应用Q开关Nd:YAG激光联合氨甲环酸治疗黄褐斑
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摘要
目的:探讨Q开关Nd:YAG 1 064nm激光联合氨甲环酸治疗黄褐斑临床疗效。方法:选取2015年9月-2018年6月笔者科室治疗的120例黄褐斑患者,采用随机数字表法分为A组和B组,每组各60例。其中A组采用Q开关Nd:YAG1 064nm激光联合氨甲环酸治疗,B组单独使用Q开关Nd:YAG1 064nm激光进行治疗。对比两组患者治疗前后黄褐斑皮损面积及严重程度评分(mMASI)、黑素指数(MCI)、临床疗效及不良反应。结果:治疗前,两组患者mMASI评分差异无统计学意义(P>0.05),治疗后1个月、3个月,A组患者mMASI评分显著低于B组,差异均具有统计学意义(P<0.05);治疗前,两组患者面部MCI值差异不具有统计学意义(P>0.05),治疗后A组面部MCI值显著低于B组,差异均具有统计学意义(P<0.05);A组临床治疗效果显著优于B组,差异具有统计学意义(P<0.05);A组不良反应发生率(8.33%)与B组(3.33%)比较,差异不具有统计学意义(P>0.05)。结论:Q开关Nd:YAG 1 064nm激光联合氨甲环酸治疗黄褐斑疗效显著,优于单用Q开关Nd:YAG 1 064nm激光治疗。
Objective To explore the effect of Q-switched Nd:YAG 1 064 nm laser combined with tranexamic acid in the treatment of patients with chloasma. Methods From September 2016 to June 2017, 120 patients with chloasma were randomly divided into two groups: group A(n=60) and group B(n=60). Group A was treated with Q-switched Nd:YAG 1 064 nm laser combined with tranexamic acid, and group B was treated with Q-switched Nd:YAG 1 064 nm laser alone. Comparison of chloasma area and severity scores(mMASI), melanin index(MCI), clinical efficacy and side effects of chloasma area and severity score before and after treatment between the two groups. Results Before treatment, the difference of mMASI scores between the two groups was not statistically significant(P>0.05), the mMASI scores of group A patients were significantly lower than those of group B at 1 month and 3 months after treatment, and the differences were statistically significant(P<0.05);before treatment, the difference of facial MCI between the two groups was not statistically significant(P>0.05), after treatment,the MCI score in group A was significantly lower than that in group B(P<0.05). The clinical treatment effect of group A was better than that of group B(P<0.05). The incidence of adverse reaction in group A(8.33%) and group B(3.33%) was not statistically significant(P>0.05). Conclusion The effect of Q-switched Nd:YAG 1 064 nm laser combined with tranexamic acid was better than that with Q-switched Nd:YAG 1064 nm laser alone.
Objective To explore the effect of Q-switched Nd:YAG 1 064 nm laser combined with tranexamic acid in the treatment of patients with chloasma. Methods From September 2016 to June 2017, 120 patients with chloasma were randomly divided into two groups: group A(n=60) and group B(n=60). Group A was treated with Q-switched Nd:YAG 1 064 nm laser combined with tranexamic acid, and group B was treated with Q-switched Nd:YAG 1 064 nm laser alone. Comparison of chloasma area and severity scores(mMASI), melanin index(MCI), clinical efficacy and side effects of chloasma area and severity score before and after treatment between the two groups. Results Before treatment, the difference of mMASI scores between the two groups was not statistically significant(P>0.05), the mMASI scores of group A patients were significantly lower than those of group B at 1 month and 3 months after treatment, and the differences were statistically significant(P<0.05);before treatment, the difference of facial MCI between the two groups was not statistically significant(P>0.05), after treatment,the MCI score in group A was significantly lower than that in group B(P<0.05). The clinical treatment effect of group A was better than that of group B(P<0.05). The incidence of adverse reaction in group A(8.33%) and group B(3.33%) was not statistically significant(P>0.05). Conclusion The effect of Q-switched Nd:YAG 1 064 nm laser combined with tranexamic acid was better than that with Q-switched Nd:YAG 1064 nm laser alone.
