注射用益气复脉(冻干)在气阴两虚型脑肿瘤术后患者中的应用效果研究
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摘要
目的:观察注射用益气复脉(冻干)在气阴两虚型脑瘤术后患者中的应用效果。方法:将80例气阴两虚型脑肿瘤术后患者随机分为治疗组及对照组各40例。对照组术后予西医常规治疗及甘露醇脱水,治疗组在对照组基础上加用注射用益气复脉(冻干)。对比2组临床疗效、神经功能、脑水肿吸收率及并发症发生情况。结果:总有效率治疗组62.50%,对照组30.00%,2组比较,差异有统计学意义(P <0.05)。治疗后,2组神经功能缺损情况均较治疗前改善(P <0.01)。治疗组神经功能缺损改善情况优于对照组(P <0.01)。治疗组脑水肿吸收率(22.63±8.45)%,对照组脑水肿吸收率(21.75±6.90)%,2组比较,差异无统计学意义(P> 0.05)。治疗期间,2组低钾血症及低钠血症发生率比较,差异均无统计学意义(P> 0.05);治疗组肾功能异常发生率低于对照组,差异有统计学意义(P <0.05)。结论:在西医常规治疗及甘露醇脱水基础上加用注射用益气复脉(冻干)治疗气阴两虚型脑肿瘤术后患者,可改善中医证候,促进神经功能恢复,且不会影响脱水效果。
Objective: To observe the effect of Yiqi Fumai(freeze-dried)for injection in postoperative patients with brain tumors of qi and Yin deficiency type. Methods: Divided 80 cases of postoperative patients with cerebral edema with brain tumors of qi and Yin deficiency type randomly into the treatment group and the control group,40 cases in each group. The control group was given routine treatment with western medicine and dehydration of mannitol,while the treatment group was additionally treated with Yiqi Fumai(freeze-dried)for injection. Compared the clinical effect,neurological function,brain edema absorption rate and the incidence of complications in the two groups. Results: The total effective rate was 62.50% in the treatment group and 30.00% in the control group compared the two group, difference being significant(P < 0.05). After treatment,the neurological deficits of the two groups were improved when compared with those before treatment(P < 0.01);the improvement of neurological deficits in the treatment group was better than that in the control group(P < 0.01). The cerebral edema absorption rate was(22.63±8.45) % in the treatment group and(21.75±6.90)% in the control group;there was no significant difference being found in the comparison between the two groups(P > 0.05). During the treatment,there were no significant differences being found in the comparison of the incidence of hypokalemia and hyponatremia between the two groups(P > 0.05). The incidence of lung dysfunction in the treatment group was lower than that in the control group,difference being significant(P < 0.05). Conclusion:On the basis of routine treatment of western medicine and dehydration of mannitol,the additional application of Yiqi Fumai(freeze-dried) for injection for postoperative patients with brain tumors of qi and yin deficiency type can improve Chinese medicine syndromes and promote the recovery of nerve function without affecting the dehydration effect..
Objective: To observe the effect of Yiqi Fumai(freeze-dried)for injection in postoperative patients with brain tumors of qi and Yin deficiency type. Methods: Divided 80 cases of postoperative patients with cerebral edema with brain tumors of qi and Yin deficiency type randomly into the treatment group and the control group,40 cases in each group. The control group was given routine treatment with western medicine and dehydration of mannitol,while the treatment group was additionally treated with Yiqi Fumai(freeze-dried)for injection. Compared the clinical effect,neurological function,brain edema absorption rate and the incidence of complications in the two groups. Results: The total effective rate was 62.50% in the treatment group and 30.00% in the control group compared the two group, difference being significant(P < 0.05). After treatment,the neurological deficits of the two groups were improved when compared with those before treatment(P < 0.01);the improvement of neurological deficits in the treatment group was better than that in the control group(P < 0.01). The cerebral edema absorption rate was(22.63±8.45) % in the treatment group and(21.75±6.90)% in the control group;there was no significant difference being found in the comparison between the two groups(P > 0.05). During the treatment,there were no significant differences being found in the comparison of the incidence of hypokalemia and hyponatremia between the two groups(P > 0.05). The incidence of lung dysfunction in the treatment group was lower than that in the control group,difference being significant(P < 0.05). Conclusion:On the basis of routine treatment of western medicine and dehydration of mannitol,the additional application of Yiqi Fumai(freeze-dried) for injection for postoperative patients with brain tumors of qi and yin deficiency type can improve Chinese medicine syndromes and promote the recovery of nerve function without affecting the dehydration effect..
