1-cofilin-1pathway coordinates actin reorganization and MTOCpolarization at the B cell immune synapse[J].J Cell Sci,2017,130(6):1094-1109.
[25]Iba?ez Vega J,Del Valle Batalla F,Saez JJ,et al.Proteasome dependent actin remodeling facilitates antigen extraction at the immune synapse of B cells[J].Front Immunol,2019,10:225-238.
[26]Keppler SJ,Gasparrini F,Burbage M,et al.WiskottAldrich syndrome interacting protein deficiency uncovers the role of the co-receptor CD19 as a generic hub for PI3kinase signaling in B cells[J].Immunity,2015,43(4):660-673.
[27]Davidson AJ,Millard TH,Evans IR,et al.Ena orchestrates remodelling within the actin cytoskeleton to drive robust Drosophila macrophage chemotaxis[J].J Cell Sci,2019,132(5):jcs224618-jcs224640.
[28]Kim HR,Lee HS,Lee KS,et al.An essential role for TAGLN2 in phagocytosis of lipopolysaccharide-activated macrophages[J].Sci Rep,2017,7(1):8731-8760.
[29]Yeo JC,Wall AA,Luo L,et al.Rab31 and APPL2 enhance FcγR mediatedphagocytosis through PI3K/Akt signaling in macrophages[J].Mol Biol Cell,2015,26(5):952-965.
[30]吴盈盈,胥文春,尹一兵.NF-κB和PI3K-Akt通路调节肺炎链球菌HSP40诱导小鼠巨噬细胞免疫应答[J].免疫学杂志,2017,33(1):18-22.
[31]Zhou J,Giannakakou P.Targeting microtubules for cancer chemotherapy[J].Curr Med Chem Anticancer Agents,2005,5(1):65-71.
[32]Olson MF,Sahai E.The actin cytoskeleton in cancer cell motility[J].Clin Exp Metastasis,2009,26(4):273-287.
[2]Jo S,Kim HR,Mun Y,et al.Transgelin-2 in immunity:Its implication in cell therapy[J].J Leukoc Biol,2018,104(5):903-910.
[3]Fritzsche M,Fernandes RA,Chang VT,et al.Cytoskeletal actin dynamics shape a ramifying actin network underpinning immunological synapse formation[J].Sci Adv,2017,3(6):e1603032-e1603050.
[4]Na BR,Jun CD.TAGLN2-mediated actin stabilization at the immunological synapse:implication for cytotoxic T cell control of target cells[J].BMB Rep,2015,48(7):369-370.
[5]Phee H,Au Yeung BB,Pryshchep O,et al.Pak2 is required for actin cytoskeleton remodeling,TCR signaling,and normal thymocyte development and maturation[J].Elife,2014,3:e02270-e02293.
[6]Jankowska KI,Williamson EK,Roy NH,et al.Integrins modulate T cell receptor signaling by constraining actin flow at the immunological synapse[J].Front Immunol,2018,9:25-43.
[7]Kumari S,Curado S,Mayya V,et al.T cell antigen receptor activation and actin cytoskeleton remodeling[J].Biochim Biophys Acta,2014,1838(2):546-556.
[8]伍仙凤,盛德乔.外周免疫耐受机制的研究进展[J].免疫学杂志,2013,29(8):710-714.
[9]Mallick CA,Dudley EC,Viney JL,et al.Rearrangement and diversity of T cell receptorbeta chain genes in thymocytes:a critical role for the beta chain in development[J].Cell,1993,73(3):513-519.
[10]Takada K,Wang X,Hart GT,et al.Kruppel-likefactor 2 is required for trafficking but not quiescence in postactivated T cells[J].J Immunol,2011,186(2):775-783.
[11]Zhao ZS,Manser E.PAK and other Rho-associated kinases-effectors with surprisingly diverse mechanismsof regulation[J].Biochem J,2005,386(Pt2):201-214.
