糖尿病周围神经病变相关血清标记物研究进展
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摘要
糖尿病周围神经病变(DPN)是糖尿病患者最普遍的慢性并发症,临床以双侧肢体对称性发病多见,主要累及运动、感觉及自主神经。近年来众多研究表明,多种生物标记物与DNP的发生发展密切相关,对DPN患者早期预测具有一定的临床价值。现就目前研究较多的神经元特异性烯醇化酶(NSE)、髓鞘碱性蛋白(MBP)、抗神经节苷脂抗体(anti-GS-ab)、血清内脏脂肪素(Visfatin)、25羟基维生素D3[25(OH)D3]、心磷脂酰基转移酶1(ALCAT1)与DPN的关系及研究进展阐述如下,为DPN的早期诊断与防治提供一定的理论依据。
Diabetic peripheral neuropathy( DPN) is the most common chronic complication in diabetic patients. The common clinical manifestation of DPN is bilateral limb symmetry which is mainly involving motor,sensory and autonomic nerves. Recently,many researches show that a variety of biological markers are closely related to the occurrence and development of DNP,which has certain clinical value in prediction of early DPN patients. This article describes the relationship between neuron specific enolase( NSE),myelin basic protein( MBP),anti-ganglioside lipid antibody( antiGS-ab),serum visfatin,25 hydroxy vitamin D3[25( OH) D3 ],cardiolipin acyltransferase 1( ALCAT1) and DNP,which could provide a theoretical basis for early diagnosis and prevention of DPN.
Diabetic peripheral neuropathy( DPN) is the most common chronic complication in diabetic patients. The common clinical manifestation of DPN is bilateral limb symmetry which is mainly involving motor,sensory and autonomic nerves. Recently,many researches show that a variety of biological markers are closely related to the occurrence and development of DNP,which has certain clinical value in prediction of early DPN patients. This article describes the relationship between neuron specific enolase( NSE),myelin basic protein( MBP),anti-ganglioside lipid antibody( antiGS-ab),serum visfatin,25 hydroxy vitamin D3[25( OH) D3 ],cardiolipin acyltransferase 1( ALCAT1) and DNP,which could provide a theoretical basis for early diagnosis and prevention of DPN.
引文
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[14]Pilz S,Kienreich K,Rutters F,et al.Role of Vitamin D in the development of insulin resistance and type 2 diabetes[J].Curr Diab Rep,2013,13(2):261-270.
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[20]陈福莲,江晓龙,赵佳,等.血清25羟维生素D3在糖尿病周围神经病变中的作用[J].中风与神经疾病杂志,2016,33(6):496-499.
[21]Cao J,Liu Y,Lockwood J,et al.A novel cardiolipin-remodeling pathway revealed by a gene encoding an endoplasmic reticulum-associated acyl-Co A:lysocardiolipin acyltransferase(ALCAT1)in mouse[J].J Biol Chem,2004,279(30):31727-31734.
[22]李亚坤,杨俊朋,马香香,等.心磷脂酰基转移酶1与糖尿病周围神经病变的相关性研究[J].中国糖尿病杂志,2016,24(3):267-270.
[23]Chowdhury SK,Dobrowsky RT,Fernyhough P.Nutrient excess and altered mitochondrial proteome and function contribute to neurodegeneration in diabetes[J].Mitochondrion,2011,11(6):845-854.
[24]Vincent AM,Edwards JL,Mc Lean LL,et al.Mitochondrial biogenesis and fission in axons in cell culture and animal models of diabetic neuropathy[J].Acta Neuropathol,2010,120(4):477-489.
[2]Hafner A,Glavan G,Obermajer N,et al.Neuroprotective role ofγ-enolase in microglia in a mouse model of Alzheimer's disease is regulated by cathepsin X[J].Aging Cell,2013,12(4):604-614.
[3]Kowno M,Watanabe-Susaki K,Ishimine H,et al.Prohibitin 2 regulates the proliferation and lineage-specific differentiation of mouse embryonic stem cells in mitochondria[J].PLo S One,2014,9(4):e81552.
