基于质量常数评价方法的天麻饮片等级划分研究
|
摘要
该文采用质量常数评价方法对天麻饮片进行等级评价。对所收集的15批天麻饮片进行外观形态指标测量,并以天麻素,对羟基苯甲醇,巴利森苷A,B,E为指标成分,进行含量测定,将传统分级标准与现代质控指标相结合,进行质量常数计算,对该饮片进行等级划分。结果显示15批天麻饮片质量常数范围为143. 3～1 027. 3;若将百分质量常数≥80%的饮片视为一等饮片,50%～80%为二等饮片,剩余为三等饮片,则一级天麻饮片质量常数≥二等饮片,二级天麻饮片质量常数为513. 0～821. 0,三级天麻饮片质量常数<513. 0。该工作在质量常数等级划分方法的研究基础上,结合饮片的自然形态及切制特点,建立了适用于顺刀片饮片质量常数等级划分模型,使该方法在科学合理的基础上"个性化"。将该模型方法应用于天麻饮片的等级划分中,阐述其具体分级方式,进一步丰富了天麻饮片等级评价的研究数据,为天麻饮片等级评价提供了有益的参考。同时将质量常数等级划分方法进一步应用、推广,以证明该方法的合理性、科学性、实用性。
The grade of Gastrodia elata pieces is evaluated by quality constant evaluation method.Fifteen batches of G. elata pieces collected were measured for their appearance and morphological indexes. The contents of gastrodin,p-hydroxybenzyl alcohol,barrisoside A,B and E were taken as index components for the content determination. The traditional grading standards were combined with modern quality control indicators,and the quality constants were calculated to grade the pieces.The results showed that the quality constants of 15 batches of G. elata ranged between 143. 3 and 1 027. 3. If the percentage mass constant( ≥80%) was the first grade,the percentage mass constant between 50%-80% indicated the second grade,and the remaining percentage mass constant indicated the third grade. The quality constant of the first gradepieces was sality,that of the second grade pieces ranged between 513. 0-821. 0,and that of the third grade pieces was <513. 0. On the basis of the study for the grading method of quality constants,and the natural morphology and cutting characteristics of the pieces,a grading model for the quality constants of the pieces cut along texture was established,which made the method scientific,rational as well as " personalized". The model method is applied in grading G. elata pieces,so as to specify the grading method,further enrich the study data of the grading evaluation of G. elata pieces and provide a useful reference for the grading evaluation of G. elata pieces. Meanwhile,the grading method of mass constants could be further applied and promoted to prove its rationality,scientificity and practicability.
The grade of Gastrodia elata pieces is evaluated by quality constant evaluation method.Fifteen batches of G. elata pieces collected were measured for their appearance and morphological indexes. The contents of gastrodin,p-hydroxybenzyl alcohol,barrisoside A,B and E were taken as index components for the content determination. The traditional grading standards were combined with modern quality control indicators,and the quality constants were calculated to grade the pieces.The results showed that the quality constants of 15 batches of G. elata ranged between 143. 3 and 1 027. 3. If the percentage mass constant( ≥80%) was the first grade,the percentage mass constant between 50%-80% indicated the second grade,and the remaining percentage mass constant indicated the third grade. The quality constant of the first gradepieces was sality,that of the second grade pieces ranged between 513. 0-821. 0,and that of the third grade pieces was <513. 0. On the basis of the study for the grading method of quality constants,and the natural morphology and cutting characteristics of the pieces,a grading model for the quality constants of the pieces cut along texture was established,which made the method scientific,rational as well as " personalized". The model method is applied in grading G. elata pieces,so as to specify the grading method,further enrich the study data of the grading evaluation of G. elata pieces and provide a useful reference for the grading evaluation of G. elata pieces. Meanwhile,the grading method of mass constants could be further applied and promoted to prove its rationality,scientificity and practicability.
引文
[1]中国药典.一部[S].2015:86.
[2]杨超,吕紫媛,伍瑞云.天麻的化学成分与药理机制研究进展[J].中国现代医生,2012,50(17):27.
[3]刘智慧,马浩,王伟平,等.天麻素及派立辛改善东莨菪碱致学习记忆障碍的构效关系[J].药学学报,2016,51(5):743.
[4]王强,俞祥生,张留纪,等.不同规格白芍中有关化学成分的HPLC分析[J].中药材,1992,15(7):31.
