小柴胡汤加减联合奥美拉唑对慢性胃炎具有治疗增效作用
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摘要
本研究选取本院收治的慢性胃炎患者114例并根据治疗方法不同分为对照组和观察组。对照组患者采用奥美拉唑治疗,观察组患者采用奥美拉唑联合小柴胡汤加减治疗,分析小柴胡汤加减联合奥美拉唑对慢性胃炎血清表皮生长因子(EGF)、胃黏膜氧化酶-2 (COX-2)蛋白表达情况的影响及护理对策。研究结果表明,治疗前两组患者胃镜检查充血水肿、糜烂、黏膜白相、颗粒增生发生率比较无统计学差异(p>0.05);治疗后,观察组患者各项指标发生率低于对照组(p<0.05);治疗前,两组患者血清EGF、Bcl-2、CRP和胃黏膜COX-2、P-p65表达水平比较无统计学差异(p>0.05),治疗后发现观察组患者血清EGF水平高于对照组,血清Bcl-2、CRP和胃黏膜COX-2、P-p65表达水平低于对照组(p<0.05);治疗前,两组患者在躯体功能、躯体职能、躯体疼痛、情感职能、心理健康评分等生活质量评分上比较无统计学差异(p<0.05),治疗后,观察组患者各项评分高于对照组(p>0.05)。本研究初步结论说明,小柴胡汤加减联合奥美拉唑治疗慢性胃炎疗效显著,可改善患者血清EGF、Bcl-2和胃黏膜COX-2表达水平,提高患者生活质量。
To analyze the effect of the combination of modified Xiaocaihu decoction and omeprazole on the expression of serum epidermal growth factor(EGFN) and gastric mucosal oxygenase-2(COX-2) protein in patients with chronic gastritis and the nursing countermeasures, 114 patients with chronic gastritis in our hospital were selected and divided into two groups: control group and observation group, according to different treating methods.The control group was treated with omeprazole. The patients in observation group were treated with omeprazole combined with Xiaocaihu decoction. It was found in this study that before treatment, there was no significant difference in the incidence of hyperemia, edema, erosion, mucosal white phase and granular hyperplasia between the two groups(p>0.05). After treatment, the items in the patients in the observation group were lower than those of the control group(p<0.05). Before treatment, serum levels of EGF-1, Bcl-2, CRP and the expression level of gastric mucosal COX-2 and P-p65 in both groups had no statistical differences(p>0.05). After treatment, the serum EGF level of the patients in the observation group was higher than that of the control group, and the levels of Bcl-2, CRP, COX-2 and P-p65 in the gastric mucosa were higher in the observation group(p<0.05). Before treatment, there was no significant difference in the scores of life quality, which were physical function, physiological role, physical pain,emotional function, and mental health, between the two groups(p>0.05). After treatment, all the scores in observation group were higher than those in the control group(p<0.05). The preliminary results of this study indicated that modified Xiaochaihu decoction combined with omeprazole was effective in the treatment of chronic gastritis. It could improve the level of serum EGF, Bcl-2 and the expression of gastric mucosal COX-2, and improve the life quality of patients with chronic gastritis.
To analyze the effect of the combination of modified Xiaocaihu decoction and omeprazole on the expression of serum epidermal growth factor(EGFN) and gastric mucosal oxygenase-2(COX-2) protein in patients with chronic gastritis and the nursing countermeasures, 114 patients with chronic gastritis in our hospital were selected and divided into two groups: control group and observation group, according to different treating methods.The control group was treated with omeprazole. The patients in observation group were treated with omeprazole combined with Xiaocaihu decoction. It was found in this study that before treatment, there was no significant difference in the incidence of hyperemia, edema, erosion, mucosal white phase and granular hyperplasia between the two groups(p>0.05). After treatment, the items in the patients in the observation group were lower than those of the control group(p<0.05). Before treatment, serum levels of EGF-1, Bcl-2, CRP and the expression level of gastric mucosal COX-2 and P-p65 in both groups had no statistical differences(p>0.05). After treatment, the serum EGF level of the patients in the observation group was higher than that of the control group, and the levels of Bcl-2, CRP, COX-2 and P-p65 in the gastric mucosa were higher in the observation group(p<0.05). Before treatment, there was no significant difference in the scores of life quality, which were physical function, physiological role, physical pain,emotional function, and mental health, between the two groups(p>0.05). After treatment, all the scores in observation group were higher than those in the control group(p<0.05). The preliminary results of this study indicated that modified Xiaochaihu decoction combined with omeprazole was effective in the treatment of chronic gastritis. It could improve the level of serum EGF, Bcl-2 and the expression of gastric mucosal COX-2, and improve the life quality of patients with chronic gastritis.