[4]Sandhu HS,Butt AN,Powrie J,et al.Measurement of circulating neuron-specific enolase mRNA in diabetes mellitus[J].Ann N Y Acad Sci,2008,1137:258-263.
[5]Odagiri E.Neuron specific enolase[J].Nippon Rinsho,2005,63Suppl 8:717-719.
[6]魏剑芬,王颖,吴乃君,等.糖尿病周围神经病变患者血清神经元特异性烯醇化酶与神经传导速度的关系[J].中国糖尿病杂志,2016,24(6):528-531.
[7]Zierath D,Kunze A,Fecteau L,et al.Promiscuity of autoimmune responses to MBP after stroke[J].J Neuroimmunol,2015,285:101-105.
[8]丛艳,李金萱,秦晓凤,等.血清S100β、MBP含量变化与糖尿病周围神经病变的相关性研究[J].世界临床药物,2013,34(7):409-411.
[9]廖斌,秦爱平,王芳.血清髓鞘碱性蛋白在糖尿病周围神经病变中的临床意义[J].心血管康复医学杂志,2008,17(2):110.
[10]李妮,周微雅,颜晓东,等.糖尿病神经病变血清抗神经节苷脂抗体的临床观察[J].临床内科杂志,2001,18(6):455-457.
[11]Krvestedt L,Mrtensson E,Grill V,et al.The prevalence of peripheral neuropathy in a population-based study of patients with type 2diabetes in Sweden[J].J Diabetes Complicat,2011,25(2):97-106.
[12]廖鑫,冷启书,阳琰,等.血清内脏脂肪素与糖尿病周围神经病变的相关性研究[J].中国糖尿病杂志,2016,24(6):524-527.
[13]Kang YS,Bae MK,Kim JY,et al.Visfatin induces neurite outgrowth in PC12 cells via ERK1/2 signaling pathway[J].Neurosci Lett,2011,504(2):121-126.
[14]Pilz S,Kienreich K,Rutters F,et al.Role of Vitamin D in the development of insulin resistance and type 2 diabetes[J].Curr Diab Rep,2013,13(2):261-270.
[15]De Luca HF.Overview of general physiologic features and functions of vitamin D[J].Am J Clin Nutr,2004,80 Suppl 6:1689-1696.
[16]Menezes AR,Lamb MC,Lavie CJ,et al.Vitamin D and atherosclerosis[J].Curr Opin Cardiol,2014,29(6):571-577.
[17]Shehab D,Al-Jarallah K,Mojiminiyi OA,et al.Does Vitamin D deficiency play a role in peripheral neuropathy in Type 2 diabetes[J].Diabet Med,2012,29(1):43-49.
[18]Dey I,Midha N,Singh G,et al.Diabetic Schwann cells suffer from nerve growth factor and neurotrophin-3 underproduction and poor associability with axons[J].Glia,2013,61(12):1990-1999.
[19]Wu-Wong JR,Nakane M,Ma J,et al.Effects of Vitamin D analogs on gene expression profiling in human coronary artery smooth muscle cells[J].Atherosclerosis,2006,186(1):20-28.
[20]陈福莲,江晓龙,赵佳,等.血清25羟维生素D3在糖尿病周围神经病变中的作用[J].中风与神经疾病杂志,2016,33(6):496-499.
[21]Cao J,Liu Y,Lockwood J,et al.A novel cardiolipin-remodeling pathway revealed by a gene encoding an endoplasmic reticulum-associated acyl-Co A:lysocardiolipin acyltransferase(ALCAT1)in mouse[J].J Biol Chem,2004,279(30):31727-31734.
[22]李亚坤,杨俊朋,马香香,等.心磷脂酰基转移酶1与糖尿病周围神经病变的相关性研究[J].中国糖尿病杂志,2016,24(3):267-270.
[23]Chowdhury SK,Dobrowsky RT,Fernyhough P.Nutrient excess and altered mitochondrial proteome and function contribute to neurodegeneration in diabetes[J].Mitochondrion,2011,11(6):845-854.
[24]Vincent AM,Edwards JL,Mc Lean LL,et al.Mitochondrial biogenesis and fission in axons in cell culture and animal models of diabetic neuropathy[J].Acta Neuropathol,2010,120(4):477-489.
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