进展期胃癌术后腹腔热灌注化疗的研究进展
|
摘要
胃癌为临床常见恶性肿瘤之一,外科手术是其重要治疗方案,进展期胃癌患者术后5年生存率较低,而术后癌灶复发成为影响患者预后的重要因素。随着国内医学水平不断发展,腹腔热灌注化疗技术得以不断改进,其在进展期胃癌患者术后辅助治疗中的应用日益广泛,长期临床实践表明预防性运用腹腔热灌注化疗可明显降低进展期胃癌术后复发率并提高其5年生存率,在改善患者生存质量及总体临床疗效方面的作用明确。本文旨在对中国进展期胃癌术后腹腔热灌注化疗的临床应用进展进行综述。
Gastric cancer is one of the most common clinical malignant tumors; surgery is an important treatment for it. The postoperative 5-year survival rate of patients with advanced gastric cancer is low; postoperative tumor recurrence is an important factor influencing the prognosis of patients. With the continuous development of domestic medicine, the technology of intraperitoneal hyperthermic perfusion chemotherapy is improved continuously, and is widely used in postoperative adjuvant therapy for patients with advanced gastric cancer. Long-term clinical practice shows that prophylactic use of hyperthermic intraperitoneal chemotherapy for advanced gastric cancer could significantly reduce the recurrence rate of gastric cancer and improve the 5-year survival rate of patients.It plays a positive role in improving the quality of life of patients and overall clinical curative effect. In this review, the clinical application of hyperthermic intraperitoneal chemotherapy for advanced gastric cancer in China was summarized.
Gastric cancer is one of the most common clinical malignant tumors; surgery is an important treatment for it. The postoperative 5-year survival rate of patients with advanced gastric cancer is low; postoperative tumor recurrence is an important factor influencing the prognosis of patients. With the continuous development of domestic medicine, the technology of intraperitoneal hyperthermic perfusion chemotherapy is improved continuously, and is widely used in postoperative adjuvant therapy for patients with advanced gastric cancer. Long-term clinical practice shows that prophylactic use of hyperthermic intraperitoneal chemotherapy for advanced gastric cancer could significantly reduce the recurrence rate of gastric cancer and improve the 5-year survival rate of patients.It plays a positive role in improving the quality of life of patients and overall clinical curative effect. In this review, the clinical application of hyperthermic intraperitoneal chemotherapy for advanced gastric cancer in China was summarized.
引文
[1] Kanda M, Mizuno A, Fujii T, et al. Tumor infiltrative pattern predicts sites of recurrence after curative gastrectomy for stages 2 and 3 gastric cancer[J]. Ann Surg Oncol, 2016, 23(6):1-7.
[2] Yamamoto M, Kurokawa Y, Miyazaki Y, et al. Usefulness of preoperative plasma fibrinogen versus other prognostic markers for predicting gastric cancer recurrence[J]. World J Surg, 2016, 40(8):1904-1909.
[3]王力,沈洪,宋国栋,等.进展期胃癌患者根治术后复发的危险因素分析[J].山东医药,2016,56(39):42-44.
[4]沈国杰,朱侃恺,邬一军,等.新辅助化疗联合胃癌根治术治疗进展期胃癌的临床疗效[J].中华消化外科杂志,2017,16(3):240-244.
[5]李雁,周云峰,谢丛华,等.细胞减灭术加腹腔热灌注化疗治疗胃癌腹膜转移癌的临床研究[J].肿瘤防治研究,2016,43(4):1734-1740.
[6]姬忠贺,梁寒,季加孚,等.细胞减灭术加腹腔热灌注化疗治疗胃癌腹膜癌的系统分析[J].肿瘤防治研究,2017,44(12):796-803.
[7]许志恒,俞金龙,崔春晖,等.老年胃癌患者术后腹腔热灌注化疗的疗效观察[J].中华胃肠外科杂志,2016,19(5):590-591.
[8]王启船,屈中玉,张辉,等.胃癌根治术后腹腔恒温热灌注联合全身化疗的临床疗效研究[J].重庆医学,2017,46(15):2134-2137.
[9] Scalabre A, Philippe-Chomette P, Passot G, et al. Cytoreductive surgery and hyperthermic intraperitoneal perfusion with chemotherapy in children with peritoneal tumor spread:A french nationwide study over14 years[J]. Pediatric Blood Cancer, 2018, 65(4):e26923.
[10]董怡,李丹,马宁,等.晚期卵巢癌腹腔热灌注化疗的临床研究[J].中国妇幼保健,2014,29(10):1543-1545.
[11] Stewart CL, Gleisner A, Halpern A, et al. Implications of hyperthermic intraperitoneal chemotherapy perfusion-related hyperglycemia[J]. Ann Surg Oncol, 2018, 16(2):1-5.
