2013—2016年北京地区孕妇维生素A、维生素E营养水平
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摘要
目的分析和描述2013—2016年北京地区孕妇维生素A和维生素E营养水平。方法选取2013年1月—2016年12月北京地区18～47岁孕妇首次到医院就诊同时检测维生素A、维生素E血清样本5487例,采用高效液相色谱法定量测定血清维生素A、维生素E的浓度,并与正常人群血清维生素A、维生素E的浓度作比较。定性分析2013—2016年4年间孕妇维生素A、维生素E营养状况变化趋势及改善状况。结果 2013—2016年间,北京地区孕妇血清维生素A的检测值[以中位数(四分位数间距)表示]分别为1.23 (1.05～1.44)、1.40 (1.19～1.68)、1.51 (1.30～1.75)和1.54 (1.30～1.79)μmol/L,总体异常率4年分别为22.3%、14.6%、8.1%和8.6%,以缺乏为主要表现(21.6%、13.4%、6.8%和6.4%);血清维生素E的检测值[以中位数(四分位数间距)表示]分别为36.00 (28.80～45.00)、30.72 (25.44～37.92)、30.00 (24.96～35.52)和31.68 (26.40～37.92)μmol/L,总体异常率4年分别为17.4%、7.5%、3.6%和4.3%,以过量为主要表现(17.4%、7.5%、3.6%和4.0%)。结论 2013—2016年北京地区孕妇血清维生素A水平呈逐年上升趋势,血清维生素E水平呈先下降后上升的趋势。维生素A、维生素E整体营养状况有所改善。
OBJECTIVE To describe the nutrition level of vitamin A and vitamin E among pregnancy of Beijing and the trends from 2013 to 2016. METHODS A total of 5487 serum samples from pregnant women who simultaneous detection for the first time from January 2013 to December 2016 in Beijing were enrolled in the study,then high performance liquid chromatography(HPLC) method was used to determine the concentration of serum vitamin A and vitamin E, and it was compared with serum concentrations of vitamin A, vitamin E in normal people. Qualitative analysis of the trend of vitamin A and vitamin E nutrition in pregnant women from 2013 to 2016. RESULTS From 2013 to 2016, the serum concentration of vitamin A(median(four guantile sapcing))was 1.23(1.05-1.44), 1.40(1.19-1.68), 1.51(1.30-1.75) and 1.54(1.30-1.79) μmol/L, respectively. The total abnormal rate for four years running was 22.3%, 14.6%, 8.1% and 8.6%, respectively, with main performance of lacking(21.6%, 13.4%, 6.8% and 6.4%, respectively). The serum concentration of vitamin E(median(four guantile sapcing)) was 36.00(28.80-45.00), 30.72(25.44-37.92), 30.00(24.96-35.52) and 31.68(26.40-37.92) μmol/L, respectively. The total abnormal rate from 2013 to 2016 was 17.4%, 7.5%, 3.6% and 4.3%, respectively, with excess(17.4%, 7.5%, 3.6% and 4.0%, respectively) as the main performance. CONCLUSION For the pregnancy of Beijing between 2013 and 2016, the nutrition level of vitamin A showed an increasing trend and serum vitamin E level showed a tendency to decrease first and then rise. The overall nutritional status of vitamin A and vitamin E had improved.
OBJECTIVE To describe the nutrition level of vitamin A and vitamin E among pregnancy of Beijing and the trends from 2013 to 2016. METHODS A total of 5487 serum samples from pregnant women who simultaneous detection for the first time from January 2013 to December 2016 in Beijing were enrolled in the study,then high performance liquid chromatography(HPLC) method was used to determine the concentration of serum vitamin A and vitamin E, and it was compared with serum concentrations of vitamin A, vitamin E in normal people. Qualitative analysis of the trend of vitamin A and vitamin E nutrition in pregnant women from 2013 to 2016. RESULTS From 2013 to 2016, the serum concentration of vitamin A(median(four guantile sapcing))was 1.23(1.05-1.44), 1.40(1.19-1.68), 1.51(1.30-1.75) and 1.54(1.30-1.79) μmol/L, respectively. The total abnormal rate for four years running was 22.3%, 14.6%, 8.1% and 8.6%, respectively, with main performance of lacking(21.6%, 13.4%, 6.8% and 6.4%, respectively). The serum concentration of vitamin E(median(four guantile sapcing)) was 36.00(28.80-45.00), 30.72(25.44-37.92), 30.00(24.96-35.52) and 31.68(26.40-37.92) μmol/L, respectively. The total abnormal rate from 2013 to 2016 was 17.4%, 7.5%, 3.6% and 4.3%, respectively, with excess(17.4%, 7.5%, 3.6% and 4.0%, respectively) as the main performance. CONCLUSION For the pregnancy of Beijing between 2013 and 2016, the nutrition level of vitamin A showed an increasing trend and serum vitamin E level showed a tendency to decrease first and then rise. The overall nutritional status of vitamin A and vitamin E had improved.
