孕酮、β-HCG对早期异常妊娠患者妊娠结局的影响
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摘要
目的探讨孕早期孕酮及血清人绒毛膜促性腺激素(β-HCG)在异常妊娠的诊断和妊娠结局的应用价值。方法回顾性分析2015年12月至2016年12月经郑州大学第三附属医院门诊确诊的孕早期异常妊娠患者449例为研究对象。分析不同孕酮、β-HCG及变化趋势对妊娠结局的影响。结果①首次孕酮<15μg/L组中,末次孕酮<15μg/L组胚胎停育的发生率高于其余两组,组间比较有统计学意义(P<0.05)。②治疗后,孕酮变化趋势分层内,β-HCG翻倍良好组胎儿大小小于实际孕周、胚胎停育发生率明显小于其余三组,组间比较有统计学意义(P<0.05)。③治疗前,孕酮<15μg/L组新生儿出生体重值最低,孕酮≥25μg/L组最高,组间比较有统计学意义(P<0.05)。结论孕酮、β-HCG对妊娠结局及新生儿出生体重具有相关性,孕酮、β-HCG变化趋势对妊娠结局具有相关性。
Objective To explore the application value of progesterone and human chorionic gonadotropin(β-HCG) combined with ultrasound in the diagnosis and prognosis of abnormal pregnancy. Method From December 2015 to December 2016, 449 cases of abnormal early pregnancy diagnosed in the outpatient department of the third affiliated hospital of zhengzhou university were analyzed retrospectively.The effects of different progesterone, β-HCG and change trend on pregnancy outcome were analyzed. Results ① In the first progesterone< 15μg/L group, the incidence rate of embryo damage was higher in the last progesterone< 15μg/L group than that in the other two groups, and the comparison between the groups was statistically significant(P<0.05). ② After treatment, the progesterone change trend stratified, the β-HCG doubled the fetus size was smaller than the actual gestational age, the embryonic stop rate was significantly smaller than the other three groups, the group was statistically significant(P<0.05). ③ Before treatment, the progesterone<15μg/L group has the lowest birth weight, progesterone≥25 μg/L group has the highest, the comparison between groups has the statistical significance(P<0.05). Conclusion Progesterone and β-HCG were correlated with pregnancy outcome and birth weight of newborn, and the change trend of progesterone and β-HCG was correlated with pregnancy outcome.
Objective To explore the application value of progesterone and human chorionic gonadotropin(β-HCG) combined with ultrasound in the diagnosis and prognosis of abnormal pregnancy. Method From December 2015 to December 2016, 449 cases of abnormal early pregnancy diagnosed in the outpatient department of the third affiliated hospital of zhengzhou university were analyzed retrospectively.The effects of different progesterone, β-HCG and change trend on pregnancy outcome were analyzed. Results ① In the first progesterone< 15μg/L group, the incidence rate of embryo damage was higher in the last progesterone< 15μg/L group than that in the other two groups, and the comparison between the groups was statistically significant(P<0.05). ② After treatment, the progesterone change trend stratified, the β-HCG doubled the fetus size was smaller than the actual gestational age, the embryonic stop rate was significantly smaller than the other three groups, the group was statistically significant(P<0.05). ③ Before treatment, the progesterone<15μg/L group has the lowest birth weight, progesterone≥25 μg/L group has the highest, the comparison between groups has the statistical significance(P<0.05). Conclusion Progesterone and β-HCG were correlated with pregnancy outcome and birth weight of newborn, and the change trend of progesterone and β-HCG was correlated with pregnancy outcome.
引文
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[11]岳红云,侯爱琴,刘华.妊娠早期绒毛膜下血肿患者孕酮及HCG水平与妊娠结局的关系[J].山西医科大学学报,2015,46(6):585-586.
[12]Alexander E K,Pearce E N,Brent G A,et al.2017 Guidelines of the American Thyroid Association for the Diagnosis and Management of Thyroid Disease During Pregnancy and the Postpartum[J].Thyroid,2017,27(3):315-389.
[13]da Cunha A C,Da S B R,Dal Pai T K,et al.Prenatal diagnosis of a true umbilical cord knot in a fetus with intrauterine growth restriction and placenta accreta[J].Taiwanese Journal of Obstetrics Gynecology,2016,55(4):616-617.
[14]罗晓芳,漆洪波.胎儿生长受限的胎盘因素及其临床诊治[J].中国实用妇科与产科杂志,2016,32(4):298-302.
[15]李笑天.重视胎盘源性疾病提高母胎医学质量[J].中国实用妇科与产科杂志,2016,32(4):289-290.
[2]陈永红.血清β-HCG与孕酮联合测定对早期异常妊娠的诊断价值[J]中国医药指南,2015,13(14):71-72.
[3]魏春梅,潘虹,袁晓群.先兆流产不同妊娠结局妇女超声、血清绒毛膜促性腺激、血清孕酮、雌二醇的检查结果分析[J].实验与检验医学,2017,35(4):540-542.
[4]李晓燕,周希亚,程歆琦,等.自然妊娠早孕期孕酮水平及其检测价值的研究[J].生殖医学杂志,2017,26(2):148-152.
[5]Kalinka J,Szekeres-Bartho J.The impact of dydrogesterone supplementation on hormonal profile and progesterone-induced blocking factor concentrations in women with threatened abortion[J].American Journal of Reproductive Immunology,2015,53(4):166-171.
[6]刘凌芝.血清孕酮及β-HCG值对异常妊娠早早孕阶段患者妊娠结局的意义[J].实用妇科内分泌电子杂志,2015,2(7):1-2.
[7]马琳琳,梁琳,吕爱明,等.孕早期首次雌二醇、黄体酮及β-HCG水平及其变化趋势对妊娠结局的预测价值研究[J].中国临床医生杂志,2016,44(2):98-100.
[8]Shi X,He Z,Gao Y,et al.Placental expression of PHLDA2 in selective intrauterine growth restriction in monozygotic twins[J].Placenta,2014,35(6):428-430.
[9]Hutson J R,Lubetsky A,Eichhorst J,et al.Adverse Placental Effect of Formic Acid on h CG Secretion Is Mitigated by Folic Acid[J].Alcohol and Alcoholism,2013,48(3):283-287.
[10]Abdelaal N,Sanad Z,Shaheen A,et al.Effect of vaginal progesterone in combination with cervical cerclage on improved gestational age and perinata outcome in twin pregnancy:A prospective randomized study[J].2017,6(8):3224.
[11]岳红云,侯爱琴,刘华.妊娠早期绒毛膜下血肿患者孕酮及HCG水平与妊娠结局的关系[J].山西医科大学学报,2015,46(6):585-586.
[12]Alexander E K,Pearce E N,Brent G A,et al.2017 Guidelines of the American Thyroid Association for the Diagnosis and Management of Thyroid Disease During Pregnancy and the Postpartum[J].Thyroid,2017,27(3):315-389.
[13]da Cunha A C,Da S B R,Dal Pai T K,et al.Prenatal diagnosis of a true umbilical cord knot in a fetus with intrauterine growth restriction and placenta accreta[J].Taiwanese Journal of Obstetrics Gynecology,2016,55(4):616-617.
[14]罗晓芳,漆洪波.胎儿生长受限的胎盘因素及其临床诊治[J].中国实用妇科与产科杂志,2016,32(4):298-302.
[15]李笑天.重视胎盘源性疾病提高母胎医学质量[J].中国实用妇科与产科杂志,2016,32(4):289-290.