精神分裂症幻听产生的生理心理机制研究进展
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摘要
幻听是精神分裂症常见的症状,其病理机制不清。本文从大脑侧化异常、大脑失抑制、大脑内源性刺激以及大脑皮层活动与功能连接异常等4个方面对幻听产生的生理心理机制进行了综述。
引文
[1]陈强庆,汪磊萍,李云峰.分裂症患者言语性幻听内容的观察分析[J].中国民康医学,2008,20(5):415-416.
[2]蔡厚德.利手与注意偏向对双耳分听汉字大脑功能优势的影响[J].南京师大学报:自然科学版,2006,29(2):73-77.
[3]史家波.精神分裂症幻听发生机制的脑功能研究[D].南京:南京医科大学,2006.
[4]史家波,张志珺,郝贵峰,等.男性精神分裂症患者脑侧化与幻听的功能磁共振成像研究[J].中华精神科杂志,2007,40(2):65-69.
[5]嵇利亚,谢世平,杨惠敏,等.精神分裂症幻听患者汉语听觉语言皮质定位的脑磁图研究[J].中国神经精神疾病杂志,2008,34(4):225-228.
[6]Woodruff P W,Wright I C,Bullmore E T,et al.Auditory hallucinations and the temporal cortical response to speech in schizophrenia:a functional magnetic resonance imaging study[J].Am J Psychiatry,1997,154(12):1676-1682.
[7]Falkai P,Bogerts B,Schneider T,et al.Disturbed planum temporale asymmetry in schizophrenia[J].Schizophr Res,1995,14(2):161-176.
[8]Shapleske J,Rossell S L,Simmons A,et al.Are auditory hallucinations the consequence of abnormal cerebral lateralization?A morphomctric MRI study of the sylvian fissure and planum temporale[J].Biol Psychiatry,2001,49(8):685-693.
[9]Rossell S L,Shapleske J,Fukuda R,et al.Corpus callosum area and functioning in schizophrenic patients with auditory-verbal hallucinations[J].Schizophrenia Res,2001,50(1/2):9-17.
[10]姚志剑,张志珺.精神分裂症听幻觉的发生机制[J].国外医学:精神病学分册,2003,30(4):213-215.
[11]Shergill S S,Bullmore E,Murray R,et al.Functional anatomy of auditory verbal imagery in schizophrenic patients with auditory hallucinations[J].Am J Psychiatry,2000,157(10):1691-1693.
[12]Ford J M,Roach B J,Faustman W O,et al.Synch before you speak:auditory hallucinations in schizophrenia[J].Am J Psychiatry,2007,164(3):458-466.
[13]Stanghelini G,Cutting J.Auditory verbal hallucinations breaking the silence of inner dialogue[J].Psychopathology,2003,36(3):120-128.
[14]Frith C,Lawrence A,Weinberger D.The role of the prefrontal cortex in self-consciousness:the case of auditory hallucinations[J].Philos Trans R Soc Lond B Biol Sci,1996,351(1346):1505-1512.
[15]Lawrie S M,Buechel C,Whalley H C,et al.Reduced frontotemporal functional connectivity in schizophrenia associated with auditory hallucinations[J].Biol Psychiatry,2002,51(12):1008-1011.
[16]Gromann P M,Tracy D K,Giampietro V,et al.Examining frontotemporal connectivity and r TMS in healthy controls:Implications for auditory hallucinations in schizophrenia[J].Neuropsychology,2012,26(1):127-132.
[17]Lai I C,Yang C C,Kuo T B,et al.Transcranial magnetic stimulation for auditory hallucinationin severe schizophrenia:Partial efficacy and acute elevation of sympathetic modulation[J].Psychiatry Clin Neurosci,2010,64(3):333-335.
[18]Nazimek J M,Hunter M D,Woodruff P W.Auditory hallucinations:expectation-perception model[J].Med Hypotheses,2012,78(6):802-810.
[19]郝贵峰,张志珺,史家波,等.精神分裂症幻听患者声音熟悉性神经基础的功能磁共振成像研究[J].中华医学杂志,2007,87(5):315-320.