引文
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[3] 胡亚美, 江载芳, 申昆玲, 等. 诸福棠实用儿科学[M].8版.北京:人民卫生出版社,2015:556.
[4] BOWMAN B A, RUSSEL R M.现代营养学[M].8版.荫士安,汪之顼,译. 北京:化学工业出版社,2004:195.
[5] KAM R K, DENG Y, CHEN Y L, et al. Retinoic acid synthesis and functions in early embryonic development [J].Cell Biosci, 2012,2(1):11
[6] RAMAKRISHNAN U, GRANT F. Effect of women’s nutrition before and during early pregnancy on maternal and infant outcomes:a systematic review[J]. Paediatr Perinat Epi, 2012, 26(s1):285-301.
[7] 张明军. 运动改善视黄醇结合蛋白4(RBP4)诱导的胰岛素抵抗的机制研究[D]. 福州:福建师范大学,2011.
[8] 胡玉红, 欧阳银.血清胆红素和维生素 A 与妊娠期高血压疾病的相关性 [J]. 黑龙江医药科学,2017,40(2):3-5.
[9] 杨亭, 谷燕, 魏小平, 等. 妊娠期妇女贫血及体内相关微量营养物水平的调查和分析[J].上海交通大学学报(医学版), 2014, 34(4):542-545.
[10] 窦清惠, 魏丽. 维生素A与骨质疏松症 [J].中国骨质疏松杂志,2008, 14(2):134-137.
[11] 李云, 罗浩, 王瑞淑, 等. 维生素 A的致畸性以及锌对其致畸作用的影响 [J].华西医科大学学报,2002,33(4): 613-616.
[12] ABDUKALYKOVA S T, ZHAO X, RUIZ-FERIA C A. Arginine and vitamin E modulate the subpopulations of Tlymphocytes in broiler chickens[J]. Poultry Sci, 2008, 85:50-55.
[13] 刘燕飞, 王娟, 刘亚飞.维生素E对体外人绒毛膜滋养细胞抗凋亡保护机制的研究 [J].中国妇幼保健, 2017,10(32):2209-2211.
[14] LEY S H, HANLEY A J, SERMER M, et al. Lower dietary vitamin E intake during the second trimester is associated with insulin resistance and hyperglycemia later in pregnancy [J].Eur J Clin Nutr, 2013, 67(11):1154-1156.
[15] ROBERTS J M, MYATT L, SPONG C Y, et al.Vitamins C and E to prevent complications of pregnancy-associated hypertension [J].Engl J Med,2010,362(4):1282-1291.
[16] SAMIRA F, MOHAMED M S, CHAHNEZ K M, et al. Vitamin A, E, and D deficiencies in tunisian very low birth weight neonates: prevalence and risk factors [J]. Pediatr Neonatol, 2014, 55(3): 196-201.
[17] FUKUI K, NAKAMURA K, SHIRAI M, et al. Long-term vitamin E-deficient mice exhibit cognitive dysfunction via elevation of brain oxidation[J]. J Nutr Sci Vitaminol, 2015, 61(5):362-368.
[18] KLEMMENSEN ? K , TABOR A, ?STERDAL M L, et al. Intake of vitamin C and E in pregnancy and risk of pre-eclampsia: prospective study among 57 346 women [J]. BJOG, 2009,116(7):964-974.
[19] 蒋红清, 陈寒, 倪君君. 北京市孕妇常规保健下血清维生素A、E水平现状[J].解放军医学院学报, 2015,35(11):1118-1121.
[20] 申南,陆娣,郑春梅,等.常规保健下不同年龄段孕妇妊娠早期血清维生素A、E水平分析[J].中国妇产科临床杂志,2018,4(19):356-358.
[21] 杨瑞利, 韩双, 沈建军,等.西安地区妊娠期女性血清维生素 A、E水平分析[J]. 湖南医学, 2017,9(28):1426-1428.
[22] 胡贻春,李敏,陈竞,等.2010—2012年中国农村孕妇贫血及维生素A维生素D营养状况[J].卫生研究,2017,46(3):361-372.
