糖尿病肾病患者炎症因子的表达及与肾功能指标的相关性分析
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摘要
目的探讨糖尿病肾病患者炎症因子的表达及与肾功能指标的相关性。方法选取2016年2月～2018年8月我院收治的90例糖尿病患者作为研究对象,按照24 h尿微量清蛋白排泄率不同分为三组,即观察1组(正常清蛋白尿)、观察2组(微量清蛋白尿)、观察3组(临床清蛋白尿),每组各30例,选择同期30例健康体检人员作为对照组。比较四组血清中炎症因子(C反应蛋白、白介素-6、细胞肿瘤坏死因子-α)及肾功能指标[血肌酐、血胱抑素C、尿清蛋白排泄率(UAER)],采用Pearson相关分析确定炎症因子与肾功能的关系。结果观察组C反应蛋白、白介素-6、细胞肿瘤坏死因子-α、血肌酐、血胱抑素C、UAER水平高于对照组,差异均有统计学意义(P<0.05);观察3组血清中炎症因子水平高于观察1、2组,差异均有统计学意义(P<0.05)。C反应蛋白、白介素-6、细胞肿瘤坏死因子-α与血肌酐、血胱抑素C、UAER成正相关(P<0.05)。结论糖尿病患者机体内的炎症因子水平与肾脏病变存在相关性。
Objective To investigate the expression of inflammatory factors in patients with diabetic nephropathy and its correlation with renal function. Methods Ninety patients with diabetes mellitus admitted to our hospital from February 2016 to August 2018 were selected as the research objects, according to the 24-hour urinary microalbuminuria excretion rate, they were divided into three groups, observation group 1(normal albuminuria), observation group 2(microalbuminuria) and observation group 3(clinical albuminuria), thirty patients in each group were selected as the control group. The levels of serum inflammatory factors(C-reactive protein, interleukin-6, tumor necrosis factor-α) and renal function indexes(serum creatinine, cystatin C, urinary albumin excretion rate(UAER) were compared among the four groups. Pearson correlation analysis was used to determine the relationship between inflammatory factors and renal function. Results The levels of C-reactive protein, interleukin-6, tumor necrosis factor-α, serum creatinine, cystatin C and UAER in the observation group were significantly higher than those in the control group, the differences were significant(P<0.05). The levels of inflammatory factors in serum of the observation groups 3 were higher than those of the observation groups 1 and 2, the differences were significant(P <0.05). C-reactive protein, interleukin-6 and tumor necrosis factor-α were positively correlated with serum creatinine, cystatin C and UAER(P<0.05). Conclusion There is a correlation between the levels of inflammatory factors and renal lesions in patients with diabetes mellitus.
Objective To investigate the expression of inflammatory factors in patients with diabetic nephropathy and its correlation with renal function. Methods Ninety patients with diabetes mellitus admitted to our hospital from February 2016 to August 2018 were selected as the research objects, according to the 24-hour urinary microalbuminuria excretion rate, they were divided into three groups, observation group 1(normal albuminuria), observation group 2(microalbuminuria) and observation group 3(clinical albuminuria), thirty patients in each group were selected as the control group. The levels of serum inflammatory factors(C-reactive protein, interleukin-6, tumor necrosis factor-α) and renal function indexes(serum creatinine, cystatin C, urinary albumin excretion rate(UAER) were compared among the four groups. Pearson correlation analysis was used to determine the relationship between inflammatory factors and renal function. Results The levels of C-reactive protein, interleukin-6, tumor necrosis factor-α, serum creatinine, cystatin C and UAER in the observation group were significantly higher than those in the control group, the differences were significant(P<0.05). The levels of inflammatory factors in serum of the observation groups 3 were higher than those of the observation groups 1 and 2, the differences were significant(P <0.05). C-reactive protein, interleukin-6 and tumor necrosis factor-α were positively correlated with serum creatinine, cystatin C and UAER(P<0.05). Conclusion There is a correlation between the levels of inflammatory factors and renal lesions in patients with diabetes mellitus.
引文
[1]宋群利,孙惠力,李顺民.2型糖尿病肾病中医证型与TWEAK等炎症因子相关性试验研究[J].广州中医药大学学报,2016,33(5):633-638.
[2]陈勇,施红.炎症因子与糖尿病肾病的关系及中医药防治进展[J].云南中医中药杂志,2017,38(3):83-85.
[3]汪笋,陈天华,彭惠,等.糖尿病肾病患者中炎症指标和血清Vaspin水平的关系[J].广东医学,2017,38(1):111-114.
[4]杨孟雪,许洁,俞捷,等.2型糖尿病肾病不同肾功能时期血清25(OH)D与部分炎症因子的相关性分析[J].遵义医学院学报,2015,38(2):133-136.
[5]安仲武,冯小娟,蒋玲,等.糖尿病肾病患者血清Vaspin水平变化及其与炎症因子的关系[J].山东医药,2017,57(45):76-78.
