基于潜类别分析模型的抑郁症分型的研究进展
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摘要
抑郁症具有高度临床异质性,根据症状学特征对抑郁症进行同质性分型可能有助于更具针对性地选择治疗决策,进行疗效评估和预后判断。潜类别分析可通过对潜变量的模型化分析对异质性人群进行同质性分类,有助于提高疾病临床分型的准确性,在抑郁症分型研究中逐渐获得广泛应用。文章对抑郁症临床描述性分型的现状及潜类别分析在疾病分型中的应用进行综述。
Depression is a highly heterogeneous syndrome. Homogeneous subtypes according to symptomatology of illness may contribute to development of individualized treatment, assessment on outcomes and prognosis. Latent class analysis is a flexible statistical approach to determine classes with similar symptom profiles in a heterogeneous group, which has been widely used in data-driven subtyping of depression to increase accuracy of subtyping. This article reviewed existing symptom-based subtypes of depression and findings of researches on latent class analysis based illness subtyping.
Depression is a highly heterogeneous syndrome. Homogeneous subtypes according to symptomatology of illness may contribute to development of individualized treatment, assessment on outcomes and prognosis. Latent class analysis is a flexible statistical approach to determine classes with similar symptom profiles in a heterogeneous group, which has been widely used in data-driven subtyping of depression to increase accuracy of subtyping. This article reviewed existing symptom-based subtypes of depression and findings of researches on latent class analysis based illness subtyping.
引文
[1]Wu Z,Fang Y.Comorbidity of depressive and anxiety disorders:challenges in diagnosis and assessment[J].Shanghai Arch Psychiatry,2014,26(4):227-231.
[2]Cuijpers P,Weitz E,Lamers F,et al.Melancholic and atypical depression as predictor and moderator of outcome in cognitive behavior therapy and pharmacotherapy for adult depression[J].Depress Anxiety,2016,34(3):246-256.
[3]Harald B,Gordon P.Meta-review of depressive subtyping models[J].J Affect Disord,2012,139(2):126.
[4]Kongsted A,Nielsen AM.Latent class analysis in health research[J].J Physiother,2017,63(1):55-58.
[5]Wraith D,Wolfe R.Classifying patients by their characteristics and clinical presentations:the use of latent class analysis[J].Respirology,2014,19(8):1138.
[6]Lanza ST,Rhoades BL.Latent class analysis:an alternative perspective on subgroup analysis in prevention and treatment[J].Prev Sci,2013,14(2):157-168.
[7]Loo HV,Wanders R,Wardenaar KJ,et al.Problems with latent class analysis to detect data-driven subtypes of depression[J].Mol Psychiatry,2018,23(3):495-496.
[8]Loo HMV,Jonge PD,Romeijn JW,et al.Data-driven subtypes of major depressive disorder:a systematic review[J].BMC Medicine,2012,10(1):156.
[9]American Psychiatric Association.Diagnostic and statistical manual of mental disorders(DSM-5?)[M].Washington,DC:American Psychiatric Publishing,2013:160-161,184-186.
[10]Parker G,Fink M,Shorter E,et al.Issues for DSM-5:whither melancholia?The case for its classification as a distinct mood disorder.[J].Am J Psychiatry,2010,167(7):745.
[11]Taylor MA,Fink M.Restoring melancholia in the classification of mood disorders[J].J Affect Disord,2008,105(3):1-14.
[12]Parker G,Bassett D,Outhred T,et al.Defining melancholia:a core mood disorder[J].Bipolar Disord.2017,19:235-237.
[13]Parker G,Roy K,Mitchell P,et al.Atypical depression:a reappraisal[J].Am J Psychiatry,2002,159(9):1470-1479.
[14]Rodgers S,Vandeleur CL,Ajdacic-Gross V,et al.Tracing the associations between sex,the atypical and the combined atypical-melancholic depression subtypes:a path analysis[J].J Affect Disord,2016,190(1):807.
[15]Fava M,Rush AJ,Alpert JE,et al.Difference in treatment outcome in outpatients with anxious versus nonanxious depression:a STAR*D report[J].Am J Psychiatry,2008,165(3):342.
[16]Wu Z,Fang Y.Comorbidity of depressive and anxiety disorders:challenges in diagnosis and assessment[J].Shanghai Arch Psychiatry,2014,26(4):227-231.
