三七总皂苷对杠柳毒苷代谢产物杠柳次苷药代动力学的影响
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摘要
[目的]研究三七总皂苷对杠柳毒苷代谢产物杠柳次苷药代动力学的影响。[方法]将18只SD大鼠随机分为杠柳毒苷单独给药组、杠柳毒苷与低剂量三七总皂苷配伍组、杠柳毒苷与高剂量三七总皂苷配伍组3组,每组6只。各组大鼠连续灌胃给药7 d后,采集不同时间点的血浆样品,测定血浆中杠柳次苷的含量,并计算其药代动力学参数。[结果]三七总皂苷配伍杠柳毒苷后,杠柳毒苷代谢产物杠柳次苷在大鼠血浆中的主要药动学参数Cmax、Tmax、AUC0-t、AUC0-∞与杠柳毒苷单独给药相比具有统计学差异。[结论]三七总皂苷与杠柳毒苷配伍使用可使杠柳毒苷代谢产物杠柳次苷的药代动力学行为发生改变。
[Objective] To study the effect of Panax notoginsenosides on pharmacokinetics of periplocin metabolite of periplocymarin in rats. [Methods] Eighteen rats were divided into periplocin alone group;periplocin combined with low-and high-dose Panax notoginsenosides groups. All rats were orally administered for seven consecutive days,blood samples were obtained from orbitalis at different time before and after the last time administration. After that,the concentration of periplocymarin in plasma was determined,and main pharmacokinetic parameters of analyte were processed. [Results] Results of pharmacokinetics showed that there were significant differences between the pharmacokinetic parameters of periplocin metabolite of periplocymarin in rats as Cmax,Tmax,AUC0-tand AUC0-∞with or without Panax notoginsenosides. [Conclusion] The compatibility of Periplocin and Panax notoginsenosides can change the pharmacokinetic behavior of periplocin metabolite of periplocymarin.
[Objective] To study the effect of Panax notoginsenosides on pharmacokinetics of periplocin metabolite of periplocymarin in rats. [Methods] Eighteen rats were divided into periplocin alone group;periplocin combined with low-and high-dose Panax notoginsenosides groups. All rats were orally administered for seven consecutive days,blood samples were obtained from orbitalis at different time before and after the last time administration. After that,the concentration of periplocymarin in plasma was determined,and main pharmacokinetic parameters of analyte were processed. [Results] Results of pharmacokinetics showed that there were significant differences between the pharmacokinetic parameters of periplocin metabolite of periplocymarin in rats as Cmax,Tmax,AUC0-tand AUC0-∞with or without Panax notoginsenosides. [Conclusion] The compatibility of Periplocin and Panax notoginsenosides can change the pharmacokinetic behavior of periplocin metabolite of periplocymarin.
引文
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[2]任晓亮,谢跃生,潘桂湘,等.香加皮强心成分杠柳毒苷肠菌代谢研究[J].天津中医药,2007,24(6):515-518.
[3]孙达,张静,陈金堂,等.香加皮中强心苷类对大鼠离体心脏的强心作用比较[J].中华中医药学刊,2011,29(12):2633-2635.
[4]Spera D,Siciliano T,Tommasi N,et al.Antiproliferative cardenolides from Periploca graeca[J].Planta Medica,2007,73(4):384-387.
[5]Bloise E,Braca A,De Tommasi N,et al.Pro-apoptotic and cytostatic activity of naturally occurring cardenolides[J].Cancer Chemotherapy Pharmacology,2009,64:793-802.
[6]Ueda J,Tezuka Y,Banskota AH,et al.Antiproliferative Activity of Cardenolides Isolated from Streptocaulon juventas[J].Biological&Pharmaceutical Bulletin,2003,26(10):1431-5.
[7]Bloise E,Braca A,De Tommasi N,et al.Pro-apoptotic and cytostatic activity of naturally occurring cardenolides[J].Cancer Chemotherapy and Pharmacology,2009,64:793-802.
[8]杨琳,林万程,施家乐.三七总皂苷药理作用的研究进展[J].安徽医药,2014,18(5):963-965.
[9]高秀梅,刘虹,周昆,等.含有人参皂苷和杠柳毒苷的药物组合物及其用途[P].天津:CN101502530,2009-08-12.
[10]刘华明,李丽,马文娟,等.三七总皂苷对杠柳毒苷药代动力学的影响[J].天津中医药,2018,35(7):539-542.