引文
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[10]祝飞,殷珊,张菊芳.氨甲环酸片联合艺霏渗透雪颜面膜治疗黄褐斑的临床疗效观察[J].中国中西医结合皮肤性病学杂志,2018,17(1):33-35.
[11]周朝晖,唐剑辉,杨天赤,等.氨甲环酸联合黄光、胶原贴治疗黄褐斑48例临床观察[J].中国皮肤性病学杂志,2016,30(1):105-107.
[12]李健和,胡焰,赵子影,等.氨甲环酸治疗黄褐斑的研究进展[J].中国新药与临床杂志,2015,32(6):440-443.
[13]田利民,王晨霞,孙立.射频导入参棘软膏联合口服氨甲环酸、谷胱甘肽治疗黄褐斑疗效观察[J].内蒙古医科大学学报,2017,39(6):499-502.
[14]赵欣欣,李平,李燕,等.口服氨甲环酸联合Q开关Nd:YAG激光治疗黄褐斑疗效观察[J].中国美容医学,2016,25(12):69-71.
[2]Kornev AF,Balmashnov RV,Kuchma IG,et al.43J/100ps Nd:YAGlaser with adaptive compensation of thermally induced lens[J].Optics Letters,2018,43(18):4394-4399.
[3]徐永平,王志鹏.Q开关1 064nm激光联合益肾健脾法治疗黄褐斑的临床观察[J].中国中医药科技,2016,23(3):331-332.
[4]王燕,高磊,张倩,等.Q开关1 064nm Nd:YAG激光治疗黄褐斑所致点状色素减退:2年随访研究[J].中国麻风皮肤病杂志,2017,33(6):337-340.
[5]张元文,徐军,刘秀峰,等.强脉冲光自动脉冲技术联合氨甲环酸治疗黄褐斑60例临床观察[J].中国皮肤性病学杂志,2015,29(12):1248-1250.
[6]Shi H,Xu F,Shi Y,et al.Effect of ear-acupoint pressing and Ear Apex(HX6,7)bloodletting on haemorheology in chloasma patients with Gan depression pattern[J].Chin J Int Med,2016,22(1):42-48.
[7]Wu X,Xiang Y.The effects of acupuncture combined with auricular acupressure in the treatment of chloasma[J].Evid Based Complement Alternat Med,2018,28(7):1-10.
[8]王敏,晏洪波,杨凌云,等.Q开关1 064nm激光联合微针导入治疗黄褐斑的临床效果[J].中华医学美学美容杂志,2015,21(6):347-349.
[9]谷晓广,续言凤,邱小圆,等.大光斑低能量Q开关Nd:YAG激光联合强脉冲光治疗黄褐斑临床观察[J].中国美容医学,2017,26(10):71-73.
[10]祝飞,殷珊,张菊芳.氨甲环酸片联合艺霏渗透雪颜面膜治疗黄褐斑的临床疗效观察[J].中国中西医结合皮肤性病学杂志,2018,17(1):33-35.
[11]周朝晖,唐剑辉,杨天赤,等.氨甲环酸联合黄光、胶原贴治疗黄褐斑48例临床观察[J].中国皮肤性病学杂志,2016,30(1):105-107.
[12]李健和,胡焰,赵子影,等.氨甲环酸治疗黄褐斑的研究进展[J].中国新药与临床杂志,2015,32(6):440-443.
[13]田利民,王晨霞,孙立.射频导入参棘软膏联合口服氨甲环酸、谷胱甘肽治疗黄褐斑疗效观察[J].内蒙古医科大学学报,2017,39(6):499-502.
[14]赵欣欣,李平,李燕,等.口服氨甲环酸联合Q开关Nd:YAG激光治疗黄褐斑疗效观察[J].中国美容医学,2016,25(12):69-71.