炉甘石洗剂联合氯雷他定片与复方甘草酸苷片治疗过敏性皮肤炎的临床效果
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摘要
目的探讨炉甘石洗剂联合氯雷他定片与复方甘草酸苷片治疗过敏性皮肤炎的临床效果。方法采用随机抽签法将2016年1月至2017年8月医院收治的72例过敏性皮肤炎患者分为对照组和试验组,每组36例。对照组口服复方甘草酸苷片治疗,试验组在对照组基础上应用炉甘石洗剂联合氯雷他定片。比较两组治疗效果、治疗前、后的血清IL-4、IL-13、MCP-1水平。结果试验组痊愈率和治疗总有效率显著高于对照组(P<0.05);治疗后,两组血清IL-4、IL-13及MCP-1水平均显著降低,且试验组低于对照组(P<0.05)。结论炉甘石洗剂联合氯雷他定片与复方甘草酸苷片治疗过敏性皮肤炎的疗效确切,可显著缓解患者的皮疹和瘙痒症状,减轻炎症反应。
Objective To explore the clinical effect of the combination of calamine lotion, loratadine tablets and compound glycyrrhizin tablets in the treatment of allergic dermatitis. Methods A total of 72 patients with allergic dermatitis admitted in the hospital from January 2016 to August 2017 were divided into control group and experimental group by random lottery method, with 36 cases in each group. The control group was treated with oral compound glycyrrhizin tablets,while the experimental group were treated with calamine lotion combined with loratadine tablets on the basis of the control group. The therapeutic effects and levels of serum IL-4, IL-13 and MCP-1 before and after treatment were compared between the two groups. Results The cure rate and total effective rate of treatment in the experimental group were significantly higher than those in the control group(P<0.05). After treatment, the levels of serum IL-4, IL-13 and MCP-1 in both groups decreased significantly, and those in the experimental group were lower than the control group(P<0.05). Conclusion Combination of calamine lotion, loratadine tablets and compound glycyrrhizin tablets in the treatment of allergic dermatitis have a definite curative effect, it can significantly relieve the symptoms of rash and pruritus, and reduce the inflammatory reaction of patients.
Objective To explore the clinical effect of the combination of calamine lotion, loratadine tablets and compound glycyrrhizin tablets in the treatment of allergic dermatitis. Methods A total of 72 patients with allergic dermatitis admitted in the hospital from January 2016 to August 2017 were divided into control group and experimental group by random lottery method, with 36 cases in each group. The control group was treated with oral compound glycyrrhizin tablets,while the experimental group were treated with calamine lotion combined with loratadine tablets on the basis of the control group. The therapeutic effects and levels of serum IL-4, IL-13 and MCP-1 before and after treatment were compared between the two groups. Results The cure rate and total effective rate of treatment in the experimental group were significantly higher than those in the control group(P<0.05). After treatment, the levels of serum IL-4, IL-13 and MCP-1 in both groups decreased significantly, and those in the experimental group were lower than the control group(P<0.05). Conclusion Combination of calamine lotion, loratadine tablets and compound glycyrrhizin tablets in the treatment of allergic dermatitis have a definite curative effect, it can significantly relieve the symptoms of rash and pruritus, and reduce the inflammatory reaction of patients.
引文
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[9]张禁,杨颜龙,姜功平,等.地氯雷他定联合复方甘草酸苷治疗慢性荨麻疹66例临床观察[J].中国皮肤性病学杂志,2013,27(7):755-756.
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[11]黄涛.马来酸氯苯那敏联合复方炉甘石洗剂治疗小儿湿疹临床疗效研究[J].首都食品与医药,2016,23(14):51.
[12]陈华.探讨醋酸泼尼松炉甘石洗剂治疗敷贴胶布致皮肤过敏的临床疗效[J].中国卫生标准管理,2016,7(6):103-104.
[13]张志娟,单士军.丁酸氢化可的松联合复方炉甘石洗剂治疗新生儿湿疹的疗效及对患儿炎性因子的影响[J].中国妇幼保健,2018,33(5):1076-1078.
[14]毛越苹,谭国珍,张楚怡,等.枸地氯雷他定片治疗慢性特发性荨麻疹有效性与临床安全性分析[J].中国皮肤性病学杂志,2014,28(9):974-976.
[15]张佩莲,李文华,代自超,等.β趋化因子MCP-1、MIP-1α、RANTES在皮肌炎患者肌肉、皮损中表达的相关性研究[J].皮肤病与性病,2013,35(1):1-4.
[16]刘强,王卿,王欣欣,等.过敏性紫癜患者外周血单个核细胞中Tim-1,Tim-3mRNA表达和血清中IL-2和IL-4含量测定[J].中国皮肤性病学杂志,2014,28(6):567-569.
[2]包丽丽,刘继贤.一级预防措施预防过敏性疾病研究进展[J].中国实用儿科杂志,2013,28(7):543-546.
[3]江明.85例面部皮炎患者过敏原检测与诱因分析[J].实用皮肤病学杂志,2014,7(6):430-431.
[4]吴铁峰.皮肤病症状鉴别诊断与治疗[M].南昌:江西科学技术出版社,1999.
[5]刘玉良,张栋,叶小梦.防风通圣散加减治疗颜面部激素耐药型过敏性皮炎临床研究[J].中医学报,2016,31(10):1582-1585.
[6]刘莲.系统性红斑狼疮患者血清GM-CSF、IL-6和TNF-α的水平测定及临床意义[J].中国现代医学杂志,2014,24(15):62-65.
[7]张红,王强,房俊,等.儿童过敏性紫癜急性期T细胞亚群及B细胞的变化及意义[J].实用医院临床杂志,2017,14(2):75-77.
[8]韦无边,卢柳伊,覃崇宁.复方甘草酸苷在皮肤性病科的应用与研究进展[J].医学综述,2014,20(16):2988-2991.
[9]张禁,杨颜龙,姜功平,等.地氯雷他定联合复方甘草酸苷治疗慢性荨麻疹66例临床观察[J].中国皮肤性病学杂志,2013,27(7):755-756.
[10]谢昭群.复方氟米松软膏联合复方甘草酸苷片治疗婴幼儿湿疹45例[J].中国药业,2012,21(23):41-42.
[11]黄涛.马来酸氯苯那敏联合复方炉甘石洗剂治疗小儿湿疹临床疗效研究[J].首都食品与医药,2016,23(14):51.
[12]陈华.探讨醋酸泼尼松炉甘石洗剂治疗敷贴胶布致皮肤过敏的临床疗效[J].中国卫生标准管理,2016,7(6):103-104.
[13]张志娟,单士军.丁酸氢化可的松联合复方炉甘石洗剂治疗新生儿湿疹的疗效及对患儿炎性因子的影响[J].中国妇幼保健,2018,33(5):1076-1078.
[14]毛越苹,谭国珍,张楚怡,等.枸地氯雷他定片治疗慢性特发性荨麻疹有效性与临床安全性分析[J].中国皮肤性病学杂志,2014,28(9):974-976.
[15]张佩莲,李文华,代自超,等.β趋化因子MCP-1、MIP-1α、RANTES在皮肌炎患者肌肉、皮损中表达的相关性研究[J].皮肤病与性病,2013,35(1):1-4.
[16]刘强,王卿,王欣欣,等.过敏性紫癜患者外周血单个核细胞中Tim-1,Tim-3mRNA表达和血清中IL-2和IL-4含量测定[J].中国皮肤性病学杂志,2014,28(6):567-569.