良性阵发性位置性眩晕与骨代谢的相关性研究
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摘要
良性阵发性位置性眩晕(BPPV)是一种临床常见的眩晕疾病。目前认为椭圆囊耳石脱落移位至半规管是其发生机制,但耳石脱落的原因尚不明确。由于耳石与骨有相似的成份及生理,近年来研究人员越来越多的关注BPPV与骨代谢的关系。本文通过复习文献,对国内外的相关研究进行归类总结,分析研究现状及进一步的研究方向。
Benign paroxysmal positional vertigo(BPPV) is a common vestibular disease in the clinic. It is largely agreed upon that symptoms are caused by displacement of otoconia from the utricle into the semicircular canals, but the reason for displacement is still obscure. In recent years, researchers have paid more attention to the relationship between BPPV and bone metabolism due to the similar composition and physiology of otoconia and bone. This paper summarizes the relevant researches around the world through article review and discusses on the research status and further directions.
Benign paroxysmal positional vertigo(BPPV) is a common vestibular disease in the clinic. It is largely agreed upon that symptoms are caused by displacement of otoconia from the utricle into the semicircular canals, but the reason for displacement is still obscure. In recent years, researchers have paid more attention to the relationship between BPPV and bone metabolism due to the similar composition and physiology of otoconia and bone. This paper summarizes the relevant researches around the world through article review and discusses on the research status and further directions.
引文
1 Vibert D,Kompis M,H?usler R.Benign Paroxysmal Positiona Vertigo in Older Women May be Related to Osteoporosis and Osteopenia[J].Ann Otol Rhinol Laryngol,2003 Oct;112(10):885-9.
2 Jeong SH,Choi SH,Kim JY,et al.Osteopenia and Osteoporosis in Idiopathic Benign Positional Vertigo[J].Neurology,2009 Mar 24;72(12):1069-1076.
3翟秀云,刘博,张玉和,等.良性阵发性位置性眩晕患者的骨密度研究与分析[J].临床耳鼻咽喉头颈外科杂志,2016,23:1865-1869,1872.Zhai XY,Liu B,Zhang YH,et al.Analysis of BPPV in Patients with Bone Mineral Density Results[J].J Clin Otorhinolaryngol Head Neck Surg(China),2016,23:1865-1869,1872.
4 Yamanaka T,Shirota S,Sawai Y,et al.Osteoporosis as a Risk Factor for the Recurrence of Benign Paroxysmal Positional Vertigo[J].Laryngoscope,2013 Nov;123(11):2813-2816.
5 Yu S,Liu F,Cheng Z,et al.Association between Osteoporosis and Benign Paroxysmal Positional Vertigo:a Systematic Review[J].BMC Neurol,2014 May 20;14:110.
6 Lee SB,Lee CH,Kim YJ,et al.Biochemical Markers of Bone Turnover in Benign Paroxysmal Positional Vertigo[J].PLo S One,2017 May 3;12(5):e0176011.
7 Parham K,Leonard G,Feinn RS.et al.Prospective Clinical Investigation of the Relationship between Idiopathic Benign Paroxysmal Positional Vertigo and Bone Turnover:a Pilot Study[J].Laryngoscope,2013 Nov;123(11):2834-2839.
8 Parham K,Sacks D,Bixby C,et al.Inner Ear Protein as a Biomarker in Circulation[J]?Otolaryngol Head Neck Surg,2014 Dec;151(6):1038-1040.
9 Deans MR,Peterson JM,Wong GW.Mammalian Otolin:a Multimeric Glycoprotein Specific to the Inner Ear that Interacts with Otoconial Matrix Protein Otoconin-90 and Cerebellin-l[J].PLo SOne,2010,5(9).
10 Sacks D,Parham K.Preliminary Report on the Investigation of the Association between BPPV and Osteoporosis Using Biomarkers[J].Otol Neurotol,2015 Sep;36(9):1532-1536.