[5]张丽宏,顾雪竹,钮正睿,等.白芍的传统规格等级与内在成分的相关性研究[J].中成药,2012,34(3):535.
[6]王浩,陈力潇,黄璐琦,等.基于德尔菲法对中药白术商品规格等级划分的研究[J].中国中药杂志,2016,41(5):802.
[7]石磊,张承程,郭兰萍,等.关于厚朴药材商品规格等级标准的研究[J].中国中药杂志,2015,40(3):450.
[8]万燕晴,李震宇,秦雪梅.黄芪商品规格等级标准考证及质量研究思考[J].现代中药研究与实践,2016,30(2):61.
[9]邓哲,焦梦姣,章军,等.相对质量常数用于甘草饮片等级评价研究[J].中国中药杂志,2017,42(13):2492.
[10]邓哲,章军,焦梦姣,等.以质量常数为核心的黄芩饮片等级评价研究[J].中国中药杂志,2017,42(9):1673.
[11]邓哲,焦梦姣,章军,等.基于质量常数评价方法划分黄柏饮片等级研究[J].中国中药杂志,2017,42(17):3356.
[12]刘玉红,易进海,陈燕,等.RP-HPLC法同时测定天麻中游离天麻素、巴利森苷和总天麻素[J].中成药,2012,34(1):182.
[13]田紫平,肖慧,冯舒涵,等.天麻有效成分巴利森苷的降解规律分析[J].中国实验方剂学杂志,2017,23(23):18.
[14]仲瑞雪.天麻饮片分级及其质量评价标准研究[D].成都:成都中医药大学,2014.
[15]王莉,王龙星,肖红斌.天麻指纹图谱模式识别研究[J].中国中药杂志,2007,32(6):536.
[16]曹雪,蔡广知,赵凌,等.基于复合质量常数的北柴胡饮片等级评价[J].中国实验方剂学杂志,2018,24(18):36.
[2]杨超,吕紫媛,伍瑞云.天麻的化学成分与药理机制研究进展[J].中国现代医生,2012,50(17):27.
[3]刘智慧,马浩,王伟平,等.天麻素及派立辛改善东莨菪碱致学习记忆障碍的构效关系[J].药学学报,2016,51(5):743.
[4]王强,俞祥生,张留纪,等.不同规格白芍中有关化学成分的HPLC分析[J].中药材,1992,15(7):31.
[5]张丽宏,顾雪竹,钮正睿,等.白芍的传统规格等级与内在成分的相关性研究[J].中成药,2012,34(3):535.
[6]王浩,陈力潇,黄璐琦,等.基于德尔菲法对中药白术商品规格等级划分的研究[J].中国中药杂志,2016,41(5):802.
[7]石磊,张承程,郭兰萍,等.关于厚朴药材商品规格等级标准的研究[J].中国中药杂志,2015,40(3):450.
[8]万燕晴,李震宇,秦雪梅.黄芪商品规格等级标准考证及质量研究思考[J].现代中药研究与实践,2016,30(2):61.
[9]邓哲,焦梦姣,章军,等.相对质量常数用于甘草饮片等级评价研究[J].中国中药杂志,2017,42(13):2492.
[10]邓哲,章军,焦梦姣,等.以质量常数为核心的黄芩饮片等级评价研究[J].中国中药杂志,2017,42(9):1673.
[11]邓哲,焦梦姣,章军,等.基于质量常数评价方法划分黄柏饮片等级研究[J].中国中药杂志,2017,42(17):3356.
[12]刘玉红,易进海,陈燕,等.RP-HPLC法同时测定天麻中游离天麻素、巴利森苷和总天麻素[J].中成药,2012,34(1):182.
[13]田紫平,肖慧,冯舒涵,等.天麻有效成分巴利森苷的降解规律分析[J].中国实验方剂学杂志,2017,23(23):18.
[14]仲瑞雪.天麻饮片分级及其质量评价标准研究[D].成都:成都中医药大学,2014.
[15]王莉,王龙星,肖红斌.天麻指纹图谱模式识别研究[J].中国中药杂志,2007,32(6):536.
[16]曹雪,蔡广知,赵凌,等.基于复合质量常数的北柴胡饮片等级评价[J].中国实验方剂学杂志,2018,24(18):36.