[6]宋光明,柴可夫,杜月光.LOX-1和炎症因子在糖尿病肾病中的作用及糖肾颗粒早期干预研究[J].内蒙古中医药,2016,35(1):137-139.
[7]邢建东.血清脂联素和炎性因子对2型肥胖糖尿病患者肾脏病变的影响[J].山西大同大学学报(自然科学版),2017,33(2):48-49.
[8]张洁,邸阜生.2型糖尿病合并下肢血管病变患者血浆网膜素-1水平与炎症因子的相关性研究[J].中国糖尿病杂志,2015,23(10):877-880.
[9]张莉,王瑜,杜桂英,等.Toll样受体4在糖尿病肾病患者肾组织中的表达及厄贝沙坦的干预作用[J].华中科技大学学报(医学版),2017,46(1):40-45.
[10]陈光泽.炎症指标和免疫学指标在糖尿病患者肾脏病变诊断与预后判断中的临床价值[J].中国现代医药杂志,2017,19(1):48-51.
[11]谢范昌.2型糖尿病炎症因子水平与心脑血管病变的相关性分析[J].糖尿病新世界,2017,20(13):42-43.
[12]邓彩春,曾翠青.益气健脾补肾法对糖尿病肾病患者炎症因子及肾功能的影响[J].中国老年学杂志,2015,35(17):4838-4840.
[13]张体华,王明.糖尿病肾病患者炎症水平、免疫功能及与肾脏病变的关系[J].中国免疫学杂志,2016,32(10):1524-1526.
[14]王静,公慧敏,梁玲.新型炎症因子IL-17表达水平与糖尿病视网膜病变的相关性[J].中华眼视光学与视觉科学杂志,2017,19(7):428-432.
[15]段雨函,李宗清.2型糖尿病患者血清抵抗素水平与血糖及炎症因子的相关性研究[J].标记免疫分析与临床,2016,23(9):1045-1048.
[16]杨帆,杨立,许旌,等.老年2型糖尿病患者的炎症因子水平与认知功能障碍的关系[J].卒中与神经疾病,2014,21(3):169-173.
[2]陈勇,施红.炎症因子与糖尿病肾病的关系及中医药防治进展[J].云南中医中药杂志,2017,38(3):83-85.
[3]汪笋,陈天华,彭惠,等.糖尿病肾病患者中炎症指标和血清Vaspin水平的关系[J].广东医学,2017,38(1):111-114.
[4]杨孟雪,许洁,俞捷,等.2型糖尿病肾病不同肾功能时期血清25(OH)D与部分炎症因子的相关性分析[J].遵义医学院学报,2015,38(2):133-136.
[5]安仲武,冯小娟,蒋玲,等.糖尿病肾病患者血清Vaspin水平变化及其与炎症因子的关系[J].山东医药,2017,57(45):76-78.
[6]宋光明,柴可夫,杜月光.LOX-1和炎症因子在糖尿病肾病中的作用及糖肾颗粒早期干预研究[J].内蒙古中医药,2016,35(1):137-139.
[7]邢建东.血清脂联素和炎性因子对2型肥胖糖尿病患者肾脏病变的影响[J].山西大同大学学报(自然科学版),2017,33(2):48-49.
[8]张洁,邸阜生.2型糖尿病合并下肢血管病变患者血浆网膜素-1水平与炎症因子的相关性研究[J].中国糖尿病杂志,2015,23(10):877-880.
[9]张莉,王瑜,杜桂英,等.Toll样受体4在糖尿病肾病患者肾组织中的表达及厄贝沙坦的干预作用[J].华中科技大学学报(医学版),2017,46(1):40-45.
[10]陈光泽.炎症指标和免疫学指标在糖尿病患者肾脏病变诊断与预后判断中的临床价值[J].中国现代医药杂志,2017,19(1):48-51.
[11]谢范昌.2型糖尿病炎症因子水平与心脑血管病变的相关性分析[J].糖尿病新世界,2017,20(13):42-43.
[12]邓彩春,曾翠青.益气健脾补肾法对糖尿病肾病患者炎症因子及肾功能的影响[J].中国老年学杂志,2015,35(17):4838-4840.
[13]张体华,王明.糖尿病肾病患者炎症水平、免疫功能及与肾脏病变的关系[J].中国免疫学杂志,2016,32(10):1524-1526.
[14]王静,公慧敏,梁玲.新型炎症因子IL-17表达水平与糖尿病视网膜病变的相关性[J].中华眼视光学与视觉科学杂志,2017,19(7):428-432.
[15]段雨函,李宗清.2型糖尿病患者血清抵抗素水平与血糖及炎症因子的相关性研究[J].标记免疫分析与临床,2016,23(9):1045-1048.
[16]杨帆,杨立,许旌,等.老年2型糖尿病患者的炎症因子水平与认知功能障碍的关系[J].卒中与神经疾病,2014,21(3):169-173.
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