阴道炎症与宫颈癌发生的相关性研究进展
|
摘要
阴道炎症是妇科疾病中发病率最高的疾病,不同年龄和种族的妇女均可患病。近年来,阴道炎症与妇科肿瘤的相关性日益受到关注。而在妇科恶性肿瘤中,宫颈癌的发病率高居第一。虽然高危型HPV感染很常见,但是宫颈癌的发病率却并不高,这是因为若缺乏协同因素作用就不会有宫颈癌的发生。目前认为阴道炎症除了与阴道黏膜被破坏、免疫功能受到抑制有关外,还与HPV感染、宫颈癌前病变和宫颈癌的发生发展密切相关。因此,阴道炎症与宫颈癌的相关性研究已成为人们关注的热点,本文就阴道炎症及其与宫颈癌的关系的研究进展作一综述。
Vaginal inflammation is the most common gynecological disease in women of all ages. In recent years, the correlation between vaginal inflammation and gynecology tumor is receiving more and more attention. The incidence of cervical cancer ranked the first in gynecologic malignant tumors. Although high-risk type HPV infection is very common, the incidence of cervical cancer is not high. This is because cervical cancer will not develop without co-factors. It is deemed nowadays that vaginal inflammation not only causes damage to vaginal mucous membrane, but also associates with the suppressed immune function. It can increase the risk of HPV infection and cervical intraepithelial neoplasias. Therefore, research on the correlation between vaginal inflammation and cervical cancer has become the hotspot of concern. This paper reviews the progress in studies on vaginal inflammation and its correlation with cervical cancer.
Vaginal inflammation is the most common gynecological disease in women of all ages. In recent years, the correlation between vaginal inflammation and gynecology tumor is receiving more and more attention. The incidence of cervical cancer ranked the first in gynecologic malignant tumors. Although high-risk type HPV infection is very common, the incidence of cervical cancer is not high. This is because cervical cancer will not develop without co-factors. It is deemed nowadays that vaginal inflammation not only causes damage to vaginal mucous membrane, but also associates with the suppressed immune function. It can increase the risk of HPV infection and cervical intraepithelial neoplasias. Therefore, research on the correlation between vaginal inflammation and cervical cancer has become the hotspot of concern. This paper reviews the progress in studies on vaginal inflammation and its correlation with cervical cancer.
引文
[1] LI Dongdong, PAN Qinxia, ZHU Min, et al. Progress on methods for establishing animal model of vaginitis[J]. Lab Anim Comparat Med, 2016, 36(4): 317-321. (in Chinese) 李冬冬, 庞琴霞, 朱敏, 等. 阴道炎动物模型制备方法研究进展[J]. 实验动物与比较医学, 2016, 36(4): 317-321.
[2] Du PL, Wu KS, Fang JY, et al. Cervical cancer mortality trends in china, 1991-2013, and predictions for the future[J]. Asian Pac J Cancer Prev, 2015, 16(15): 6391-6396.
[3] 沈铿, 马丁. 妇产科学[M]. 3版. 北京: 人民卫生出版社, 2015: 257-266.
[4] LU Yu, ZHAO Jianwu. Research progress on correlation between persistent HR-HPV infection of cervix and vaginal microecology[J]. China Med Herald, 2018, 15(3): 26-29. (in Chinese) 卢玉. 赵建武. 宫颈高危HPV持续感染与阴道微生态相关性研究进展[J]. 中国医药导报, 2018, 15(3): 26-29.
[5] Ghosh I, Muwonge R, Mittal S, et al. Association between high risk human papillomavirus infection and co-infection with Candida spp. and Trichomonas vaginalis in women with cervical premalignant and malignant lesions[J]. J Clinl Virol, 2017, 87: 43-48.
[6] 潘静. 生殖道细菌感染和HPV感染与宫颈癌关系的研究[D]. 乌鲁木齐: 新疆医科大学, 2013.
[7] Rabachini T, Boccardo E, Andrade R, et al. HPV-16 E7 expression up-regulates phospholipase D activity and promotes rapamycin resistance in a pRB-dependent manner[J]. BMC Cancer, 2018, 18: 485.