[12]Tybulewicz VLJ,Henderson RB.Rho family GTPases and their regulators in lymphocytes[J].Nat Rev Immunol,2009,9(9):630-644.
[13]Tybulewicz VL.Vav-family proteins in T-cell signaling[J].Curr Opin Immunol,2005,17(3):267-274.
[14]Guo F,Zhang S,Tripathi P,et al.Distinct roles of Cdc42 in thymopoiesis and effector and memory T cell differentiation[J].PLoS One,2011,6(3):e18002-e18014.
[15]Del Valle Batalla F,Lennon Duménil AM,Yuseff MI.Tuning B cell responsesto antigens by cell polarity and membrane trafficking[J].Mol Immunol,2018,101:140-145.
[16]Burbage M,Keppler SJ.Shaping the humoral immune response:Actin regulators modulate antigen presentation and influence B-T interactions[J].Mol Immunol,2018,101:370-376.
[17]Tolar P.Cytoskeletal control of B cell responses to antigens[J].Nat Rev Immunol,2017,17(10):621-634.
[18]Keppler SJ,Burbage M,Gasparrini F,et al.The Lack of WIP binding to actin results in impaired B cell migration and altered humoral immune responses[J].Cell Rep,2018,24(3):619-629.
[19]Treanor B,Depoil D,Gonzalez Granja A,et al.The membrane skeleton controls diffusion dynamics and signaling through the B cell receptor[J].Immunity,2010,32(2):187-199.
[20]Harwood NE,Batista FD.Early events in B cell activation[J].Ann Rev Immunol,2010,28:185-210.
[21]Fleire SJ.B cell ligand discrimination through a spreading and contraction response[J].Science,2006,312(5774):738-741.
[22]Song W,Liu C,Upadhyaya A.The pivotal position of the actin cytoskeleton in the initiation and regulation of B cell receptor activation[J].Biochim Biophys Acta,2013,1838(2):569-578.
[23]Batista FD,Iber D,Neuberger MS.B cells acquire antigen from target cells after synapse formation[J].Nature,2001,411(6836):489-494.
[24]Wang JC,Lee JY,Christian S,et al.The Rap1-cofilin-1pathway coordinates actin reorganization and MTOCpolarization at the B cell immune synapse[J].J Cell Sci,2017,130(6):1094-1109.
[25]Iba?ez Vega J,Del Valle Batalla F,Saez JJ,et al.Proteasome dependent actin remodeling facilitates antigen extraction at the immune synapse of B cells[J].Front Immunol,2019,10:225-238.
[26]Keppler SJ,Gasparrini F,Burbage M,et al.WiskottAldrich syndrome interacting protein deficiency uncovers the role of the co-receptor CD19 as a generic hub for PI3kinase signaling in B cells[J].Immunity,2015,43(4):660-673.
[27]Davidson AJ,Millard TH,Evans IR,et al.Ena orchestrates remodelling within the actin cytoskeleton to drive robust Drosophila macrophage chemotaxis[J].J Cell Sci,2019,132(5):jcs224618-jcs224640.
[28]Kim HR,Lee HS,Lee KS,et al.An essential role for TAGLN2 in phagocytosis of lipopolysaccharide-activated macrophages[J].Sci Rep,2017,7(1):8731-8760.
[29]Yeo JC,Wall AA,Luo L,et al.Rab31 and APPL2 enhance FcγR mediatedphagocytosis through PI3K/Akt signaling in macrophages[J].Mol Biol Cell,2015,26(5):952-965.
[30]吴盈盈,胥文春,尹一兵.NF-κB和PI3K-Akt通路调节肺炎链球菌HSP40诱导小鼠巨噬细胞免疫应答[J].免疫学杂志,2017,33(1):18-22.
[31]Zhou J,Giannakakou P.Targeting microtubules for cancer chemotherapy[J].Curr Med Chem Anticancer Agents,2005,5(1):65-71.
[32]Olson MF,Sahai E.The actin cytoskeleton in cancer cell motility[J].Clin Exp Metastasis,2009,26(4):273-287.
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