[20]Ford J M,Mathalon D H.Corollary discharge dysfunction in schizophrenia:Can it explain auditory hallucinations[J].Int J Psychophysiol,2005,58(2/3):179-189.
[21]David A S,Woodruff P W,Howard R,et al.Auditory hallucinations inhibit exogenous activation of auditory association cortex[J].Neuroreport,1996,7(4):932-936.
[22]郝贵峰,张志珺,史家波,等.男性精神分裂症患者幻听发生机制的神经心理学研究[J].中外医学研究,2010,8(30):1-4.
[23]Zikic S,Eng P,Barrat O A.Auditory hallucinations:hypothesis in the context of spread spectrum communications[J].Med Hypotheses,2002,59(1),79-84.
[24]Hoffman R E,Hawkins K A,Gueorguieva R,et al.Transcranial magnetic stimulation of left temporoparietal cortex and medicationresistant auditory hallucinations[J].Arch Gen Psychiatey,2003,60(1):49-56.
[25]Plaze M,Bartrés-Faz D,Martinot J L,et al.Left superior temporal gyrus activation during sentence perception negatively correlates with auditory hallucination severity in schizophrenia patients[J].Schizophrenia Research,2006,87(1/3):109-115.
[26]Line P,Silberstein R B,Wright J J,et al.Steady state visually evoked potential correlates of auditory hallucinations in schizophrenia[J].Neuroimage,1998,8(4):370-376.
[27]Spencer K M,Niznikiewicz M A,Nestor P G,et al.Left auditory cortex gamma synchronization and auditory hallucination symptoms in schizophrenia[J].BMC Neuroscience,2009,10:85.
[28]陈诚,王惠玲,吴士豪,等.基于Re Ho方法的精神分裂症幻听患者静息态f MRI的研究[J].神经疾病与精神卫生,2013,13(2):150-153.
[29]Lennox B R,Park S B,Jones P B,et al.Spatial and temporal mapping of neural activity associated with auditory hallucinations[J].Lancet,1999,353(9153):644.
[30]Tiihonen J,Hari R,Naukkarinen H,et al.Modified activity of the human auditory cortex during auditory hallucinations[J].Am J Psychiatry,1992,149(2):255-257.
[2]蔡厚德.利手与注意偏向对双耳分听汉字大脑功能优势的影响[J].南京师大学报:自然科学版,2006,29(2):73-77.
[3]史家波.精神分裂症幻听发生机制的脑功能研究[D].南京:南京医科大学,2006.
[4]史家波,张志珺,郝贵峰,等.男性精神分裂症患者脑侧化与幻听的功能磁共振成像研究[J].中华精神科杂志,2007,40(2):65-69.
[5]嵇利亚,谢世平,杨惠敏,等.精神分裂症幻听患者汉语听觉语言皮质定位的脑磁图研究[J].中国神经精神疾病杂志,2008,34(4):225-228.
[6]Woodruff P W,Wright I C,Bullmore E T,et al.Auditory hallucinations and the temporal cortical response to speech in schizophrenia:a functional magnetic resonance imaging study[J].Am J Psychiatry,1997,154(12):1676-1682.
[7]Falkai P,Bogerts B,Schneider T,et al.Disturbed planum temporale asymmetry in schizophrenia[J].Schizophr Res,1995,14(2):161-176.
[8]Shapleske J,Rossell S L,Simmons A,et al.Are auditory hallucinations the consequence of abnormal cerebral lateralization?A morphomctric MRI study of the sylvian fissure and planum temporale[J].Biol Psychiatry,2001,49(8):685-693.
[9]Rossell S L,Shapleske J,Fukuda R,et al.Corpus callosum area and functioning in schizophrenic patients with auditory-verbal hallucinations[J].Schizophrenia Res,2001,50(1/2):9-17.
[10]姚志剑,张志珺.精神分裂症听幻觉的发生机制[J].国外医学:精神病学分册,2003,30(4):213-215.