[12]宋林杰,那兴邦,李松岩,等.腹腔热灌注化疗用于进展期结直肠癌术后辅助治疗的临床观察[J].解放军医学院学报,2017,38(12):1098-1101.
[13]武海涛,杨肖军,孙建华,等.洛铂联合多西他赛行肿瘤细胞减灭术加腹腔热灌注化疗治疗腹膜癌的临床观察[J].肿瘤防治研究,2016,43(2):150-157.
[14]钱国武,张海洋,王新伟,等.术中及术后早期腹腔热灌注化疗在局部进展期胃癌的临床价值[J].重庆医学,2018,47(14):1928-1930.
[15]张增梅,李胜云,魏薇.温热灌注液在经皮肾镜手术中的应用效果[J].中华实验外科杂志,2014,31(3):657-658.
[16]郭履平,江艳.加温灌注液对经皮肾镜手术患者生理指标影响的研究[J].热带医学杂志,2010,10(7):845-847.
[17]周欣峰,姬舒荣,陈中皓,等.腹腔灌注化疗联合内生场热疗治疗胰腺癌恶性腹水的疗效[J].现代生物医学进展,2016,16(1):88-90.
[18]卢宜民,孔忆寒,张东兴.内生场加热腹腔热灌注化疗治疗晚期恶性肿瘤[J].肿瘤学杂志,2007,13(4):329-330.
[19]崔书中,巴明臣,唐鸿生.腹腔热灌注化疗技术方法变迁及展望[J].中华临床医师杂志(电子版),2011,5(7):2039-2042.
[20]曲展,刘晓丽,李红梅.桂枝茯苓加味汤直肠灌注法结合微波治疗盆腔瘀血综合征临床观察[J].黑龙江中医药,2011,40(6):17-18.
[21]崔欢,张菊新.高精度持续循环腹腔热灌注化疗联合静脉化疗治疗卵巢癌的临床研究[J].国际妇产科学杂志,2014,41(1):77-79.
[22]郑曦,张青,郭宏骞.热灌注化疗治疗非肌层浸润性膀胱癌的研究进展[J].东南大学学报(医学版),2016,35(4):617-621.
[23] Desiderio J, Chao J, Melstrom L, et al. The 30-year experience-A metaanalysis of randomised and high-quality non-randomised studies of hyperthermic intraperitoneal chemotherapy in the treatment of gastric cancer[J]. Eur J Cancer, 2017,(79):1-14.
[24]陆维祺,万柳华,锁涛,等.我国进展期胃癌围手术期行预防性腹腔热灌注化疗的研究进展[J].中国肿瘤临床,2012,39(22):1750-1753.
[25] Chua TC, Yan TD, Morris DL. Outcomes of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for peritoneal mesothelioma:the Australian experience[J]. J Surg Oncol, 2009, 99(2):109-113.
[26]姚春梅,肖克源,马淑盟,等.进展期胃癌术后辅助放化疗与单纯化疗的比较[J].重庆医学,2016,45(17):2348-2351.
[27]张跃,柴杰,张毅,等.进展期胃癌术中术后腹腔热灌注化疗初步结果分析[J].中华肿瘤防治杂志,2015,22(18):1475-1478.
[28]陈瑞云,张琳,刘文.胃癌术中腹腔热灌注化疗对术后胃肠道功能恢复的影响[J].中国现代普通外科进展,2017,20(6):458-459.
[29]腹腔热灌注化疗技术临床应用专家协作组.腹腔热灌注化疗技术临床应用专家共识(2016版)[J].中华胃肠外科杂志,2016,19(3):125-129.
[2] Yamamoto M, Kurokawa Y, Miyazaki Y, et al. Usefulness of preoperative plasma fibrinogen versus other prognostic markers for predicting gastric cancer recurrence[J]. World J Surg, 2016, 40(8):1904-1909.
[3]王力,沈洪,宋国栋,等.进展期胃癌患者根治术后复发的危险因素分析[J].山东医药,2016,56(39):42-44.
[4]沈国杰,朱侃恺,邬一军,等.新辅助化疗联合胃癌根治术治疗进展期胃癌的临床疗效[J].中华消化外科杂志,2017,16(3):240-244.
[5]李雁,周云峰,谢丛华,等.细胞减灭术加腹腔热灌注化疗治疗胃癌腹膜转移癌的临床研究[J].肿瘤防治研究,2016,43(4):1734-1740.
[6]姬忠贺,梁寒,季加孚,等.细胞减灭术加腹腔热灌注化疗治疗胃癌腹膜癌的系统分析[J].肿瘤防治研究,2017,44(12):796-803.