[8] 王美藏, 高建宏, 杨雅琴, 等. HPV感染患者阴道菌群与宫颈局部免疫功能的相关性研究[J]. 河北医科大学学报, 2018, 39(1): 104-107.
[9] WANG Chun, ZENG Baihua, YANG Qin. Pathogen detection of common vaginitis and analysison micro-ecological status[J]. J North Sichuan Med Coll, 2016, 31(6): 877-880. (in Chinese) 王春, 曾白华, 杨琴. 常见阴道炎病原体检测及微生态状况分析[J]. 川北医学院学报, 2016, 31(6): 877-880.
[10] HE Huanrong. Clinical treatment of vaginitis in gynecology clinic and the influencing factors of vaginitis[J]. Chin Commun Doctors, 2017, 33(7): 61-62. (in Chinese) 何欢蓉. 妇科门诊对阴道炎的临床治疗措施及影响阴道炎的相关因素探讨[J]. 中国社区医师, 2017, 33(7): 61-62.
[11] Maria de Castro-Sobrinho J, Helena Rabelo-Santos S, Ribeiro Fugueiredo-Alves R, et al. Bacterial vaginosis and inflammatory response showed association with severity of cervical neoplasia in HPV-positive women[J]. Diagn Cytopathol, 2017, 45(5): 474-476.
[12] Friel G, Liu CS, Kolomeyevskaya NV, et al. Aspirin and acetaminophen use and the risk of cervical cancer[J]. J Low Genit Tract Dis, 2015, 19(3): 189-193.
[13] SU Xiaohua, SONG Dianrong, ZHANG Wei, et al. Effect on the COX2-PGE2 pathways of endometriosis by Fu Tong Ning[J]. Tianjin J TCM, 2016, 33(8): 481-486. (in Chinese) 苏晓华, 宋殿荣, 张崴, 等. 妇痛宁对子宫内膜异位症COX2-PGE2作用途径的影响[J]. 天津中医药, 2016, 33(8): 481-486.
[14] ZHANG Min, XIAO Fengyi, LI Bo, et al. Correlation between high-risk HPV and γ-interferon and interleukin-10 expression in cervical lesions[J]. J Hainan Med Univ, 2015, 21(6): 772-774. (in Chinese) 张敏, 肖凤仪, 李波, 等. 高危型HPV感染与宫颈病变组织IFN-γ、IL-10表达的相关性研究[J]. 海南医学院学报, 2015, 21(6): 772-774.
[15] LIU Lu, CHENG Guili, LIU Shilan, et al. Analysis of the significance of serum Th1, Th2 cytokine expression in cervical cancer[J]. Oncol Prog, 2017, 15(2): 156-158. (in Chinese) 刘璐, 程桂丽, 刘世兰, 等. 宫颈癌患者血清Th1、Th2细胞因子表达水平及意义[J]. 癌症进展, 2017, 15(2): 156-158.
[16] CHENG Yang, GU Zhengtian. VEGF-C promotes cervical cancer invasion via regulation of microRNA-145/Smad interacting protein 1[J]. J Sun Yat-sen Univ(Med Sci), 2018, 39(2): 215-219. (in Chinese) 程杨, 顾正田. VEGF-C调节miR-145/SIP1增强宫颈癌细胞侵袭能力[J]. 中山大学学报(医学版), 2018, 39(2): 215-219.
[17] Champer M, Wong AM, Champer J, et al. The role of the vaginal microbiome in gynaecological cancer[J]. BJOG, 2018, 125(3): 309-315.
[18] Kiseki H, Tsukahara Y, Tajima N, et al. Influence of co-infection complicated with human papillomavirus on cervical intraepithelial neoplasia development in patients with atypical squamous cells of undetermined significance[J]. J Infect Chemother, 2017, 23(12): 814-819.
[19] Lewis FM, Bernstein KT, Aral SO. Vaginal microbiome and its relationship to behavior, sexual health, and sexually transmitted diseases[J]. Obstet Gynecol, 2017, 129(4): 643-654.