引文
[1]孙炜欣,林立辉,曹春虹,等.甘露醇的毒副作用及相应对策[J].中国现代药物应用,2009,3(11):142-143.
[2]郑筱萸.中药新药临床研究指导原则(试行)[M].北京:中国医药科技出版社,2002:376-380.
[3]颜雪,张红智,张秋娟.张秋娟教授运用化痰逐瘀法治疗脑垂体瘤经验介绍[J].新中医,2013,45(6):195-196.
[4]LONJARET L,GUYONNET M,BERARD E,et al.Postoperative complications after craniotomy for brain tumor surgery[J].Anaesth Crit Care Pain Med,2016,36(4):213-218.
[5]翁蓓,陶遵威.麦冬皂苷的药理活性研究进展[J].内蒙古中医药,2014,33(31):111-113.
[6]鲁文茜,张斯琪,沈尚竹,等.人参皂苷Rc药理作用和药动学研究进展[J].中草药,2018,49(24):5961-5967.
[7]元莲花.红参对2型糖尿病大鼠肾组织Nephrin影响的研究[D].延边:延边大学,2013.
[8]杨江辉,孙成博,耿嘉男,等.五味子提取物对糖尿病大鼠肾脏组织中基质金属蛋白酶表达的影响及其肾脏保护作用[J].吉林大学学报(医学版),2017,43(3):512-517.
[9]李晶,苏薇薇,王永刚,等.麦冬提取物对实验性2型糖尿病大鼠的保护作用[J].中山大学学报(自然科学版),2017,56(3):119-124.
[10]马翮.生脉散加味治疗气阴两虚兼阳虚型慢性肾衰临床观察[J].世界最新医学信息文摘,2017,17(59):135-136.
[2]郑筱萸.中药新药临床研究指导原则(试行)[M].北京:中国医药科技出版社,2002:376-380.
[3]颜雪,张红智,张秋娟.张秋娟教授运用化痰逐瘀法治疗脑垂体瘤经验介绍[J].新中医,2013,45(6):195-196.
[4]LONJARET L,GUYONNET M,BERARD E,et al.Postoperative complications after craniotomy for brain tumor surgery[J].Anaesth Crit Care Pain Med,2016,36(4):213-218.
[5]翁蓓,陶遵威.麦冬皂苷的药理活性研究进展[J].内蒙古中医药,2014,33(31):111-113.
[6]鲁文茜,张斯琪,沈尚竹,等.人参皂苷Rc药理作用和药动学研究进展[J].中草药,2018,49(24):5961-5967.
[7]元莲花.红参对2型糖尿病大鼠肾组织Nephrin影响的研究[D].延边:延边大学,2013.
[8]杨江辉,孙成博,耿嘉男,等.五味子提取物对糖尿病大鼠肾脏组织中基质金属蛋白酶表达的影响及其肾脏保护作用[J].吉林大学学报(医学版),2017,43(3):512-517.
[9]李晶,苏薇薇,王永刚,等.麦冬提取物对实验性2型糖尿病大鼠的保护作用[J].中山大学学报(自然科学版),2017,56(3):119-124.
[10]马翮.生脉散加味治疗气阴两虚兼阳虚型慢性肾衰临床观察[J].世界最新医学信息文摘,2017,17(59):135-136.
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