[11]Shergill S S,Bullmore E,Murray R,et al.Functional anatomy of auditory verbal imagery in schizophrenic patients with auditory hallucinations[J].Am J Psychiatry,2000,157(10):1691-1693.
[12]Ford J M,Roach B J,Faustman W O,et al.Synch before you speak:auditory hallucinations in schizophrenia[J].Am J Psychiatry,2007,164(3):458-466.
[13]Stanghelini G,Cutting J.Auditory verbal hallucinations breaking the silence of inner dialogue[J].Psychopathology,2003,36(3):120-128.
[14]Frith C,Lawrence A,Weinberger D.The role of the prefrontal cortex in self-consciousness:the case of auditory hallucinations[J].Philos Trans R Soc Lond B Biol Sci,1996,351(1346):1505-1512.
[15]Lawrie S M,Buechel C,Whalley H C,et al.Reduced frontotemporal functional connectivity in schizophrenia associated with auditory hallucinations[J].Biol Psychiatry,2002,51(12):1008-1011.
[16]Gromann P M,Tracy D K,Giampietro V,et al.Examining frontotemporal connectivity and r TMS in healthy controls:Implications for auditory hallucinations in schizophrenia[J].Neuropsychology,2012,26(1):127-132.
[17]Lai I C,Yang C C,Kuo T B,et al.Transcranial magnetic stimulation for auditory hallucinationin severe schizophrenia:Partial efficacy and acute elevation of sympathetic modulation[J].Psychiatry Clin Neurosci,2010,64(3):333-335.
[18]Nazimek J M,Hunter M D,Woodruff P W.Auditory hallucinations:expectation-perception model[J].Med Hypotheses,2012,78(6):802-810.
[19]郝贵峰,张志珺,史家波,等.精神分裂症幻听患者声音熟悉性神经基础的功能磁共振成像研究[J].中华医学杂志,2007,87(5):315-320.
[20]Ford J M,Mathalon D H.Corollary discharge dysfunction in schizophrenia:Can it explain auditory hallucinations[J].Int J Psychophysiol,2005,58(2/3):179-189.
[21]David A S,Woodruff P W,Howard R,et al.Auditory hallucinations inhibit exogenous activation of auditory association cortex[J].Neuroreport,1996,7(4):932-936.
[22]郝贵峰,张志珺,史家波,等.男性精神分裂症患者幻听发生机制的神经心理学研究[J].中外医学研究,2010,8(30):1-4.
[23]Zikic S,Eng P,Barrat O A.Auditory hallucinations:hypothesis in the context of spread spectrum communications[J].Med Hypotheses,2002,59(1),79-84.
[24]Hoffman R E,Hawkins K A,Gueorguieva R,et al.Transcranial magnetic stimulation of left temporoparietal cortex and medicationresistant auditory hallucinations[J].Arch Gen Psychiatey,2003,60(1):49-56.
[25]Plaze M,Bartrés-Faz D,Martinot J L,et al.Left superior temporal gyrus activation during sentence perception negatively correlates with auditory hallucination severity in schizophrenia patients[J].Schizophrenia Research,2006,87(1/3):109-115.
[26]Line P,Silberstein R B,Wright J J,et al.Steady state visually evoked potential correlates of auditory hallucinations in schizophrenia[J].Neuroimage,1998,8(4):370-376.
[27]Spencer K M,Niznikiewicz M A,Nestor P G,et al.Left auditory cortex gamma synchronization and auditory hallucination symptoms in schizophrenia[J].BMC Neuroscience,2009,10:85.
[28]陈诚,王惠玲,吴士豪,等.基于Re Ho方法的精神分裂症幻听患者静息态f MRI的研究[J].神经疾病与精神卫生,2013,13(2):150-153.
[29]Lennox B R,Park S B,Jones P B,et al.Spatial and temporal mapping of neural activity associated with auditory hallucinations[J].Lancet,1999,353(9153):644.
[30]Tiihonen J,Hari R,Naukkarinen H,et al.Modified activity of the human auditory cortex during auditory hallucinations[J].Am J Psychiatry,1992,149(2):255-257.