[17]Wu Z,Chen J,Yuan C,et al.Difference in remission in a Chinese population with anxious versus nonanxious treatment-resistant depression:a report of OPERATION study[J].J Affect Disord,2013,150(3):834-839.
[18]Nelson JC.Anxiety does not predict response to duloxetine in major depression:results of a pooled analysis of individual patient data from 11 placebocontrolled trials[J].Depress Anxiety,2016,27(1):12-18.
[19]Delaparte L,Yeh FC,Adams P,et al.A comparison of structural connectivity in anxious depression versus non-anxious depression[J].J Psychiatr Res,2017,89:38.
[20]Arnow BA,Blasey C,Williams LM,et al.Depression subtypes in predicting antidepressant response:a report from the i SPOT-D trial[J].Am J Psychiatry,2015,172(8):743.
[21]Uher R,Dernovsek MZ,Mors O,et al.Melancholic,atypical and anxious depression subtypes and outcome of treatment with escitalopram and nortriptyline[J].J Affect Disord,2011,132(1-2):112.
[22]Musil R,Seemüller F,Meyer S,et al.Subtypes of depression and their overlap in a naturalistic inpatient sample of major depressive disorder[J].Int J Methods Psychiatr Res,2017(2/3):e1569.
[23]王孟成.潜类别分析模型概述[M]//王孟成.潜变量建模与Mplus应用(基础篇).重庆:重庆大学出版社,2014:3-8.
[24]邱皓政.潜在类别分析原理[M]//邱皓政.潜在类别模型的原理与技术.北京:北京大学出版社,2008:32-34.
[25]Ten HM,Lamers F,Wardenaar K,et al.The identification of symptom-based subtypes of depression:a nationally representative cohort study[J].J Affect Disord,2016,190(1):395-406.
[26]Lamers F,De JP,Nolen WA,et al.Identifying depressive subtypes in a large cohort study:results from the Netherlands Study of Depression and Anxiety(NESDA)[J].J Clin Psychiatr,2010,71(12):1582.
[27]Li Y,Aggen S,Shi S,et al.Subtypes of major depression:latent class analysis in depressed Han Chinese women[J].Psychol Med,2014,44(15):3275.
[28]Prisciandaro JJ,Roberts JE.A comparison of the predictive abilities of dimensional and categorical models of unipolar depression in the National Comorbidity Survey[J].Psychol Med,2009,39(7):1087-1096.
[29]Ulbricht CM,Rothschild AJ,Lapane KL.The association between latent depression subtypes and remission after treatment with citalopram:a latent class analysis with distal outcome[J].J Affect Disord,2015,188(12):270.
[30]李丽霞,赵丽,周舒冬,等.群体异质性研究的潜变量分析方法[J].中国卫生统计,2015,32(4):711-715.
[31]Ulbricht CM,Dumenci L,Rothschild AJ,et al.Changes in depression subtypes for women during treatment with citalopram:a latent transition analysis[J].Arch Womens Ment Health,2016,19(5):769-778.
[2]Cuijpers P,Weitz E,Lamers F,et al.Melancholic and atypical depression as predictor and moderator of outcome in cognitive behavior therapy and pharmacotherapy for adult depression[J].Depress Anxiety,2016,34(3):246-256.
[3]Harald B,Gordon P.Meta-review of depressive subtyping models[J].J Affect Disord,2012,139(2):126.
[4]Kongsted A,Nielsen AM.Latent class analysis in health research[J].J Physiother,2017,63(1):55-58.
[5]Wraith D,Wolfe R.Classifying patients by their characteristics and clinical presentations:the use of latent class analysis[J].Respirology,2014,19(8):1138.
[6]Lanza ST,Rhoades BL.Latent class analysis:an alternative perspective on subgroup analysis in prevention and treatment[J].Prev Sci,2013,14(2):157-168.
[7]Loo HV,Wanders R,Wardenaar KJ,et al.Problems with latent class analysis to detect data-driven subtypes of depression[J].Mol Psychiatry,2018,23(3):495-496.
[8]Loo HMV,Jonge PD,Romeijn JW,et al.Data-driven subtypes of major depressive disorder:a systematic review[J].BMC Medicine,2012,10(1):156.
[9]American Psychiatric Association.Diagnostic and statistical manual of mental disorders(DSM-5?)[M].Washington,DC:American Psychiatric Publishing,2013:160-161,184-186.
