婴幼儿斯坦利沙门氏菌院内感染病例病原学调查分析
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摘要
目的对平顶山市婴幼儿斯坦利沙门氏菌院内感染病例进行病原学分析,为科学防控提供依据。方法采集外环境标本和可疑菌株进行斯坦利沙门氏菌检测,对阳性菌株进行血清分型和耐药性试验。结果共发现斯坦利沙门氏菌感染病例14例,均为1岁以下婴幼儿,发病时间集中于4月。分离斯坦利沙门氏菌阳性菌株8株,耐药谱一致,均对阿莫西林、头孢噻肟、头孢吡肟等8种抗生素耐药。结论病例间存在院内感染,应加强沙门氏菌病原学监测,合理规范使用抗菌药物,加强消毒效果监测和管理。
Objective To analyze the pathogenic features of Salmonella stanley hospital infection infant cases in Pingdingshan,so as to provide a reference for scientific control and prevention. Methods External environment specimens and suspicious strains were collected for stanley detection,and the positive strains were tested for serotyping and drug resistance. Results A total of 14 Salmonella stanley cases were found,all of which were infants under 1 year of age. The onset time was concentrated in April. Eight strains of stanley positive strains were isolated,and the drug resistance spectrum was consistent. They were resistant to 8 kinds of antibiotics,such as amoxicillin,cefotaxime,cefepime and so on. Conclusion There are nosocomial infections between cases,and the pathogen monitoring of Salmonella should be strengthened. The use of antibiotics should be rationally regulated,and the monitoring and management of disinfection effects should be enhanced.
Objective To analyze the pathogenic features of Salmonella stanley hospital infection infant cases in Pingdingshan,so as to provide a reference for scientific control and prevention. Methods External environment specimens and suspicious strains were collected for stanley detection,and the positive strains were tested for serotyping and drug resistance. Results A total of 14 Salmonella stanley cases were found,all of which were infants under 1 year of age. The onset time was concentrated in April. Eight strains of stanley positive strains were isolated,and the drug resistance spectrum was consistent. They were resistant to 8 kinds of antibiotics,such as amoxicillin,cefotaxime,cefepime and so on. Conclusion There are nosocomial infections between cases,and the pathogen monitoring of Salmonella should be strengthened. The use of antibiotics should be rationally regulated,and the monitoring and management of disinfection effects should be enhanced.
引文
[1]黄宝兴,马东礼.深圳市某儿童医院沙门菌属菌群分布及耐药性分析[J].实用预防医学,2015,22(7):872,880-881.
[2]黄永亮,张宏雅.一起沙门菌食物中毒的病原学鉴定及药敏试验结果分析[J].实用医学杂志,2012,28(1):143-145.
[3]张建梅,翁琴云,陈泽辉,等.一起沙门菌食物中毒事件的病原检测和溯源分析[J].现代预防医学,2013,40(20):3815-3818.
[4]国红娟,王春艳,祖文刚,等.一起由芝麻酱蘸料引起的都柏林沙门氏菌食物中毒流行病学调查[J].医学动物防制,2018,34(1):77-79.
[5]中华人民共和国卫生部.GB 4789.4-2010食品安全国家标准食品微生物学检验沙门氏菌检验[S].北京:中国标准出版社,2010.
[6]修宁宁,潘俊均,邓沛汶,等.东莞地区2岁以下婴幼儿沙门菌感染血清型分布特征研究[J].国际检验医学杂志,2017,38(11):1502-1504.
[7]张晶,张欣强,侯水平,等.广州市566株腹泻病例沙门菌的血清型分布及耐药性分析[J].实用预防医学,2016,23(5):616-617,623.
[8]鞠长燕,潘伟光,黄锐敏,等.2010-2013年广东省深圳市南山区腹泻患者沙门菌血清学和脉冲场凝胶电泳分析[J].疾病监测,2015,30(1):30-34.
[9]方艳梅,杨春晓,张丽荣,等.珠海市斯坦利沙门菌耐药特征和分子分型分析[J].中国热带医学,2017,17(9):862-866.