11 Clarke BL,Khosla S.Physiology of Bone Loss[J].Radiol Clin North Am,2010 May;48(3):483-495.
12王淑芳,张莉,李国慧,等.围绝经期女性良性阵发性位置性眩晕患者雌孕激素水平和血钙浓度的变化[J].中华耳鼻咽喉头颈外科杂志,2017,52(4):287-290.Wang SF,Zhang L,Li GH,et al.The Change of Female Progesterone Level and Blood Calcium Concentration in Perimenopausal Women with Benign Paroxysmal Positional Vertigo[J].Chin J Otorhinolaryngol Head Neck Surg,2017,52(4):287-290.
13 Vibert D,Sans A,Kompis M,et al.Ultrastructural Changes in Otoconia of Osteoporotic Rats[J].Audiol Neurootol,2008;13(5):293-301.
14 Yamauchi D,Nakaya K,Raveendran NN,et al.Expression of Epithelial Calcium Transport System in Rat Cochlea and Vestibular Labyrinth[J].BMC Physiology,2010;10:1-12.
15 Lteif AA,Han K,Mather KJ.0besity,Insulin Resistance,and the Metabolic Syndrome:Determinants of Endothelial Dysfunction in Whites and Blacks[J].Circulation,2013,112(1):32-38.
16 von Brevern M,Radtke A,Lezius F,et al.Epidemiology of Benign Paroxysmal Positional Vertigo:a Population Based Study[J].JNeurol Neurosurg Psychiatry,2007 Jul;78(7):710-715.
17 Jang Y,Hwang CH,Shin JY.Age-related Changes on the Morphology of the Otoconia[J].Laryngoscope,2006 Jun;116(6):996-1001.
18 Walther LE,Wenzel A,Buder J,et al.Detection of Human Utricular Otoconia Degeneration in Vital Specimen and Implications for Benign Paroxysmal Positional Vertigo[J].Eur Arch Otorhinolaryngol,2014 Dec;271(12):3133-3138.
19汪晓锋,林昶,程金妹.ABAD、雌激素受体、bcl-2、Bax在小鼠内耳中的表达差异[J].中华耳科学杂志,2008,6(4):454-458.Wang XF,Lin C,Cheng JM.Expression of ABAD,Estrogen,bcl-2and Bax in the Mouse Inner Ears.Chinese Journal of Otology2008,6(4):454-458.
20 Sheneen Meghji,et al.The Seasonal Variation of Benign Paroxysmal Positional Vertigo[J].Otol Neurotol,2017 Oct;38(9)1315-1318.
21 Basil M.N.Saeed,Alyaa Farouk Omari.Climatic Variations and Benign Paroxysmal Positional Vertigo[J].Chinese Journal of Otology,2016,1:33-37.
22 Jeong SH,Kim JS,Shin JW,et al.Decreased Serum Vitamin D in Idiopathic Benign Paroxysmal Positional Vertigo[J].J Neurol2013 Mar;260(3):832-838.
23 Kahraman SS,Ozcan O,Arli C,et al.Calcium Homeostasis During Attack and Remission in Patients With Idiopathic Benign Paroxysmal Positional Vertigo[J].Otol Neurotol,2016 Oct;37(9)1388-1392.
24 Yamauchi D,Raveendran NN,Pondugula SR,et al.Vitamin DUpregulates Expression of ECa C1 m RNA in Semicircular Cana[J].Biochem Biophys Res Commun,2005,331(4):1353-1357.
25杨佩珍,陈彦林,马焱燚,等.良性阵发性位置性眩晕诊治分析[J].中华耳科学杂志,2017,15(6):653-656.Yang PZ,Chen YL,Ma YY,et al.Diagnosis and Treatment of Benign Paroxysmal Positional Vertigo:A Case Series Report.Chinese Journal of Otology,2017,15(6):653-656.
26王英歌,潘黎静,顾晰,等.顽固性良性阵发性位置性眩晕的发病机制及治疗[J].中华耳科学杂志,2011,9(4):372-375.Wang YG,Pan LJ,Gu X,et al.Pathogenesis and Treatment of Intractable Benign Paroxysmal Positional Vertigo.Chinese Journal of Otology,2011,9(4):372-375.
27 Kim SY,Han SH,Kim YH,et al.Clinical Features of Recurrence and Osteoporotic Changes in Benign Paroxysmal Positional Vertigo[J].Auris Nasus Larynx,2017 Apr;44(2):156-161.