[20] Menon S, Broeck DV, Rossi R, et al. Associations between vaginal infections and potential high-risk and high-risk human papillomavirus genotypes in female sex workers in western Kenya[J]. Clin Ther, 2016, 38(12): 2567-2577.
[21] Gomes de Oliveira G, Eleuterio RM, Silveira Goncalves AK, et al. Atypical Squamous cells in liquid-based cervical cytology: Microbiology, inflammatory infiltrate, and human papillomavirus-DNA testing[J]. Acta cytol, 2018, 62(1): 28-33.
[22] WANG Dongdong, YANG Zhenyong, LI Xiaonan, et al. Vaginalis trichomoniasis and its correlation with genital cancers: Research progress[J]. Chin J Microecol, 2017, 29(8): 962-965. (in Chinese) 王冬冬, 杨真勇, 李笑南, 等. 阴道毛滴虫病及其与生殖器恶性肿瘤相关性的研究进展[J]. 中国微生态学杂志, 2017, 29(8): 962-965.
[23] Lazenby GB, Taylor PT, Badman BS, et al. An association between Trichomonas vaginalis and high-risk human papillomavirus in rural Tanzanian women undergoing cervical cancer screening[J]. Clin Ther, 2014, 36(1): 38-45.
[2] Du PL, Wu KS, Fang JY, et al. Cervical cancer mortality trends in china, 1991-2013, and predictions for the future[J]. Asian Pac J Cancer Prev, 2015, 16(15): 6391-6396.
[3] 沈铿, 马丁. 妇产科学[M]. 3版. 北京: 人民卫生出版社, 2015: 257-266.
[4] LU Yu, ZHAO Jianwu. Research progress on correlation between persistent HR-HPV infection of cervix and vaginal microecology[J]. China Med Herald, 2018, 15(3): 26-29. (in Chinese) 卢玉. 赵建武. 宫颈高危HPV持续感染与阴道微生态相关性研究进展[J]. 中国医药导报, 2018, 15(3): 26-29.
[5] Ghosh I, Muwonge R, Mittal S, et al. Association between high risk human papillomavirus infection and co-infection with Candida spp. and Trichomonas vaginalis in women with cervical premalignant and malignant lesions[J]. J Clinl Virol, 2017, 87: 43-48.
[6] 潘静. 生殖道细菌感染和HPV感染与宫颈癌关系的研究[D]. 乌鲁木齐: 新疆医科大学, 2013.
[7] Rabachini T, Boccardo E, Andrade R, et al. HPV-16 E7 expression up-regulates phospholipase D activity and promotes rapamycin resistance in a pRB-dependent manner[J]. BMC Cancer, 2018, 18: 485.
[8] 王美藏, 高建宏, 杨雅琴, 等. HPV感染患者阴道菌群与宫颈局部免疫功能的相关性研究[J]. 河北医科大学学报, 2018, 39(1): 104-107.
[9] WANG Chun, ZENG Baihua, YANG Qin. Pathogen detection of common vaginitis and analysison micro-ecological status[J]. J North Sichuan Med Coll, 2016, 31(6): 877-880. (in Chinese) 王春, 曾白华, 杨琴. 常见阴道炎病原体检测及微生态状况分析[J]. 川北医学院学报, 2016, 31(6): 877-880.
[10] HE Huanrong. Clinical treatment of vaginitis in gynecology clinic and the influencing factors of vaginitis[J]. Chin Commun Doctors, 2017, 33(7): 61-62. (in Chinese) 何欢蓉. 妇科门诊对阴道炎的临床治疗措施及影响阴道炎的相关因素探讨[J]. 中国社区医师, 2017, 33(7): 61-62.
[11] Maria de Castro-Sobrinho J, Helena Rabelo-Santos S, Ribeiro Fugueiredo-Alves R, et al. Bacterial vaginosis and inflammatory response showed association with severity of cervical neoplasia in HPV-positive women[J]. Diagn Cytopathol, 2017, 45(5): 474-476.
[12] Friel G, Liu CS, Kolomeyevskaya NV, et al. Aspirin and acetaminophen use and the risk of cervical cancer[J]. J Low Genit Tract Dis, 2015, 19(3): 189-193.