[23] CHEN Y J, LI Z D, MAO C Y, et al.An investigation of the levels of vitamins A, D, and E in the serum of Chinese pregnant women [J]. J Clin Lab Anal,2018,32:e22176.
[2] HOVDENAK N,HARAM K. Influence of mineral and vitamin supplementson pregnancy outcome[J]. Eur J Obstet Gynecol Reprod Biol,2012,164(2):127-132.
[3] 胡亚美, 江载芳, 申昆玲, 等. 诸福棠实用儿科学[M].8版.北京:人民卫生出版社,2015:556.
[4] BOWMAN B A, RUSSEL R M.现代营养学[M].8版.荫士安,汪之顼,译. 北京:化学工业出版社,2004:195.
[5] KAM R K, DENG Y, CHEN Y L, et al. Retinoic acid synthesis and functions in early embryonic development [J].Cell Biosci, 2012,2(1):11
[6] RAMAKRISHNAN U, GRANT F. Effect of women’s nutrition before and during early pregnancy on maternal and infant outcomes:a systematic review[J]. Paediatr Perinat Epi, 2012, 26(s1):285-301.
[7] 张明军. 运动改善视黄醇结合蛋白4(RBP4)诱导的胰岛素抵抗的机制研究[D]. 福州:福建师范大学,2011.
[8] 胡玉红, 欧阳银.血清胆红素和维生素 A 与妊娠期高血压疾病的相关性 [J]. 黑龙江医药科学,2017,40(2):3-5.
[9] 杨亭, 谷燕, 魏小平, 等. 妊娠期妇女贫血及体内相关微量营养物水平的调查和分析[J].上海交通大学学报(医学版), 2014, 34(4):542-545.
[10] 窦清惠, 魏丽. 维生素A与骨质疏松症 [J].中国骨质疏松杂志,2008, 14(2):134-137.
[11] 李云, 罗浩, 王瑞淑, 等. 维生素 A的致畸性以及锌对其致畸作用的影响 [J].华西医科大学学报,2002,33(4): 613-616.
[12] ABDUKALYKOVA S T, ZHAO X, RUIZ-FERIA C A. Arginine and vitamin E modulate the subpopulations of Tlymphocytes in broiler chickens[J]. Poultry Sci, 2008, 85:50-55.
[13] 刘燕飞, 王娟, 刘亚飞.维生素E对体外人绒毛膜滋养细胞抗凋亡保护机制的研究 [J].中国妇幼保健, 2017,10(32):2209-2211.
[14] LEY S H, HANLEY A J, SERMER M, et al. Lower dietary vitamin E intake during the second trimester is associated with insulin resistance and hyperglycemia later in pregnancy [J].Eur J Clin Nutr, 2013, 67(11):1154-1156.
[15] ROBERTS J M, MYATT L, SPONG C Y, et al.Vitamins C and E to prevent complications of pregnancy-associated hypertension [J].Engl J Med,2010,362(4):1282-1291.
[16] SAMIRA F, MOHAMED M S, CHAHNEZ K M, et al. Vitamin A, E, and D deficiencies in tunisian very low birth weight neonates: prevalence and risk factors [J]. Pediatr Neonatol, 2014, 55(3): 196-201.
[17] FUKUI K, NAKAMURA K, SHIRAI M, et al. Long-term vitamin E-deficient mice exhibit cognitive dysfunction via elevation of brain oxidation[J]. J Nutr Sci Vitaminol, 2015, 61(5):362-368.
[18] KLEMMENSEN ? K , TABOR A, ?STERDAL M L, et al. Intake of vitamin C and E in pregnancy and risk of pre-eclampsia: prospective study among 57 346 women [J]. BJOG, 2009,116(7):964-974.
[19] 蒋红清, 陈寒, 倪君君. 北京市孕妇常规保健下血清维生素A、E水平现状[J].解放军医学院学报, 2015,35(11):1118-1121.
[20] 申南,陆娣,郑春梅,等.常规保健下不同年龄段孕妇妊娠早期血清维生素A、E水平分析[J].中国妇产科临床杂志,2018,4(19):356-358.
[21] 杨瑞利, 韩双, 沈建军,等.西安地区妊娠期女性血清维生素 A、E水平分析[J]. 湖南医学, 2017,9(28):1426-1428.
[22] 胡贻春,李敏,陈竞,等.2010—2012年中国农村孕妇贫血及维生素A维生素D营养状况[J].卫生研究,2017,46(3):361-372.
[23] CHEN Y J, LI Z D, MAO C Y, et al.An investigation of the levels of vitamins A, D, and E in the serum of Chinese pregnant women [J]. J Clin Lab Anal,2018,32:e22176.