水杨酸治疗奶牛蹄皮炎效果评价
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摘要
[目的]探讨水杨酸治疗奶牛蹄皮炎的效果。[方法]选取45只蹄皮炎患病奶牛,对其进行随机分组,其中,5只为阴性对照组,不给予治疗措施;20只为抗菌药物对照组,给予林可霉素进行治疗;20只为水杨酸治疗组,给予40%水杨酸软膏。分别于给药第0、3、14、30天对奶牛进行跛行评分与皮肤疼痛评分并记录结果,对治疗效果进行评价。[结果]在给药第3天时,抗菌药物对照组和水杨酸治疗组都没有出现痊愈的病例,经过治疗后跛行程度明显减轻。给药第14天时,水杨酸治疗组的治愈率为45%,明显高于抗菌药物对照组(25%);治疗有效率为75%,高于抗菌药物对照组(60%)。给药第30天时,水杨酸治疗组的有效率为65%,高于抗菌药物对照组(55%)。[结论]水杨酸临床治疗效果较好,可以作为治疗奶牛蹄皮炎的药物使用。
[Objective]To assess the therapeutic effect of salicylic acid on pododermatitis in dairy cow. [Method]A total of 45 dairy cows clinically diagnosed as pododermatitis were selected and randomly assigned into the following three groups: a negative control group(n=5) received no treatment, an antimicrobial control group(n=20) received administration of lincomycin, and a salicylic acid treatment group(n=20) received 40% salicylic acid ointment. To evaluate the therapeutic effect, the dairy cows were subjected to lameness scoring and skin pain scoring on the 0, 3 rd, 14 th, and 30 thday of the administration, respectively.[Result]On the 3 rdday of administration, no fully recovered cases were observed in the antimicrobial control group and salicylic acid treatment group, and the symptom of lameness was obviously alleviated after treatment. On the 14 thday of administration, the cure rate of salicylic acid treatment group was 45%, which was obviously higher than that of the antimicrobial control group(25%), and the effective rate was 75%, which was higher than that of the antimicrobial control group(60%). On the 30 thday of administration, the effective rate of salicylic acid treatment group was 65%, which was higher than that of the antimicrobial control group(55%).[Conclusion]Salicylic acid has a good clinical therapeutic effect and can be used as alternative medicine for the treatment of pododermatitis in dairy cow.
[Objective]To assess the therapeutic effect of salicylic acid on pododermatitis in dairy cow. [Method]A total of 45 dairy cows clinically diagnosed as pododermatitis were selected and randomly assigned into the following three groups: a negative control group(n=5) received no treatment, an antimicrobial control group(n=20) received administration of lincomycin, and a salicylic acid treatment group(n=20) received 40% salicylic acid ointment. To evaluate the therapeutic effect, the dairy cows were subjected to lameness scoring and skin pain scoring on the 0, 3 rd, 14 th, and 30 thday of the administration, respectively.[Result]On the 3 rdday of administration, no fully recovered cases were observed in the antimicrobial control group and salicylic acid treatment group, and the symptom of lameness was obviously alleviated after treatment. On the 14 thday of administration, the cure rate of salicylic acid treatment group was 45%, which was obviously higher than that of the antimicrobial control group(25%), and the effective rate was 75%, which was higher than that of the antimicrobial control group(60%). On the 30 thday of administration, the effective rate of salicylic acid treatment group was 65%, which was higher than that of the antimicrobial control group(55%).[Conclusion]Salicylic acid has a good clinical therapeutic effect and can be used as alternative medicine for the treatment of pododermatitis in dairy cow.
引文
[1]CHELI R,MORTELLARO C M.Digital dermatitis in cattle[C]//Proceedings of the 8th International Meeting on Diseases of Cattle.Milan:The World Association for Buiatries,1974:208-213.
[2]BERRY S L,READ D H,WALKER R L,et al. Clinical,histologic,and bacteriologic findings in dairy cows with digital dermatitis(footwarts)one month after topicaltreatment with lincomycin hydrochloride or oxytetracycline hydrochloride[J].Journal of The American Veterinary Medical Association,2010,237(5):555-560.
[3]GOMEZ A,COOK N B,BERNARDONI N D,et al.An experimental infection model to induce digital dermatitis infection in cattle[J].Journal of Dairy Science,2012,95(4):1821-1830.
[4]BLOWEY R W,SHARP M W.Digital dermatitis in dairy cattle[J].Veterinary Record,1988,122(21):505-508.
[5]EVANS N J,BROWN J M,DEMIRKAN I,et al.In vitrosusceptibility of bovine digital dermatitis associated spirochaetes to antimicrobial agents[J].Veterinary Microbiology,2009,136(1/2):115-120.
[6]温伟.水杨酸酒精液配合泻黄散加味治疗纯血马脂溢性皮炎[J].中国兽医杂志,2010,46(9):76-77.
[7]刘素霞,张淑宁.鸡眼膏与角皮清治疗鸡眼的临床疗效分析[J].中国处方药,2016,14(1):52-53.
[8]唐莉,尹锐,罗娜,等.超分子水杨酸外用治疗轻、中度痤疮疗效观察[J].中国美容医学,2018,27(9):31-33.
[2]BERRY S L,READ D H,WALKER R L,et al. Clinical,histologic,and bacteriologic findings in dairy cows with digital dermatitis(footwarts)one month after topicaltreatment with lincomycin hydrochloride or oxytetracycline hydrochloride[J].Journal of The American Veterinary Medical Association,2010,237(5):555-560.
[3]GOMEZ A,COOK N B,BERNARDONI N D,et al.An experimental infection model to induce digital dermatitis infection in cattle[J].Journal of Dairy Science,2012,95(4):1821-1830.
[4]BLOWEY R W,SHARP M W.Digital dermatitis in dairy cattle[J].Veterinary Record,1988,122(21):505-508.
[5]EVANS N J,BROWN J M,DEMIRKAN I,et al.In vitrosusceptibility of bovine digital dermatitis associated spirochaetes to antimicrobial agents[J].Veterinary Microbiology,2009,136(1/2):115-120.
[6]温伟.水杨酸酒精液配合泻黄散加味治疗纯血马脂溢性皮炎[J].中国兽医杂志,2010,46(9):76-77.
[7]刘素霞,张淑宁.鸡眼膏与角皮清治疗鸡眼的临床疗效分析[J].中国处方药,2016,14(1):52-53.
[8]唐莉,尹锐,罗娜,等.超分子水杨酸外用治疗轻、中度痤疮疗效观察[J].中国美容医学,2018,27(9):31-33.