[13] SU Xiaohua, SONG Dianrong, ZHANG Wei, et al. Effect on the COX2-PGE2 pathways of endometriosis by Fu Tong Ning[J]. Tianjin J TCM, 2016, 33(8): 481-486. (in Chinese) 苏晓华, 宋殿荣, 张崴, 等. 妇痛宁对子宫内膜异位症COX2-PGE2作用途径的影响[J]. 天津中医药, 2016, 33(8): 481-486.
[14] ZHANG Min, XIAO Fengyi, LI Bo, et al. Correlation between high-risk HPV and γ-interferon and interleukin-10 expression in cervical lesions[J]. J Hainan Med Univ, 2015, 21(6): 772-774. (in Chinese) 张敏, 肖凤仪, 李波, 等. 高危型HPV感染与宫颈病变组织IFN-γ、IL-10表达的相关性研究[J]. 海南医学院学报, 2015, 21(6): 772-774.
[15] LIU Lu, CHENG Guili, LIU Shilan, et al. Analysis of the significance of serum Th1, Th2 cytokine expression in cervical cancer[J]. Oncol Prog, 2017, 15(2): 156-158. (in Chinese) 刘璐, 程桂丽, 刘世兰, 等. 宫颈癌患者血清Th1、Th2细胞因子表达水平及意义[J]. 癌症进展, 2017, 15(2): 156-158.
[16] CHENG Yang, GU Zhengtian. VEGF-C promotes cervical cancer invasion via regulation of microRNA-145/Smad interacting protein 1[J]. J Sun Yat-sen Univ(Med Sci), 2018, 39(2): 215-219. (in Chinese) 程杨, 顾正田. VEGF-C调节miR-145/SIP1增强宫颈癌细胞侵袭能力[J]. 中山大学学报(医学版), 2018, 39(2): 215-219.
[17] Champer M, Wong AM, Champer J, et al. The role of the vaginal microbiome in gynaecological cancer[J]. BJOG, 2018, 125(3): 309-315.
[18] Kiseki H, Tsukahara Y, Tajima N, et al. Influence of co-infection complicated with human papillomavirus on cervical intraepithelial neoplasia development in patients with atypical squamous cells of undetermined significance[J]. J Infect Chemother, 2017, 23(12): 814-819.
[19] Lewis FM, Bernstein KT, Aral SO. Vaginal microbiome and its relationship to behavior, sexual health, and sexually transmitted diseases[J]. Obstet Gynecol, 2017, 129(4): 643-654.
[20] Menon S, Broeck DV, Rossi R, et al. Associations between vaginal infections and potential high-risk and high-risk human papillomavirus genotypes in female sex workers in western Kenya[J]. Clin Ther, 2016, 38(12): 2567-2577.
[21] Gomes de Oliveira G, Eleuterio RM, Silveira Goncalves AK, et al. Atypical Squamous cells in liquid-based cervical cytology: Microbiology, inflammatory infiltrate, and human papillomavirus-DNA testing[J]. Acta cytol, 2018, 62(1): 28-33.
[22] WANG Dongdong, YANG Zhenyong, LI Xiaonan, et al. Vaginalis trichomoniasis and its correlation with genital cancers: Research progress[J]. Chin J Microecol, 2017, 29(8): 962-965. (in Chinese) 王冬冬, 杨真勇, 李笑南, 等. 阴道毛滴虫病及其与生殖器恶性肿瘤相关性的研究进展[J]. 中国微生态学杂志, 2017, 29(8): 962-965.
[23] Lazenby GB, Taylor PT, Badman BS, et al. An association between Trichomonas vaginalis and high-risk human papillomavirus in rural Tanzanian women undergoing cervical cancer screening[J]. Clin Ther, 2014, 36(1): 38-45.
© 2004-2018 中国地质图书馆版权所有 京ICP备05064691号 京公网安备11010802017129号 地址：北京市海淀区学院路29号 邮编：100083 电话：办公室：(+86 10)66554848；文献借阅、咨询服务、科技查新：66554700 |