[7]许志恒,俞金龙,崔春晖,等.老年胃癌患者术后腹腔热灌注化疗的疗效观察[J].中华胃肠外科杂志,2016,19(5):590-591.
[8]王启船,屈中玉,张辉,等.胃癌根治术后腹腔恒温热灌注联合全身化疗的临床疗效研究[J].重庆医学,2017,46(15):2134-2137.
[9] Scalabre A, Philippe-Chomette P, Passot G, et al. Cytoreductive surgery and hyperthermic intraperitoneal perfusion with chemotherapy in children with peritoneal tumor spread:A french nationwide study over14 years[J]. Pediatric Blood Cancer, 2018, 65(4):e26923.
[10]董怡,李丹,马宁,等.晚期卵巢癌腹腔热灌注化疗的临床研究[J].中国妇幼保健,2014,29(10):1543-1545.
[11] Stewart CL, Gleisner A, Halpern A, et al. Implications of hyperthermic intraperitoneal chemotherapy perfusion-related hyperglycemia[J]. Ann Surg Oncol, 2018, 16(2):1-5.
[12]宋林杰,那兴邦,李松岩,等.腹腔热灌注化疗用于进展期结直肠癌术后辅助治疗的临床观察[J].解放军医学院学报,2017,38(12):1098-1101.
[13]武海涛,杨肖军,孙建华,等.洛铂联合多西他赛行肿瘤细胞减灭术加腹腔热灌注化疗治疗腹膜癌的临床观察[J].肿瘤防治研究,2016,43(2):150-157.
[14]钱国武,张海洋,王新伟,等.术中及术后早期腹腔热灌注化疗在局部进展期胃癌的临床价值[J].重庆医学,2018,47(14):1928-1930.
[15]张增梅,李胜云,魏薇.温热灌注液在经皮肾镜手术中的应用效果[J].中华实验外科杂志,2014,31(3):657-658.
[16]郭履平,江艳.加温灌注液对经皮肾镜手术患者生理指标影响的研究[J].热带医学杂志,2010,10(7):845-847.
[17]周欣峰,姬舒荣,陈中皓,等.腹腔灌注化疗联合内生场热疗治疗胰腺癌恶性腹水的疗效[J].现代生物医学进展,2016,16(1):88-90.
[18]卢宜民,孔忆寒,张东兴.内生场加热腹腔热灌注化疗治疗晚期恶性肿瘤[J].肿瘤学杂志,2007,13(4):329-330.
[19]崔书中,巴明臣,唐鸿生.腹腔热灌注化疗技术方法变迁及展望[J].中华临床医师杂志(电子版),2011,5(7):2039-2042.
[20]曲展,刘晓丽,李红梅.桂枝茯苓加味汤直肠灌注法结合微波治疗盆腔瘀血综合征临床观察[J].黑龙江中医药,2011,40(6):17-18.
[21]崔欢,张菊新.高精度持续循环腹腔热灌注化疗联合静脉化疗治疗卵巢癌的临床研究[J].国际妇产科学杂志,2014,41(1):77-79.
[22]郑曦,张青,郭宏骞.热灌注化疗治疗非肌层浸润性膀胱癌的研究进展[J].东南大学学报(医学版),2016,35(4):617-621.
[23] Desiderio J, Chao J, Melstrom L, et al. The 30-year experience-A metaanalysis of randomised and high-quality non-randomised studies of hyperthermic intraperitoneal chemotherapy in the treatment of gastric cancer[J]. Eur J Cancer, 2017,(79):1-14.
[24]陆维祺,万柳华,锁涛,等.我国进展期胃癌围手术期行预防性腹腔热灌注化疗的研究进展[J].中国肿瘤临床,2012,39(22):1750-1753.
[25] Chua TC, Yan TD, Morris DL. Outcomes of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for peritoneal mesothelioma:the Australian experience[J]. J Surg Oncol, 2009, 99(2):109-113.
[26]姚春梅,肖克源,马淑盟,等.进展期胃癌术后辅助放化疗与单纯化疗的比较[J].重庆医学,2016,45(17):2348-2351.
[27]张跃,柴杰,张毅,等.进展期胃癌术中术后腹腔热灌注化疗初步结果分析[J].中华肿瘤防治杂志,2015,22(18):1475-1478.
[28]陈瑞云,张琳,刘文.胃癌术中腹腔热灌注化疗对术后胃肠道功能恢复的影响[J].中国现代普通外科进展,2017,20(6):458-459.
[29]腹腔热灌注化疗技术临床应用专家协作组.腹腔热灌注化疗技术临床应用专家共识(2016版)[J].中华胃肠外科杂志,2016,19(3):125-129.