引文
Cai Y.J.,Hu Y.,Lin X.F.,Hong J.D.,and Li X.M.,2012,Efficacy of integrated traditional Chinese medicine and western medicine therapy on Laryrigophargngeal Reflux with chronic gastritis,Hebei Zhongyi(Hebei Journal of Traditional Chinese Medicine),34(4):506-507,510(蔡银君,胡毅,林晓芬,洪已东,李晓敏,2012,利咽消滞汤联合奥美拉唑及多潘立酮治疗喉咽反流合并慢性胃炎临床观察,河北中医,34(4):506-507,510)
Glass B.D.,and Haywood A.,2015,Stability considerations in liquid dosage forms extemporaneously prepared from commercially available products,Journal of Pharmacy&Pharmaceutical Sciences,9(3):398-426
Li S.H.,Liu H.Y.,and Tang Y.P.,2016,Clinical observation on48 cases of peptic ulcer of spleen and stomach deficiency type caused by helicobacter pylori infection treated by xiangsha liujunzi decoction combined with quadruple therapy,Zhongyi Zazhi(Journal of Traditional Chinese Medicine),57(21):1854-1857(李淑红,刘华一,唐艳萍,2016,香砂六君子汤联合四联疗法治疗幽门螺杆菌感染致脾胃虚弱型消化性溃疡48例临床观察,中医杂志,57(21):1854-1857)
Li X.J.,Li J.X.,Tang F.B.,Wang T.Y.,Zhang L.,Guan W.Y.,Zhang L.,Ma J.L.,and Liu W.D.,2015,Factors associated with the efficacy of Helicobacter pylori eradication,Zhonghua Zhongliu Fangzhi Zazhi(Chinese Journal of Cancer Prevention and Treatment),22(15):1165-1169(李晓娟,李哲轩,汤富兵,王天怡,张雷,关炜庠,张联,马峻岭,刘卫东,2015,幽门螺杆菌根除效果影响因素分析,中华肿瘤防治杂志,22(15):1165-1169)
Naunton M.,Peterson G.M.,and Bleasel M.D.,2015,Overuse of proton pump inhibitors,J.Clin.Pharm.Ther.,25(5):333-340
Park W.G.,Shaheen N.J.,Cohen J.,Pike I.M.,Adler D.G.,Inadomi J.M.,Laine L.A.,Lieb J.G.,Rizk M.K.,Sawhney M.S.,and Wani S.,2015,Quality indicators for EGD,Gastrointestinal Endoscopy,81(1):17-30
Pinto L.A.,Cordeiro K.W.,Carrasco V.,Carollo C.A.,Cardoso C.A.,Argado觡a E.J.,and Freitas Kde C.,2015,Antiulcerogenic activity of Carica papaya,seed in rats,Naunyn.Schmiedebergs Arch.Pharmacol.,388(3):305-317
Tang F.S.,Zhang X.H.,Lan X.,Meng C.,and Wang Y.H.,2016,Study on the dissolution of xiaochaihu pill from different manufacturers,Zhongguo Yaofang(China Pharmacy),27(30):4272-4274(唐富山,张晓慧,兰雪,孟翠,王玉和,2016,不同厂家小柴胡汤丸的溶出度研究,中国药房,27(30):4272-4274)
Wang N.,Wang C.J.,and Li Y.F.,2016,Clinical observation on kangyou heji combined with quadri-combination therapy treating 25 patients with chronic gastritis with positive Helicobacter pylori,Zhongyi Zazhi(Journal of Traditional Chinese Medicine),57(2):136-139(汪楠,王垂杰,李玉锋,2016,抗幽合剂联合四联疗法治疗慢性胃炎合并幽门螺杆菌阳性患者25例临床观察,中医杂志,57(2):136-139)
Ye J.F.,2013,Clinical observation of omeprazole joint clarithromycin in the treatment of 48 case chronic gastritis,Liaoning Yixueyuan Xuebao(Journal of Liaoning Medical University),34(1):21-22(叶剑飞,2013,奥美拉唑联合克拉霉素治疗48例慢性胃炎临床疗效观察,辽宁医学院学报,34(1):21-22)
