桂枝麻黄各半汤加味联合西替利嗪治疗寒冷性荨麻疹60例临床观察
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摘要
目的观察桂枝麻黄各半汤加味联合西替利嗪治疗寒冷性荨麻疹的临床疗效和安全性。方法将120例寒冷性荨麻疹患者随机分为两组各60例,对照组用常规西药西替利嗪、维生素C治疗,治疗组在用桂枝麻黄各半汤加味联合西替利嗪治疗,观察治疗组与对照组各项症状积分(瘙痒程度、风团数量、风团大小、风团持续时间、腹痛程度和皮肤划痕症)、复发率及血清学指标。结果治疗后治疗组瘙痒程度、风团数量、风团持续时间、腹痛程度症状积分显著低于对照组(P<0.05);治疗组患者皮损的复发率低于对照组(P<0.05);治疗组患者血清Ig E含量低于对照组(P<0.05);治疗组总有效率96.7%,对照组总有效率83.3%,两组比较差异有统计学意义(P<0.05)。结论桂枝麻黄各半汤加味联合西替利嗪治疗寒冷性荨麻疹可有效改善患者临床症状,降低患者复发率,提高患者生活质量。
Objective To observe the clinical effect and safety on urticaria of cold type treated with guizhi mahuang geban tang and cetirizine.Methods A total of 120 cases of urticaria of cold type were randomized into two groups,60 cases in each one.In the control group,cetirizine and vitamin C were prescribed.In the treatment group,the combined medication of guizhi mahuang geban tang and cetirizine was used.The every symptom score(pruritus degree,wind wheal amounts,wheal size,persistent time of wheals,degree of abdominal pain and skin scratches),recurrence rate and serological indexes were observed in the treatment group and the control group.Results After treatment,the scores of pruritus degree,wheal amount,persistent time of wheals and abdominal pain degree in the treatment group were all lower significantly than the control group(P<0.05).The recurrence rate of skin lesion in the treatment group was lower than the control group(P<0.05).The level of Ig E in the treatment group was lower than the control group(P<0.05).The total effective rate was 96.7% in the treatment group and was 83.3% in the control group,indicating the significant difference(P<0.05).Conclusion The combined medication of guizhi mahuang geban tang and cetirizine achieves the effective improvements in the clinical symptoms,reduces the recurrence rate and improves the quality of life in the patients with urticaria of cold type.
Objective To observe the clinical effect and safety on urticaria of cold type treated with guizhi mahuang geban tang and cetirizine.Methods A total of 120 cases of urticaria of cold type were randomized into two groups,60 cases in each one.In the control group,cetirizine and vitamin C were prescribed.In the treatment group,the combined medication of guizhi mahuang geban tang and cetirizine was used.The every symptom score(pruritus degree,wind wheal amounts,wheal size,persistent time of wheals,degree of abdominal pain and skin scratches),recurrence rate and serological indexes were observed in the treatment group and the control group.Results After treatment,the scores of pruritus degree,wheal amount,persistent time of wheals and abdominal pain degree in the treatment group were all lower significantly than the control group(P<0.05).The recurrence rate of skin lesion in the treatment group was lower than the control group(P<0.05).The level of Ig E in the treatment group was lower than the control group(P<0.05).The total effective rate was 96.7% in the treatment group and was 83.3% in the control group,indicating the significant difference(P<0.05).Conclusion The combined medication of guizhi mahuang geban tang and cetirizine achieves the effective improvements in the clinical symptoms,reduces the recurrence rate and improves the quality of life in the patients with urticaria of cold type.
引文
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[10]赵学义,朱爱明.玉屏桂枝乌梅汤治疗风寒型慢性荨麻疹90例临床观察[J].世界中西医结合杂志,2015,10(11):1552-1553.
[11]张倩曼,梁碧华,李润祥.慢性自发性尊麻疹发病机制及其治疗的研究进展[J].皮肤性病诊疗学杂志,2015,22(4):332-335.
[12]李艳.孟鲁司特联合西替利嗪治疗小儿变应性鼻炎的安全性评价[J].世界最新医学信息文摘,2017,17(92):61.
[13]查伟锋,郭波,芦俊巍,等.盐酸西替利嗪联合益气养血消风汤对慢性荨麻疹患者血清Ig E、IFN-γ、IL-13、IL-17的影响[J].中国中医药科技,2017,24(5):551-553.
[14]俞彩霞,李忻红.仲景桂枝类方治疗常见皮肤科疾病浅悟[J].浙江中医药大学学报,2014(3):261-262.
[2]Negro-Alvarez JM,Mirallse-LopzJC. Chronic idiopathic urticaria treatment[J]. Allergol Immunopathol,2001,29(4):129-132.
[3]王侠生.皮炎湿疹荨麻疹[M].北京:中国中医药出版社,2009:188-189.
[4]赵辨.临床皮肤病学[M]. 7版.南京:江苏科学技术出版社,2010:123-124.
[5]中华医学会皮肤性病学分会免疫学组.中国荨麻疹诊疗指南(2014版)[J].中华皮肤科杂志,2014,47(7):388-390.
[6]国家中医药管理局.中华人民共和国中医药行业标准:中医病证诊断疗效标准[S].南京:南京大学出版社,1994:265.
[7]刘力,孙艳萍,魏荣友,等.中医综合疗法对寒冷性荨麻疹患者生活质量影响的观察[J].中国实用医药,2018,13(11):8-10.
[8]吴冬,刘瑛琦.皮肤病用药宜忌与日常调养[M].哈尔滨:黑龙江科学技术出版社,2010:45.
[9]李巍,李娜.玉屏风散合当归四逆汤治疗寒冷型荨麻疹临床疗效分析[J].四川中医,2016,34(10):149-151.
[10]赵学义,朱爱明.玉屏桂枝乌梅汤治疗风寒型慢性荨麻疹90例临床观察[J].世界中西医结合杂志,2015,10(11):1552-1553.
[11]张倩曼,梁碧华,李润祥.慢性自发性尊麻疹发病机制及其治疗的研究进展[J].皮肤性病诊疗学杂志,2015,22(4):332-335.
[12]李艳.孟鲁司特联合西替利嗪治疗小儿变应性鼻炎的安全性评价[J].世界最新医学信息文摘,2017,17(92):61.
[13]查伟锋,郭波,芦俊巍,等.盐酸西替利嗪联合益气养血消风汤对慢性荨麻疹患者血清Ig E、IFN-γ、IL-13、IL-17的影响[J].中国中医药科技,2017,24(5):551-553.
[14]俞彩霞,李忻红.仲景桂枝类方治疗常见皮肤科疾病浅悟[J].浙江中医药大学学报,2014(3):261-262.