沙丁胺醇的检测方法研究进展
|
摘要
沙丁胺醇是β-兴奋剂的一种,在临床应用中能有效地治疗支气管哮喘、肺气肿等常见哮喘类呼吸道疾病。在畜牧业中能提高瘦肉率,但由于β-兴奋剂易产生残留而危害食用者的身体健康,因此大部分国家通过立法以禁止β-兴奋剂的使用。本文就β-兴奋剂中沙丁胺醇的危害以及常用检测方法作一简述。
Salbutamol sulfate is a kind of beta adrenergic agonists,which have effective treatment of bronchial asthma,emphysema and other common asthma respiratory diseases in the clinical.In animal husbandry,salbutamol can effectively improve the rate of lean meat,while due to beta doping particularly prone to produce residual and harm the health of the human body,most countries legislation prohibit the use of stimulants beta.In this paper,the dangers of salbutamol and its detection methods were reviewed.
Salbutamol sulfate is a kind of beta adrenergic agonists,which have effective treatment of bronchial asthma,emphysema and other common asthma respiratory diseases in the clinical.In animal husbandry,salbutamol can effectively improve the rate of lean meat,while due to beta doping particularly prone to produce residual and harm the health of the human body,most countries legislation prohibit the use of stimulants beta.In this paper,the dangers of salbutamol and its detection methods were reviewed.
引文
[1]毕玉香.瘦肉精的残留危害及监控对策[J].畜牧兽医科技信息,2009,4(6):136.
[2]戴华,袁智能,黄志强,等.饲料中盐酸克伦特罗、沙丁胺醇高效液相色谱测定[J].分析测试学报,2003,22(3):57~60.
[3]管健,王立媛,吴平谷,等.同位素作内标气质联机测定动物源食品中4种β2-兴奋剂的含量[J].中国卫生检验杂志,2007,17(12):2194~2196.
[4]谷丽丽,李飞,牛英豪,等.沙丁胺醇的病理作用研究及其液相色谱-串联质谱方法的检测[J].食品科学,2010,31(3):224~229.
[5]韩京朋,吴小平,邱检萍,等.动物尿液中沙丁胺醇残留检测试纸条的研制[J].黑龙江畜牧兽医,2014,7:174~176.
[6]胡萍,余少文,李红.中国13省1999年-2005年瘦肉精食物中毒个案分析[J].深圳大学学报(理工版),2008,25(1):1~6.
[7]黄素文,周宏斌,赵秀玲,等.饲料中沙丁胺醇快速检测技术研究[J].中国饲料,2007,17:30~31.
[8]彭涛.胶体金免疫层析法快速定量检测猪尿中β2-受体激动剂残留的研究:[硕士学位论文][D].江西南昌:南昌大学,2015.
[9]秦永平,邹远高,梁茂植,等.柱切换-反相高效液相色谱法测定血浆中沙丁胺醇浓度[J].四川大学学报(医学版),2003,3:576~579.
[10]尚红霞,张智,周晓辉.用高效液相色谱法分析克仑特罗和沙丁胺醇[J].化学世界,2003,44(8):412~415.
[11]孙书刚,李建伟,张富刚,等.沙丁胺醇及其常用检测方法[J].中国畜牧业,2015,3:57~58.
[12]王凤美,何京橙,张鸿伟,等.超高效液相色谱-串联质谱法检测动物血浆中克伦特罗、莱克多巴胺、沙丁胺醇[J].食品安全质量检测学报,2015,12:5024~5028.
[13]王建平,史为民,沈建忠.免疫亲和色谱-气相色谱/质谱法(I-AC-GC/MS)检测猪肝中的沙丁胺醇与克伦特罗[J].畜牧兽医学报,2007,38(3):271~275.
[14]王俊平,赵云襄,王硕,等.沙丁胺醇直接酶联免疫快速检测的方法[J].食品研究与开发,2011,32(2):97~100.
[15]吴巧丽,叶春生.胶体金免疫层析技术快速检测沙丁胺醇残留[J].现代食品科技,2012,11:1595~1599.
[16]王振玲,章丽娇,段跃强,等.猪轮状病毒的分离与电镜观察[J].畜牧与兽医,2014(1):74.
[17]赵德明.猪病学[M].北京:中国农业大学出版社,2008:493.
[18]Josefsson M,Sabanovic A.Sample preparation on polymeric solid phase ex-traction sorbents for liquid chromatograph-ic-tandem mass spectrometric analysis of human whole blood-A study on a number of beta-agonists and beta-antagonists[J].J Chromatogr A,2006,1120(12):1~12.
[19]Korfchen W A.Foundation review:Principles and applications of LC-MSin newdrug dicovery[J].Drug Discov Today,2005,10:1357.
[20]Sawayawn,Lone,Husain A,et al.Screening forβ-agonists in sheep urine and eyes by an enzyme-linked immunosorbent assay in the state of Kuwait[J].Food Control,2000,11:1~5.
[21]Shen S H,Ouyang J,Baeyens W R G,et al.Determination ofβ-agonists by ion chromatography with direct conductivity detection[J].JPharmaceuti-caland Biomedical Analysis,2005,38:166~172.
[22]Shelver W L,Smith D J.Determi-nation of Ractopamine in Cattle and Sheep Urine Samples Using an Optical Biosensor Analysis:Comparative Study with HPLC and ELISA[J].Jour nal of Agricultural and Food Chemistry,2003,51:3721~3751.
[23]Spyridaki M H,Vonaparti P K A,Vala-vani P,et al.Doping control analysis in hu-man urine by liquid chromatography-elec-trospray ionization ion trap mass spectrome-try for the Olympic Games Athens 2004:Determinationof corticosteroids and quan-tification of ephedrines,salbutamol andmorphine[J].Anal Chim Acta,2006,573(1):242~249.