28 Talaat HS,Abuhadied G,Talaat AS,et al.Low Bone Mineral Density and Vitamin D Deficiency in Patients with Benign Positional Paroxysmal Vertigo[J].Eur Arch Otorhinolaryngol,2015 Sep;272(9):2249-2253.
29 Mikulec AA,Kowalczyk KA,Pfitzinger ME,et al.Negative Association between Treated Osteoporosis and Benign Paroxysmal Positional Vertigo in Women[J].J Laryngol Otol,2010 Apr;124(4):374-376.
30 Büki B,Ecker M,Jünger H,et al.Vitamin D Deficiency and Benign Paroxysmal Positioning Vertigo[J].Med Hypotheses,2013Feb;80(2):201-204.
2 Jeong SH,Choi SH,Kim JY,et al.Osteopenia and Osteoporosis in Idiopathic Benign Positional Vertigo[J].Neurology,2009 Mar 24;72(12):1069-1076.
3翟秀云,刘博,张玉和,等.良性阵发性位置性眩晕患者的骨密度研究与分析[J].临床耳鼻咽喉头颈外科杂志,2016,23:1865-1869,1872.Zhai XY,Liu B,Zhang YH,et al.Analysis of BPPV in Patients with Bone Mineral Density Results[J].J Clin Otorhinolaryngol Head Neck Surg(China),2016,23:1865-1869,1872.
4 Yamanaka T,Shirota S,Sawai Y,et al.Osteoporosis as a Risk Factor for the Recurrence of Benign Paroxysmal Positional Vertigo[J].Laryngoscope,2013 Nov;123(11):2813-2816.
5 Yu S,Liu F,Cheng Z,et al.Association between Osteoporosis and Benign Paroxysmal Positional Vertigo:a Systematic Review[J].BMC Neurol,2014 May 20;14:110.
6 Lee SB,Lee CH,Kim YJ,et al.Biochemical Markers of Bone Turnover in Benign Paroxysmal Positional Vertigo[J].PLo S One,2017 May 3;12(5):e0176011.
7 Parham K,Leonard G,Feinn RS.et al.Prospective Clinical Investigation of the Relationship between Idiopathic Benign Paroxysmal Positional Vertigo and Bone Turnover:a Pilot Study[J].Laryngoscope,2013 Nov;123(11):2834-2839.
8 Parham K,Sacks D,Bixby C,et al.Inner Ear Protein as a Biomarker in Circulation[J]?Otolaryngol Head Neck Surg,2014 Dec;151(6):1038-1040.
9 Deans MR,Peterson JM,Wong GW.Mammalian Otolin:a Multimeric Glycoprotein Specific to the Inner Ear that Interacts with Otoconial Matrix Protein Otoconin-90 and Cerebellin-l[J].PLo SOne,2010,5(9).
10 Sacks D,Parham K.Preliminary Report on the Investigation of the Association between BPPV and Osteoporosis Using Biomarkers[J].Otol Neurotol,2015 Sep;36(9):1532-1536.
11 Clarke BL,Khosla S.Physiology of Bone Loss[J].Radiol Clin North Am,2010 May;48(3):483-495.
12王淑芳,张莉,李国慧,等.围绝经期女性良性阵发性位置性眩晕患者雌孕激素水平和血钙浓度的变化[J].中华耳鼻咽喉头颈外科杂志,2017,52(4):287-290.Wang SF,Zhang L,Li GH,et al.The Change of Female Progesterone Level and Blood Calcium Concentration in Perimenopausal Women with Benign Paroxysmal Positional Vertigo[J].Chin J Otorhinolaryngol Head Neck Surg,2017,52(4):287-290.
13 Vibert D,Sans A,Kompis M,et al.Ultrastructural Changes in Otoconia of Osteoporotic Rats[J].Audiol Neurootol,2008;13(5):293-301.
14 Yamauchi D,Nakaya K,Raveendran NN,et al.Expression of Epithelial Calcium Transport System in Rat Cochlea and Vestibular Labyrinth[J].BMC Physiology,2010;10:1-12.