[10]Parker G,Fink M,Shorter E,et al.Issues for DSM-5:whither melancholia?The case for its classification as a distinct mood disorder.[J].Am J Psychiatry,2010,167(7):745.
[11]Taylor MA,Fink M.Restoring melancholia in the classification of mood disorders[J].J Affect Disord,2008,105(3):1-14.
[12]Parker G,Bassett D,Outhred T,et al.Defining melancholia:a core mood disorder[J].Bipolar Disord.2017,19:235-237.
[13]Parker G,Roy K,Mitchell P,et al.Atypical depression:a reappraisal[J].Am J Psychiatry,2002,159(9):1470-1479.
[14]Rodgers S,Vandeleur CL,Ajdacic-Gross V,et al.Tracing the associations between sex,the atypical and the combined atypical-melancholic depression subtypes:a path analysis[J].J Affect Disord,2016,190(1):807.
[15]Fava M,Rush AJ,Alpert JE,et al.Difference in treatment outcome in outpatients with anxious versus nonanxious depression:a STAR*D report[J].Am J Psychiatry,2008,165(3):342.
[16]Wu Z,Fang Y.Comorbidity of depressive and anxiety disorders:challenges in diagnosis and assessment[J].Shanghai Arch Psychiatry,2014,26(4):227-231.
[17]Wu Z,Chen J,Yuan C,et al.Difference in remission in a Chinese population with anxious versus nonanxious treatment-resistant depression:a report of OPERATION study[J].J Affect Disord,2013,150(3):834-839.
[18]Nelson JC.Anxiety does not predict response to duloxetine in major depression:results of a pooled analysis of individual patient data from 11 placebocontrolled trials[J].Depress Anxiety,2016,27(1):12-18.
[19]Delaparte L,Yeh FC,Adams P,et al.A comparison of structural connectivity in anxious depression versus non-anxious depression[J].J Psychiatr Res,2017,89:38.
[20]Arnow BA,Blasey C,Williams LM,et al.Depression subtypes in predicting antidepressant response:a report from the i SPOT-D trial[J].Am J Psychiatry,2015,172(8):743.
[21]Uher R,Dernovsek MZ,Mors O,et al.Melancholic,atypical and anxious depression subtypes and outcome of treatment with escitalopram and nortriptyline[J].J Affect Disord,2011,132(1-2):112.
[22]Musil R,Seemüller F,Meyer S,et al.Subtypes of depression and their overlap in a naturalistic inpatient sample of major depressive disorder[J].Int J Methods Psychiatr Res,2017(2/3):e1569.
[23]王孟成.潜类别分析模型概述[M]//王孟成.潜变量建模与Mplus应用(基础篇).重庆:重庆大学出版社,2014:3-8.
[24]邱皓政.潜在类别分析原理[M]//邱皓政.潜在类别模型的原理与技术.北京:北京大学出版社,2008:32-34.
[25]Ten HM,Lamers F,Wardenaar K,et al.The identification of symptom-based subtypes of depression:a nationally representative cohort study[J].J Affect Disord,2016,190(1):395-406.
[26]Lamers F,De JP,Nolen WA,et al.Identifying depressive subtypes in a large cohort study:results from the Netherlands Study of Depression and Anxiety(NESDA)[J].J Clin Psychiatr,2010,71(12):1582.
[27]Li Y,Aggen S,Shi S,et al.Subtypes of major depression:latent class analysis in depressed Han Chinese women[J].Psychol Med,2014,44(15):3275.
[28]Prisciandaro JJ,Roberts JE.A comparison of the predictive abilities of dimensional and categorical models of unipolar depression in the National Comorbidity Survey[J].Psychol Med,2009,39(7):1087-1096.
[29]Ulbricht CM,Rothschild AJ,Lapane KL.The association between latent depression subtypes and remission after treatment with citalopram:a latent class analysis with distal outcome[J].J Affect Disord,2015,188(12):270.
[30]李丽霞,赵丽,周舒冬,等.群体异质性研究的潜变量分析方法[J].中国卫生统计,2015,32(4):711-715.
[31]Ulbricht CM,Dumenci L,Rothschild AJ,et al.Changes in depression subtypes for women during treatment with citalopram:a latent transition analysis[J].Arch Womens Ment Health,2016,19(5):769-778.