Yu H.L.,Ma C.J.,Han X.M.,Zhao P.W.,and Zhao L.Y.,2016,Experimental study of effect of Xiao Chai Hu Tang on C6glioma,Zhongguo Mianyixue Zazhi(Chinese Journal of Immunology),32(7):988-991(于慧玲,麻春杰,韩雪梅,赵鹏伟,赵灵燕,2016,小柴胡汤对C6胶质瘤抑瘤作用的实验研究,中国免疫学杂志,32(7):988-991)
Glass B.D.,and Haywood A.,2015,Stability considerations in liquid dosage forms extemporaneously prepared from commercially available products,Journal of Pharmacy&Pharmaceutical Sciences,9(3):398-426
Li S.H.,Liu H.Y.,and Tang Y.P.,2016,Clinical observation on48 cases of peptic ulcer of spleen and stomach deficiency type caused by helicobacter pylori infection treated by xiangsha liujunzi decoction combined with quadruple therapy,Zhongyi Zazhi(Journal of Traditional Chinese Medicine),57(21):1854-1857(李淑红,刘华一,唐艳萍,2016,香砂六君子汤联合四联疗法治疗幽门螺杆菌感染致脾胃虚弱型消化性溃疡48例临床观察,中医杂志,57(21):1854-1857)
Li X.J.,Li J.X.,Tang F.B.,Wang T.Y.,Zhang L.,Guan W.Y.,Zhang L.,Ma J.L.,and Liu W.D.,2015,Factors associated with the efficacy of Helicobacter pylori eradication,Zhonghua Zhongliu Fangzhi Zazhi(Chinese Journal of Cancer Prevention and Treatment),22(15):1165-1169(李晓娟,李哲轩,汤富兵,王天怡,张雷,关炜庠,张联,马峻岭,刘卫东,2015,幽门螺杆菌根除效果影响因素分析,中华肿瘤防治杂志,22(15):1165-1169)
Naunton M.,Peterson G.M.,and Bleasel M.D.,2015,Overuse of proton pump inhibitors,J.Clin.Pharm.Ther.,25(5):333-340
Park W.G.,Shaheen N.J.,Cohen J.,Pike I.M.,Adler D.G.,Inadomi J.M.,Laine L.A.,Lieb J.G.,Rizk M.K.,Sawhney M.S.,and Wani S.,2015,Quality indicators for EGD,Gastrointestinal Endoscopy,81(1):17-30
Pinto L.A.,Cordeiro K.W.,Carrasco V.,Carollo C.A.,Cardoso C.A.,Argado觡a E.J.,and Freitas Kde C.,2015,Antiulcerogenic activity of Carica papaya,seed in rats,Naunyn.Schmiedebergs Arch.Pharmacol.,388(3):305-317
Tang F.S.,Zhang X.H.,Lan X.,Meng C.,and Wang Y.H.,2016,Study on the dissolution of xiaochaihu pill from different manufacturers,Zhongguo Yaofang(China Pharmacy),27(30):4272-4274(唐富山,张晓慧,兰雪,孟翠,王玉和,2016,不同厂家小柴胡汤丸的溶出度研究,中国药房,27(30):4272-4274)
Wang N.,Wang C.J.,and Li Y.F.,2016,Clinical observation on kangyou heji combined with quadri-combination therapy treating 25 patients with chronic gastritis with positive Helicobacter pylori,Zhongyi Zazhi(Journal of Traditional Chinese Medicine),57(2):136-139(汪楠,王垂杰,李玉锋,2016,抗幽合剂联合四联疗法治疗慢性胃炎合并幽门螺杆菌阳性患者25例临床观察,中医杂志,57(2):136-139)
Ye J.F.,2013,Clinical observation of omeprazole joint clarithromycin in the treatment of 48 case chronic gastritis,Liaoning Yixueyuan Xuebao(Journal of Liaoning Medical University),34(1):21-22(叶剑飞,2013,奥美拉唑联合克拉霉素治疗48例慢性胃炎临床疗效观察,辽宁医学院学报,34(1):21-22)
Yu H.L.,Ma C.J.,Han X.M.,Zhao P.W.,and Zhao L.Y.,2016,Experimental study of effect of Xiao Chai Hu Tang on C6glioma,Zhongguo Mianyixue Zazhi(Chinese Journal of Immunology),32(7):988-991(于慧玲,麻春杰,韩雪梅,赵鹏伟,赵灵燕,2016,小柴胡汤对C6胶质瘤抑瘤作用的实验研究,中国免疫学杂志,32(7):988-991)