15 Lteif AA,Han K,Mather KJ.0besity,Insulin Resistance,and the Metabolic Syndrome:Determinants of Endothelial Dysfunction in Whites and Blacks[J].Circulation,2013,112(1):32-38.
16 von Brevern M,Radtke A,Lezius F,et al.Epidemiology of Benign Paroxysmal Positional Vertigo:a Population Based Study[J].JNeurol Neurosurg Psychiatry,2007 Jul;78(7):710-715.
17 Jang Y,Hwang CH,Shin JY.Age-related Changes on the Morphology of the Otoconia[J].Laryngoscope,2006 Jun;116(6):996-1001.
18 Walther LE,Wenzel A,Buder J,et al.Detection of Human Utricular Otoconia Degeneration in Vital Specimen and Implications for Benign Paroxysmal Positional Vertigo[J].Eur Arch Otorhinolaryngol,2014 Dec;271(12):3133-3138.
19汪晓锋,林昶,程金妹.ABAD、雌激素受体、bcl-2、Bax在小鼠内耳中的表达差异[J].中华耳科学杂志,2008,6(4):454-458.Wang XF,Lin C,Cheng JM.Expression of ABAD,Estrogen,bcl-2and Bax in the Mouse Inner Ears.Chinese Journal of Otology2008,6(4):454-458.
20 Sheneen Meghji,et al.The Seasonal Variation of Benign Paroxysmal Positional Vertigo[J].Otol Neurotol,2017 Oct;38(9)1315-1318.
21 Basil M.N.Saeed,Alyaa Farouk Omari.Climatic Variations and Benign Paroxysmal Positional Vertigo[J].Chinese Journal of Otology,2016,1:33-37.
22 Jeong SH,Kim JS,Shin JW,et al.Decreased Serum Vitamin D in Idiopathic Benign Paroxysmal Positional Vertigo[J].J Neurol2013 Mar;260(3):832-838.
23 Kahraman SS,Ozcan O,Arli C,et al.Calcium Homeostasis During Attack and Remission in Patients With Idiopathic Benign Paroxysmal Positional Vertigo[J].Otol Neurotol,2016 Oct;37(9)1388-1392.
24 Yamauchi D,Raveendran NN,Pondugula SR,et al.Vitamin DUpregulates Expression of ECa C1 m RNA in Semicircular Cana[J].Biochem Biophys Res Commun,2005,331(4):1353-1357.
25杨佩珍,陈彦林,马焱燚,等.良性阵发性位置性眩晕诊治分析[J].中华耳科学杂志,2017,15(6):653-656.Yang PZ,Chen YL,Ma YY,et al.Diagnosis and Treatment of Benign Paroxysmal Positional Vertigo:A Case Series Report.Chinese Journal of Otology,2017,15(6):653-656.
26王英歌,潘黎静,顾晰,等.顽固性良性阵发性位置性眩晕的发病机制及治疗[J].中华耳科学杂志,2011,9(4):372-375.Wang YG,Pan LJ,Gu X,et al.Pathogenesis and Treatment of Intractable Benign Paroxysmal Positional Vertigo.Chinese Journal of Otology,2011,9(4):372-375.
27 Kim SY,Han SH,Kim YH,et al.Clinical Features of Recurrence and Osteoporotic Changes in Benign Paroxysmal Positional Vertigo[J].Auris Nasus Larynx,2017 Apr;44(2):156-161.
28 Talaat HS,Abuhadied G,Talaat AS,et al.Low Bone Mineral Density and Vitamin D Deficiency in Patients with Benign Positional Paroxysmal Vertigo[J].Eur Arch Otorhinolaryngol,2015 Sep;272(9):2249-2253.
29 Mikulec AA,Kowalczyk KA,Pfitzinger ME,et al.Negative Association between Treated Osteoporosis and Benign Paroxysmal Positional Vertigo in Women[J].J Laryngol Otol,2010 Apr;124(4):374-376.
30 Büki B,Ecker M,Jünger H,et al.Vitamin D Deficiency and Benign Paroxysmal Positioning Vertigo[J].Med Hypotheses,2013Feb;80(2):201-204.