[10]穆玉娇,张白帆,赵嘉咏,等.河南省腹泻患者沙门菌血清型及其耐药性变迁研究[J].中国卫生检验杂志,2016,26(9):1335-1338.
[11]赵嘉咏,郝宝林,谢志强,等.河南省一起斯坦利沙门菌聚集性病例的病原学研究及溯源分析[J].中国人兽共患病学报,2016,32(5):497-501.
[12]杨毅,王超,巴特尔,等.沙门氏菌的PFGE分型及耐药分析[J].医学动物防制,2016,32(10):1134-1136.
[13]KOUTSLIOUTSOU A,MARTIS EA,WHITE DG,et al.A soxRS-constitutive mutation contributing to antibiotic resistance in a clinical isolate of Salmonella enterica(Serovar typhimurium)[J].Antimicrob Agents Chemother,2001,45(10):38-43.
[14]梁达炜,卢解红,江凌晓,等.广州市136株沙门菌耐药表型与分子分型研究[J].现代预防医学,2016,43(4):696-699.
[15]郭皓,王仁凡,王卓,等.脉冲场凝胶电泳技术对一起肠炎沙门菌疫情分子生物学分析[J].预防医学情报杂志,2010,26(7):594-595.
[2]黄永亮,张宏雅.一起沙门菌食物中毒的病原学鉴定及药敏试验结果分析[J].实用医学杂志,2012,28(1):143-145.
[3]张建梅,翁琴云,陈泽辉,等.一起沙门菌食物中毒事件的病原检测和溯源分析[J].现代预防医学,2013,40(20):3815-3818.
[4]国红娟,王春艳,祖文刚,等.一起由芝麻酱蘸料引起的都柏林沙门氏菌食物中毒流行病学调查[J].医学动物防制,2018,34(1):77-79.
[5]中华人民共和国卫生部.GB 4789.4-2010食品安全国家标准食品微生物学检验沙门氏菌检验[S].北京:中国标准出版社,2010.
[6]修宁宁,潘俊均,邓沛汶,等.东莞地区2岁以下婴幼儿沙门菌感染血清型分布特征研究[J].国际检验医学杂志,2017,38(11):1502-1504.
[7]张晶,张欣强,侯水平,等.广州市566株腹泻病例沙门菌的血清型分布及耐药性分析[J].实用预防医学,2016,23(5):616-617,623.
[8]鞠长燕,潘伟光,黄锐敏,等.2010-2013年广东省深圳市南山区腹泻患者沙门菌血清学和脉冲场凝胶电泳分析[J].疾病监测,2015,30(1):30-34.
[9]方艳梅,杨春晓,张丽荣,等.珠海市斯坦利沙门菌耐药特征和分子分型分析[J].中国热带医学,2017,17(9):862-866.
[10]穆玉娇,张白帆,赵嘉咏,等.河南省腹泻患者沙门菌血清型及其耐药性变迁研究[J].中国卫生检验杂志,2016,26(9):1335-1338.
[11]赵嘉咏,郝宝林,谢志强,等.河南省一起斯坦利沙门菌聚集性病例的病原学研究及溯源分析[J].中国人兽共患病学报,2016,32(5):497-501.
[12]杨毅,王超,巴特尔,等.沙门氏菌的PFGE分型及耐药分析[J].医学动物防制,2016,32(10):1134-1136.
[13]KOUTSLIOUTSOU A,MARTIS EA,WHITE DG,et al.A soxRS-constitutive mutation contributing to antibiotic resistance in a clinical isolate of Salmonella enterica(Serovar typhimurium)[J].Antimicrob Agents Chemother,2001,45(10):38-43.
[14]梁达炜,卢解红,江凌晓,等.广州市136株沙门菌耐药表型与分子分型研究[J].现代预防医学,2016,43(4):696-699.
[15]郭皓,王仁凡,王卓,等.脉冲场凝胶电泳技术对一起肠炎沙门菌疫情分子生物学分析[J].预防医学情报杂志,2010,26(7):594-595.