[24]Wang J P,Li X W,Zhang W,et al.Development of immunoaffinity sample-purific-ation for GC-MS analysis of ractopamine in swine tissue[J].Chromatographia,2006,64(9):613.
[25]Zhang Y T,Zhang Z J,Sun Y H,et al.Development of analytical method for thedetermination ofβ-agonist residuesin animal tissues by high-performanceliquidchromatography with on-line electrogenerated[Cu(HIO6)2]5--luminol chemiluminescencedetection[J].Journalof agriculture andfood chemistry,2007,55(13):4949~4956.
[2]戴华,袁智能,黄志强,等.饲料中盐酸克伦特罗、沙丁胺醇高效液相色谱测定[J].分析测试学报,2003,22(3):57~60.
[3]管健,王立媛,吴平谷,等.同位素作内标气质联机测定动物源食品中4种β2-兴奋剂的含量[J].中国卫生检验杂志,2007,17(12):2194~2196.
[4]谷丽丽,李飞,牛英豪,等.沙丁胺醇的病理作用研究及其液相色谱-串联质谱方法的检测[J].食品科学,2010,31(3):224~229.
[5]韩京朋,吴小平,邱检萍,等.动物尿液中沙丁胺醇残留检测试纸条的研制[J].黑龙江畜牧兽医,2014,7:174~176.
[6]胡萍,余少文,李红.中国13省1999年-2005年瘦肉精食物中毒个案分析[J].深圳大学学报(理工版),2008,25(1):1~6.
[7]黄素文,周宏斌,赵秀玲,等.饲料中沙丁胺醇快速检测技术研究[J].中国饲料,2007,17:30~31.
[8]彭涛.胶体金免疫层析法快速定量检测猪尿中β2-受体激动剂残留的研究:[硕士学位论文][D].江西南昌:南昌大学,2015.
[9]秦永平,邹远高,梁茂植,等.柱切换-反相高效液相色谱法测定血浆中沙丁胺醇浓度[J].四川大学学报(医学版),2003,3:576~579.
[10]尚红霞,张智,周晓辉.用高效液相色谱法分析克仑特罗和沙丁胺醇[J].化学世界,2003,44(8):412~415.
[11]孙书刚,李建伟,张富刚,等.沙丁胺醇及其常用检测方法[J].中国畜牧业,2015,3:57~58.
[12]王凤美,何京橙,张鸿伟,等.超高效液相色谱-串联质谱法检测动物血浆中克伦特罗、莱克多巴胺、沙丁胺醇[J].食品安全质量检测学报,2015,12:5024~5028.
[13]王建平,史为民,沈建忠.免疫亲和色谱-气相色谱/质谱法(I-AC-GC/MS)检测猪肝中的沙丁胺醇与克伦特罗[J].畜牧兽医学报,2007,38(3):271~275.
[14]王俊平,赵云襄,王硕,等.沙丁胺醇直接酶联免疫快速检测的方法[J].食品研究与开发,2011,32(2):97~100.
[15]吴巧丽,叶春生.胶体金免疫层析技术快速检测沙丁胺醇残留[J].现代食品科技,2012,11:1595~1599.
[16]王振玲,章丽娇,段跃强,等.猪轮状病毒的分离与电镜观察[J].畜牧与兽医,2014(1):74.
[17]赵德明.猪病学[M].北京:中国农业大学出版社,2008:493.
[18]Josefsson M,Sabanovic A.Sample preparation on polymeric solid phase ex-traction sorbents for liquid chromatograph-ic-tandem mass spectrometric analysis of human whole blood-A study on a number of beta-agonists and beta-antagonists[J].J Chromatogr A,2006,1120(12):1~12.
[19]Korfchen W A.Foundation review:Principles and applications of LC-MSin newdrug dicovery[J].Drug Discov Today,2005,10:1357.
[20]Sawayawn,Lone,Husain A,et al.Screening forβ-agonists in sheep urine and eyes by an enzyme-linked immunosorbent assay in the state of Kuwait[J].Food Control,2000,11:1~5.
[21]Shen S H,Ouyang J,Baeyens W R G,et al.Determination ofβ-agonists by ion chromatography with direct conductivity detection[J].JPharmaceuti-caland Biomedical Analysis,2005,38:166~172.
[22]Shelver W L,Smith D J.Determi-nation of Ractopamine in Cattle and Sheep Urine Samples Using an Optical Biosensor Analysis:Comparative Study with HPLC and ELISA[J].Jour nal of Agricultural and Food Chemistry,2003,51:3721~3751.
[23]Spyridaki M H,Vonaparti P K A,Vala-vani P,et al.Doping control analysis in hu-man urine by liquid chromatography-elec-trospray ionization ion trap mass spectrome-try for the Olympic Games Athens 2004:Determinationof corticosteroids and quan-tification of ephedrines,salbutamol andmorphine[J].Anal Chim Acta,2006,573(1):242~249.
[24]Wang J P,Li X W,Zhang W,et al.Development of immunoaffinity sample-purific-ation for GC-MS analysis of ractopamine in swine tissue[J].Chromatographia,2006,64(9):613.
[25]Zhang Y T,Zhang Z J,Sun Y H,et al.Development of analytical method for thedetermination ofβ-agonist residuesin animal tissues by high-performanceliquidchromatography with on-line electrogenerated[Cu(HIO6)2]5--luminol chemiluminescencedetection[J].Journalof agriculture andfood chemistry,2007,55(13):4949~4956.